evaluation of papilladema in the pediatric population€¦ · &dvh \r :) 3hduoh 9lvlrq &f...
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Evaluation of Papilledema in the Pediatric Population
Todd A. Zelczak, OD, FAAO
Midwest Optometric Society
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“
”
…classified as the ostensible elevation of the optic disc secondary to local underlying structural conditions, such as optic disc drusen without edema of the nerve fiber layer…
Pseudopapilledema
Accurate diagnosis important to avoid anxiety-provoking and expensive testing
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PseudopapilledemaOptic Disc Drusen (ODD)
• Etiology?
• Genetic predisposition?
• Incidence -Approx 0.4% in children
-Up to 2.4% in adults
-higher in white pop
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Buried Drusen
• Typically begin as buried deposits
• Migrate toward surface in adulthood
• Appearance mimics papilledema
• Mistaken for true papilledema in up to 76% of cases
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“
”…optic disc swelling due to elevated
intracranial pressure (ICP)
Papilledema
…can represent a harbinger of vision or life-threatening etiologies…
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Intracranial Hypertensionmeningitis serosa, pseudotumor cerebri, benign intracranial hypertension, idiopathic intracranial
hypertension, pseudotumor cerebri syndrome
Idiopathic (IIH)
• Elevated intracranial pressure without clinical, radiologic, or laboratory evidence of a secondary cause
• Little is known about the pathophysiology of idiopathic intracranial hypertension
Secondary (SIH)
• Used for those cases in which an underlying cause is identified
• What is currently termed “idiopathic” may be termed “secondary” as the disease process becomes better understood.
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Medications associated with elevated ICP
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Pediatric Idiopathic Intracranial Hypertension and Weight Gain
• Pre-Pubertal pediatric patientsLess association w obesity and gender
More likely to be secondary than idiopathic in nature
Pathology not fully understood
• Post-Pubertal pediatric patientsDemographics and characteristics similar to adults
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Diagnosis of Pseudopapilledema vs PapilledemaHistory/Symptoms
• More common in the absence of symptoms
• Incidence and type variesHeadaches?
Transient visual obscurations
• Asymptomatic?
• Symptoms of elevated intracranial pressureHeadaches
Nausea/vomiting
Pulsatile tinnitus
Binocular horiz diplopia (6th n palsies)
Transient visual obscurations
• Weight gain history and obesity
• Medication
Pseudopapilledema Papilledema
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Diagnosis of PseudopapilledemaClinical presentation
• Visual acuity/Color vision/Pupils
• Cupless, elevated optic disc
• Visible vessels in peripapillary NFL
• Peripapillary hemorrhages
• Spontaneous venous pulsation
• Surface refractile ODD
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Diagnosis of PapilledemaClinical presentation
• Visual acuity/Color vision/Pupils
• Disc appearance and presence of cup
• Vascular changesVenous engorgement
Capillary leakage and hemorrhage
Peripapillary lipid and cotton-wool spots
• Blurring of disc margin/retinal NFL
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Diagnosis of PseudopapilledemaAncillary testing
• Fundus photography
• Visual Field DefectsIncreased frequency w age
Types
• Fundus Autofluorescence (FAF)
• B-Scan Ultrasonography
• Optical Coherence Tomography (OCT)RNFL, NFL defects
• Orbital Imaging
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Diagnosis of PapilledemaAncillary testing
• Visual Fields
• B-Scan Ultrasonography
• Optical Coherence Tomography (OCT)
• CT scan
• Magnetic Resonance Imaging MRI/MRV
• Lumbar Puncture (LP) With opening pressure
CSF analysis
*Other testing to rule out secondary causes should be guided by the history and physical findings.
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PapilledemaPseudopapilledema
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Optic Disc DrusenComplications and Management
Complications
• Rare
• Vision loss/VF defects
• Vascular
Management
• Annual exam/VFs
• Ocular hypotensive drops
• Neuroprotective agents?
• Serial OCT to confirm if suspicious for Papilledema
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Treatment of Pediatric Idiopathic Intracranial HypertensionBased on severity of presentation/Goals
Treatment Goals: alleviate symptoms and prevention of permanent vision loss
• Steroids (oral or IV)
• Acetylzolamide (oral or IV)
• Weight loss (post pubertal)
• Mgmt of secondary/predisposing factors
• Surgical: Optic nerve sheath fenestration
CSF shunt
• Serial testing: Visual acuity, Perimetry, ONH appearance
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CASES
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Case #1: 15yo IF
Routine examCc: mild distance blur ouBCVA: 20/20 OUIOP: 19/19Pupils: PERRLA –APDC/D: 0.1/0.1 OUFundus: Elevated disc margins OS
Ancillary testing?
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Case #1: 15yo IF
Diagnosis: Pseudopapilledema OS Secondary to Optic Disc Drusen
Mgmt: 1. Education2. Baseline visual acuity
perimetryfundus photography/FAF
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Case #2: 14yo WF (Pearle Vision)
Cc: Reports headache behind eyes 1-2 weeks, worsening over last week with increasing blurry visionReports feels eyes crossing. Horizontal double vision worse on left gaze, onset last 3 days, increasing frequency. Neg hx cold, sickness, or trauma
Medical Hx: OTC Allergy med, Minocycline 100mg/day (acne)for past 2 mos
Entering VA: 20/30+ OD 20/20- OSPupils/Color: WNL OUEOMs: Left ESO in primary position
Left abduction deficitIOP: 18/21Fundus: Disc edema OU
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Case #2: 15yo WF
Diagnosis: Presumed Bilateral PapilledemaSymptoms consistent w elevated ICPLeft CN VI Palsy
Mgmt: Urgent referral CCH for MRI to r/o space occupying lesion
Cinti Children’s Hosp: MRI neg for intracranial massDiff diagnosis for Minocycline induced increased ICPPending results Lumbar Puncture, initiate DiamoxStop Minocycline!
Prognosis: Good. Vision and color intact, minimal scattered peripapillary VF defects
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Case #3: 17yo WF
Cc: Patient presents for REE. Reports on/off HA’s past 6-12 mos increasing w chores. Recently reportsblurred vision ou and occasional nausea. Neg for trauma, DV, or ear ringing. Went to local OD earlierthis year and got new glasses.
Hx: patient is 5’3” 178lbs, reports weight gain ~40lbs over 1 ½ yrs
BCVA: 20/20 ouColor plates: 14/14EOM’s: full in all positionsPupils: PERRLA –apd ouIOP: 14/13 C/D: 0.1/0.1 Fundus: Elevated, blurred disc margins ou
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Case #3: 17 WF
Diagnosis: Papilledema OUPresentation consistent for IIH sec to weight gain, young female
Mgmt: MRI w and w/o contrast r/o intracranial mass, hydrocephalus
Results: MRI neg for intracranial pathologyDiagnosis IIHNeuro referral for medical mgmt. Initiated oral Diamox 500mg/day
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Case #4: 17yo WF* (Pearle Vision)Cc: Reports “black spots” in peripheral vision OS>OD onset 4 weeksHx: Previous exam name noted as “Olivia”. Now goes by “Lucas”
Further discussion reveals patient taking testosterone and minocyclineGoing through gender reassignment
Evaluation: BCVA 20/30 OD 20/20-OSColor 14/14 OUPupils: PERRLA –apd OUIOP: 15/11C/D: 0.25/0.25 OUFundus: Disc edema OU
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2016
2017
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Case #4: 17yoWF*
Diagnosis: Papilledema OU
Mgmt: Immediate neuro consultMRI to r/o intracranial mass/pathologyPresentation and history consistent w Minocycline or Hormonal therapy induced elevated ICP
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Case #5: 11yo AWF10/15/19Cc: REE, gradual blur dist ou. No other oc/vis complaints
BCVA: 20/20 OU, increase -050/-075 correctionEOMs: full in all positionsPERRLA –apd ouIOP: 18/18C/D: 0.15/0.25 Fundus: Blurred disc margins OU, nasal>temp, peripapillary heme OS?
Further Hx: Patient is 5’4” 108lbs, neg for HA’s, nausea, trauma, ear ringing,weight gain, prepubertal. Mother has hx migraines, but patienthas non-specific, non-positional, occasional mild HA’s
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OD OS
2019
2015
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Case #5: 11AWF
Diagnosis: Pseudopapilledema vs Papilledema OUSymptoms of HA’s vague and non-diagnostic Lack of additional signs/symp related to elevated ICPNotable disc edema change from 2015 photoInconclusive B-Scan to confirm Optic Disc Drusen
Mgmt: Consult Cincinnati Children’s NeuroMRI to r/o intracranial pathology
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Initial Visit CCH Neuro 10/21/19
PLAN: Ultrasound to r/o buried drusen, monitor HA’s/symptoms, repeat MRI 3 mos
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2nd Visit CCH Ophthalmology 11/20/19
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Initial visit CEI NeuroOPH 12/31/19Cc: No other complaints other than HA’s but thought to be “normal” HA’s
Reports has stopped Diamox couple weeks due to intolerance/allergy
Evaluation: Nasal elevation of discs OU with otherwise normal vision and examination
Diagnosis: Psuedopapilledema OU
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2nd visit CEI NeuroOPHTH 02/26/20Cc: Patient reports vision stable, no additional symptoms noted from previous visit
Evaluation: Nasal disc elevation OU, Stable vision and 24-2 visual fields w normal fixation losses
Diagnosis: Pseudopapilledema of the optic discs OUBuried disc drusen OU
Mgmt: ReassuranceMonitor symptoms and VASerial visual fields, OCT and photos 6-12 mos
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Case #6 21yo WF
• CC: Blurry vision, occasional HA’s?? Poor historian responses inconsistent
• Hx: +obesity, >50+lb weight gain <1yr
• BCVA: OD +175-100x180
OS +225-150x170
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Case #6 21yo WF
• Diagnosis: Probable Idiopathic Intracranial Hypertension
Consistent profile and symptoms?
• Plan: Immediate MRI imaging to r/o intracranial lesion
Neuro consultation
If MRI negative, initiate weight loss and Acetylzolamide
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Summary