Canine Estrous Cycle

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Canine Estrus

Normal Physiology

Review

HypothalamusAnterior pituitary

Ovaries

Uterine horns

Uterine body

Cervix

Vagina/vestibule

BrainAnatomy

Follicular growth:Proestrus and Estrus

ProestrusGnRH

FSH

FSH

Estrogen

GnRH Ovulation

Corpus luteum

Progesterone

Ovulation -Pregnancy/Diestrus

LHLH

LH

LHLH

LH

LH

LH

LH

LHLH

LH LHLH

LHLH

LH

LH

LH

LH

LH

LH

LH

LH

LH

LH

LH

LH

Estrogen

Proestrus9 days

Estrus9 days

Pregnancy/Diestrus60 days

Anestrus90 days

Follicular growth:Proestrus and Estrus

ProestrusGnRH

FSH

FSH

Estrogen

Proestrus1 92 3 54 6 7 8

GnRH Ovulation

Corpora lutea

Progesterone

Ovulation - Estrus

LHLH

LH

LHLH

LH

LH

LH

LH

LHLH

LH LHLH

LHLH

LH

LH

LH

LH

LH

LH

LH

LH

LH

LH

LH

LH

Estrogen

Proestrus1 92 3 54 6 7 8

Estrus1 92 3 54 6 7 8

LH

Su

rge

Progesterone initial rise starts with LH

peak and rises during estrus (not diestrus)

Ovu

lati

on o

ver

24 h

ours

Estrus

1 92 3 54 6 7 8

LH

Su

rge

Ovu

lati

on

LH

LHLH

LHLH

LH

LH

24 hours

Metaphase Metaphase II and polar II and polar body body extrusionextrusion

Metaphase II Metaphase II secondary secondary oocyte with oocyte with polar bodypolar body

24 hours

0 1 2 43 5 6

Estrus

1 92 3 54 6 7 8

LH

Su

rge

Ovu

lati

on

Red

uct

ion

Div

isio

n

Eggs ready for fertilization

Fertile period = 3-6 days post LH

LH = day 0

You are done!