ety494 – introduction to biomedical engineering (2019 ... · a lab-on-a-chip (loc) is a device...
TRANSCRIPT
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Lecture 16
ETY494 – Introduction to Biomedical Engineering (2019 Spring Semester)
MATERIALS SCIENCE AND TECHNOLOGY DEPARTMENT UNIVERSITY OF CRETE
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TECHNOLOGY
Biocompatible CAD Holes Optical fiber n-type/ p-type Parameters (Phy, Che, Bio) Photoresist Semiconductor Substrate Quantum dots (QDs) Waveguide
BIOLOGY
Antibody Bacterium Biomarker Buffer solution Caenorhabditis elegans (C.
elegans) Fluorophore Larva Protein Virus
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http://www.shutterstock.com/pic-352653281/stock-vector-two-old-wooden-beer-mugs-clink-glasses-of-them-pouring-foam.html
Ancient Greece Medieval Europe
https://www.vivino.com/wine-news/cheers-why-exactly-do-we-toast-with-wine http://www.greek2m.org/wines-like-nectar
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Sight
Touch
Smell Taste
Hearing
Vitruvian man
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5 http://paperzip.co.uk/topics/misc/ourselves/5-senses-cards
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6 http://www.academia.dk/Blog/a-canary-in-a-coal-mine-in-the-19th-century-and/
http://www.wisegeek.org/what-does-it-mean-to-be-a-canary-in-a-coal-mine.htm
http://collider.com/best-indiana-jones-movies-ranked-worst-to-best/
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http://chemwiki.ucdavis.edu/Core/Analytical_Chemistry/Analytical_Chemistry_2.0/11_Electrochemical_Methods/11D%3A_Voltammetric_Methods
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http://www.limerickfamilyplanning.ie/pregnancy-testing/
Detects hCG protein in urine Detects glucose in blood
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TRANSDUCER SIGNAL RECEPTOR INSTRUMENT
SENSOR
OPEN
CLOSE
ENVIRONMENT
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Enzyme
Antibody
Micro-organism
Cell
BIORECEPTOR
Electroactive substance
pH change
Heat
Light
Mass change
Electrode
SemiconductorpH electrode
Thermistor
Photon counter
Piezoelectric device
TRANSDUCER ANALYTE SIGNAL
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A sensor device for detecting and measuring very small quantities or changes in a biochemical or chemical substance, in which a microelectronic component registers reactions related to the substance and translates them into data
A device which uses a living organism or biological molecules, especially enzymes or antibodies, to detect the presence of chemicals.
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BioMEMS
Biosensor Biodevice
Biochip
The biochip is a microarray (a collection of miniaturized test sites) arranged on a solid substrate that permits many simultaneous tests to be performed, allowing higher throughput volume and speed.
A hypothetical computer logic circuit or storage device in which the physical or chemical properties of large biological molecules (such as proteins) are used to process information
A small glass or silicon plate containing an array of biochemical molecules or structures, used as a biosensor or in gene sequencing
μTAS
interested in developing, studying and using innovative materials, devices and systems inspired by biological systems and/or addressing biomedical requirements. Monitoring and diagnostics devices, sensors and instrumentation systems, biorobotics and prosthetics, micro-nanotechnologies including microfluidics systems and biomaterials are some of the technologies addressed at this conference.
Any device constructed from biological components
Total Analysis System (TAS) describes a device that automates and includes all necessary steps for chemical analysis of a sample e.g. sampling, sample transport, filtration, dilution, chemical reactions, separation and detection. A lab-on-a-chip (LoC) is
a device that integrates multiple laboratory operations on a single chip platform and utilizes micro volumes of liquids to perform chemical or biochemical operations
A lab-on-a-chip is a miniaturized device that integrates onto a single chip one or several analyses, which are usually done in a laboratory
Lab-on-a-chip BioMEMS use micro-size components such as sensors, transducers, actuators, and electronic devices for biological and/or biomedical functions or applications
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11
Sight
Touch
Smell Taste
Hearing
Vitruvian man
senses!
Electrochemical
Acoustic-Mechanical
Sensors?
Optical
SENSOR
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Piezoelectric material Electric circuit Supports mechanical waves Amplitude Wavelength Frequency
Amplitude
Wavelength
High and Low Frequency
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Pads
IDTs
Piezoelectric material
Electric circuit
DELAY LINE How to determine operation frequency?
1) Choose the material (v) • Quartz •LiTaO3 •LiNbO3 •AlN •ZnO
λ
v=λ·f ⇝ f=v/λ
Frequency
Am
plitu
de
fo
3) Find operation frequency (f)
4) Signal response
2) Choose the geometry (λ)
Operation frequency 10 MHz – 5 GHz
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+ - + - + - + -
Amplitude
Phase
Penetration depth Affects the acoustic wave
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ΔA ΔPh
Viscocity
Mass loading
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0 Time
Sign
al
Buffer Buffer Protein G Buffer IgG
Signal
Amplitude
Phase
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Bacteria Buffer
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Type of electrochemical sensors Amperometric Conductimetric Impedimetric Potentiometric
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Substrate
Contact Contact
• Nanowire • Graphene • Semiconductor • …
http://www.britannica.com/technology/metal-semiconductor-field-effect-transistor
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A detector Polarization Amplitude Phase Wavelength …
Most diverse class of biosensors Absorption Fluorescence Refraction Scattering Transmission …
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http://www.microsiervos.com/archivo/ciencia/hubble-ojo-sauron.html
http://www.biosci.ohio-state.edu/~plantbio/osu_pcmb/pcmb_lab_resources/pcmb101_activities/phtsynthsis/phtsynthss_lightAbsorptionTransmission.htm
https://www.thermofisher.com/us/en/home/life-science/cell-analysis/flow-cytometry/cell-health-and-viability-assays-for-flow-cytometry.html
http://www.physics.emory.edu/faculty/weeks//confocal/
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https://plus.google.com/+TarunAgarwalEdgefx
https://en.wikipedia.org/wiki/Light-emitting_diode
http://electronics.howstuffworks.com/led1.htm
https://learn.sparkfun.com/tutorials/light-emitting-diodes-leds
P region
N region
Substrate
V
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Highly specific Response Cost Small sample volume Easy to use Accurate and repeatable Robust and stable Biocompatible Independent of physical parameters
(temperature, noise, …) Portable Integration
https://jagjohn.wordpress.com/volume/
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http://lenagold.ru/fon/clipart/k/kluc2.html
http://www.centroderelevo.gov.co/index.php/relevo-de-llamadas
http://www.softwarethinktank.com/articles/how-to-improve-your-bottom-line-with-cost-accounting/
http://www.cardensaccountants.com/cloud-accounting-is-it-easy-to-use/
http://documentdynamics.equisys.com/the-3-rs-for-a-successful-nav-add-on-repeatability-repeatability-repeatability/ http://www.gogps.com.au/Blog%20Posts/how-accurate-is-gps-tracking.html
https://en.wikipedia.org/wiki/Jenga
http://morris.umh.ac.be/smpc/ResearchTheme.aspx?id=2
http://www.greatrealtyusa.com/realtors/CA/Independence.htm http://www.carriage-trade.com/plastic-shopping-carts.html
http://www.proenergyconsulting.com/portfolio_category/business-integration/