Everyday Relief. Everyday Protection.

Premier® Dental Products Company • 888-670-6100 • www.premusa.com

Clinical Results1 90% of dentists indicate their patients experienced a reduction in generalized tooth sensitivity using Enamelon Treatment gel.

8x Greater Protection2,3 Enamelon is dramatically more effective than remineralising pastes in preventing demineralisation of tooth surfaces when exposed to acids.

Contains No SLS (Sodium Lauryl Sulfate), Triclosan, parabens, gluten or dyes.

Pleasant Tasting - mint with a hint of vanilla heightens flavor and offers a refreshing and revitalising finish.

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Premier® Dental Products Company introduces Enamelon® Preventive Treatment Gel to help dental professionals provide everyday relief and everyday protection for their patients.

Enamelon’s exclusive formulation combines stabilized stannous fluoride optimized with Amorphous Calcium Phosphate (ACP) technology to help treat and prevent sensitivity, promote remineralisation, inhibit demineralisation and soothe and moisturize dry-mouth tissues. ACP

Enamel Therapy

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9007295 Enamelon® Preventive Treatment Gel - 0.40% Stannous Fluoride 113g (4.0 oz), Clean Mint, 12/Case

Protect against acid attackEnamelon provides 3x greater reduction of enamel solubility with twice as much fluoride uptake as 5000 ppm F toothpastes.2, 3

Enamelon® Preventive Treatment Gel contains 970 ppm fluoride ion, yet this patent-pending formula utilises calcium and phosphate ions to uniquely deliver more fluoride uptake to teeth.

The unique formula provides an enhanced ability to form loosely-bound calcium fluoride reservoirs. These reservoirs provide a vital source of remineralising ions in the presence of an acid challenge. The release of these ions helps to pro-mote remineralisation and inhibit demineralisation.4

More protection with only 970 ppm FEnamel Fluoride Uptake (ppm F) FDA Method #403

Enamelon® provides over 2x more beneficial fluoride with only one-fifth the amount contained in 5000 ppm fluoride toothpastes. NOTE: Colgate offers high fluoride concentration toothpaste (5000ppm F; Sodium Fluoride 1.1 % w/w) under the brand names PreviDent, Duraphat and NeutraFluor in different markets. GC’s MI Paste Plus is also available under the brand name Tooth Mousse Plus.

1. Comisi DDS.,MAGD, John C., The Catapult Group presents its review on this unique, protective, remineralizing and moisture-enhancing preventive treatment gel, Dental Product Report, 2015, October; Issue 10 Vol. 9 :68-69 / 2. Schemehorn BR, DiMarino JC, Movahed N. Comparison of the enamel solubility reduction from various prescription and OTC fluoride toothpastes and gels. J Clin Dent 2014;25:61-4. / 3. Schemehorn BR, DiMarino JC, Movahed N. Comparison of the incipient lesion enamel fluoride uptake from various prescription and OTC fluoride toothpastes and gels. J Clin Dent 2014;25:57–60. 4. Schemehorn, B.R., Orban, J.C.,Wood, G.D., et al. Remineralization by Fluoride Enhanced with Calcium and Phosphate Ingredients. Journal of Clinical Dentistry, 1999; 10(1 spec. no.),:13-16. / 5. Research sponsored by WhiteHill Oral Technologies, Inc., data available by request. / 6. 6. Boutsiouki , C., Lucker, S., Domann., Kramer, N. Is Calcium-phosphate gel abl;e to inhibit formation of secondary caries?, Oralprophylaxe & Kinderzahnheilkunde 38 (2016) 4 / Enamelon® United States Patent Numbers: US 5,993,784, US 5,711,936, US 5,651,959 and other patents pending. / Made in U.S.A. / Ultramulsion® is a registered trademark of WhiteHill Oral Technologies, Inc. / PreviDent®, Duraphat® and NeutraFluor ® are registered trademarks of Colgate. / Clinpro™ is a trademark of 3M. / MI Paste Plus™ and Tooth Mousse Plus are trademarks of GC. / Enamelon® is a registered trademark of Premier® Dental Products Company.

3x greater reduction of enamel solubilityEnamel Solubility Reduction FDA Method #332

Negative Control (Water) recorded a -5.45% Enamel Solubility Reduction.

In-vitro testing shows that Enamelon® reduces the solubility of enamel, preventing demineralisation of the tooth surface when exposed to acids, providing greater protection against acid challenges.

Daily use of Enamelon Gel may positively influence demineralisation which can result in secondary caries.6

Premier® Dental Products Company • 1710 Romano Drive, Plymouth Meeting, PA 19462, USA Phone 610-239-6000 • Fax 610-239-6171 • www.premusa.com • E-mail: intlinfo@premusa.com

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Children and adults with high caries risk are prone to secondary caries after restorative treatment. A study at the University of Giessen (Germany) determined daily use of Enamelon Gel positively influences demineralisation values at the restoration margins.

MDSS GmbHSchiffgraben 4130175 Hannover, Germany

MDSS GmbHSchiffgraben 4130175 Hannover, Germany

MDSS GmbHSchiffgraben 4130175 Hannover, Germany

Enamelon® may help to interfere with the harmful effects of plaque associated with gingivitis.Enamelon features Ultramulsion®, a patented slow-dissolving, saliva-soluble coating that may help prevent formation of biofilm5 which often results in the harmful accumulation of plaque.

Prevent and Treat Sensitivity

Dentin Enamel

Control Group without Enamelon

EnamelDentin

100 µm

100 µm

Enamelon Group

Shows restoration level in comparison to the demineralisation

Shows the demineralisation in enamel and in dentin

Shows substance loss due to demineralisation of enamel & dentin

Indicates marginal gap width in dentin

Enamelon® creates a physical barrier. Tubules are almost completely filled in with a precipitate of Amorphous Calcium Phosphate Fluoride.

Longitudinal View of Treated DentinDentin Surface Post-TreatmentScanning Electron Micrograph (SEM)

of dentinal tubules after 5 day application with Enamelon.

SEM Image of the newly occluded dentinal tubules after day 5

with Enamelon.

Occluded precipitate present deep within the tubule.

Restoration

Restoration