epstein-barr virus brittany seyler. what is it? herpes virus that infects b cells and epithelial...
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Epstein-Barr Virus
Brittany Seyler
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What is it?
• Herpes virus that infects B Cells and Epithelial cells- linked to malignancies in both
• Responsible for Infectious Mononucleosis
• 2nd most common
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BackgroundNamed after M. Anthony Epstein and
Yvonne Barr in 1961
Humans are the only known reservoir
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TransmissionSaliva
Blood transfusions
Infects 95% of the world’s population
90% of US population infected by age 25
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Symptoms •Fever
•Fatigue
•Sore throat
•Swollen lymph glands
•Weight Loss
•Vomiting
•Hemolysis
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Demographics
• Occurs worldwide• No racial predilection• Occurs earlier in
females than males
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Structure Crystal structure
Linear, double stranded DNA
“spikes”
Viral envelope easily damaged
Toroidal shaped core
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Representation Of Immuno response vs viral incubation.
•Each Line Plot represents different antigens to the EBV over the incubation period of the virus as a whole.
•This scaling can be used in the testing of carriers, and previous carriers of the EBV
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Viral Detail•Family:Herpesviridae
•Subfamily:Gammaherpesvirinae
•Genus:Lymphocryptovirus
•Species:Human herpesvirus 4 (HHV-4)
•Associated with several forms of cancer, lymphoma in HIV patients, and believed to be associated with higher risks of autoimmune conditions in those affected.
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Prevention
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Sources
http://www.cdc.gov/ncidod/diseases/ebv.htmhttp://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001617/http://emedicine.medscape.com/article/963894-overviewhttp://www.pnas.org/contenthttp://www.nature.com/nsmb/journalhttp://virus.stanford.edu/herpes/transmission.htmlhttp://bioweb.uwlax.edu
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Thank You :)