expanding clean label excipients globally - ribus• clean label, non-gmo, vegan, organic “clean...
TRANSCRIPT
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SupplySide West 2016
Presented by:
Steve Peirce
Steve Dybdal
Expanding Clean Label
Excipients Globally
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OVERVIEW
1. Expanding Clean Label Excipients
2. New Product Launch
3. Breakthrough Data
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LIFESTYLE INFLUENCES ON CONSUMER DECISIONS
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IMPACT OF CLEAN LABEL
Consumer Demand
• Capsules
• Tablets
Your Production Needs
• Flow Agent (Not SiO2)
• Lubricant (Not Mg Stearate)
Organic Legislation
• SiO2 not allowed in organics as
long as rice hulls are
commercially available
• Mg Stearate use causes
product to become “Made With”
• Stearic Acid not approved for
organics
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2011 RIBUS Brings Clean Label
Excipient Options to the Market
Anatomy of a Rice Plant
20% Hulls => Nu-FLOW®
10% Bran => Nu-RICE®
70% => White Rice
—GENERATION 1—
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• Functions like stearates as a
lubricant & compaction aid
• 2 or 3:1 replacer for Mg Stearate
(E-470b)
• Label declaration “Rice Extract”
• Over-mixing is not a problem
• Clean label, Non-GMO, Vegan,
Organic
“Clean Label” Alternatives for Excipients
• Functions as flow aid and glidant
(~20% plant based silica)
• 1:1 replacer for SiO2 (E-551)
• Label declaration “Rice Hulls” or
“Rice Concentrate”
• Clean label, Non-GMO, Vegan,
Organic
For use in capsules, tablets and powders.
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—GENERATION 2 ARRIVES—
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• Organic or Natural
• Enhanced Functionality
Label as “Rice Extract Blend”
– Nu-RICE®
– Nu-FLOW®
– Gum Arabic
– Sunflower Oil
Developed by BioGrund & Licensed by RIBUS.
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PERFORMANCE DATA
Tablets
– Romaco
– Natoli
Capsules
– Customers
Romaco Kilian’s Tableting robot STYL One Evolution,
speed 1,125 tablets /min.
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• Ejection Force
• Powder Flow / Rheology
• Break Force, Hardness
• Friability, Disintegration
• Blend Time Study (Compaction)
• Dwell Time Study
Formulation
– Emcocel 50M 50%
– Explotab 5%
– Emdex 42 - 44.5%
– Lubricants
• Mg Stearate 0.5, 1, 2, 3%
• Nu-MAG 0.5, 1, 2, 3%
…“Nu-MAG™ Performed as well as Mg Stearate”Robert Sedlock, Natoli Institute, Long Island University
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EJECTION FORCE IS COMPARABLE
Test conducted by, Natoli Institute at Long Island University.
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HARDNESS IS COMPARABLE
Test conducted by, Natoli Institute at Long Island University.
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BREAK FORCE COMPARABLE AT SPEEDS
Test conducted by, Natoli Institute at Long Island University.
Nu-MAG™ is
17.5% Harder
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POWDER FLOW (ENERGY REQUIREMENTS)
Test conducted by, Natoli Institute at Long Island University.
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100
150
200
250
300
350
400
0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5
Tim
e (
sec)
% Lubricant
Disintegration Time
Mg. St.Nu-MagCommon Blend
DISINTEGRATION ADVANTAGE TO Nu-MAG™
Test conducted by, Natoli Institute at Long Island University.
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Clean White Tablets with 1%
1% Nu-MAG™, paddle feed, 3 minute mix.
Test conducted by, Natoli Institute at Long Island University.
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EARLY DATA
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EARLY DATA
Romaco Kilian’s Tableting robot STYL One
Evolution, speed 1,125 tablets / minute.
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CUSTOMER COMMENTS ON CAPSULES
“Wanted to give you some feedback. The product is working GREAT!!!
We are looking to scale up to over a million capsules…”
“We have done R&D, and will use it in 2
products. We are now going to test in tablets.”
“Looking forward to the organic version.”
Data CollectionLubrication
Slug
TransferSplits
Deformed
Capsules
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0
10
20
30
40
50
0 100 200 300 400
Mg. St.(0.5)
Breaking Force vs. Compaction Pressure
Compaction Pressure (MPa)
Bre
akin
g Fo
rce
(kp
)
…“Nu-MAG™ Performed as well as
Mg Stearate”Robert Sedlock,
Natoli Institute
Long Island University
“Nu-MAG works GREAT in capsules!”
SUMMARY
LIFESTYLE INFLUENCES ON CONSUMER DECISIONS
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Excipients Growing from Generation 1 to 2
From Clean Label Alternatives to Alternatives with
Enhanced Functionality!
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Booth W 106
Presented by:
Steve Peirce
Steve Dybdal
THANK YOU!