CURRICULUM VITAE

AGAMEMNON ANTONIOU EPENETOS

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NAME: Agamemnon Antoniou Epenetos DATE OF BIRTH: 15th October 1949 PLACE OF BIRTH: Nicosia, Cyprus NATIONALITY: British STATUS: Married PRIVATE ADDRESS: Flat 1, 6 Upper Park Road, London, NW3 2UP QUALIFICATIONS: MB, ChB. (Glasgow) 1973 MRCP (UK) 1977 PhD (University College London) 1983

FRCP (London) 1992, FRCP (Glasgow) 1992 PRESENT APPOINTMENTS Academic 2001-present Visiting Professor, Imperial College, London UK and School of Pharmacy, London, UK Clinical February 2001-present Honorary Consultant in Medical Oncology, St

Bartholomew’s Hospital, London, UK September 1998- present Consultant in Clinical Oncology, The Harley Street

Cancer Clinic, Harley Street, London, UK Biotech 1999- present Chairman of Trojantec Ltd. (www.trojantec.com),

Lifeline Biotech Ltd. (www.lifeline.com.cy) and Alexis Biotech Ltd.

2007- present Chief Scientific Officer- Europe Access Pharmaceuticals Inc. (www.accesspharma.com)

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2001 – present Founder and Chairman of Lifeline Biotech Ltd. (www.lifeline.com.cy) . 2000 – present Founder and Chairman of Trojantec Ltd.

(www.trojantec.com ) 1999 – present Founder, Director and Chairman of Alexis Biotech Ltd. PREVIOUS APPOINTMENTS 2001–2008 Founder, Director and CEO of Somanta Inc. (www.accesspharma.com) . 1999 – 2002 Founder and Chairman, Lipoxen plc. (www.lipoxen.com) . 1998 – 2001 Founder and Chairman, Zein Biotec plc.

( www.zeincro.com)

1996-2001 Consultant in Clinical Oncology, St. Mary's Hospital, Praed Street, London, UK

1995-1996 Deputy Director, Department of Clinical Oncology, Royal

Postgraduate Medical School, Hammersmith Hospital, London, UK

1994-2002 Founder and Chairman, IX Imaging plc. 1993-1996 Head of Clinical Research for ICRF clinical projects, ICRF

Oncology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London and Head of Research and Development, Department of Clinical Oncology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK

1990 – 2001 Founder, Director and Chairman (till 1996), Research and

Development Director and Chief Scientific Officer, Antisoma plc (1997-2001) . ( www.antisoma.com)

1985-1996 Consultant in Clinical Oncology, Professor and Senior

Scientist, Imperial Cancer Research Fund Oncology Unit, Department of Clinical Oncology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK

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1984-1985 Senior Lecturer and Consultant in Clinical Oncology, RPMS, Hammersmith Hospital, London, UK

1983-1984 Senior Research Fellow and Honorary Senior Registrar,

Department of Radiotherapy and Oncology, Hammersmith Hospital, London, UK and Honorary Senior Registrar in Clinical Oncology, Institute of Urology, Shaftesbury Avenue, London, UK (This post was supported by a Medical Research Council project grant and the Imperial Cancer Research Fund

1979-1982 Clinical Research Scientist, Imperial Cancer Research

Fund, Lincoln's Inn Field's, London, UK 1978-1979 Registrar to Professor J.S. Malpas, Dr. j. Wrigley and Dr.

T.A. Lister, Medical Oncology, Hackney and St. Bartholomew's Hospitals, London, UK

1977-1978 Senior House Officer to Professor J.S. Malpas and Dr.

P.F.M. Wrigley, Medical Oncology, Hackney and St. Bartholomew's Hospitals, London, UK

1975-1977 Registrar to Dr. T. Semple, General Medicine, Victoria

Infirmary, Glasgow, UK 1974-1975 Senior House Officer to Dr. R. Carslaw, Dermatology,

Victoria Infirmary, Glasgow, UK 1974-1975 House Officer to Dr. K.E. Morris, General Medicine,

Hairmyers Hospital, East Kilbride, Glasgow, UK 1973-1974 House Officer to Sir Robert B. Wright, General Surgery,

Southern General Hospital, Glasgow, UK 1971 Externship in Psychiatry, Warren State Hospital, Warren,

Pennsylvania, USA UNIVERSITY EDUCATION 1967-1973 Medical Faculty, Glasgow University, Glasgow, Scotland FUND RAISING My academic laboratory and clinical research programme (1985-1996) was funded by the Imperial Cancer Research Fund. This amounted to approximately £250,000 per annum. Between 1996 – present, I have been instrumental in raising more than £50m from financial investors and pharmaceutical partners in the UK, EU and the USA for several biotech companies conducting cancer research and drug development.

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1 Constantinou A, Epenetos AA, Hreczuk-Hirst D, Jain S, Deonarain MP. Modulation of antibody pharmacokinetics by chemical polysialylation. Bioconjug Chem. 2008 Mar;19(3):643-50. Epub 2008 Feb 29. PMID: 18307285 [PubMed - indexed for MEDLINE] 2 Savage P, Dyson J, Milrain M, Mathews D, King B, Chan HT, Barber L, Epenetos A, Ogg G, McMichael A, Glennie MJ, French RR. Immunotherapy with antibody-targeted HLA class I complexes: results of in vivo tumour cell killing and therapeutic vaccination. Tumour Biol. 2007;28(4):205-11. Epub 2007 Aug 20. PMID: 17709989 [PubMed - indexed for MEDLINE] 3 Oei AL, Verheijen RH, Seiden MV, Benigno BB, Lopes A, Soper JT, Epenetos AA, Massuger LF. Decreased intraperitoneal disease recurrence in epithelial ovarian cancer patients receiving intraperitoneal consolidation treatment with yttrium-90-labeled murine HMFG1 without improvement in overall survival. Int J Cancer. 2007 Jun 15;120(12):2710-4. PMID: 17354223 [PubMed - indexed for MEDLINE] 4 Verheijen RH, Massuger LF, Benigno BB, Epenetos AA, Lopes A, Soper JT, Markowska J, Vyzula R, Jobling T, Stamp G, Spiegel G, Thurston D, Falke T, Lambert J, Seiden MV. Phase III trial of intraperitoneal therapy with yttrium-90-labeled HMFG1 murine monoclonal antibody in patients with epithelial ovarian cancer after a surgically defined complete remission. J Clin Oncol. 2006 Feb 1;24(4):571-8. PMID: 16446329 [PubMed - indexed for MEDLINE] 5 Pericleous LM, Richards J, Epenetos AA, Courtenay-Luck N, Deonarain MP. Characterisation and internalisation of recombinant humanised HMFG-1 antibodies against MUC1. Br J Cancer. 2005 Nov 28;93(11):1257-66. PMID: 16265351 [PubMed - indexed for MEDLINE] 6 Zbar AP, Thomas H, Wilkinson RW, Wadhwa M, Syrigos KN, Ross EL, Dilger P, Allen-Mersh TG, Kmiot WA, Epenetos AA, Snary D, Bodmer WF. Immune responses in advanced colorectal cancer following repeated intradermal vaccination with the anti-CEA murine monoclonal antibody, PR1A3: results of a phase I study.

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Int J Colorectal Dis. 2005 Sep;20(5):403-14. Epub 2005 Apr 30. PMID: 15864608 [PubMed - indexed for MEDLINE] 7 Stebbing J, Gazzard B, Patterson S, Bower M, Nelson M, Epenetos A, Ogg G, Gotch F, Savage P. Simplified one-step antibody-HLA directed expansion of HIV-specific cytotoxic T lymphocytes: a system suited for use in vivo. AIDS. 2004 Oct 21;18(15):2099-101. No abstract available. PMID: 15577637 [PubMed - indexed for MEDLINE] 8 Savage P, Gao L, Vento K, Cowburn P, Man S, Steven N, Ogg G, McMichael A, Epenetos A, Goulmy E, Stauss HJ. Use of B cell-bound HLA-A2 class I monomers to generate high-avidity, allo- restricted CTLs against the leukemia-associated protein Wilms tumor antigen. Blood. 2004 Jun 15;103(12):4613-5. Epub 2004 Feb 26. PMID: 14988155 [PubMed - indexed for MEDLINE] 9 Stebbing J, Gazzard B, Patterson S, Bower M, Perumal D, Nelson M, McMichael A, Ogg G, Epenetos A, Gotch F, Savage P. Antibody-targeted MHC complex-directed expansion of HIV-1- and KSHV-specific CD8+ lymphocytes: a new approach to therapeutic vaccination. Blood. 2004 Mar 1;103(5):1791-5. Epub 2003 Nov 6. PMID: 14604955 [PubMed - indexed for MEDLINE] 10 Jain S, Hreczuk-Hirst DH, McCormack B, Mital M, Epenetos A, Laing P, Gregoriadis G. Polysialylated insulin: synthesis, characterization and biological activity in vivo. Biochim Biophys Acta. 2003 Jun 20;1622(1):42-9. PMID: 12829260 [PubMed - indexed for MEDLINE] 11 Savage P, Cowburn P, Clayton A, Man S, McMichael A, Lemoine N, Epenetos A, Ogg G. Induction of viral and tumour specific CTL responses using antibody targeted HLA class I peptide complexes. Br J Cancer. 2002 Apr 22;86(8):1336-42. PMID: 11953895 [PubMed - indexed for MEDLINE] 12 Kousparou CA, Epenetos AA, Deonarain MP. Antibody-guided enzyme therapy of cancer producing cyanide results in necrosis of targeted cells. Int J Cancer. 2002 May 1;99(1):138-48.

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PMID: 11948505 [PubMed - indexed for MEDLINE] 13 Savage P, Cowburn P, Clayton A, Man S, Lawson T, Ogg G, Lemoine N, McMichael A, Epenetos A. Anti-viral cytotoxic T cells inhibit the growth of cancer cells with antibody targeted HLA class I/peptide complexes in SCID mice. Int J Cancer. 2002 Apr 1;98(4):561-6. PMID: 11920616 [PubMed - indexed for MEDLINE] 14 Kalofonos HP, Karamouzis MV, Epenetos AA. Radioimmunoscintigraphy in patients with ovarian cancer. Acta Oncol. 2001;40(5):549-57. Review. PMID: 11669325 [PubMed - indexed for MEDLINE] 15 Epenetos AA, Hird V, Lambert H, Mason P, Coulter C. Long term survival of patients with advanced ovarian cancer treated with intraperitoneal radioimmunotherapy. Int J Gynecol Cancer. 2000 Jan;10(S1):44-46. PMID: 11240732 [PubMed - as supplied by publisher] 16 Linardou H, Epenetos AA, Deonarain MP. A recombinant cytotoxic chimera based on mammalian deoxyribonuclease-I. Int J Cancer. 2000 May 15;86(4):561-9. PMID: 10797272 [PubMed - indexed for MEDLINE] 17 Koumarianou AA, Hudson M, Williams R, Epenetos AA, Stamp GW. Development of a novel bi-specific monoclonal antibody approach for tumour targeting. Br J Cancer. 1999 Oct;81(3):431-9. PMID: 10507767 [PubMed - indexed for MEDLINE] 18 Syrigos KN, Deonarian DP, Epenetos AA. Use of monoclonal antibodies for the diagnosis and treatment of bladder cancer. Hybridoma. 1999 Jun;18(3):219-24. Review. PMID: 10475235 [PubMed - indexed for MEDLINE] 19 Kalofonos HP, Giannakenas C, Kosmas C, Apostolopoulos D, Onienadum A, Petsas T, Dimopoulos D, Epenetos AA, Vassilakos PJ. Radioimmunoscintigraphy in patients with ovarian cancer. Acta Oncol. 1999;38(5):629-34. PMID: 10427953 [PubMed - indexed for MEDLINE]

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20 Syrigos KN, Khawaja M, Krausz T, Williams G, Epenetos AA. Intravesical administration of radiolabelled tumour-associated monoclonal antibody in bladder cancer. Acta Oncol. 1999;38(3):379-82. PMID: 10380831 [PubMed - indexed for MEDLINE] 21 Syrigos KN, Epenetos AA. Antibody directed enzyme prodrug therapy (ADEPT): a review of the experimental and clinical considerations. Anticancer Res. 1999 Jan-Feb;19(1A):605-13. Review. PMID: 10226606 [PubMed - indexed for MEDLINE] 22 Syrigos KN, Rowlinson-Busza G, Epenetos AA. In vitro cytotoxicity following specific activation of amygdalin by beta-glucosidase conjugated to a bladder cancer-associated monoclonal antibody. Int J Cancer. 1998 Dec 9;78(6):712-9. PMID: 9833764 [PubMed - indexed for MEDLINE] 23 Sivolapenko GB, Skarlos D, Pectasides D, Stathopoulou E, Milonakis A, Sirmalis G, Stuttle A, Courtenay-Luck NS, Konstantinides K, Epenetos AA. Imaging of metastatic melanoma utilising a technetium-99m labelled RGD-containing synthetic peptide. Eur J Nucl Med. 1998 Oct;25(10):1383-9. PMID: 9818277 [PubMed - indexed for MEDLINE] 24 Maraveyas A, Rowlinson-Busza G, Murray S, Epenetos AA. Improving tumour targeting and decreasing normal tissue uptake by optimizing the stoichiometry of a two-step biotinylated-antibody/streptavidin-based targeting strategy: studies in a nude mouse xenograft model. Int J Cancer. 1998 Nov 23;78(5):610-7. PMID: 9808531 [PubMed - indexed for MEDLINE] 25 Lundin J, Osterborg A, Brittinger G, Crowther D, Dombret H, Engert A, Epenetos A,. Gisselbrecht C, Huhn D, Jaeger U, Thomas J, Marcus R, Nissen N, Poynton C, Rankin E, Stahel R, Uppenkamp M, Willemze R, Mellstedt H CAMPATH-1H monoclonal antibody in therapy for previously treated low-grade non- Hodgkin's lymphomas: a phase II multicenter study. European Study Group of CAMPATH-1H Treatment in Low-Grade Non-Hodgkin's Lymphoma. J Clin Oncol. 1998 Oct;16(10):3257-63.

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PMID: 9779699 [PubMed - indexed for MEDLINE] 26 Kosmas C, Kalofonos HP, Hird V, Epenetos AA. Monoclonal antibody targeting of ovarian carcinoma. Oncology. 1998 Sep-Oct;55(5):435-46. PMID: 9732222 [PubMed - indexed for MEDLINE] 27 Nicholson S, Gooden CS, Hird V, Maraveyas A, Mason P, Lambert HE, Meares CF, Epenetos AA. Radioimmunotherapy after chemotherapy compared to chemotherapy alone in the treatment of advanced ovarian cancer: a matched analysis. Oncol Rep. 1998 Jan-Feb;5(1):223-6. PMID: 9458326 [PubMed - indexed for MEDLINE] 28 Deonarain MP, Epenetos AA. Design, characterization and anti-tumour cytotoxicity of a panel of recombinant, mammalian ribonuclease-based immunotoxins. Br J Cancer. 1998 Feb;77(4):537-46. PMID: 9484808 [PubMed - indexed for MEDLINE] 29 Mariani G, Lasku A, Pau A, Villa G, Motta C, Calcagno G, Taddei GZ, Castellani P, Syrigos K, Dorcaratto A, Epenetos AA, Zardi L, Viale GA. A pilot pharmacokinetic and immunoscintigraphic study with the technetium-99m- labeled monoclonal antibody BC-1 directed against oncofetal fibronectin in patients with brain tumors. Cancer. 1997 Dec 15;80(12 Suppl):2484-9. PMID: 9406699 [PubMed - indexed for MEDLINE] 30 Deonarain MP, Rowlinson-Busza G, George AJ, Epenetos AA. Redesigned anti-human placental alkaline phosphatase single-chain Fv: soluble expression, characterization and in vivo tumour targeting. Protein Eng. 1997 Jan;10(1):89-98. PMID: 9051739 [PubMed - indexed for MEDLINE] 31 Sivolapenko GB, Imami N, Larché M, Epenetos AA, Ritter MA. Enhanced in vivo immunogenicity induced by an antibody to the IL-4 receptor- associated gp200-MR6 molecule. Scand J Immunol. 1996 Aug;44(2):135-42. PMID: 8711426 [PubMed - indexed for MEDLINE] 32 Nicholson S, Fox M, Epenetos A, Rustin G.

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Immunoglobulin Inhibiting Reagent: evaluation of a new method for eliminating spurious elevations in CA125 caused by HAMA. Int J Biol Markers. 1996 Jan-Mar;11(1):46-9. PMID: 8740642 [PubMed - indexed for MEDLINE] 33 Syrigos KN, Krausz T, Waxman J, Pandha H, Rowlinson-Busza G, Verne J, Epenetos AA, Pignatelli M. E-cadherin expression in bladder cancer using formalin-fixed, paraffin-embedded tissues: correlation with histopathological grade, tumour stage and survival. Int J Cancer. 1995 Dec 20;64(6):367-70. PMID: 8550236 [PubMed - indexed for MEDLINE] 34 Boleti E, George AJ, Epenetos AA. Therapeutic monoclonals. Biochem Soc Trans. 1995 Nov;23(4):1044-7. Review. No abstract available. PMID: 8654678 [PubMed - indexed for MEDLINE] 35 Boleti E, Deonarain MP, Spooner RA, Smith AJ, Epenetos AA, George AJ. Construction, expression and characterisation of a single chain anti-tumour antibody (scFv)-IL-2 fusion protein. Ann Oncol. 1995 Nov;6(9):945-7. PMID: 8624300 [PubMed - indexed for MEDLINE] 36 Deonarain MP, Spooner RA, Epenetos AA. Genetic delivery of enzymes for cancer therapy. Gene Ther. 1995 Jun;2(4):235-44. Review. PMID: 7552983 [PubMed - indexed for MEDLINE] 37 Gooden CS, Snook DE, Maraveyas A, Rowlinson-Busza G, Peters AM, Epenetos AA. Direct technetium-99m labeling of three anticancer monoclonal antibodies: stability, pharmacokinetics and imaging. J Nucl Med. 1995 May;36(5):842-9. PMID: 7738662 [PubMed - indexed for MEDLINE] 38 Kosmas C, Maraveyas A, Gooden CS, Snook D, Epenetos AA. Anti-chelate antibodies after intraperitoneal yttrium-90-labeled monoclonal antibody immunoconjugates for ovarian cancer therapy. J Nucl Med. 1995 May;36(5):746-53. PMID: 7738643 [PubMed - indexed for MEDLINE] 39 Spooner RA, Deonarain MP, Epenetos AA.

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DNA vaccination for cancer treatment. Gene Ther. 1995 May;2(3):173-80. Review. PMID: 7614247 [PubMed - indexed for MEDLINE] 40 Rowlinson-Busza G, Maraveyas A, Epenetos AA. Effect of tumour necrosis factor on the uptake of specific and control monoclonal antibodies in a human tumour xenograft model. Br J Cancer. 1995 Apr;71(4):660-5. PMID: 7710925 [PubMed - indexed for MEDLINE] 41 Syrigos KN, Epenetos AA. Radioimmunotherapy of ovarian cancer. Hybridoma. 1995 Apr;14(2):121-4. Review. PMID: 7590766 [PubMed - indexed for MEDLINE] 42 Maraveyas A, Stafford N, Rowlinson-Busza G, Stewart JS, Epenetos AA. Pharmacokinetics, biodistribution, and dosimetry of specific and control radiolabeled monoclonal antibodies in patients with primary head and neck squamous cell carcinoma. Cancer Res. 1995 Mar 1;55(5):1060-9. PMID: 7866989 [PubMed - indexed for MEDLINE] 43 Maraveyas A, Myers M, Stafford N, Rowlinson-Busza G, Stewart JS, Epenetos AA. Radiolabeled antibody combined with external radiotherapy for the treatment of head and neck cancer: reconstruction of a theoretical phantom of the larynx for radiation dose calculation to local tissues. Cancer Res. 1995 Mar 1;55(5):1020-7. PMID: 7866985 [PubMed - indexed for MEDLINE] 44 Hatzistilianou MN, Sivolapenko GB, Courtenay-Luck NS, Epenetos AA, Ritter MA. Generation of monoclonal antibodies utilizing the host anti-idiotypic network. In Vivo. 1995 Mar-Apr;9(2):139-44. PMID: 7548789 [PubMed - indexed for MEDLINE] 45 George AJ, Spooner RA, Epenetos AA. Applications of monoclonal antibodies in clinical oncology. Immunol Today. 1994 Dec;15(12):559-61. PMID: 7848515 [PubMed - indexed for MEDLINE] 46 Deonarain MP, Epenetos AA. Targeting enzymes for cancer therapy: old enzymes in new roles.

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Br J Cancer. 1994 Nov;70(5):786-94. Review. PMID: 7947082 [PubMed - indexed for MEDLINE] 47 Sivolapenko GB, Paganelli G, Epenetos AA, Ritter MA. Antigen "suicide": a preliminary study on the induction of specific anti- immunoglobulin immunological suppression in vivo, using radiolabelled immunoglobulin as "lethal" antigen. Int J Biol Markers. 1994 Oct-Dec;9(4):211-8. PMID: 7836798 [PubMed - indexed for MEDLINE] 48 Arka A, Aktolun C, Gooden C, Epenetos A, Papadimitriou A. Tc-99m-labeled nonspecific polyclonal human immunoglobulin G is taken up by malignant tumors. Clin Nucl Med. 1994 Aug;19(8):708-12. PMID: 7955752 [PubMed - indexed for MEDLINE] 49 Kosmas C, Epenetos AA, Courtenay-Luck NS. Activation of cellular immunity after intracavitary monoclonal antibody therapy of ovarian cancer. Cancer. 1994 Jun 15;73(12):3000-10. PMID: 8199996 [PubMed - indexed for MEDLINE] 50 Spooner RA, Murray S, Rowlinson-Busza G, Deonarain MP, Chu A, Epenetos AA. Genetically engineered antibodies for diagnostic pathology. Hum Pathol. 1994 Jun;25(6):606-14. PMID: 8013953 [PubMed - indexed for MEDLINE] 51 Taylor-Papadimitriou J, Epenetos AA. Exploiting altered glycosylation patterns in cancer: progress and challenges in diagnosis and therapy. Trends Biotechnol. 1994 Jun;12(6):227-33. Review. PMID: 7765069 [PubMed - indexed for MEDLINE] 52 Rowlinson-Busza G, Snook D, Epenetos AA. 90Y-labeled antibody uptake by human tumor xenografts and the effect of systemic administration of EDTA. Int J Radiat Oncol Biol Phys. 1994 Mar 30;28(5):1257-65. PMID: 8175414 [PubMed - indexed for MEDLINE] 53 Spooner RA, Allen DJ, Epenetos AA, Lord JM. Expression of immunoglobulin heavy chain-ricin A chain fusions in mammalian cells.

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Mol Immunol. 1994 Feb;31(2):117-25. PMID: 8309475 [PubMed - indexed for MEDLINE] 54 Maraveyas A, Snook D, Hird V, Kosmas C, Meares CF, Lambert HE, Epenetos AA. Pharmacokinetics and toxicity of an yttrium-90-CITC-DTPA-HMFG1 radioimmunoconjugate for intraperitoneal radioimmunotherapy of ovarian cancer. Cancer. 1994 Feb 1;73(3 Suppl):1067-75. PMID: 8306249 [PubMed - indexed for MEDLINE] 55 Kalofonos HP, Kosmas C, Hird V, Snook DE, Epenetos AA. Targeting of tumours with murine and reshaped human monoclonal antibodies against placental alkaline phosphatase: immunolocalisation, pharmacokinetics and immune response. Eur J Cancer. 1994;30A(12):1842-50. PMID: 7880616 [PubMed - indexed for MEDLINE] 56 Zorzos J, Skarlos DV, Pozatzidou P, Zizi A, Bakiras A, Koritsiadis S, Pectasidis D, Koutsioumba P, Epenetos AA, Likourinas M. Immunoscintigraphy with iodine-131-labelled monoclonal antibody AUA1 in patients with transitional cell carcinoma of the bladder. Urol Res. 1994;22(5):323-7. PMID: 7879319 [PubMed - indexed for MEDLINE] 58 Harrington KJ, Epenetos AA. Recent developments in radioimmunotherapy. Clin Oncol (R Coll Radiol). 1994;6(6):391-8. Review. PMID: 7873487 [PubMed - indexed for MEDLINE] 59 Deonarain MP, Epenetos AA. Targeting phosphodiesterases as a strategy for killing tumor cells. Cell Biophys. 1994;24-25:249-57. PMID: 7736530 [PubMed - indexed for MEDLINE] 60 Linardou H, Deonarain MP, Spooner RA, Epenetos AA. Deoxyribonuclease I (DNAse I). A novel approach for targeted cancer therapy. Cell Biophys. 1994;24-25:243-8. PMID: 7736529 [PubMed - indexed for MEDLINE] 61 Savage P, Rowlinson-Busza G, Verhoeyen M, Spooner RA, So A, Windust J, Davis PJ, Epenetos AA. Construction, characterisation and kinetics of a single chain antibody recognising the

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tumour associated antigen placental alkaline phosphatase. Br J Cancer. 1993 Oct;68(4):738-42. PMID: 8398702 [PubMed - indexed for MEDLINE] 62 Hird V, Maraveyas A, Snook D, Dhokia B, Soutter WP, Meares C, Stewart JS, Mason P, Lambert HE, Epenetos AA. Adjuvant therapy of ovarian cancer with radioactive monoclonal antibody. Br J Cancer. 1993 Aug;68(2):403-6. PMID: 8347497 [PubMed - indexed for MEDLINE] 63 Bamias A, Bowles MJ, Krausz T, Williams G, Epenetos AA. Intravesical administration of indium-111-labelled HMFG2 monoclonal antibody in superficial bladder carcinomas. Int J Cancer. 1993 Jul 30;54(6):899-903. PMID: 8335396 [PubMed - indexed for MEDLINE] 64 Savage P, So A, Spooner RA, Epenetos AA. A recombinant single chain antibody interleukin-2 fusion protein. Br J Cancer. 1993 Feb;67(2):304-10. PMID: 8431359 [PubMed - indexed for MEDLINE] 65 Pavlović S, Jovanović D, Radosavljević G, Kozarević N, Nastić-Mirić D, Rebić R, Bosnjáković V, Epenetos A. Targeting of non-small cell lung cancer using HMFG1-99mTc monoclonal antibodies. Med Pregl. 1993;46 Suppl 1:26-8. PMID: 8569597 [PubMed - indexed for MEDLINE] 66 Epenetos AA, Linardou H. New molecular targets and therapeutic strategies against cancer. Int J Biol Markers. 1993 Jan-Mar;8(1):1-7. No abstract available. PMID: 8496626 [PubMed - indexed for MEDLINE] 67 Maraveyas A, Epenetos AA. Targeted immunotherapy. An update with special emphasis on ovarian cancer. Acta Oncol. 1993;32(7-8):741-6. Review. PMID: 8305221 [PubMed - indexed for MEDLINE] 68 Zorzos J, Skarlos DV, Epenetos AA, Pectasides D, Koutsioumba P, Elemenoglou J, Bakiras A, Likourinas M, Dimopoulos K. Intravesical administration of tumor-associated monoclonal antibody AUA1 in transitional cell carcinoma of the bladder: a study of biodistribution.

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Urol Res. 1993;21(6):435-8. PMID: 8171767 [PubMed - indexed for MEDLINE] 69 Kosmas C, Linardou H, Epenetos AA. Review: advances in monoclonal antibody tumour targeting. J Drug Target. 1993;1(2):81-91. Review. PMID: 8069556 [PubMed - indexed for MEDLINE] 70 Savage P, So A, Spooner RA, Epenetos AA. A recombinant single-chain antibody interleukin-2 fusion protein. Cell Biophys. 1993 Jan-Jun;22(1-3):61-77. PMID: 7889543 [PubMed - indexed for MEDLINE] 71 Gooden CS, Snook DE, Epenetos AA. Technetium-99m-labeled antibodies. Stability compared to 125I labeled antibodies.

Cell Biophys. 1993 Jan-Jun;22(1-3):49-59. PMID: 7889542 [PubMed - indexed for MEDLINE]

72 Spooner RA, Deonarain MP, Savage P, Epenetos AA.

A universal antibody-derived targeting agent.

Cell Biophys. 1993 Jan-Jun;22(1-3):225-42. PMID: 7889540 [PubMed - indexed for MEDLINE]

73 Rowlinson-Busza G, Epenetos AA.

Targeted delivery of biologic and other antineoplastic agents.

Curr Opin Oncol. 1992 Dec;4(6):1142-8. Review. PMID: 1457528 [PubMed - indexed for MEDLINE]

74 Kosmas C, Epenetos AA, Courtenay-Luck NS.

Effects of phorbol esters and cytokines (interleukin-2,-4, and -6) on the proliferation and surface phenotype of Epstein-Barr virus immortalised human B lymphocytes.

Leuk Lymphoma. 1992 Sep;8(1-2):109-15. PMID: 1337296 [PubMed - indexed for MEDLINE]

75 Malik ST, Epenetos AA.

The immune system and gynaecological cancer.

Baillieres Clin Obstet Gynaecol. 1992 Sep;6(3):641-56. Review. PMID: 1280188 [PubMed - indexed for MEDLINE]

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76 Kosmas C, Snook D, Gooden CS, Courtenay-Luck NS, McCall MJ, Meares CF, Epenetos AA. Development of humoral immune responses against a macrocyclic chelating agent (DOTA) in cancer patients receiving radioimmunoconjugates for imaging and therapy.

Cancer Res. 1992 Feb 15;52(4):904-11. PMID: 1737353 [PubMed - indexed for MEDLINE]

77 Schatten C, Pateisky N, Vavra N, Angelberger P, Ehrenböck P, Barrada M, Epenetos

AA. [Lymphoscintigraphy with (123)I-marked epidermal growth factor in cervix cancer]

Gynakol Geburtshilfliche Rundsch. 1992;32(1):17-21. German. PMID: 1515777 [PubMed - indexed for MEDLINE]

78 Bast RC Jr, Knauf S, Epenetos A, Dhokia B, Daly L, Tanner M, Soper J, Creasman

W, Gall S, Knapp RC, et al. Coordinate elevation of serum markers in ovarian cancer but not in benign disease.

Cancer. 1991 Oct 15;68(8):1758-63. PMID: 1913520 [PubMed - indexed for MEDLINE]

79 Kosmas C, Epenetos AA, Courtenay-Luck NS.

Patients receiving murine monoclonal antibody therapy for malignancy develop T cells that proliferate in vitro in response to these antibodies as antigens.

Br J Cancer. 1991 Sep;64(3):494-500. PMID: 1911190 [PubMed - indexed for MEDLINE]

80 Sivolapenko GB, Moreno C, Smith W, Corválan J, Ritter MA, Epenetos AA.

Xenogeneic monoclonal antibodies in the management of cancer: control of their in vivo immunogenicity and induction of specific unresponsiveness using an antibody-drug immunoconjugate.

Br J Cancer. 1991 Aug;64(2):281-7. PMID: 1892756 [PubMed - indexed for MEDLINE]

81 Rowlinson-Busza G, Bamias A, Krausz T, Epenetos AA.

Uptake and distribution of specific and control monoclonal antibodies in subcutaneous xenografts following intratumor injection.

Cancer Res. 1991 Jun 15;51(12):3251-6. PMID: 2040000 [PubMed - indexed for MEDLINE]

82 Schatten C, Pateisky N, Vavra N, Ehrenbock P, Angelberger P, Sivolapenko G,

Epenetos A. Lymphoscintigraphy with 123I-labelled epidermal growth factor.

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Lancet. 1991 Feb 16;337(8738):395-6. PMID: 1671427 [PubMed - indexed for MEDLINE]

83 Wilson CB, Snook DE, Dhokia B, Taylor CV, Watson IA, Lammertsma AA,

Lambrecht R, Waxman J, Jones T, Epenetos AA. Quantitative measurement of monoclonal antibody distribution and blood flow using positron emission tomography and 124iodine in patients with breast cancer.

Int J Cancer. 1991 Feb 1;47(3):344-7. PMID: 1847121 [PubMed - indexed for MEDLINE]

84 Bamias A, Keane P, Krausz T, Williams G, Epenetos AA.

Intravesical administration of radiolabeled antitumor monoclonal antibody in bladder carcinoma.

Cancer Res. 1991 Jan 15;51(2):724-8. PMID: 1985790 [PubMed - indexed for MEDLINE]

85 Pateisky N, Schatten C, Vavra N, Ehreböck P, Angelberger P, Barrada M, Epenetos

A. Lymphoscintigraphy using epidermal growth factor as tumour-seeking agent in uterine cervical cancer.

Wien Klin Wochenschr. 1991;103(21):654-6. PMID: 1771899 [PubMed - indexed for MEDLINE]

86 Maraveyas A, Epenetos AA.

An overview of radioimmunotherapy.

Cancer Immunol Immunother. 1991;34(2):71-3. Review. PMID: 1760818 [PubMed - indexed for MEDLINE]

87 Kalofonos HP, Rusckowski M, Siebecker DA, Sivolapenko GB, Snook D, Lavender

JP, Epenetos AA, Hnatowich DJ. Imaging of tumor in patients with indium-111-labeled biotin and streptavidin-conjugated antibodies: preliminary communication.

J Nucl Med. 1990 Nov;31(11):1791-6. PMID: 2230992 [PubMed - indexed for MEDLINE]

88 Kalofonos HP, Kosmas C, Pawlikowska TR, Bamias A, Snook D, Dhokia B,

Sivolapenko GB, Courtenay-Luck NS, Epenetos AA. Immunolocalisation of testicular tumours using radiolabelled monoclonal antibody to placental alkaline phosphatase.

J Nucl Med Allied Sci. 1990 Oct-Dec;34(4):294-8. PMID: 2090793 [PubMed - indexed for MEDLINE]

18

89 Snook DE, Rowlinson-Busza G, Sharma HL, Epenetos AA. Preparation and in vivo study of 124I-labelled monoclonal antibody H17E2 in a human tumour xenograft model. A prelude to positron emission tomography (PET).

Br J Cancer Suppl. 1990 Jul;10:89-91. PMID: 2383487 [PubMed - indexed for MEDLINE]

90 Kosmas C, Man S, Epenetos AA, Courtenay-Luck NS.

The role of humoral and cellular immunity in patients developing human anti-murine immunoglobulin antibody responses after radioimmunotherapy.

Br J Cancer Suppl. 1990 Jul;10:85-8. PMID: 2383486 [PubMed - indexed for MEDLINE]

91 Hird V, Stewart JS, Snook D, Dhokia B, Coulter C, Lambert HE, Mason WP, Soutter

WP, Epenetos AA. Intraperitoneally administered 90Y-labelled monoclonal antibodies as a third line of treatment in ovarian cancer. A phase 1-2 trial: problems encountered and possible solutions.

Br J Cancer Suppl. 1990 Jul;10:48-51. PMID: 2383480 [PubMed - indexed for MEDLINE]

92 Meares CF, Moi MK, Diril H, Kukis DL, McCall MJ, Deshpande SV, DeNardo SJ,

Snook D, Epenetos AA. Macrocyclic chelates of radiometals for diagnosis and therapy.

Br J Cancer Suppl. 1990 Jul;10:21-6. PMID: 2383477 [PubMed - indexed for MEDLINE]

93 Löhde E, Schwarzendahl P, Schlicker H, Abri O, Kalthoff H, Matzku S, Epenetos

AA, Kraas E. Accumulation characteristics of human colon carcinomas after monoclonal antibody ex vivo perfusion.

Br J Cancer Suppl. 1990 Jul;10:12-4. PMID: 2383474 [PubMed - indexed for MEDLINE]

94 Athanassiou A, Pectasides D, Pateniotis K, Tzimis L, Lafi A, Cross A, Epenetos A.

131I-labelled monoclonal antibody H17E2 in the detection of subcutaneous metastasis from gestational choriocarcinoma.

Anticancer Res. 1990 Jul-Aug;10(4):913-5. PMID: 2382988 [PubMed - indexed for MEDLINE]

19

95 Pectasides D, Vonorta P, Tsialta-Salihou A, Pateniotis K, Barbounis V, Kayianni H, Arapantoni P, Taylor-Papadimitriou J, Epenetos A, Koutsiouba P, et al. Immunoscintigraphy with 131I-labelled H17E2 monoclonal antibody compared with conventional lymphangiography and computed tomography in the detection of metastases in patients with testicular germ cell tumours.

Br J Cancer Suppl. 1990 Jul;10:74-7. PMID: 2166553 [PubMed - indexed for MEDLINE]

96 Paganelli G, Pervez S, Siccardi AG, Rowlinson G, Deleide G, Chiolerio F, Malcovati

M, Scassellati GA, Epenetos AA. Intraperitoneal radio-localization of tumors pre-targeted by biotinylated monoclonal antibodies.

Int J Cancer. 1990 Jun 15;45(6):1184-9. PMID: 2351490 [PubMed - indexed for MEDLINE]

97 Davies KA, Hird V, Stewart S, Sivolapenko GB, Jose P, Epenetos AA, Walport MJ.

A study of in vivo immune complex formation and clearance in man.

J Immunol. 1990 Jun 15;144(12):4613-20. PMID: 2141040 [PubMed - indexed for MEDLINE]

98 Bergh J, Nilsson S, Liljedahl C, Maripuu E, Sivolapenko G, Epenetos A, Stavrou D.

Radioimaging of human malignant gliomas using indium-labelled monoclonal antibodies.

Nucl Med Commun. 1990 Jun;11(6):437-44. PMID: 2385429 [PubMed - indexed for MEDLINE]

Bergh J, Nilsson S, Liljedahl C, Sivolapenko G, Maripuu E, Stavrou D, Epenetos A.

99 In vivo imaging and treatment of human brain tumours utilizing the radiolabelled monoclonal antibody MUC 2-63.

Anticancer Res. 1990 May-Jun;10(3):655-60. PMID: 2369081 [PubMed - indexed for MEDLINE]

100 Bergh J, Nilsson S, Liljedahl C, Lennartsson L, Maripuu E, Blomqvist E, Sivolapenko

G, Epenetos A, Stavrou D. [Indium-labelled monoclonal antibodies for diagnosis of malignant glioma in vivo?]

Lakartidningen. 1990 Feb 7;87(6):373-5. Swedish. No abstract available. PMID: 2156120 [PubMed - indexed for MEDLINE]

101 Stewart JS, Sivolapenko GB, Hird V, Davies KA, Walport M, Ritter MA, Epenetos

AA. Clearance of 131I-labeled murine monoclonal antibody from patients' blood by intravenous human anti-murine immunoglobulin antibody.

20

Cancer Res. 1990 Feb 1;50(3):563-7. PMID: 2297697 [PubMed - indexed for MEDLINE]

102 Kalofonos H, Rowlinson G, Epenetos AA.

Enhancement of monoclonal antibody uptake in human colon tumor xenografts following irradiation.

Cancer Res. 1990 Jan 1;50(1):159-63. PMID: 2403414 [PubMed - indexed for MEDLINE]

103 Kosmas C, Kalofonos HP, Epenetos AA.

Radiolabelled monoclonal antibodies in tumour diagnosis and therapy.

Dev Biol Stand. 1990;71:93-102. PMID: 2401391 [PubMed - indexed for MEDLINE]

104 Steven FS, Griffin MM, Barnett FB, Epenetos AA.

Competitive inhibition of a tumour cell surface protease. A rapid technique for in vitro testing of selective targeting systems.

J Enzyme Inhib. 1990;4(1):63-73. PMID: 2094772 [PubMed - indexed for MEDLINE]

105 Courtenay-Luck NS, Epenetos AA.

Diversity of the human immune response to clinically used murine monoclonal antibodies.

Cancer Treat Res. 1990;51:353-62. Review. No abstract available. PMID: 1977455 [PubMed - indexed for MEDLINE]

106 Pervez S, Kirkland SC, Epenetos AA, Mooi WJ, Evans DJ, Krausz T. 107 Effect of polarity and differentiation on antibody localization in multicellular tumour

spheroid and xenograft models and its potential importance for in vivo immunotargeting.

Int J Cancer. 1989 Nov 15;44(5):940-7. PMID: 2583872 [PubMed - indexed for MEDLINE]

108 Kosmas C, Kalofonos H, Epenetos AA.

Monoclonal antibodies. Future potential in cancer chemotherapy.

109 Drugs. 1989 Nov;38(5):645-57. Review. No abstract available. PMID: 2689135 [PubMed - indexed for MEDLINE]

Sivolapenko GB, Kanariou M, Edwards RJ, Epenetos AA, Ritter MA. Immunosuppression by immunoglobulin deaggregation is not effective in reducing the anti-xenogeneic immunoglobulin response: experimental and clinical studies.

21

Br J Cancer. 1989 Oct;60(4):511-6. Erratum in: Br J Cancer 1990 Feb;61(2):347. PMID: 2803922 [PubMed - indexed for MEDLINE]

110 Stewart JS, Hird V, Epenetos AA.

Alternative to toxicity and dosimetry of Y-90 labeled antibody. Int J Radiat Oncol Biol Phys. 1989 Jul;17(1):241. No abstract available. PMID: 2745200 [PubMed - indexed for MEDLINE]

111 Hird V, Thomas H, Stewart JS, Epenetos AA.

Malignant ascites: review of the literature, and an update on monoclonal antibody-targeted therapy.

Eur J Obstet Gynecol Reprod Biol. 1989 Jul;32(1):37-45. Review. PMID: 2670627 [PubMed - indexed for MEDLINE]

112 Skarlos DV, Malamitsi J, Sivolapenko GB, Demakopoulos N, Avgoustatos G,

Koutoulidis C, Epenetos AA. A preliminary study of brain gliomas with H17E2 monoclonal antibody: immunoscintigraphy and pharmacokinetics.

Int J Biol Markers. 1989 Jul-Sep;4(3):135-41. PMID: 2614081 [PubMed - indexed for MEDLINE]

113 Kalofonos HP, Sackier JM, Hatzistylianou M, Pervez S, Taylor-Papadimitriou J,

Waxman JH, Lavender JP, Wood C, Epenetos AA. Kinetics, quantitative analysis and radioimmunolocalization using indium-111-HMFG1 monoclonal antibody in patients with breast cancer.

Br J Cancer. 1989 Jun;59(6):939-42. PMID: 2736231 [PubMed - indexed for MEDLINE]

114 Al Jabaari B, Ladyman HM, Larché M, Sivolapenko GB, Epenetos AA, Ritter MA.

Elevated expression of the interleukin 4 receptor in carcinoma: a target for immunotherapy?

Br J Cancer. 1989 Jun;59(6):910-4. PMID: 2736228 [PubMed - indexed for MEDLINE]

115 Stewart JS, Hird V, Sullivan M, Snook D, Epenetos AA.

Intraperitoneal radioimmunotherapy for ovarian cancer.

Br J Obstet Gynaecol. 1989 May;96(5):529-36. PMID: 2757980 [PubMed - indexed for MEDLINE]

116 Epenetos AA, Kosmas C.

Monoclonal antibodies for imaging and therapy.

22

Br J Cancer. 1989 Feb;59(2):152-5. Review. No abstract available. PMID: 2649128 [PubMed - indexed for MEDLINE]

117 Barbounis VP, Kalofonos HP, Munro AJ, McKenzie CG, Sackier JM, Epenetos AA.

Treatment of colorectal cancer and other malignancies with continuous infusion of 5-fluorouracil.

Anticancer Res. 1989 Jan-Feb;9(1):33-9. PMID: 2705753 [PubMed - indexed for MEDLINE]

118 Courtenay-Luck NS, Epenetos AA.

Targeting of monoclonal antibodies to tumours.

Curr Opin Immunol. 1989-1990;2(6):880-3. Review. No abstract available. PMID: 2486568 [PubMed - indexed for MEDLINE]

119 Courtenay-Luck NS, Epenetos AA, Sivolapenko GB, Larche M, Barkans JR, Ritter

MA. Development of anti-idiotypic antibodies against tumour antigens and autoantigens in ovarian cancer patients treated intraperitoneally with mouse monoclonal antibodies.

Lancet. 1988 Oct 15;2(8616):894-7. PMID: 2902328 [PubMed - indexed for MEDLINE]

120 Rowlinson G, Paganelli G, Snook D, Epenetos AA.

Radiolocalisation of an anti-CEA monoclonal antibody (FO23C5) and its fragments in a colon carcinoma xenograft model.

Int J Biol Markers. 1988 Oct-Dec;3(4):259-64. PMID: 3235854 [PubMed - indexed for MEDLINE]

121 Loutfi I, Batchelor JR, Chisholm PM, Epenetos AA, Lavender JP.

Targeting of lymphocytes with 111In-labelled monoclonal antibodies.

Nucl Med Commun. 1988 Oct;9(10):787-96. PMID: 3211438 [PubMed - indexed for MEDLINE]

122 Wilson C, Pickering D, Stewart S, Vallis K, Kalofonos H, Cross A, Snook D,

Goldman JM, McKenzie CG, Epenetos AA. High dose chemotherapy with autologous bone marrow rescue in small cell lung cancer.

In Vivo. 1988 Sep-Oct;2(5):331-4. PMID: 2856521 [PubMed - indexed for MEDLINE]

123 Coupe M, Foroni L, Stamp G, Lovatt D, Barnard M, Krausz T, Kalofonos H,

Epenetos A, Luzzatto L, Cox TM.

23

Clonal rearrangement of the T-cell receptor gamma gene associated with a bizarre lymphoproliferative syndrome.

Eur J Haematol. 1988 Sep;41(3):289-94. PMID: 2846342 [PubMed - indexed for MEDLINE]

124 Foxwell BM, Band HA, Long J, Jeffery WA, Snook D, Thorpe PE, Watson G, Parker

PJ, Epenetos AA, Creighton AM. Conjugation of monoclonal antibodies to a synthetic peptide substrate for protein kinase: a method for labelling antibodies with 32P. Br J Cancer. 1988 May;57(5):489-93. PMID: 3395553 [PubMed - indexed for MEDLINE]

125 Kalofonos HP, Sivolapenko GB, Courtenay-Luck NS, Snook DE, Hooker GR, Winter

R, McKenzie CG, Taylor-Papadimitriou JJ, Lavender PJ, Epenetos AA. Antibody guided targeting of non-small cell lung cancer using 111In-labeled HMFG1 F(ab')2 fragments.

Cancer Res. 1988 Apr 1;48(7):1977-84. PMID: 2832056 [PubMed - indexed for MEDLINE]

126 Hawkins PN, Myers MJ, Epenetos AA, Caspi D, Pepys MB.

Specific localization and imaging of amyloid deposits in vivo using 123I-labeled serum amyloid P component.

J Exp Med. 1988 Mar 1;167(3):903-13. PMID: 3351437 [PubMed - indexed for MEDLINE]

127 Loutfi I, Batchelor JR, Lavender JP, Epenetos AA.

Lymphocyte targeting with 111In-labelled monoclonal antibodies.

Int J Cancer Suppl. 1988;2:45-9. PMID: 3280507 [PubMed - indexed for MEDLINE]

128 Athanassiou A, Pectasides D, Pateniotis K, Tzimis L, Natsis P, Lafi A, Arapantoni P,

Koutsiouba P, Taylor-Papadimitriou J, Epenetos A. Immunoscintigraphy with 131I-labelled HMFG2 and HMFG1 F(ab')2 in the pre-operative detection of clinical and subclinical lymph node metastases in breast cancer patients.

nt J Cancer Suppl. 1988;3:89-95. PMID: 3209306 [PubMed - indexed for MEDLINE]

129 Pectasides D, Pateniotis K, Tzimis L, Trapalli X, Natsis P, Arapantoni P, Taylor-

Papadimitriou J, Epenetos A, Koutsiouba P, Athanassiou A.

24

Immunoscintigraphy with 131I-labelled monoclonal antibodies HMFG2 and HMFG1 F(ab')2 versus abdominal CT scan in the detection of residual disease in ovarian cancer patients.

Int J Cancer Suppl. 1988;3:83-8. PMID: 3209305 [PubMed - indexed for MEDLINE]

130 Stewart JS, Hird V, Snook D, Sullivan M, Myers MJ, Epenetos AA.

Intraperitoneal 131I- and 90Y-labelled monoclonal antibodies for ovarian cancer: pharmacokinetics and normal tissue dosimetry.

Int J Cancer Suppl. 1988;3:71-6. PMID: 3209303 [PubMed - indexed for MEDLINE]

131 Pervez S, Paganelli G, Epenetos AA, Mooi WJ, Evans DJ, Krausz T. Localization of biotinylated monoclonal antibody in nude mice bearing subcutaneous and intraperitoneal human tumour xenografts.

Int J Cancer Suppl. 1988;3:30-3. PMID: 3209297 [PubMed - indexed for MEDLINE]

132 Pervez S, Epenetos AA, Mooi WJ, Evans DJ, Rowlinson G, Dhokia B, Krausz T.

Localization of monoclonal antibody AUA1 and its F(ab')2 fragments in human tumour xenografts: an autoradiographic and immunohistochemical study.

nt J Cancer Suppl. 1988;3:23-9. Penta:PMID: 3209296 [PubMed - indexed for MEDLINE]

133 Kalofonos HP, Stewart S, Epenetos AA.

Antibody-guided diagnosis and therapy of malignant lesions.

Int J Cancer Suppl. 1988;2:74-80. PMID: 3162448 [PubMed - indexed for MEDLINE]

134 Hnatowich DJ, Snook D, Rowlinson G, Stewart S, Epenetos AA.

Preparation and use of DTPA-coupled antitumor antibodies radiolabeled with yttrium-90.

Targeted Diagn Ther. 1988;1:353-74. Review. No abstract available. PMID: 2979062 [PubMed - indexed for MEDLINE]

135 Rowlinson G, Snook D, Busza A, Epenetos AA.

Antibody-guided localization of intraperitoneal tumors following intraperitoneal or intravenous antibody administration.

Cancer Res. 1987 Dec 15;47(24 Pt 1):6528-31. PMID: 3677091 [PubMed - indexed for MEDLINE]

25

136 Epenetos AA, Munro AJ, Stewart S, Rampling R, Lambert HE, McKenzie CG,

Soutter P, Rahemtulla A, Hooker G, Sivolapenko GB, et al. Antibody-guided irradiation of advanced ovarian cancer with intraperitoneally administered radiolabeled monoclonal antibodies.

J Clin Oncol. 1987 Dec;5(12):1890-9. PMID: 3681374 [PubMed - indexed for MEDLINE]

137 Epenetos AA, Courtenay-Luck N, Dhokia B, Snook D, Hooker G, Lavender JP,

Hemmingway A, Carr D, Paraharalambous M, Bosslet K. Antibody-guided irradiation of hepatic metastases using intrahepatically administered radiolabelled anti-CEA antibodies with simultaneous and reversible hepatic blood flow stasis using biodegradable starch microspheres.

Nucl Med Commun. 1987 Dec;8(12):1047-58. PMID: 3449789 [PubMed - indexed for MEDLINE]

138 Courtenay-Luck NS, Epenetos AA, Winearls CG, Ritter MA.

Preexisting human anti-murine immunoglobulin reactivity due to polyclonal rheumatoid factors.

Cancer Res. 1987 Aug 15;47(16):4520-5. PMID: 2440569 [PubMed - indexed for MEDLINE]

139 Mooi WJ, Krausz T, Kirkland SC, Cross A, Epenetos AA.

Accessibility of antigenic sites recognized by AUA1, HMFG1 and HMFG2 monoclonal antibodies: its influence on antibody binding of live cells.

Int J Biol Markers. 1987 May-Aug;2(2):57-63. PMID: 2454274 [PubMed - indexed for MEDLINE]

140 Shepherd JH, Granowska M, Britton KE, Mather S, Epenetos AA, Ward BG, Slevin

M. Tumour-associated monoclonal antibodies for the diagnosis and assessment of ovarian cancer.

Br J Obstet Gynaecol. 1987 Feb;94(2):160-7. PMID: 3828255 [PubMed - indexed for MEDLINE]

141 Epenetos AA, Lavender JP, Kenemans P, Poels L.

Early results of the monoclonal antibody OVTL3 in specific detection of ovarian cancer.

J Clin Oncol. 1987 Jan;5(1):160. No abstract availPMID: 3806157 [PubMed - indexed for MEDLINE]

142 Wilson CB, Epenetos AA.

26

Use of monoclonal antibodies for diagnosis and treatment of liver tumours.

Baillieres Clin Gastroenterol. 1987 Jan;1(1):115-30. Review. PMID: 3034355 [PubMed - indexed for MEDLINE]

143 Shihab F, Azar HA, Finney R, Tyson IB, Tenorio LE, Courtenay-Luck N, Epenetos

AA, Hadden JW. Intraperitoneal administration of an I125 labelled monoclonal antibody for localization of human colorectal cancer in the nude mouse.

nt J Immunopharmacol. 1987;9(7):783-92. PMID: 2828253 [PubMed - indexed for MEDLINE]

144 Peters AM, Lavender JP, Needham SG, Loutfi I, Snook D, Epenetos AA, Lumley P,

Keery RJ, Hogg N. Imaging thrombus with radiolabelled monoclonal antibody to platelets.

Br Med J (Clin Res Ed). 1986 Dec 13;293(6561):1525-7. PMID: 3099941 [PubMed - indexed for MEDLINE]

145 Dhokia B, Pectasides D, Self C, Habib NA, Hershman M, Wood CB, Munro AJ,

Epenetos AA. A low pH enzyme linked immunoassay using two monoclonal antibodies for the serological detection and monitoring of breast cancer.

Br J Cancer. 1986 Dec;54(6):885-9. PMID: 3801285 [PubMed - indexed for MEDLINE]

146 Kalofonos HP, Epenetos AA.

The role of monoclonal antibodies in tumour diagnosis.

Cancer Treat Rev. 1986 Dec;13(4):243-52. Review. No abstract available. PMID: 3545464 [PubMed - indexed for MEDLINE]

147 Dhokia B, Canney PA, Pectasides D, Munro AJ, Moore M, Wilkinson PM, Self C,

Epenetos AA. A new immunoassay using monoclonal antibodies HMFG1 and HMFG2 together with an existing marker CA125 for the serological detection and management of epithelial ovarian cancer.

Br J Cancer. 1986 Dec;54(6):891-5. PMID: 3467785 [PubMed - indexed for MEDLINE]

148 Rowlinson G, Balkwill F, Snook D, Hooker G, Epenetos AA.

Enhancement by gamma-interferon of in vivo tumor radiolocalization by a monoclonal antibody against HLA-DR antigen.

Cancer Res. 1986 Dec;46(12 Pt 1):6413-7.

27

PMID: 3096562 [PubMed - indexed for MEDLINE]

149 Courtenay-Luck NS, Epenetos AA, Moore R, Larche M, Pectasides D, Dhokia B, Ritter MA. Development of primary and secondary immune responses to mouse monoclonal antibodies used in the diagnosis and therapy of malignant neoplasms.

Cancer Res. 1986 Dec;46(12 Pt 1):6489-93. PMID: 2430699 [PubMed - indexed for MEDLINE]

150 Epenetos AA, Hooker G, Krausz T, Snook D, Bodmer WF, Taylor-Papadimitriou J.

Antibody-guided irradiation of malignant ascites in ovarian cancer: a new therapeutic method possessing specificity against cancer cells.

Obstet Gynecol. 1986 Sep;68(3 Suppl):71S-74S. PMID: 3737085 [PubMed - indexed for MEDLINE]

151 Epenetos AA, Snook D, Durbin H, Johnson PM, Taylor-Papadimitriou J.

Limitations of radiolabeled monoclonal antibodies for localization of human neoplasms.

Cancer Res. 1986 Jun;46(6):3183-91. PMID: 3516393 [PubMed - indexed for MEDLINE]

Epenetos AA, Carr D, Johnson PM, Bodmer WF, Lavender JP. Antibody-guided radiolocalisation of tumours in patients with testicular or ovarian cancer using two radioiodinated monoclonal antibodies to placental alkaline phosphatase.

Br J Radiol. 1986 Feb;59(698):117-25. PMID: 3947819 [PubMed - indexed for MEDLINE]

152 Myers MJ, Epenetos AA, Hooker G.

Practical assessment of radiation doses using labelled antibodies for therapy.

Int J Rad Appl Instrum B. 1986;13(4):437-46. PMID: 3793499 [PubMed - indexed for MEDLINE]

153 Dhokia B, Pectasides D, Epenetos AA, Sikora K, Habib NA, Hershman M, Wood CB.

Serum levels of c-myc and c-ras oncogene products in normal subjects and in patients with neoplastic and non neoplastic conditions.

Int J Biol Markers. 1986 Jan-Apr;1(1):29-32. PMID: 3320223 [PubMed - indexed for MEDLINE]

154 Epenetos AA, Snook D, Hooker G, Begent R, Durbin H, Oliver RT, Bodmer WF,

Lavender JP.

28

Indium-111 labelled monoclonal antibody to placental alkaline phosphatase in in the detection of neoplasms of testis, ovary, and cervix.

Lancet. 1985 Aug 17;2(8451):350-3. PMID: 2862513 [PubMed - indexed for MEDLINE]

155 Epenetos AA.

Antibody guided lymphangiography in the staging of cervical cancer.

Br J Cancer. 1985 Jun;51(6):805-8. PMID: 4005140 [PubMed - indexed for MEDLINE]Antibody guided irradiation of brain glioma by arterial infusion of radioactive monoclonal antibody against epidermal growth factor receptor and blood group A antigen.

Br Med J (Clin Res Ed). 1985 May 18;290(6480):1463-6. PMID: 2986752 [PubMed - indexed for MEDLINE]

156 Epenetos AA, Munro AJ, Tucker DF, Gregory W, Duncan W, MacDougall RH, Faux

M, Travers P, Bodmer WF. Monoclonal antibody assay of serum placental alkaline phosphatase in the monitoring of testicular tumours.

Br J Cancer. 1985 May;51(5):641-4. PMID: 3994908 [PubMed - indexed for MEDLINE]

157 Epenetos AA, Shepherd J, Britton KE, Mather S, Taylor-Papadimitriou J, Granowska

M, Durbin H, Nimmon CC, Hawkins LR, Malpas JS, et al. 123I radioiodinated antibody imaging of occult ovarian cancer.

Cancer. 1985 Mar 1;55(5):984-7. PMID: 3881163 [PubMed - indexed for MEDLINE]

158 Epenetos AA, Bobrow LG, Adams TE, Collins CM, Isaacson PG, Bodmer WF.

A monoclonal antibody that detects HLA-D region antigen in routinely fixed, wax embedded sections of normal and neoplastic lymphoid tissues.

J Clin Pathol. 1985 Jan;38(1):12-7. PMID: 3881477 [PubMed - indexed for MEDLINE]

159 Epenetos AA.

Antibody-guided therapy of cancer.

Practitioner. 1984 Oct;228(1396):931-4. No abstract available. PMID: 6483753 [PubMed - indexed for MEDLINE]

160 Granowska M, Shepherd J, Britton KE, Ward B, Mather S, Taylor-Papadimitriou J, Epenetos AA, Carroll MJ, Nimmon CC, Hawkins LA, et al.

29

Ovarian cancer: diagnosis using 123I monoclonal antibody in comparison with surgical findings.

Nucl Med Commun. 1984 Aug;5(8):485-99. No abstract available. PMID: 6533499 [PubMed - indexed for MEDLINE]

161 Epenetos AA, Snook D, Hooker G, Lavender JP, Halnan KE.

Tumour imaging using an improved method of DTPA-coupled monoclonal antibodies radiolabelled with metallic radionuclides.

Lancet. 1984 Jul 21;2(8395):169. No abstract available. PMID: 6146068 [PubMed - indexed for MEDLINE]

162 Epenetos AA.

Recovery of testicular function after chemotherapy - a case report.

Anticancer Res. 1984 May-Jun;4(3):203. 163

PMID: 6465857 [PubMed - indexed for MEDLINE] Epenetos AA, Shepherd J, Britton KE, Hawkins L, Nimmon CC, Taylor-Papadimitriou J, Durbin H, Malpas JS, Mather S, Granowska M, et al. Radioimmunodiagnosis of ovarian cancer using 123I-labelled, tumor-associated monoclonal antibodies.

Cancer Detect Prev. 1984;7(1):45-9. PMID: 6367983 [PubMed - indexed for MEDLINE]

164 Epenetos AA, Travers P, Gatter KC, Oliver RD, Mason DY, Bodmer WF.

An immunohistological study of testicular germ cell tumours using two different monoclonal antibodies against placental alkaline phosphatase.

Br J Cancer. 1984 Jan;49(1):11-5. PMID: 6362705 [PubMed - indexed for MEDLINE]

165 Epenetos AA, Britton KE, Mather S, Shepherd J, Granowska M, Taylor-

Papadimitriou J, Nimmon CC, Durbin H, Hawkins LR, Malpas JS, Bodmer WF. Targeting of iodine-123-labelled tumour-associated monoclonal antibodies to ovarian, breast, and gastrointestinal tumours.

Lancet. 1982 Nov 6;2(8306):999-1005. PMID: 6127540 [PubMed - indexed for MEDLINE]

166 Epenetos AA, Canti G, Taylor-Papadimitriou J, Curling M, Bodmer WF.

Use of two epithelium-specific monoclonal antibodies for diagnosis of malignancy in serous effusions.

Lancet. 1982 Nov 6;2(8306):1004-6. PMID: 6127499 [PubMed - indexed for MEDLINE]

30

167 Epenetos AA, Bodmer WF, Britton KE.

Radioimmunodetection of Cancer.

Eur J Cancer Clin Oncol. 1982 Nov;18(11):1221-3. No abstract available. PMID: 6891659 [PubMed - indexed for MEDLINE]

168 Epenetos AA, Nimmon CC, Arklie J, Elliott AT, Hawkins LA, Knowles RW, Britton

KE, Bodmer WF. Detection of human cancer in an animal model using radio-labelled tumour-associated monoclonal antibodies.

Br J Cancer. 1982 Jul;46(1):1-8. PMID: 7104190 [PubMed - indexed for MEDLINE]

169 Epenetos AA, Amos C, Collis C, Slevin M, Rohatiner A, Baille-Johnson H, Pitts J,

Wrigley PF. Comparison of two combination chemotherapy regimens in advanced colorectal cancer. Br Med J. 1980 Aug 30;281(6240):587-8. No abstract available. PMID: 7427380 [PubMed - indexed for MEDLINE]

170 Epenetos AA, Rohatiner A, Slevin M, Woothipoom W.

Ankylosing spondylitis and Waldenström's macroglobulinaemia: a case report.

Clin Oncol. 1980 Mar;6(1):83-4. No abstract available. PMID: 6768483 [PubMed - indexed for MEDLINE]

171 Epenetos AA.

Sunshine and malignant melanoma.

Br Med J. 1980 Jan 12;280(6207):112-3. No abstract available. PMID: 7353109 [PubMed - indexed for MEDLINE]

172 Epenetos AA, Collis CH.

Seminoma in Marfan's syndrome.

Postgrad Med J. 1979 Oct;55(648):762-4. PMID: 537969 [PubMed - indexed for MEDLINE]

173 Ballantyne FC, Epenetos AA, Caslake M, Forsythe S, Ballantyne D.

The composition of low-density lipoprotein and very-low-density lipoprotein subfractions in primary hypothyroidism and the effect of hormone-replacement therapy.

Clin Sci (Lond). 1979 Jul;57(1):83-8. No abstract available. PMID: 225098 [PubMed - indexed for MEDLINE]

31

174 Ballantyne FC, Morrison BA, Ballantyne D, Dryburgh FJ, Epenetos AA.

Plasma protein concentrations in hypertriglyceridaemic subjects. Effect of clofibrate and comparison with normal subjects.

Clin Chim Acta. 1978 Jul 1;87(1):43-7. PMID: 668144 [PubMed - indexed for MEDLINE]

Review articles or Guest Editorials 1. Nicholson S, Epenetos AA. Radioimmunoscintigraphy and ovarian cancer, Oncology

in Practice 2/95 6-8. 2. Epenetos, AA., and Kosmas, C. Monoclonal antibodies for imaging and therapy.

Guest Editorial, British Journal of Cancer 1989, 59, 152-155. 3. Kosmas, C., Kalofonos, H., Epenetos, AA. Monoclonal antibodies. Future Potential

in Cancer Chemotherapy. Drugs 1989, 4, 1-13. 4. Maraveyas, A., Epenetos, AA. An overview of radioimmunotherapy. Cancer

Immunology Immunotherapy. 1991, 34, 71-73. 5. Epenetos, AA. Mutant Oncogenes: Targets for Therapy? European Journal of Cancer

1992, 28A, 617, 1286-1288. 6. Spooner, R., Kosmas, C., Epenetos, AA. New developments in monoclonal antibody

therapy of cancer. Cancer Topics volume 8, 12, May/June 1992, 137-139. 7. Rowlinson-Busza, G., Epenetos, AA. Targeted delivery of biologic and other

antineoplastic agents. Current Opinion in Oncology, 1992, 4, 1142-1148. 8. Bamias, A, Epenetos, AA. Two step strategies for the diagnosis and treatment of

cancer with bioconjugates. Antibody, Immunoconjugates and Radiopharmaceuticals, 1992, 5, 385-395.

9. Epenetos, AA., Linardou, H. New molecular targets and therapeutic strategies against

cancer. International Journal of Biological Markers, 1993, 8, 1-7. 10. Kosmas, C., Linardou, H., Epenetos, AA. Advances in monoclonal antibody tumour

targeting. Journal of Drug Targeting 1993, 1, 81-91. 11. Epenetos, AA. Recent developments in radiolabelling for imaging and therapy of

cancer. Oncology Today 1994, 10, 4-8. 12. Taylor-Papadimitriou, J., Epenetos, AA. Exploiting altered glycosylation patterns in

cancer: progress and challenges in diagnosis and therapy. Trends in Biotechnology 1994, 12, 227-233.

13. George, AJT., Spooner, RA., Epenetos, AA. Applications of Monoclonal Antibodies

in Clinical Oncology. Immunology Today 1994, 15, 559-561. 14. Spooner, RA., Epenetos, AA. Anti-cancer antibodies: Patent activity in 1993. Expert

32

opinion in therapeutic patents 1994 (in press). 15. Harrington, KJ., Epenetos, AA. Recent developments in radioimmunotherapy.

Clinical Oncology 1994, 6, 391-398. 16. Epenetos AA. Developments in radiolabelling for cancer imaging and therapy.

Oncology Today July 1994, 4-8. 17. George, AJT., Spooner, RA., Epenetos, AA. Applications of monoclonal antibodies

in clinical oncology. Immunology Today, 1994, 15, 559-561. 18. Deonarain, MP., Epenetos, AA. Targeting enzymes for cancer therapy: Old enzymes

in new roles. British Journal of Cancer 1994, 70, 786-794. 19. Spooner, RA, Bell, S, Epenetos, AA. Polynucleotide vaccination for cancer

treatment. International Journal of Oncology 1995, 6, in press. 20. Spooner, RA, Deonarain, MP, Neri, G, Epenetos, AA. Cancer vaccines: Prevention is

better than cure. Tumour Targeting 1995, 1 1-12. 21. Deonarain MP, Spooner RA, Epenetos AA. Genetic delivery of enzymes for cancer

therapy. Gene Therapy 1995, 2, 235-244. 22. Syrigos KS, Epenetos AA, Radioimmunotherapy of ovarian cancer. Hybridoma,

1995, 14, 121-124. 23. Boleti E, George AJT, Epeetos AA. Therapeutic monoclonals. The Biochemical

Society meeting no 655, 18-21 July, 1995. 24. Papakostas P, Epenetos AA. Antibody targeting in Oncology. Tumour Marker

Update, in press. 25. George AJT, Epenetos AA. Advances in antibody engineering. Expert Opinion in

Therapeutic Patents 1996, 6, 441-456. 26. Papakostas P, Harrington K, Epenetos AA. Monoclonal antibodies in cancer

detection and therapy. Hellenic Medical Journal 1997, 1, 5-8. Chapters in books: 1. Epenetos AA, Nimmon CC, Britton KE, Bodmer WF, Hawkins LR,

Taylor-Papadimitriou J, Mather S, Granowska M and Malpas JS. Can 123I radioiodine labelled monoclonal antibodies be used as specific diagnostic reagents for cancer in man ?. Proceedings of the Third World Congress of the World Federation of Nuclear Medicine and Biology. 1982, 2 : 233-234.

2. Epenetos AA. Radiolabelled monoclonal antibodies in the diagnosis of cancer.

Proceedings of NATO Advanced Studies Institute on Receptor-Medicated Targetting of Drugs, 1983, : i : 15-16.

3. Epenetos, AA. Monoclonal antibodies for the localisation of human neoplasms in

33

vitro and in vivo. Proceedings of the First International Symposium on Neutron Capture Therapy, 1984, 184-192.

4. Epenetos, AA. "Clinical applications of monoclonal antibodies". In "Technical

Advances in Clinical Immunology" edited by WG. Reeves and published by Elsevier Science Publishers BV. 1984, 161-178.

5. Epenetos, AA. "In vivo uses of monoclonal antibodies". In "Receptor-mediated

targetting of drugs" edited by G. Gregoriades and published by Plenum Press, 1984, 30- 42,.

6. Epenetos, AA. Antibody guided therapy of cancer. The Practitioner, 1984, 228,

931-934. 7. Epenetos, AA. Attempted therapy of a human xenograft colonic cancer HT29 using

131I-labelled monoclonal antibodies. In Receptor-Mediated Targeting of Drugs. Edited by G. Gregoriades, G. Poste, J. Senior, A. Trouet. Plenum Publishing Corporation - 1985, 235-242.

8. Pawlikowska, TRB, Hooker, B., Myers, M., Epenetos, AA. Treatment of tumours

with radiolabelled antibodies. In Clinics in Oncology, 1986, 5, 1, 93-107. 9. Pawlikowska, TRB, Epenetos, AA. Radiolabelled monoclonal antibodies to placental

alkaline phosphatase in the diagnosis and treatment of neoplasms of testis, ovary and cervix. In Advances in Clinical Enzymology, Edited by DW.Moss, E. Schmidt and FW Schmidt, Karger, Basel, 1986 3, 53-59.

10. Hooker, GR., Epenetos, AA. The intracavitary application of monoclonal antibodies

as vehicles for therapeutic radionuclides. In Radionuclides for Therapy edited by PA. Schubiger and PH. Hasler, Roche Scientific Service 1986, 183-199.

11. Myers, MJ., Hooker, GR., Epenetos, AA. Dosimetry of radiolabelled monoclonal

antibodies used for therapy. In Fourth International Dosimetry Symposium. Edited by Schlalke-Stelson, AT. and Watson, EG. Oak Ridge Associated Universities 1986, 409-420.

12. Kalofonos, HP., Epenetos, AA. The role of monoclonal antibodies in tumour

diagnosis. pp 243-252 In Cancer Treatment Reviews. Edited by G. Hellman, Academic Press Inc. Ltd. 1986, vol 13.

13. Wilson, CB., Epenetos, AA. Use of monoclonal antibodies for diagnosis and

treatment of liver tumours. pp. 115-130. In Bailliere's Clinical Gastroenterology, 1987 vol. 1.

14. Epenetos, AA. Tumour-associated monoclonal antibodies. In Bone Tumour

Management. Edited by R. Coombs and E. Friedlander, Butterworth Scientific Ltd, 1986, 294-287.

15. Kalofonos, HP., Epenetos, AA. Antibody-guided diagnosis and therapy of patients

with breast cancer. In Immunological approaches to the diagnosis of breast cancer. Edited by RL. Ceriani. Plenum Publishing Corporation. 1987.

16. Epenetos, AA. Conventional and new investigations for the diagnosis,staging and

management of malignant lymhomas. In Malignant Lymphomas. Edited by I. Lauder and J. Habeshaw, Churchill Livingstone. 1987, 239-252.

34

17. Epenetos, AA. Tumour associated antibodies. In: Bone Tumour management. Edited by R. Coombs and G. Friedlander, Butterworths and Co. 1987, 37, 244-297.

18. Epenetos, AA. Phase I clinical trial of intraperitoneally administered radiolabelled

monoclonal antibodies in the treatment of advanced ovarian cancer. In: New Tumour Markers and their Monoclonal Antibodies. Edited by R Klapdor. Georg Thieme Verlag, 1987.

19. Vallis, K. and Epenetos, A. The future potential therapeutic use of radiolabelled

monoclonal antibodies. In: Medical Imaging Research ed. M Amiel, D. Ducasson, G. Frija, Ph. Grenier. Collogue INSERM. 1987, 160, 173-186.

20. Epenetos, AA. Intraperitoneal radioimmunotherapy for ovarian cancer. In

Immunotherapy and scintigraphy of tumours with monoclonal antibodies of tumours with monoclonal antibodies. Edited by AA Epenetos, E. Oberhausen, RA Reisfeld. Verlag 1987, 65-73.

21. Kalofonos, H., Epenetos, AA. Antibody guided targeting of ovarian carcinoma. In

Ovarian Cancer: The Way Ahead. Edited by F. Sharp and WP Soutter. Chameleon Press Ltd, London, 1987, 159-169.

22. Stewart, JSW., Epenetos, AA. Intraperitoneal radiolabelled monoclonal antibody

therapy for residual ovarian cancer following chemotherapy. In Ovarian Cancer: The Way Ahead. Edited by F Sharp and WP Soutter. Chameleon Press Ltd, London. 1987, 451-460.

23. Hnatowich, DJ., Snook, D., Rowlinson, G., Stewart, S. and Epenetos, AA.

Preparation and use of DTPA-coupled antitumour antibodies radiolabeled with yttrium-90. In: Antibody-mediated delivery systems. Edited by: JD Rodwell. Marcel Dekker, New York, 1988.

24. Verheyhen, R., Haisma, H., Epenetos, AA. Antibodies against sialomucins. Cancer

Reviews. 1988, 353-374, 11-12: 55-101. 25. Kalofonos, H., and Epenetos, AA. Radioimmunotherapy with Iodine 131-labelled

antibodies in ovarian, colonic and brain tumours. In: Cancer Therapy. Edited by HG. Berger et al. Springer-Verlag Berlin, Heideberg 1989.

26. Sivolapenko, GB., Kalofonos, H., Epenetos, AA. Monoclonal antibodies. Treatment

of Cancer. Edited by Sikora K and Halnan KE. Second Edition. Chapman and Hall Medical 1989.

27. Courtenay-Luck, NS., Epenetos, AA. Targeting of monoclonal antibodies to tumours.

Current opinions in Immunology. Edited by FW Alt, P Marraci, IM Roitt. Current Biology Ltd, London. 1990, 2:880-883.

28. Hird, V., Epenetos, AA. Immunotherapy with monoclonal antibodies. Edited by D

Carney, K Sikora, Publ. John Wiley and Sons Ltd, 1990, 183-189. 29. Courtenay-Luck, NS., Epenetos, AA. Diversity of the human immune response to

clinically used murine monoclonal antibodies. Edited by Goldenberg, DM. Cancer Imaging with radiolabelled antibodies. Kluwer Academic Publishers. 1990, 353-362.

30. Kosmas, C., Kalofonos, HP., Epenetos, AA. Radiolabelled monoclonal antibodies in tumour diagnosis and therapy. In symposium on Monoclonal antibodies for therapy, prevention and in vivo diagnosis of human disease. Utrecht, The Netherlands 1989.

35

Develop. Biol. Standard. S Karger, Basel, 1990, 71, 93-102. 31. Sivolapenko, GB., Kalofonos, HP., Hird, V., Stewart, S., Snook, D., Courtenay-Luck,

NS., Dhokia, B., Epenetos, AA. The potential of radiolabelled monoclonal antibodies as anti-cancer agents. In Monoclonal antibodies and immunoconjugates, Edited by RW Baldwin, VS Byers, RD Mann. Published by Parthenon (UK) 1990, 159-174.

32. Bamias, A., Sackier, JM., Kalofonos, HP., Dhokia, B., Snook, D., Bosslet, K., Wood,

C., Epenetos, AA. Use of 123-I radiolabelled F(ab')2 fragments of anti-CEA monoclonal antibody for the detection of primary and metastic gastrointestinal carcinomas. In Clinical Use of Antibodies, Edited by RP Baum et al, Published by Kluwer Academic Publishers, Netherlands. 1991, 45-53,.

33. Hird, V., Stewart, JSW., Epenetos, AA. Intraperitoneal radioimmunotherapy with 90Y

labelled monoclonal antibodies. In: Ovarian Cancer: Biological and Therapeutic Challenges, Edited by F Sharp, WP Mason, RE Leake. Chapman and Hall Medical, 1991, 391-399.

34. Rowlinson-Busza, G., Bamias, A., Krausz, T., Epenetos, AA. Monoclonal antibody

uptake and distribution following intra-tumour injection. In 'Monoclonal Antibodies: Applications in Clinical Oncology'. Edited by AA Epenetos. Chapman and Hall Medical, 1991, 15, 149-156.

35. Snook, DE., Rowlinson-Busza, G., Meares, C., Epenetos, AA. Indium-111 and

Yttrium-90 labelled macrocyclic chelating agents. In 'Monoclonal Antibodies: Applications in Clinical Oncology', Edited by AA Epenetos. Chapman and Hall Medical, 1991, 16, 157-166.

36. Rowlinson-Busza, G., Bamias, A., Krausz, T., Evans, DJ., Epenetos, AA.

Cytotoxicity following specific action of amygdalin. In 'Monoclonal Antibodies: Applications in Clinical Oncology'. Edited by AA Epenetos. Chapman and Hall Medical, 1991, 18, 179-183.

37. Bergh, J., Nilsson, S., Sivolapenko, G., Maripuu, E., Stavrou, D., Epenetos, AA.

Localisation and immunohistochemistry of human gliomas using MUC 2-63. In 'Monoclonal Antibodies: Applications in Clinical Oncology'. Edited by AA Epenetos. Pub: Chapman and Hall Medical, 1991, 27, 245-251.

38. Kalofonos, H., James, N., Hooker, GR., Courtenay-Luck, NS., Lavender, PJ.,

Epenetos, AA. Antibody uptake in non-small cell lung cancer following irradiation. In 'Monoclonal Antibodies: Applications in Clinical Oncology'. Edited by AA Epenetos. Chapman and Hall Medical, 1991, 28, 253-259.

39. Bamias, A., Keane, P., Krausz, T., Williams, G., and Epenetos, AA. Monoclonal

antibody uptake by bladder carcinomas following intravesical administration. In 'Monoclonal Antibodies: Applications in Clinical Oncology'. Edited by AA Epenetos. Chapman and Hall Medical, 1991, 29, 261-266.

40. Hird, V., Snook, D., Kosmas, C., Dhokia, B., Stewart, S., Mason, P., Lambert, J.,

Meares, C., and Epenetos, AA. Intraperitoneal radioimmunotherapy with Yttrium-90 labelled immunoconjugates. In 'Monoclonal Antibodies: Applications in Clinical Oncology'. Edited by AA Epenetos. Chapman and Hall Medical, 1991, 30, 267-271.

41. Kosmas, C., Epenetos, AA., Courtenay-Luck, NS. T cell proliferation following

monoclonal antibody treatment. In 'Monoclonal Antibodies: Applications in Clinical Oncology'. Edited by AA Epenetos. Chapman and Hall Medical, 1991, 31, 273-281.

36

42. Pateisky, N., Schatten, C., Vavra, N., Ehrebock, P., Angelberger, P., Barrada, M., and

Epenetos, AA. Lymphscintigraphy with recombinant epidermal growth factor in uterine cervical cancer. In 'Monoclonal Antibodies: Applications in Clinical Oncology'. Edited by AA Epenetos. Chapman and Hall Medical, 1991, 35, 309-313.

43. Bamias, A., Rowlinson-Busza, G., Epenetos, AA. Intratumoural administration of

radiolabelled monoclonal antibodies: a new potential treatment for prostatic carcinoma. In Radionuclides for prostate gland. Current status and future aspects. Edited by GS Limouris and SK Shukla. Pub: CNR, Rome, Italy 1991, 135-158.

44. Bamias, A., Epenetos, AA. The role of monoclonal antibodies in the management of

patients with cancer. Oncology. Munchen, Sympomed 1992, 1, 47-67. 45. Malik, STA., Epenetos, AA. The immune system and gynaecological cancer. In The

Immune System in Disease in Bailliere's Clinical Obstetrics and Gynaecology. Edited by GM Stirrat and JR Scott.,1992, 6, 3, 641-656.

46. Maraveyas, A., Epenetos, AA. Specific targeting of cancer -Targeted cancer therapy.

In 'Tumour Associated Antigens, Oncogenes, Receptors, Cytokines in Tumour Diagnosis and Therapy at the Beginning of the Nineties'. 1992, 593-598. Edited by R Klapdor, Verlag GmbH.

47. Maraveyas, M., Epenetos, AA. Immunotherapy for ovarian carcinoma. In Frontiers

in Gynecologic and Obstetric Investigation. Edfited by AR Genazzani, F Petraglia, AD Genazzani, 993, 297-309.

48. Spooner, RA., Epenetos, and Lord, JM. Biological activity of antibody variable

domain-ricin A-chain fusions. In: Monoclonal Antibodies 2: Applications in Clinical Oncology. 1993, 7-15. Edited by AA Epenetos. Chapman and Hall Medical.

49. Westling, J-E., Snook, D., Nilsson, S., Husin, S., Enblad, P., Stavrou, S., Epenetos,

AA. and Bergh, J. Intravenous and intratumoural therapy of patients with malignant gliomas with 90yttrium-labelled monoclonal antibody MUC 2-63. In: Monoclonal Antibodies 2: Applications in Clinical Oncology. 1993, 17-25. Edited by AA Epenetos. Chapman and Hall Medical.

50. Kosmas, C., Snook, DE., Gooden, CS., Courtenay-Luck, NS., McCall, MJ., Meares,

CF. and Epenetos, AA. Immunogenicity of macrocyclic chelating agent (DOTA) in patients receiving radiolabelled antibody-guided imaging and therapy. In: Monoclonal Antibodies 2: Applications in Clinical Oncology. 1993, 39-51. Edited by AA Epenetos. Chapman and Hall Medical.

51. Kosmas, C., Epenetos, AA. and Courtenay-Luck, NS. Monoclonal antibodies as

recall agents. In: Monoclonal Antibodies 2: Applications in Clinical Oncology. 1993, 53-66. Edited by AA Epenetos. Chapman and Hall Medical.

52. Kosmas, C., Epenetos, AA. and Courtenay-Luck, NS. Alteration of th proliferation

and phenotypic expression of EBV-immortalized B cells by cytokines and phorbol esters. In: Monoclonal Antibodies 2: Applications in Clinical Oncology. 1993, 67-77. Edited by AA Epenetos. Chapman and Hall Medical.

53. Bamias, A., Ogden, C., Krausz, T., Williams, G. and Epenetos, AA. Intravesical

administration of HMFG2 monoclonal antibody in superficial bladder carcinoma. In: Monoclonal Antibodies 2: Applications in Clinical Oncology. 1993, 97-101. Edited by AA Epenetos. Chapman and Hall Medical.

37

54. Rowlinson-Busza, G., Bamias, A., Krausz, T. and Epenetos, AA. Antiobdy-guided

enzyme nitrile therpay (AGENT): in vitro cytotoxicity and in vivo tumour localization. In: Monoclonal Antibodies 2: Applications in Clinical Oncology. 1993, 111-118. Edited by AA Epenetos. Chapman and Hall Medical.

55. Kalofonos, HP., Kosmas, C., Courtenay-Luck, NS., Waxman, J., McKenzie, CG.,

Lavender, JP. and Epenetos, AA. Immunoscintigraphy and biodistribution studies using 111In-HMFG1 F(ab')2 fragments in patients with breast and lung cancer. In: Monoclonal Antibodies 2: Applications in Clinical Oncology. 1993, 345-353. Edited by AA Epenetos. Chapman and Hall Medical.

56. Snook, DE., Verhoeyen, M., Kosmas, C., Badley, RA., Hird, V., Meares, C.,

Lavender, JP. and Epenetos, AA. A preliminary comparison of a tumour-associated reshaped human monoclonal antibody (Hu2PLAP) with its murine equivalent (H17E2). In: Monoclonal Antibodies 2: Applications in Clinical Oncology. 1993, 391-400. Edited by AA Epenetos. Chapman and Hall Medical.

57. Gooden, CSR., Snook, DE., Henderson, B., Lavender, JP. and Epenetos, AA. The

quality and stability of 99mtechnetium-labelled monoclonal antibodies. In: Monoclonal Antibodies 2: Applications in Clinical Oncology. 1993, 401-411. Edited by AA Epenetos. Chapman and Hall Medical.

58. Syrigos, KN., Epenetos, AA. Achievements, failings and promises of

radioimmunotherapy. In Current Tumor Diagnosis: Applications, Clinical Relevance, Research. ed R Klapdor 1994. W Verlag Munchen.

59. Linardou, H., Epenetos, AA. The role of monoclonal antibodies in the management

of cancer. In Immunotherapy of Cancer, 1996, 201-220. Ed. M Gore, P. Riches, Wiley Limited.

60. Spooner, RA., Deonarain, MP., Epenetos, AA. Tumour Targeting. ed K Sikora (in

press). 61. Pavlovic, S., Sobic, D., Jovanovic, D., Radoavljevic, G., Bosnjakovic, V., Epenetos,

AA. Anti-HMFG1-99mTc monoclonal antibodies in lung cancer imaging. pp 53-56. In International Congress for Lung Cancer 1994. ed G Antypas, Monduzzi Editore.

62. Gooden, CSR., Epenetos, AA. Design, synthesis, and cellular delivery of antibody

antisense oligonucleotide conjugates for cancer therapy in delivery strategies for antisense oligonucleotide therapeutics. ed P Akhtar. CRC Press pp 283 - 293, 1995.

63. Maraveyas, A, Epenetos, AA. Radioimmunotherapy of ovarian cancer. In: Cancer

Therapy with Radiolabelled Antibodies. pp 155-172, 1995. ed D Goldenberg, CRC Press Inc.

64. Syrigos, K, Epenetos AA. Other AIDS related malignancies. In: AIDS and

Malignancies, 1996, pp 165-173. Ed. B.C. Golematis, V.T. Devita, Wiley Ltd. 65. Gooden, CSR, Epenetos, AA. Design, synthesis and cellular delivery of antibody

targeted, radiolabelled oligonucleotide conjugates for cancer therapy. In: Targeting of Drugs 5: Strategies of oligonucleotide and gene delivery in Theragyn, 1996. Ed. Gregoriadis and McCormack, Plenum Press, New York.

66. Bast Jr., R.C., Kousparou, C.A., Epenetos, A.A., Zalutsky, M.R., Kreitman, R.J.,

Sausville, E.A., and Frankel, A.E. Monoclonal Serotherapy. In: Cancer Medicine 6,

38

2003, 881-899. Ed. Holland and Frei, BC Decker Inc, London.

Books Editor of the following books: 1. Monoclonal Antibodies : Applications in Clinical Oncology. ed. AA Epenetos, 1991.

Publ. Chapman and Hall Medical. 2. Monoclonal Antibodies 2: Applications in Clinical Oncology. ed. AA Epenetos,

1992. Publ. Chapman and Hall Medical. 3. Mutant Oncogenes. Targets for Therapy. ed. N Lemoine and AA Epenetos, 1992.

Publ. Chapman and Hall Medical. 4. Cell Adhesion Molecules in Cancer and Inflammation. ed AA Epenetos and M

Pignatelli 1994. Publ. Harwood academic publishers.