er - lthd...filtration iest-rp-cc034.1 iest-rp-cc001.3 iest-rp-cc007.1 en 1822 electrical safety...
TRANSCRIPT
Symme3D Biotech One is the world's first fully integrated, high precision
3D printer for biomass that features a state of the art temperature and
humidity controlled incubator.
Our product supports extensive prints using live stem cells and it features
twin HRV active filters with germicidal lamps for laminar air flow
processing. Its capabilities extend to extremely high precision movement
below 1 micrometer on all axis, as well as modular and multifunctional
pneumatic extruders for a wide range of bio compatible materials.
With conventional cell monitoring procedures, a culture vessel has to be
taken out of the incubator for microscope observation, where cells are
subjected to stressful environmental changes and vibration. Researchers
then have to spend additional time re-positioning the vessel to find the
same observation points. The integrated automatic micropipette
dispenser eliminates these problems by providing a stable environment
so that the cultures don't suffer while they are being imaged and allowing
for a complete trace of the same live cells, including stem cells.
Interchangeable Hybrid Extruder
Triple FDM Conventional extruder
Temperature: 100 to 350C
Nozzle: 200 to 400μm diameter for FDA approved thermoplas-
tic (PLA, PETG, Nylon680, PET, PC, SoftPLA)
Pneumatic dispenser: Hamilton dual PSD/4 pump
Accuracy ±1% @ 100% of stroke
Precision 0.05% @ > 100% stroke
Fluid Path Borosilicate glass, PTFE, CTFE, PFA
Bio dispenser:
Triple Syringes of up to 50ml of bioink and biocompatible
gells (Collagen, Gelatin, Fibrin, Hyaluronic Acid, Alginate)
Nozzle Size: 80 to 200um
Automatic micropipette dispenser system
8-Channel
20-300 µL
Ultra high positioning system (<1μm)
360 degree rotation range
Temperature control
from +5 up to +80C (substrate holder)
from +10 to 39C (incubation chamber)
Humidiier
Resonant frequency (KHz) FR=2.6+-0.5
Resonant impedance (ohm) Rr<=500
Range: 30-70%
Ultraviolet germicidal irradiation (UVGI)
UV Lamp 9W at 265nm wavelength
UV LED: 3W at 415nm wavelength
HEPA iltering system
H14 (99.995 <=0.3um D.O.P) HEPAFilter
Flow rate: 1900m^3/h
Heat recovery ventilation (HRV) technology
Laminar low hood
400W impeller drive
Airlow: 0.45m/s (90fpm)
Monitoring: internal display, CO2 and air quality
monitoring sensors
Air Quality ISO 14644-1, Class 3
Sterile Compounding USP 797
Filtration IEST-RP-CC034.1, IEST-RP-CC001.3,
IEST-RP-CC007.1, EN 1822
Electrical Safety UL-C-61010-1, CE Mark ROHS
Double walled polycarbonate door
UV-Ray Penetrability wave length 500nm(UV/VIS): 1.2%
Impact Strength: CNS11335 (Unbreakable)
Inlammability: UL 94V2 (Self-extinguishing)
Delection Temperature ASTM D648,18.6KG/cm²130-degree left side OR right side swing
Electronics removable drawer
Eight independent CPUsSoC: Broadcom BCM2837
CPU: 4× ARM Cortex-A53, 1.2GHz
GPU: Broadcom VideoCore IV
RAM: 1GB LPDDR2 (900 MHz)
Networking: 10/100 Ethernet, 2.4GHz 802.11n wireless
Bluetooth: Bluetooth 4.1 Classic, Bluetooth Low Energy
Storage: 32GB internal microSD, external USB
7 Inch touchscreen displayScreen Dimensions: 194mm x 110mm x 20mm
Viewable screen size: 155mm x 86mm
Screen Resolution 800 x 480 pixels
Triple disposable iltering system
Integrated toolhead 1000x
automatic focus microscope
Image Sensor: 0.3M HD CMOS Sensor (Digital 2M)
Focus Range: Automatic Focus from 0~200mm
Video Capture Resolution: 640x480
Still Image Capture Resolution: 1600x1200(2M Pixel),
1280x960(1.3M Pixel),800x600, 640x480
Frame Rate: Max. 30f/s Under 600 Lux Brightness
Flicker Control: 50Hz / 60Hz Option
Video Format: AVI
Snap Shot Format: JEPG
Magniication Ratio: 1000X
TYPICAL USE CASES:
3D Drug discovery
Complex in-vitro modelling of human diseases
Scafold based tissue engineering
APPLICATIONS TO STUDY & IDENTIFY BIOLOGICAL
PROCESSES:
Cell-cell interactions
Diferentiation
Response to stimuli
Diferentiation, Proliferation and morphology
In vivo relevance
Drug metabolism and expression (gene, proteins)
Environment and Extracellular matrix contact
MATERIAL CANDIDATES:
Cells, bioactives and signal molecules
Hydrogels and biopolymers
Polycaprolactone and thermopolymers
Calcium phosphates
Collagen, Hyaluronic acid, and gelatins
MODULARITY:
Selection of multiple dispensing technologies
(bioactive friendly ink-jet, extrusion, metering)
Cell friendly UV laser unit for hydrogel cross-linking
and photo-polymerization
Bioprinting in a controlled environment
(modular triple iltering system incubator with
UV germicidal lamps, hepa particle ilter and
laminar low hood)
Printing under physiological condition with
piezo-based printing heads
Smallest footprint on the market
Micrometer scale process repeatability
Speciications
Monitoring: internal display and air quality monitoring sensors
Air Quality ISO 14644-1, Class 3
Sterile Compounding USP 797
Filtration IEST-RP-CC034.1
IEST-RP-CC001.3
IEST-RP-CC007.1
EN 1822
Electrical Safety UL-C-61010-1
CE Mark ROHS
Physical dimensions: 480 x 480 x 750mm
Working range: 200 x 200 x 200mm
Precision: +- 0.06709μm
Triple disposable independent smart iltering systems featuring
Temperature control:
from +5 up to +80C (substrate holder)
from +10 to 39C (incubation chamber)
Humidiier:
Resonant frequency (KHz) FR=2.6+-0.5
Resonant impedance (ohm) Rr<=500
Range: 30-70%
Ultraviolet germicidal irradiation (UVGI)
UV Lamp 9W at 265nm wavelength
UV LED 3W at 415nm wavelength
APPLICATIONS TO STUDY & IDENTIFY BIOLOGICAL PROCESSES
Cell-cell interactions
Diferentiation
Response to stimuli
Diferentiation, Proliferation and morphology
In vivo relevance
Drug metabolism and expression (gene, proteins)
Environment and Extracellular matrix contact
Cells, bioactives and signal molecules
Hydrogels and biopolymers
Polycaprolactone and thermopolymers
Calcium phosphates
Collagen, Hyaluronic acid, and gelatins
MATERIAL CANDIDATES
Interchangeable Hybrid Extruder:
Triple FDM Conventional extruder,
Temperature: 100 to 350C
Nozzle: 200 to 400um diameter for FDA approved thermoplastic
(PLA, PETG, Nylon680, PET, PC, SoftPLA)
Pneumatic dispenser: Hamilton dual PSD/4 pump
Accuracy: ±1% @ 100% of stroke
Precision: 0.05% @ > 100% stroke
Fluid Path: Borosilicate glass, PTFE, CTFE, PFA or ceramic
Bio dispenser:
Triple Syringes of up to 50ml of bioink and biocompatible gells
(Collagen, Gelatin, Fibrin, Hyaluronic Acid, Alginate
Nozzle Size: 80 to 200μm
HEPA iltering system: H14 (99.995 <=0.3um D.O.P) HEPAFilter
Flow rate: 1900m^3/h
Laminar low hood: 400W impeller drive
Airlow: 0.45m/s (90fpm)