eyepromise overview brochure

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866-833-2800 [email protected]

What Your Eyes Need Most.

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www.eyepromise.com

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Our MissionTo fight vision loss and preserve healthy vision through evidence-based

nutraceutical products and medical instrumentation.

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Our Company ZeaVision®, the parent company of EyePromise®, was co-founded in Chesterfield, Missouri in 2001 by Dennis Gierhart, PhD. With more than 20 years of research, Dr. Gierhart pioneered the use of Zeaxanthin for eye health use, and ZeaVision is considered one of the leading companies in ocular nutrition.

Our Quality Product quality is ZeaVision’s highest priority, which is why EyePromise nutracueticals are pharmaceutical-grade, contain the highest-quality ingredients, and are manufactured to the exacting standards of the FDA current Good Manufacturing Practices (cGMP) requirements. These regulations define standards and require compliance regarding ingredient identity, strength, purity, and composition.

font = proxima nova bold

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Our BrandsEyePromise are science-based, doctor-recommended nutraceuticals for supporting eye health. With more than 40-million doses consumed, EyePromise products are made in the U.S.A. from the highest-quality, natural ingredients. Backed by an unconditional 60-day, money-back guarantee, our patented formulas contain the highest levels of dietary Zeaxanthin available, and EyePromise is the only brand Guaranteed to Increase MPOD (Macular Pigment Optical Density).

The QuantifEye® MPS II MPOD measurement instrument is the most reliable and accurate device for measuring Macular Pigment Optical Density (MPOD). This scientifically validated instrument allows EyeCare Professionals to assess a key AMD risk factor – low macular pigment, as well as other visual performance challenges.

highest quality highest quality

NATURALIngredients

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Our DistinctionZeaxanthin – the Heart of ZeaVisionStudies show that Zeaxanthin (zee-uh-zan-thin) increases low macular pigment levels – a leading risk factor for Age-related Macular Degeneration (AMD). However, Zeaxanthin is particularly scarce in the average daily U.S. diet leaving a significant dietary gap for most people, as referenced in the diagram to the right. Our patented formulas contain the highest levels of dietary Zeaxanthin available, helping bridge that dietary gap and supporting ocular health.

All EyePromise nutraceuticals feature only the finest ingredients including ZeaGold®*, a natural, highly bio-available Zeaxanthin derived from an exclusive whole food source grown in West Texas – paprika.

Sourced from marigold flowers and purified from marigold flower oleoresin, FloraGLO®** Lutein is the world’s leading patented, purified lutein.

* ZeaGold is a registered trademark of Kalsec. ** FloraGLO is a registered trademark of Kemin Industries, Inc.

ZEAXANTHIN DIETARY GAP

6-10 mg

1-6 mg

0.5-1.0 mg

Amount Associated with Reduced AMD Risk

Dietary Gap

Average U.S. Dietary Intake

ZEAXANTHIN DIETARY GAP

6-10 mg

1-6 mg

0.5-1.0 mg

Amount Associated with Reduced AMD Risk

Dietary Gap

Average U.S. Dietary Intake

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The Scarcity of Zeaxanthin in the DietThe macular pigments, Zeaxanthin and Lutein, are found at a 2:1 ratio in the fovea. The body does not produce Zeaxanthin or Lutein, so nutritional intake and supplementation are key in maintaining healthy Macular Pigment Optical Density (MPOD).

Approximate Ratios of Zeaxanthin & Lutein

0

5

10

15

20

25

0.6

20.2

0.3

14.8

0.4

13.3

0.4

11.7

0.6

3.4

0.51.5

Collard GreensKale Spinach Turnip Greens Broccoli Corn Orange Pepper

1.2

250.0

The Scarcity of Zeaxanthin in the Diet

SO

UR

CE

: US

DA

-NC

C C

arot

enoi

d D

atab

ase

for

U.S

. Foo

ds

milli

gram

s

(1 cup per serving – cooked)

0.3

K l ll d G

0.00.40.4

Zeaxanthin

Lutein

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What is MPOD?MPOD (Macular Pigment Optical Density) is important to patients for three (3) specific reasons:

1. Low macular pigment is a key risk factor for AMD, the leading cause of significant vision loss over age 55.

2. Macular pigment absorbs harmful blue light, protecting the photo-receptors from damage.

3. Macular pigment improves visual performance, including:

Visual Acuity – ability to see clearly, especially in fine detail situations like needlepoint or reading in low light situations

Contrast Sensitivity – ability to discern objects from their background (i.e. seeing a white golf ball or baseball clearly against a light blue sky)

Light Sensitivity – visual discomfort in sunlight or when exposed to bright light

Glare Recovery – recovery from temporary “blindness” caused by high intensity lighting, such as automobiles or stadium lights

BEFORE AFTER

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Internal SunglassesMacular pigment is comprised of Zeaxanthin and Lutein, which are found in the center of the macula (fovea) at a natural 2:1 ratio. Healthy macular pigment acts as “internal sunglasses” to protect against harmful blue light that enters the eye and negatively impact the visual cells responsible for central and peripheral vision. Did you know that blue light comes from everyday sources such as: Harmful blue light

adversely affects the photo-receptors

Harmful bluelight is blocked,protecting the

photo-receptors

Blue Light Sources:

Computers Sunlight TVs Lights CellPhones

Tablets

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Blue Light ProtectionHealthy macular pigment acts like “internal sunglasses” to protect the photo-receptors (rods and cones) from harmful blue light. As indicated in the diagram below, low macular pigment (0 - .49 on the left side) allows as much as 100% of harmful blue light through to the photoreceptors. Healthy macular pigment (.50 – 1.00 on the right side) significantly blocks harmful blue light like a very effective pair of “internal sunglasses.”

100%

71%

50%

36%31%

25% 18%13%

9%

6 %

5%

3%0

.00

0.10

0.20

0.30 0.34

US Avg.

0.40 0.500.60

0.70

0.80

0.901.0

0

VISION PROTECTION

from harmful blue light

VISION RISK from harmful

blue light

Computers Sunlight TVs Lights

% H

armful Blue Light Reaching Photoreceptors

78%

of p

opulation 22% of population

Harmful blue light reaches the photoreceptors

400 - 520BLUE LIGHT HAZARD

Protect Retina withInternal Sunglasses

300 - 400UV RANGE

Protect Cornea/Lens with sun protection,

sunglasses

Harmful bluelight is blocked

before reaching thephotoreceptors

300 800Light Spectrum Wavelength

TabletsCell Phones

Blue Light SOURCES:

MPOD score

** Ciulla, Ophthalmology 2001, 108: 730-737 Hammond, Recent Research Dev. Nutr. 2002 (5)

866-833-2800 www.eyepromise.com

Our ProductsWith more than 40-million doses consumed and counting,

EyePromise is the leading brand of doctor-recommended

nutraceuticals for eye health. EyePromise products are made

in the U.S.A. from the highest-quality, natural ingredients and

backed by an unconditional 60-day, money-back guarantee.

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Nutraceutical Product Portfolio

EyePromise Restore

Flagship formula replicating the natural 2:1 ratio of Zeaxanthin to Lutein in a healthy fovea, along with other essential vitamins and nutrients. Also available in a zinc-free formula!

Formulated for:

• Patients with AMD risk factors

• Low MPOD

• Improved visual performance

EyePromise AREDS 2 Plus (Zinc-Free)

Contains the ingredients studied in the AREDS 2 clinical trial – PLUS additional protective nutrients, including Zeaxanthin, Vitamin D3, and Omega-3’s demonstrated to support healthy vision.

Formulated for:

• Patient types studied in the National Eye Institute AREDS 2 clinical trial

• Low MPOD


• Patients that want to avoid zinc

EyePromise AREDS 2 Plus (with a Multi-Vitamin)

Convenience pack containing the ingredients studied in the AREDS 2 clinical trial – PLUS a multivitamin and additional protective nutrients, including Zeaxanthin, Vitamin D3, and Omega 3’s.

Formulated for:


• Low MPOD


EyePromise Zeaxanthin + Lutein

Macular pigment formula designed to increase MPOD and protect the photoreceptors.

Formulated for:

• Vegans (contains no animal by-products)

• Patients with fish oil allergies

• Low MPOD

• AMD risk factors


ZINCFREE

ZINCFREE

Macular Health Formulas

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NSF® is a registered trademark of NSF

EyePromise Zeaxanthin

Macular pigment formula designed to increase MPOD and protect the photoreceptors.

Formulated for:

• Vegans (contains no animal by-products)

• Patients with fish oil allergies

• Low MPOD


• Patients that want only Zeaxanthin


EyePromise EZ Tears™

Dry eye and contact lens comfort formula with eight anti-inflammatory ingredients to attack dry eye from the inside, offering fast relief with the highest-quality dietary ingredients. Enteric-coated for optimal tolerability.

Formulated for:

• Contact lens dryness

• Dry eye sufferers

• Pre-and post-surgery related dry eye

• Dry eye induced by medications

• Dry eye caused by environmental irritants

EyePromise Diabetes Vision Support (DVS)

Retinal health formula designed to support blood vessel health.

Formulated for:

• Patients at risk of developing macular edema

• Patients at risk of retinal blood vessel degeneration


• Low MPOD


EyePromise vizual EDGE PRO™

Formulated and tested to improve clarity through contrast improvement, maximize performance through improved reaction time, and improve safety by enhancing vision in low lights. NSF® certified for sport.

Formulated for:

• Athletes (tennis, baseball, hockey, shooters, etc.)

• Professions where eyesight is critical for job performance

• Improved visual acuity


Diabetes Retinal Health Formula

Vision Performance Formula

Dry Eye & Contact Lens Comfort Formula

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EyePromise Restore

EyePromise AREDS 2 Plus EyePromise AREDS 2 Plus EyePromise EyePromise Zeaxanthin EyePromise EZ Tears EyePromise DVS

EyePromise (Zinc-Free) (with a Multi-Vitamin) Zeaxanthin + Lutein vizual EDGE PRO

Recommended Dose 1 or 2 softgels/day 2 softgels/day 1 Convenience Pack (CP)/day 1 or 2 vegetarian softgels/day 1 or 2 vegetarian softgels/day 2 softgels/day 2 softgels/day 1 Convenience Pack (CP)/day

Formulation per 1 softgel per 2 softgels per 1 CP (1 softgel, 1 tablet) per 1 veggie gel per 1 veggie gel per 2 softgels per 2 softgels per 1 CP ( 5 softgels)

Zeaxanthin* 8 mg 10 mg 10 mg 10 mg 10 mg - 8 mg 26 mg

Lutein* 4 mg 10 mg 10 mg 10 mg - - 4 mg 8 mg

Vitamin A (Retinyl Palmitate) - - - - - 1,000 IU - 1,000 IU

Vitamin B12 - - - - - - 6 mcg -

Vitamin C* 120 mg 500 mg 500 mg - - - 60 mg 240 mg

Vitamin D3 1,000 IU 2,000 IU 2,000 IU - - 2,000 IU 2,000 IU 4,000 IU

Vitamin E* 60 IU 400 IU 400 IU - - 60 IU 60 IU 180 IU

Zinc* 15 mg - 40 mg - - - 15 mg 30 mg

Copper* - - 2 mg - - - - -

Fish Oil EE* 250 mg 250 mg 250 mg - - 1,480 mg 320 mg 1,980 mg

Total Omega-3* 190 mg 190 mg 190 mg - - 1,100 mg 240 mg 1,480 mg

EPA/DHA* 100/75 mg 100/75 mg 100/75 mg - - 590/440 mg 128/96 mg 790/590 mg

Alpha Lipoic Acid 10 mg 10 mg 20 mg - - - 150 mg 20 mg

Coenzyme Q-10 - - - - - - 20 mg -

Mixed Tocopherols 6 mg 20 mg 20 mg - - - 20 mg 12 mg

PROPRIETARY BLEND - - - - - 250 mg 530 mg 220 mg

Evening Primrose Oil - - - - - 100 mg - 100 mg

Tocotrienols/Tocopherols - - - - - 20 mg - 20 mg

Benfotiamine - - - - - - 200 mg -

N-Acetyl-Cysteine - - - - - 30 mg 100 mg -

Grape Seed Extract - - - - - - 100 mg -

Resveratrol - - - - - - 40 mg -

Turmeric Root Extract - - - - - 50 mg 50 mg 50 mg

Green Tea Leaf - - - - - 50 mg 20 mg 50 mg

Pycnogenol® - - - - - - 20 mg -

Centrum® Silver®** Multi-Vitamin Equivalent NO NO YES NO NO NO NO NO

Gluten NO NO NO NO NO NO NO NO

Yeast NO NO NO NO NO NO NO NO

Soy YES YES YES NO NO YES YES YES

Fish (cod, Pollack, Whiting) YES YES YES NO NO YES YES YES*Ingredients studied in the AREDS 2 clinical trial **Centrum Silver is a registered trademark of Pfizer

ZINC FREE FORMULA AVAILABLE

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EyePromise Restore

EyePromise AREDS 2 Plus EyePromise AREDS 2 Plus EyePromise EyePromise Zeaxanthin EyePromise EZ Tears EyePromise DVS

EyePromise (Zinc-Free) (with a Multi-Vitamin) Zeaxanthin + Lutein vizual EDGE PRO

Recommended Dose 1 or 2 softgels/day 2 softgels/day 1 Convenience Pack (CP)/day 1 or 2 vegetarian softgels/day 1 or 2 vegetarian softgels/day 2 softgels/day 2 softgels/day 1 Convenience Pack (CP)/day

Formulation per 1 softgel per 2 softgels per 1 CP (1 softgel, 1 tablet) per 1 veggie gel per 1 veggie gel per 2 softgels per 2 softgels per 1 CP ( 5 softgels)

Zeaxanthin* 8 mg 10 mg 10 mg 10 mg 10 mg - 8 mg 26 mg

Lutein* 4 mg 10 mg 10 mg 10 mg - - 4 mg 8 mg

Vitamin A (Retinyl Palmitate) - - - - - 1,000 IU - 1,000 IU

Vitamin B12 - - - - - - 6 mcg -

Vitamin C* 120 mg 500 mg 500 mg - - - 60 mg 240 mg

Vitamin D3 1,000 IU 2,000 IU 2,000 IU - - 2,000 IU 2,000 IU 4,000 IU

Vitamin E* 60 IU 400 IU 400 IU - - 60 IU 60 IU 180 IU

Zinc* 15 mg - 40 mg - - - 15 mg 30 mg

Copper* - - 2 mg - - - - -

Fish Oil EE* 250 mg 250 mg 250 mg - - 1,480 mg 320 mg 1,980 mg

Total Omega-3* 190 mg 190 mg 190 mg - - 1,100 mg 240 mg 1,480 mg

EPA/DHA* 100/75 mg 100/75 mg 100/75 mg - - 590/440 mg 128/96 mg 790/590 mg

Alpha Lipoic Acid 10 mg 10 mg 20 mg - - - 150 mg 20 mg

Coenzyme Q-10 - - - - - - 20 mg -

Mixed Tocopherols 6 mg 20 mg 20 mg - - - 20 mg 12 mg

PROPRIETARY BLEND - - - - - 250 mg 530 mg 220 mg

Evening Primrose Oil - - - - - 100 mg - 100 mg

Tocotrienols/Tocopherols - - - - - 20 mg - 20 mg

Benfotiamine - - - - - - 200 mg -

N-Acetyl-Cysteine - - - - - 30 mg 100 mg -

Grape Seed Extract - - - - - - 100 mg -

Resveratrol - - - - - - 40 mg -

Turmeric Root Extract - - - - - 50 mg 50 mg 50 mg

Green Tea Leaf - - - - - 50 mg 20 mg 50 mg

Pycnogenol® - - - - - - 20 mg -

Centrum® Silver®** Multi-Vitamin Equivalent NO NO YES NO NO NO NO NO

Gluten NO NO NO NO NO NO NO NO

Yeast NO NO NO NO NO NO NO NO

Soy YES YES YES NO NO YES YES YES

Fish (cod, Pollack, Whiting) YES YES YES NO NO YES YES YES

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Macular Health FormulasEyePromise macular health formulas are designed to increase macular pigment, providing vision protection and enhancement. Low macular pigment is a leading risk factor for Age-related Macular Degeneration (AMD), which is the leading cause of severe vision loss in adults over the age of 55, affecting millions of Americans each year. The leading risk factors for AMD and visual performance challenges include:

AMD Risk Factors

Non-modifiable:

• Age

• Family history

• Light skin and eyes

• Female gender

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Visual Performance Challenges

• Night driving difficulty

• Discomfort due to glare (day or night)

• Sensitivity to bright light

• Difficulty seeing objects against their background (contrast sensitivity)

Healthy Vision Vision Affected by AMD

Modifiable:

• Smoking

• Poor diet

• Low macular pigment

• High body mass index


Did You Know…Seventy-eight percent (78%) of the U.S. population has less than optimal macular pigment, but significant increases can be achieved through nutritional intake and supplements containing Zeaxanthin and Lutein.

EyePromise Restore Flagship formula replicating the natural 2:1 ratio of Zeaxanthin to Lutein in a healthy fovea, along with other essential vitamins and nutrients.

Formulated for:

• Patients with AMD risk factors• Low MPOD• Visual performance

Recommended Dose:• 1 or 2 softgels per day

Formulation (per 1 softgel):• Zeaxanthin – 8 mg• Lutein – 4 mg• Vitamin C – 120 mg• Vitamin D3 – 1,000 IU• Vitamin E – 60 IU• Zinc – 15 mg• Fish Oil – 250 mg

Total Omega 3’s – 190 mg EPA – 100 mg DHA – 75 mg

• Alpha Lipoic Acid – 10 mg• Mixed Tocopherols – 6 mg• Gluten Free• Contains NO Yeast• Contains Soy and Fish (cod, Pollack, whiting)

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Healthy Night Driving Vision

Night Driving Vision Affected by Glare


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EyePromise AREDS 2 Plus (Zinc-Free)

Formulated for:• Patient types studied in the

National Eye Institute AREDS 2 clinical trial

• Low MPOD• Visual performance• Patients that want to

avoid zinc

Recommended Dose:• 2 softgels per day

Formulation (per 2 softgels):• Zeaxanthin – 10 mg • Lutein – 10 mg• Vitamin C – 500 mg• Vitamin D3 – 2,000 IU• Vitamin E – 400 IU• Fish Oil – 250 mg

Total Omega 3’– 190 mg EPA – 100 mg DHA – 75 mg

• Mixed Tocopherols – 20 mg• Alpha Lipoic Acid – 10 mg• Gluten Free• Contains NO Yeast• Contains Soy and Fish

(cod, Pollack, whiting)

EyePromise AREDS 2 Plus (Zinc-Free) Contains the ingredients studied in the AREDS 2 clinical trial – PLUS additional protective nutrients, including Zeaxanthin, Vitamin D3, and Omega-3’s demonstrated to support healthy vision.

EyePromise AREDS 2 Plus (with a Multi-Vitamin) Convenience pack contains the ingredients studied in the AREDS 2 clinical trial – PLUS a multivitamin and additional protective nutrients, including Zeaxanthin, Vitamin D3, and Omega-3’s.

EyePromise AREDS 2 Plus (with a Multi-Vitamin)

Formulated for:• Low MPOD• Visual performance

Recommended Dose:• 1 convenience pack per day (1 softgel & 1 tablet)

Formulation (per 1 convenience pack):Tablet• Vitamin A –

5,000 IU • Vitamin C – 500 mg• Vitamin K1 – 25 mcg• Vitamin B1 – 1.5 mg• Vitamin B2 – 1.7 mg• Vitamin B3 – 20 mg • Vitamin B6 – 2 mg• Folic Acid – 400 mcg• Vitamin B12 – 6 mcg• Biotin – 30 mcg• Iron – 18 mg• Pantothenic

Acid – 10 mg• Iodine – 150 mcg

• Magnesium – 100 mg

• Zinc – 40 mg• Selenium – 20 mcg• Copper – 2 mg• Manganese – 2 mg• Chromium – 5 mcg• Boron – 150 mcg• Alpha Lipoic Acid –

20 mg• Vanadium – 10 mcg• Nickel – 120 mcg• Molybdenum –

75 mcg• Tin – 10 mcg

Softgel• Zeaxanthin – 10 mg • Lutein – 10 mg• Vitamin D3 – 2,000 IU• Vitamin E – 400 IU• Fish Oil – 250 mg

Total Omega 3’s – 190 mg EPA – 100 mg DHA – 75 mg

• Mixed Tocopherols – 20 mg

• Gluten Free• Contains NO Yeast• Contains Soy and Fish

(cod, Pollack, whiting)


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EyePromise Zeaxanthin Zeaxanthin-only formula designed to increase MPOD and protect the photo-receptors.

Formulated for:• Vegans (contains no animal by-products)• Patients with fish oil allergies• Low MPOD• AMD risk factors• Patients who want Zeaxanthin only• Visual performance

Recommended Dose:• 1 or 2 vegetarian softgels per day

Formulation (per 1 veggie softgel):• Zeaxanthin – 10 mg• Gluten Free• Contains NO Yeast

EyePromise Zeaxanthin + Lutein Macular pigment formula designed to increase MPOD and protect the photo-receptors.

Formulated for:• Vegans (contains no animal by-products)• Patients with fish oil allergies• Low MPOD• AMD risk factors• Visual performance

Recommended Dose:• 1 or 2 vegetarian softgels per day

Formulation (per 1 veggie softgel):• Zeaxanthin – 10 mg• Lutein – 10 mg• Gluten Free• Contains NO Yeast

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Vision Performance FormulaThe most advanced, high-quality formula containing the highest level of dietary Zeaxanthin and other essential ingredi-ents proven to maximize performance for improved vision. See your best. Perform your best.

• Reduced glare

• Reduced light sensitivity

• Improved visual acuity

• Improved photo stress recovery

• Improved contrast sensitivity

• Improved processing speed

Like most of our EyePromise nutraceuticals, EyePromise vizual EDGE PRO™ vision performance formula is NSF® Certified.*

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BEFORE AFTER

*NSF® is a registered trademark of NSF.

EyePromise vizual EDGE PRO Formulated and tested to improve clarity through contrast improve-ment, maximize performance through improved reaction time, and improve safety by enhancing vision in low lights. NSF certified for sport.

Formulated for:• Athletes (tennis, baseball, hockey, shooters, etc.)• Professions where eyesight is critical

for job performance• Improved visual acuity

Recommended Dose:• 1 convenience pack per day (5 softgels)

Formulation (per 1 convenience pack):• Zeaxanthin – 26 mg• Lutein – 8 mg• Vitamin A – 1,000 IU• Vitamin C – 240 mg• Vitamin D3 – 4,000 IU• Vitamin E – 180 IU• Zinc – 30 mg• Fish Oil – 1.980 mg

Total Omega 3’s – 1,480 mg EPA – 790 mg DHA – 590 mg

• Mixed Tocopherols – 20 mg• Alpha Lipoic Acid – 12 mg• Proprietary Blend – 220 mg

Evening Primrose Oil, Tumeric Extract, Green Tea Extract, Tocotrienols/Tocopherols

• Gluten Free• Contains NO Yeast• Contains Soy and Fish (cod, Pollack, whiting)

EyePromise EZ Tears Dry eye formula with nine anti-inflammatory ingredients to attack dry eye from the inside, offering fast relief with the highest quality dietary ingredients; enteric-coated for optimal tolerability.

Formulated for:


Formulation (per 2 softgels):• Fish Oil – 1,480 mg

Total Omega 3’s – 1,100 mg EPA – 590 mg DHA – 440 mg

• Vitamin A – 1,000 IU• Vitamin D3 – 2,000 IU• Vitamin E – 60 IU• Proprietary Blend – 250 mg

Evening Primrose Oil, Tumeric Extract, Green Tea Extract, N-Aceyl-Cysteine, Tocotrienols/Tocopherols


Dry Eye & Contact Lens Comfort FormulaForty percent (40%) of Americans suffer from dry eye, and it is estimated that the average contact lens drop-out rate results in approximtely $45,000 of lost annual practice revenue. Discomfort due to dryness is a leading reason many patients stop wearing contact lenses. Some of the many patient benefits of EyePromise EZ Tears™ are:

• Rapid relief from dry eye symptoms in as little as 2 weeks

• Reduced contact lens discomfort

• Improved ability to wear and stay in contact lenses

• Minimized eye drop use

19* Based upon a 90-patient contact lens comfort study

of patients reported improved comfort

in 3 weeks


in 4 weeks


in 2 weeks

Contact Lens Comfort*

* Based upon a 56-patient dry eye study

of patients reported relief in 2 weeks



Dry Eye Relief*

• Contact lens dryness• Dry eye sufferers• Pre-and post-surgery

related dryness

• Dry eye induced by medications

• Dry eye caused by environmental irritants

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Retinal Health FormulaEyePromise Diabetes Vision Support (DVS) is designed to support blood vessel health – essential in preserving healthy vision – through a unique combination of ingredients with documented effects for eye health.

EyePromise DVS offers the most comprehensive, science-based retinal health formula designed to:

• Support retinal metabolism, structure, and function

• Promote blood vessel health

• Combat oxidative stress

• Increase Macular Pigment Optical Density (MPOD), which is often low in patients with diabetes

EyePromise DVS Retinal health formula designed to support blood vessel health.

Formulated for:


Formulation (per 2 softgels):• Zeaxanthin – 8 mg• Lutein – 4 mg• Vitamin C – 60 mg• Vitamin D3 – 2,000 IU• Vitamin E – 60 IU• Vitamin B12 – 6 mcg• Zinc – 15 mg• Fish Oil – 320 mg

EPA – 128 mg DHA – 96 mg

• Alpha Lipoic Acid – 150 mg• Coenzyme Q-10 – 20 mg• Mixed Tocotrienols/Tocopherols – 20 mg• Proprietary Blend – 530 mg

Benfotiamine, N-Acetyl Cysteine, Grape Seed Extract, Resveratrol, Turmeric Root Extract, Green Tea Leaf, Pycnogenol®


• Patients at risk of macular edema

• AMD risk factors• Low MPOD

• Patients at risk of retinal blood vessel degeneration

• Visual performance


The Next Generation in Macular Pigment MeasurementThe next generation in macular pigment measurement is here – QuantifEye® MPS II. Since 2006, the original QuantifEye macular pigment measurement instrument has been the most reliable and accurate device for measuring Macular Pigment Optical Density (MPOD). MPOD measurement allows EyeCare Professionals to assess a key AMD risk factor, low macular pigment, as well as other visual performance challenges. With more than 4-million eyes measured, QuantifEye is:

• Market Leader • Reliable

• Scientifically Validated • Repeatable

• Accurate • Affordable

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Faster, Easier, More Intuitive

Building upon the success of the original QuantifEye instrument, the NEW QuantifEye MPS II offers the same reliable technology with significant software enhancements including:

• Unsurpassed technician usability with a new Data Quality Index (DQI)

• Significantly faster time in the lane

• Enhanced features and user-interface

• Intuitive workflow with multiple reports

• Network accessibility for EHR compatibility

Right

Accept

–

Right

Reject

–

Right

Caution

–

New DQI provides test results based on a familiar green-yellow-red scale.

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Our ServicesImprove your patients’ buying experience utilizing the

value-added services provided by ZeaVision – most at no

additional charge to your practice! Our service support

programs are designed to assist EyeCare Professionals in

helping patients, and building practices.

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ESP™ EyeCare Support Program ESP is a comprehensive support program to ensure practice success with ZeaVision products. From a fully-staffed Customer Support team and dedicated Implementation Specialists to complimentary marketing materials, ESP is a FREE service to all ZeaVision customers.

ESP Portal and EyePromise University Staff training, patient education, and marketing support are available through the ESP Portal at www.eyepromise.com/esp.

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Customer Support TeamZeaVision’s fully-staffed Customer Support Team is also your Customer Support Team. Our trained team members are ready to answer questions from both staff and patients. If your patients want to order EyePromise nutraceuticals over the phone, no problem! We’ll take the order and ship it right to their door. Every sale is tracked, recorded, and reported

back to you. Customer support is available to your practice via phone, email, or chat from 8:00 a.m. – 5:00 p.m. CST, Monday – Friday. For added convenience, email is also monitored on weekends.

Start-up KitZeaVision provides free ongoing support including a wide variety of materials for use in your practice such as patient brochures, posters, comparison charts, and more!

Customer Success PlanThe Customer Success Plan (CSP) is tailored to your practice, and includes a collection of Best Practices proven through thousands of EyeCare Professionals throughout the U.S.

Customer Success P

lan

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Our ProgramsOur business is developed around Zeaxanthin and high-quality

nutraceuticals to help manage AMD risk and preserve healthy

vision. ZeaVision offers three (3) programs featuring EyePromise

nutraceuticals designed to help your patients… and your practice.

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ZeaVision offers three (3) programs featuring EyePromise nutraceuticals – all with free ongoing practice support.

Eye-Q Intelligent AMD Risk Management Program®

The Eye-Q Intelligent AMD Risk Management Program is our premiere program that includes EyePromise nutraceuticals, QuantifEye MPS II MPOD Measurement Instrument, and ESP EyeCare Support Program.

EyePromise Dispenser Program Dispense the EyePromise brand of nutraceuticals out of your office with no minimum case buy-in, inventory requirements, or ongoing commitment – simply place your case orders (24 bottles per case), as needed.

EyePromise Prescriber ProgramRecommend or “prescribe” EyePromise nutraceuticals to patients without carrying them in your practice - patients order directly from ZeaVision, and you earn a consultation fee on every bottle ordered.

All EyePromise products have a 60-Day, Money-Back Guarantee!

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PROGRAM BENEFITS Eye-Q Program

Dispenser Program

Prescriber Program

EyePromise Nutraceuticals • • •

Carry EyePromise Inventory • •

EyePromise Nutraceutical Revenue Stream • • •

QuantifEye MPS II MPOD Measurement Device •

MPOD Measurement Revenue Stream •

60-Day, Risk Free Evaluations •

60-Day, Money-Back Guarantee on EyePromise Products • • •

ESP EyeCare Support Program - Staff Training - Patient Education - Marketing Support

• • •

Complimentary Start-up Kit • • •

Complimentary Onsite Training •

Complimentary Ongoing Training • • •

EyePromise ConvenienceShip In-practice Patient Ordering • • •

Z-Link for Practice Website • • •

(Premiere Program)

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Our Guarantee EyePromise Guaranteed to Increase MPOD!EyePromise is the only brand guaranteed to increase MPOD! Simply prescribe any EyePromise Zeaxanthin-based nutraceutical to a patient at a dosage of two (2) softgels per day, re-measure their macular pigment in six (6) months using the QuantifEye MPS II MPOD measurement instrument, and we guarantee an increase in your patients’ macular pigment – or their money back!


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Convenience

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Convenience


Convenience


EyePromise ConvenienceShip Step 1… and Done! In less than one minute, you can quickly and easily sign-up patients to receive EyePromise supplements at home with ConvenienceShip. A simple one-screen, web-based ordering system, EyePromise ConvenienceShip allows patients to automatically receive one (1) bottle of EyePromise each month, or three (3) bottles each quarter with the ability to cancel at any time.

Quickly and easily review all patient orders through any web browser or free smartphone app.

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AMD, Macular Pigment, and Visual Performance (Zeaxanthin & Lutein)

AREDS 2 Study Chew, MD. et. al.

The AREDS 1 formula plus Lutein & Zeaxanthin vs. AREDS 1 & beta-carotene:• 18% reduction in the progression to advanced AMD• 22% reduction in the risk of progression to neovascular AMD

AREDS formula along with Lutein + Zeaxanthin vs. AREDS formula with no Lutein + Zeaxanthin:• 10% additional reduction in the risk of progression to advanced AMD• 11% reduction in the risk of progression to neovascular AMD• 26% reduction to advanced AMD in the lowest quintile – the group with the

lowest dietary intake of Lutein and Zeaxanthin, which is more representative of the general population

Gale Study: Zeaxanthin & Lutein and the Risk of AMD(Ophthalmology and Visual Science: 2003)

• Low levels of Zeaxanthin in plasma = significantly higher risk of AMD

• Did not show similar effect for Lutein

• Possible that studies that combine Zeaxanthin and Lutein may have obscured protective effect of Zeaxanthin

POLA Study: Zeaxanthin & Lutein (Investigative Ophthalmology and Visual Science: 2006)

• Large European trial (899 patients)

• Patients with high plasma levels of Zeaxanthin had a 93% reduction in AMD and 77% reduction in nuclear cataracts

• Patients with high plasma levels of Lutein had a 79% reduction in AMD

Blue Mountain Study (American Academy of Ophthalmology: 2008)

• Higher dietary intake of Zeaxanthin and Lutein reduced risk of AMD (in 3654 patients) by 65%

• Confirmed protective influence of zinc

• Higher beta-carotene associated with increased risk of AMD

AREDS Report 22 (Archives of Ophthalmology: 2007)

• Participants reporting highest intake of Zeaxanthin and Lutein at baseline less likely to have advanced AMD (NV & GA) or intermediate drusen

Our Scientific Support To date, more than 300 published studies exist on nutrition, macular pigment, and the impact on eye health.

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Bone & Landrum (Investigative Ophthalmology and Visual Science 2001)

• 12 cadaver donors, 224 eyes

• Donor eyes in the highest quartile of Lutein and Zeaxanthin per unit area had an 82% lower prevalence of AMD compared with those in the lowest quartile

Improvement of Retinal Function in Early Age-Related Macular Degeneration After Lutein and Zeaxanthin Supplementation: A Randomized, Double-Masked, Placebo-Controlled Trial(Ma et. al. - American Journal of Ophthalmology, October 2012 Peking University Eye Center, Beijing, China)

• 108 subjects with early AMD supplemented with 10 mgs Lutein, 10 mgs Lutein & 10 mgs Zeaxanthin, 20 mgs Lutein, or placebo plus 36 age matched controls. (144 subjects)

• Pre and post supplementation multi-focal ERG was measured in 6 concentric annular zones around the macula

• Increased MPOD related positively to increases in N1P1 response density in ring 1 and ring 2 with little effect in ring 3 thru 6

• Improvement of N1P1 response densities was positively associated with MPOD increase, suggesting a causative effect of MPOD on retinal function and health

• Early functional abnormalities of the central retina in the early AMD patients may be improved by Lutein and Zeaxanthin supplementation

• The 10 mgs Lutein/10 mgs dietary Zeaxanthin arm had the greatest ERG documented retinal function increase in ring 1.

Zeaxanthin & Visual Performance Benefits:Zeaxanthin and Visual Function (ZVF) Trial(Richer, Stuart, et. al. - Journal of Optometry November 2011)

• 60 elderly subjects with early to moderate AMD

• Consumed 8 mgs of dietary Zeaxanthin per day for 12 months

• Improved high contrast near visual acuity by 8.5 letters or 1.5 lines on an eye chart

• Achieved clearing of central scotomas

• Improved foveal shape discrimination

• Improved night driving skills

Macular Re-pigmentation Enhances Driving in Elderly Adults(Richer, Stuart, et. al. - Clinical & Experimental Ophthalmology April 2012)

• 60 elderly subjects with early to moderate AMD

• Consumed 8 mgs of dietary zeaxanthin per day for 12 months

• Self-described improvement of driving skills were strongly associated with macular re-pigmentation

• The greatest effect was seen with zeaxanthin

• Older male drivers with AMD are encouraged to have their foveal macular pigment measured annually

Rotterdam Study: Reducing the Genetic Risk of AMD (Lintje Ho, MD et. al - Archives of Ophthalmology 2011)

• 2,167 subjects

• Subjects with genetic AMD risk factors in the highest tertile of dietary zinc, ß-carotene, lutein/zeaxanthin, and EPA/DHA intake had a significant hazard ratio reduction for early AMD of approximately 40%

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Our Promise A Partner You Can TrustSince 2001, ZeaVision has been passionate about prevention and dedicated to fighting AMD. Through science-based nutraceuticals, MPOD measurement technology, and the most extensive implementation experience, we are dedicated to the success of every practice.

For more information on ZeaVision or any of our products, services, or programs, visit our website at eyepromise.com, or contact us at 866.833.2800 or via email at [email protected].

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Our CustomersTake a look at what EyeCare Professionals, like you, are saying

about EyePromise products and services.

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“ The Eye-Q Intelligent AMD Risk Management Program® from ZeaVision is a key part of our Center for Macular Health at Gailmard Eye Center. It allows us to take a preventative approach to macular degeneration, which our patients greatly appreciate. We test MPOD as a major AMD risk factor and our doctors actively prescribe the EyePromise line of nutritional supplements. The entire program is quite successful for us.”

Neil Gailmard, OD, MBA, FAAO – President, Prima Eye Group (Munster, Indiana)

“ Zeavision has been a great partner in helping our practice become proactive with our patients eye health as it relates to the risks associated with Macular Degeneration. Our patients are educated, engaged and motivated participants in this process. Macular pigment testing has become an integral procedure in our office.” Dr. Michael Bernier – Chippewa Eye Centre, Inc. (Saint Louis, Missouri)

“ ZeaVision products have been a great fit for our practice and patients. We were not being as preventative as we should have been when it came to Macular Degeneration. ZeaVision staff members helped us implement their program and provided us with the information and knowledge needed to get started. We have now been in full swing for over a year with MPOD testing and EyePromise supplements. We appreciate the ongoing support we receive and I’m pleased to report that ZeaVision really stands behind their product and customers.”

Dr. Jennifer Redmond (Aurora, Colorado)

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“ The EyePromise supplements and QuantifEye macular pigment testing device have allowed me to proactively identify patients at risk of AMD and create an excellent profit center for my office. This type of technology is the key to practicing optometry in the present health care environment… good for my patients and my practice!”

Jason Lake, OD (Eyecare Specialties)

“ We began our relationship with ZeaVision three months ago. I have to say it has been one of the best partnerships with a company we’ve ever had. They installed the Eye-Q Program (QuantifEye macular pigment measurement equipment and EyePromise supplements) promptly and gave our staff exceptional training on the program. The ZeaVision rep was very hands on and helpful. He even brought a QuantifEye machine to a health fair we were involved in and helped with the testing! We have had great acceptance of the test by patients as well as acceptance of the supplements. Best of all, we now have a way of measuring and tracking our patients progress and the ability to help delay or prevent macular degeneration. Our patients, doctors, and staff are very enthusiastic about this new technology. It has been easy to implement, increased our ability to care for our patients, and is making our practice more profitable.”

Dr. Shelley Williams (Williams & Hussey Eyecare)

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