faik oruçoğlu (orucov) kudret eye hospital / istanbul
DESCRIPTION
Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness. Faik Oruçoğlu (Orucov) Kudret Eye Hospital / Istanbul. Purpose. - PowerPoint PPT PresentationTRANSCRIPT
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Pachymetric changes during corneal collagen cross-linking and
effect of hydroxipropylmethylcellulose on
corneal thickness
Faik Oruçoğlu(Orucov)
Kudret Eye Hospital / Istanbul
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Purpose
To evaluate central corneal pachymetric changes during corneal collagen cross-linking (CXL) and effect of hydroxipropylmethylcellulose (HPMC) drops.
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Hydroxipropylmethylcellulose
Hypromellose• Hydrophylic• pH: 7,2-7,9• Osmolarity 240-300 mOsm
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Spoerl E,.Safety of UVA-riboflavin cross-linking of the cornea. Cornea 2007;26:385–9
Ophthalmology 2009; 116(12) 2336-9
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Methods
Grup 1. (N=18). • Epithelial abrasion (9mm)• 0.1 % Riboflavin drops in dextrane every 3 minutes for 30 minutes. • UVA 3mw/cm2 at 365nm for 30 min
Grup 2. (N=21). • Epithelial abrasion (9mm)• 0.1 % Riboflavin drops in dextrane every 3 minutes and
hydroxipropylmethylcellulose (HPMC) every 5 minutes for 30 minutes. • UVA 3mw/cm2 at 365nm for 30 min
Two groups were formed in patients with keratoconus undergoing cross-linking ;
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Central corneal thicknesses were measured by ultrasound pachimetry
– before epithelial abrasion, – after epithelial abrasion and – 30 minutes after beginning riboflavin installation
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Before epithelial abrasion After epithelial abrasion P
Grup 1 457.2 + 62.6 395±54,9 <0,001
Grup 2 449.7 + 62.6 389,4±44,2 0,009
After epithelial abrasion 30 minutes after riboflavin installation
P
Grup 1 395±54,9 360±44,4 <0,001
Grup 2 389,4±44,2 374,4±38,1 0,08
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Group 1
Group 2
After epithelial abrasion 30 minutes after riboflavin
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Conclusion Decrease of corneal thickness continues with
epithelial peeling. This decrease in corneal thickness is significantly reduced by continuing the procedure with the addition of HPMC.
Rb+Dextran H2O Rb+Dextran H2OHPMC
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Thank you for your attention