evaluation of the diffusion tension imaging (dti) …...this presentation uses a free template...
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Evaluation of the Diffusion Tension Imaging (DTI) Technique for Biometry and Morphology of the Fetal Corpus Callosum
Nadia Mordenfeld, MD MPH candidate
Noa Sanveta
Supervised by: Prof. Eldad Katorza
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Introduction
• The Corpus Callosum (CC) is by far the largest fiber bundle in the human brain, interconnecting the two cerebral hemispheres.
• The fetal CC serves as a sensitive indicator for normal brain development and maturation.
Corpus Callosum
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Introduction
• Earliest callosal fibers: 11-12 g.w.
• First systematic evaluation at the
mid-trimester ultrasound scan.
• Complete/ partial agenesis (dysgenesis) of the fetal CC may be associated with developmental delays and additional malformations.
Corpus Callosum
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Introduction Corpus Callosum
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Introduction
• Clinical standard evaluation of the CC: sonography (2D/ 3D US) and MRI on suspicious findings.
• Diffusion-Weighted Imaging (DWI) is a variant of conventional MRI based on the tissue water diffusion rate.
• Diffusion Tensor Imaging (DTI) is a specific type of modeling of the DWI datasets.
MRI, DTI & Tractography
New Possibilities in the research of white matter anatomy (e.g. CC)
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Introduction MRI, DTI & Tractography
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Introduction MRI, DTI & Tractography
T2-weighted sequence DTI
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Aim Assessment of the Diffusion Tension Imaging (DTI) technique for biometry and morphology evaluation of the fetal corpus callosum (CC).
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Methods Subjects & Measurements
• Cross-sectional study, based on fetal MRI examinations performed at the Sheba Medical Center, between 2017-2019.
• 2 study groups:
• MRI examinations indications included: suspected pathologic findings on US, maternal CMV infection, ventricles enlargement.
• Inclusion criteria: a singleton pregnancy, good quality sagittal DTI & T2-weighted sequences.
Normal CC CC malformations
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T2-weighted sequence
Methods Statistical Analysis
DTI
Biometry
• Interclass Correlation Coefficient (ICC)
Morphology Evaluation
• Cohen’s Kappa Coefficient (k)
• Reliability analysis: Inter- and intra-observer variability – ICC
• Mean Differences: Bland-Altman plot will be presented for all ICCs.
Agreement between DTI & T2:
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Methods Statistical Analysis
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Summary - The corpus callosum (CC) is a sensitive
indicator for normal brain development.
- DTI is an MRI processing model which has opened new possibilities in the research and the clinical evaluation of white matter tracts like the CC.
- The aim of our study is to assess the DTI technique for biometry and morphology evaluation of the fetal CC.
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סיכוםהוא מבנה המחבר בין שתי קאלוסוםקורפוס ה-
.ההמיספרות של המוח
נמצא כאינדיקטור להתפתחות תקינה של המוח - .בעוברים
-DTI המשתמשת , היא שיטת עיבוד חדשה יחסיתהקיימת ופותחת אפשרויות MRI-בטכנולוגיית ה
להערכה קלינית ומחקרית של מבנים בחומר הלבן .קאלוסוםהקורפוס ביניהם , שבמוח
DTI-להעריך את שיטת המטרת המחקר היא -לטובת הערכת הגודל והמורפולוגיה של
.העוברי קלוסוםהקורפוס
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Any
Questions?