face and body designer...with lack of firmness & slackening of facial skin as well as cheek and...

Slim-Excess®

Face and Body

Designer

2 BASF Personal Care

1 | The Challenge

2 | The Solution

3 | Efficacy Data

4 | Summary & Conclusion

BASF Personal Care 2

Fat & Face

BASF Personal Care

When fats accumulate in these pockets, the face

appears too round and its profile becomes

heavier.

How is fat distributed on our face?

& - two on the cheeks

& - two under the jaw

- one under the chin.

1 2

3 4 5

V-shape U-shape

Overtime facial bones and muscle fibers,

that hold fat pockets at the right places,

lose volume.

Fat shifts downward baggy chins and

jowls, double-chin.

20 60

3

Young

face

Aging

face

Superficial fat pads

V-shape physiology



1 | The Challenge

2 | The Solution

3 | Efficacy Data



Helping to "clear" excess

fat from the face

Slim-Excess®

The face designer

Slim-Excess™ turns “U” shape into “V” shape

for a more triangular & feminine lower face by:

Unveil a more feminine and younger face

Creating perfect V-shaped

contours from every facet

Refining and defining facial

contours on cheeks, jawline and

chin

U Face V Face


Ingredient Presentation

Slim-Excess® : How does it work ?

fatty acid uptake lipid synthesis and triglyceride storage glucose uptake

cAMP signalling

Preadipocyte differentiation

Lipogenesis

Lipolysis

Adipogenesis

Spermine / Spermidine

SLIM-EXCESS®

Trapped polyamines


Spermidine Slim-Excess®

sulfo-carrabiose

Slim-Excess®

Molecular modelling and interactions

Spermidine

Slim-

Excess® Slim-

Excess™

Spermidine

Slim-

Excess®

Interaction of one Slim-Excess® molecule

with one spermidine molecule

Interaction of three Slim-Excess® molecules

with one spermidine molecule



1 | The Challenge

2 | The Solution

3 | Efficacy Data



Slim-Excess® increases lipolysis by 87%.

Cultured adipocytes from abdominal biopsy, measurement of Free Fatty Acid release

Lipolysis

The Breakdown of Adipose Tissue


Lipogenesis

The Production of Adipose Tissue

Cultured adipocytes from abdominal biopsy, measurement of radio-labeled acetate incorporation.

Slim-Excess® reduces lipogenesis by 79%.


Pre-adipocyte

culture

Mature

adipocytes

Adipogenesis

Pre-adipocyte proliferation

Cultured adipocytes from abdominal biopsy, cell counting after 7 days.

Slim-Excess® reduces adipocyte proliferation by 35%.


BASF Personal Care

In vivo study design

Protocol

* Same

concentration in

active matter as in

commercial product

Slim-Excess™

23-26 Chinese female volunteers over 45-year-old, with lack of firmness & slackening of facial skin as well as cheek and chin sagging

Randomized, double-blind, baseline-controlled full-face study

Twice daily-applications for 12 weeks of a serum containing Slim-Excess® 2%*

Evaluation time-points: baseline, 4, 8 and 12 weeks

Macrophotographs analysis

Biomechanical properties evaluation

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BASF Personal Care

Cheek/chin angle (degree) from the front photographs of the face

Measurement of inflexion angle between the cheek and the chin.

All the results are expressed in percentage of modification versus D0.

An improvement is characterized by

an increase of the cheek/chin angle

Photographs analysis

Cheek/chin angle

14

< 180°

Increase of the chin/cheek

inflexion angle

=

Face contour correction

BASF Personal Care


Cheek/chin angle

Statistically significant

improvement of

cheek/chin angle

Slim-Excess®

significantly better

than the placebo

after 8 weeks

15

improves the

cheek/chin angle in

case of 82 % of the

volunteers.

BASF Personal Care

Double chin measurement (mm²) from the profile photographs of the face

The area of the double chin is defined by:

inflexion point between the chin and the double chin,

inflexion point between the neck and the double chin,

the profile of the double chin which will be modeled by a manual

capture and a polynomial interpolation.

All the results are expressed in percentage of modification versus D0.

An improvement is characterized by

a decrease of the double chin area


Double chin area

16

BASF Personal Care


Double chin area

Slim-Excess ®

demonstrated superior

activity comparatively to

placebo treatment.

Efficacy after 4 weeks 17

Statistically significant

decrease of double

chin surface

Principle: Contactless method

Application of the force (4g) between the times T0 and T1

Hold of the force between the time T1 and T2

Cut off the force at T2

Studied parameters:

Ratio Cr/Yf: express the elastic/viscous behavior

of the skin

A decrease of the ratio Cr/Yf express an improvement of skin elasticity

and a reduction of skin sagging behavior.

BASF Personal Care


Tonoderm™ equipment

18

Slim-Excess® demonstrated superior activity comparatively to

placebo treatment


Statistically

significant

decrease of the

ratio Cr/Yf

Skin elasticity

Skin sagging


Baseline Baseline 12 weeks

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Volunteer result examples

Slim-Excess ® 2%

Clear visible results

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12 weeks

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-12% double chin

area

Cheek/chin angle

improved by +5%



1 | The Challenge

2 | The Solution

3 | Efficacy Data




In vitro

In vivo

Increases lipolysis (the breakdown of fat) by 87%

Decrease in lipogenesis (fat production) by 79%

Decrease in adipogenesis (fat cell proliferation and maturation) by 35% a

Improvement of chin/cheek angle (indicating proper “v-shaping” effect) in

over 82% of volunteers and was statistically significant in comparison to

placebo

Decrease in double chin surface area found in over 63% of volunteers and

was statistically significant

Improvement in skin elasticity and reduction in skin sagging

Slim-Excess®

Summary of Tests – Face


INCI: Water (and) Butylene Glycol (and) Pentylene

Glycol (and) Sodium Chloride (and) Hydrolyzed

Rhodophycea Extract (and) Xanthan Gum

Dose of use: 2-3%

Solubility: water-soluble liquid

Shelf life: 12 months

Preservatives: none

Product Properties

China/ Japan Regulations

Benefits & Unique Selling Points

Targets a unique set of polyamines for inhibition of excess fat

production

Controls fat production through three pathways: increases the

breakdown of fat, inhibits fat production, and inhibits fat cell

proliferation and maturation

Visibly improves facial contour and reduces sagging skin, jowls, and

double chin

Formula suggestions: Facial Sculpting Cream SC-US-14-31208-34-1, Vibrant Glow

Renewal SC-US-31208-33-1

Body Care

Applications

Face Care Wipes Anti-Aging

Care

Formulation Instructions

Incorporate into water phase below 80◦C or at room temperature with

cold processing.

Firming

Care

Slim-Excess®

The face & body designer

PCPC INCI 2007 INCI 2010 Not Listed

Jap.

Pharma.

IECIC

2014

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Facial Sculpting Cream

Formula Chisel age away as you smooth fine lines and sagging skin. This sculpting cream visibly transforms

your facial contour as it lifts, tones, and illuminates to accentuate cheekbones and the jawline.

This document, or any answers or information provided herein by BASF, does not constitute a legally binding

obligation of BASF. While the descriptions, designs, data and information contained herein are presented in good faith

and believed to be accurate, they are provided for your guidance only. Because many factors may affect processing

or application/use, we recommend that you make tests to determine the suitability of a product for your particular

purpose prior to use. It does not relieve our customers of the obligation to perform a full inspection of the products

upon delivery or any other obligation. The claims and supporting data provided in this publication have not been

evaluated for compliance with any jurisdiction’s regulatory requirements and the results reported may not be generally

true under other conditions or in other matrices. Users must evaluate what claims and information are appropriate and

comply with a jurisdiction’s regulatory requirements. NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR

IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, ARE

MADE REGARDING PRODUCTS DESCRIBED OR DESIGNS, DATA OR INFORMATION SET FORTH, OR THAT

THE PRODUCTS, DESIGNS, DATA, OR INFORMATION MAY BE USED WITHOUT INFRINGING THE

INTELLECTUAL PROPERTY RIGHTS OF OTHERS. IN NO CASE SHALL THE DESCRIPTIONS, INFORMATION,

DATA, OR DESIGNS PROVIDED BE CONSIDERED A PART OF OUR TERM SAND CONDITIONS OF SALE.

DISCLAIMER


face and body designer...with lack of firmness & slackening of facial skin as well as cheek and...

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