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ELECTIVE STUDYPRESENTATION

 The Interaction of AntibioticLevooxacin with Glipzide as an

Anti Diabetic Drug in Leading theCause of Hpoglce!ia"

#i $ade% &etawati

'()())*'+'&e!ester II

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BACKGROUND

PROBLEMIDENTIFICATION

CHAPTER III

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BENEFIT

AIM

CHAPTER II

CHAPTER I

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OUTLINE

3AC$G2,-#D

Diabetes !ellitus Diabetes !ellitus infection

Insulin 4 non insulintreat!ent

Glipzide

Antibiotic treat!ent

Levooxacin

Hpoglce!ia

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OUTLINE

12,3L.5 ID.#TI6ICATI,#

12,3L.5 ID.#TI6ICATI,#

1. What kin !" ia#$t$% &$''it(%

)(*% &(%t #$ a+!i ,!n,!&itant'-(%$ ith '$+!/!0a,in

2. Wh- th$ (%$ !" '$+!/!0a,in ,an,a(%$ h-3!*'-,$&ia

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OUTLINE

AI5 4 3.#.6IT

AI5

T! an%$)th$ 3)!#'$&

i$nti4,ati!n

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3.#.6IT

F!) 3)a,ti,a'

F!)

)$%$a),h$)

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CHAPTER III

CHAPTER I

CHAPTER II

Dia#$t$% M$''it(%

Dia#$t$% M$''it(%D)(*%

L$+!/!0a,in

Int$)a,ti!n

,-TLI#.

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CHAPTER II

DIA3.T.& 5.LLIT-&

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Dia#$t$% &$''it(% i% a

 &$ta#!'i, i%!)$)

$"$,ti+$ in%('in%$,)$ti!n5 $"$,ti+$

in%('in a,ti!n !) #!th.

1. T-3$ 1 66 in%('in$3$n$nt

2. T-3$ 2 66 a%n!nin%('in $3$n$nt

7. G$%tati!na'ia#$t$% &$''it(%

T)$at&$nt 8

1. In%('in t)$at&$nt

2. N!n in%('int)$at&$nt

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CHAPTER II

DIA3.T.& 5.LLIT-&D2-G&

GLI17ID.

sulfonlureas

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CHAPTER II

L./,6L,8ACI#

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 P$ak 3'a%&a,!n,$nt)ati!n% a)$(%(a''- attain$ !n$ t!t! h!()% a"t$) !)a'!%in*

Th$ &$an t$)&ina' 3'a%&a $'i&inati!nha'"9'i"$ )an*$% ")!& a33)!0i&at$'- : t! ;h!()% "!''!in* %in*'$ !) &('ti3'$ !%$%*i+$n !)a''- !) int)a+$n!(%'-

E0,)$t$ 'a)*$'- a%(n,han*$ )(* in th$()in$.

 R E P O

 R T E D

 

 C A U S I N G

 H Y P O

 G L Y C E M I A

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CHAPTER III#T.2ACTI,#&

GLIP

LEVOFLO?ACIN=anti#i!ti,>

 insulinsecretion

D5

t r  e a t ! e n t 

3loodGlucoseLevel

H01,GL0C.5IA

  9  H  0   :  :  :

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GLIP

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ADDITIONAL SOURCEE?PLANATION

CHAPTER III#T.2ACTI,#&

1ri!ar insoenz!

pathwa for glipzide!etabolis!

Levooxacin inhibitC01(C?

 glipzide!etabolis

!inhibited

C01(C?

 G l i p z i d

 e  s t i l l 

 i n  o u r  b

 o d  

 a n d  s t i

 l l 

 c o n t i n u

 i n g 

 c o n s u ! i n

 g

 There is no glipzide !etabo

 L o n g e r  e @ e c

 t  o f 

 G l i p z i d e

 3 l o o d 

 g l u c o s

 e 

 ! o r e 

 d e c r e a

 s

 e

H   0   1  ,  

G  

L  0   C   .   5   I   A  

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CHAPTER I

CHAPTER II

C!n,'(%i!n

,-TLI#.

CHAPTER III

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BAB IIIC,#CL-&I,#

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THANK YOU