factores que modifican la toxicidad
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EDAD GERIÁTRICA
Deterioro de la función hepática y renal.Incremento del pH del jugo gástrico.
Disminución de la motilidad intestinaly atrofia de la mucosa.
Menor proporción de albúmina plasmáticay otras proteínas transportadoras.
Aumento del tejido adiposo y disminuciónde la masa muscular y el agua total.
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Insuficiencia hepática(por reducción de lacapacidad metabolizante general)
Aumentan la vida media del tóxicoal prolongar el tiempo de
permanencia en el organismo
Insuficiencia renal
Insuficiencia hepática+
ESTADO DE SALUD
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