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Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal, Pradipta Ray, John W. Whitaker, Shulan Tian, R. David Hawkins, Danny Leung, Hongbo Yang, Tao Wang, Ah Young Lee, Scott A. Swanson, Jiuchun Zhang, Yun Zhu, Audrey Kim, Joseph R. Nery, Mark A. Urich, Samantha Kuan, Chia-an Yen, Sarit Klugman, Pengzhi Yu, Kran Suknuntha, Nicholas E. Propson, Huaming Chen, Lee E. Edsall, Ulrich Wagner, Yan Li, Zhen Ye, Ashwinikumar Kulkarni, Zhenyu Xuan, Wen-Yu Chung, Neil C. Chi, Jessica E. Antosiewicz-Bourget, Igor Slukvin, Ron Stewart, Michael Q. Zhang, Wei Wang, James A. Thomson, Joseph R. Ecker, Bing Ren Cell Volume 153, Issue 5, Pages 1134-1148 (May 2013) DOI: 10.1016/j.cell.2013.04.022 Copyright © 2013 Elsevier Inc. Terms and Conditions

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Page 1: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells 

Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal, Pradipta Ray, John W. Whitaker, Shulan Tian, R. David Hawkins, Danny Leung, Hongbo Yang, Tao Wang, Ah Young Lee, Scott A. Swanson, Jiuchun Zhang, Yun Zhu, Audrey Kim, Joseph R. Nery, Mark A. Urich, Samantha Kuan, Chia-an Yen, Sarit Klugman, Pengzhi Yu, Kran Suknuntha, Nicholas E. Propson, Huaming Chen,

Lee E. Edsall, Ulrich Wagner, Yan Li, Zhen Ye, Ashwinikumar Kulkarni, Zhenyu Xuan, Wen-Yu Chung, Neil C. Chi, Jessica E. Antosiewicz-Bourget, Igor Slukvin, Ron Stewart, Michael Q. Zhang, Wei Wang, James A. Thomson, Joseph R. Ecker, Bing Ren  

Cell Volume 153, Issue 5, Pages 1134-1148 (May 2013)

DOI: 10.1016/j.cell.2013.04.022

Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 2: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Figure 1

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 3: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Figure 2

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 4: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Figure 3

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 5: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Figure 4

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 6: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Figure 5

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 7: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Figure 6

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 8: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Figure 7

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 9: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Figure S1

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 10: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Figure S2

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 11: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Figure S3

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 12: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Figure S4

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 13: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Figure S5

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 14: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Figure S6

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 15: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Figure S7

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 16: Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal,

Cell 2013 153, 1134-1148DOI: (10.1016/j.cell.2013.04.022) Copyright © 2013 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

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