Reactions 922 - 5 Oct 2002

■ Female gender appears to be a strongindependent predictor of non-nucleoside reversetranscriptase inhibitor (NNRTI)-induced rash,according to researchers from England. Theyconducted a retrospective review of records of 337patients with HIV infection who started treatment witheither nevirapine (n = 285) or efavirenz (52), incombination with 2 other antiretrovirals, at theirinstitution between January 1997 and January 2000;103 patients were women and 160 patients were ofBlack ethnicity. 19 (6.7%) patients receiving nevirapineand 3 (5.8%) patients receiving efavirenz developed arash. The incidence of rash was significantly higheramong women than among men [odds ratio (OR)5.53; 95% CI 2.18–14.01] and higher among Blackpatients than among Caucasian patients (1.93;0.78–4.73), although this difference was notsignificant. After adjustment for ethnicity, femalegender remained a strong independent predictor ofrash (OR 8.66; 95% CI 2.42–31.08).Mazhude C, et al. Female sex but not ethnicity is a strong predictor of non-nucleoside reverse transcriptase inhibitor-induced rash. AIDS 16: 1566-1568,26 Jul 2002 800918244

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Reactions 5 Oct 2002 No. 9220114-9954/10/0922-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved