中華民國風濕病醫學會第 32 週年年會¹´會節目... ·...

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1 中華民國風濕病醫學會第 32 週年年會 2014 Annual Meeting 32 th Annual Meeting of Taiwan Rheumatology Association. 期:2014 12 050607 (星期五、六、日) 點:台中日月千禧酒店(台中市西屯區市政路 77 )

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1

中華民國風濕病醫學會第 32 週年年會

2014 Annual Meeting 32th Annual Meeting of Taiwan Rheumatology Association

日 期2014 年 12 月 050607 日 (星期五六日)

地 點台中日月千禧酒店(台中市西屯區市政路 77 號)

2

2014 社團法人中華民國風濕病醫學會會員大會暨學術演講會

會員注意事項

1 社團法人中華民國風濕病醫學會會員(以下簡稱本會會員)欲住宿者請與

惠康旅行社 Sophie 張小姐連絡洽詢住宿及費用相關事宜行動電話

0927-115512 (07)285-0067

2 報到時間12 月 06 日(星期六)0730~1700

12 月 07 日(星期日)0730~1500

3 報到處設於台中日月千禧酒店 B2 宴會廳電梯出口

4 本會會員於報到時請繳交參加費 NT$500 元非本會會員繳交參加費

NT$5000 元並領取大會資料

5 今年度常年會費與參加費可經以下兩種方式繳納

(1) 郵政劃撥劃撥帳號07641125 號

(2) 超商繳納

本次年會盡可能不接受現場繳費請於 11 月 25 日前完成繳費以免造成

報到處壅擠

6 今年度年會繼續教育學分可以以身份證條碼或健保卡登錄請會員擕帶身

份證或健保卡非會員仍比照往年簽名於紙本

7 壁報論文注意事項

(1)壁報規格寬 90 times 高 150

(2) 12 月 06 日(星期六)上午 900 開放海報張貼

(3) 12 月 07 日(星期日)下午 1500 後才可撤下壁報

(4)海報論文作者應在 Poster section 時間內在其海報論文前現場備詢以

便評選優秀壁報獎

(5)Poster view and discussion 共有二個時段

(a)12 月 06 日(六)下午 1320~1410

由謝松洲主任帶領請有興趣者於規定時間至 P001 集合

NoP001P002P003P004P005P006P007P008P009P010P011P012

P013P014P015P016P017P018P019P020P021

特別指定 5 篇為 P004P005P012P016P019當天需準備在海報前與主持人做

3

討論亦即被指定之 poster 負責人需在 poster 前面向主持人及觀眾作口頭報告研究成

果(報告時間為六分鐘討論四分鐘)每人不可超過 10 分鐘其他未被指定之 poster

則 poster 之負責人不用主動向主持人報告有觀眾來看時有須要再討論

(b)12 月 07 日(日)下午 1400~1450

由顏正賢教授帶領請有興趣者於規定時間至 P022 集合

No P022P023P024P025P026P027P028P029P030P031P032P033

P034P035P036P037P038P039P040P041P042

特別指定 5 篇為 P041P034P036P037P033當天需準備在海報前與主持人

做討論亦即被指定之 poster 負責人需在 poster 前面向主持人及觀眾作口頭報告研

究成果(報告時間為六分鐘討論四分鐘)每人不可超過 10 分鐘其他未被指定之

poster 則 poster 之負責人不用主動向主持人報告有觀眾來看時有須要再討論

8 午餐06 日(星期六)於 B2 宴會廳有 lunch symposium07 日(星期日)B2

宴會廳有 lunch symposium

9 大會晚宴12 月 06 日(星期六)晚上 1900 於 B2 宴會廳

4

主持人注意事項

1 請準時開始準時結束

2 主持人請於節目開始前 10 分鐘到現場

3 請每時段之座長事先準備介紹及討論(我們將寄上摘要內容)

4 提醒會議進行時請會員將手機轉為震動

演講者注意事項

1 本會提供單槍投影機Notebook演講者請使用 PowerPoint 檔案

2 演講內容請先於演講前 1 小時至報到處之試片處儲存於大會電腦恕無法

接受自備手提電腦轉接

3 簡報內容請以 Microsoft PowerPoint 2003 版本儲存勿使用 2007 版本以免

發生播放困難

4 口頭論文報告演講時間以8分鐘為限2分鐘討論時間結束前2分鐘按一

次鈴時間到按兩次鈴並開燈結束報告報告完畢後一併做討論

5

中華民國風濕病醫學會2014年年會節目時間地點一覽表

6

中華民國風濕病醫學會 2014 年會

Review Course

SLEVasculitisSjoumlgrenrsquos 時間103 年 12 月 05 日(星期五)0830~1100 Time0830~1100 05-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5

時間 講題 主講人 主持人

0840-0920 SLE-review 洪維廷 醫師

台中榮民總醫院 過敏免疫風濕科

社團法人中華民

國風濕病醫學會

理事長 陳得源

0920-1000 Vasculitis-review 黃建中 醫師

中國醫藥大學附設醫院 風濕免疫過敏科

1000-1040 Sjoumlgrenrsquos-review

翁孟玉 醫師 成大醫院

過敏免疫風濕科

1040-1100 Coffee break

7

中華民國風濕病醫學會 2014 年會

Sono-guided pain control in rheumatology 時間103 年 12 月 5 日(星期五)1100~1200 地點台中日月千禧酒店 5 樓 Vee5 主辦單位社團法人中華民國風濕病醫學會 主講人陳建行醫師 主持人中國醫藥大學附設醫院 藍忠亮教授

Soft tissue lesions From clinical presentation to ultrasound guided intervention

A non-osseous orthopedic disorders are one of the major causes of human suffering The manifest themselves with symptoms felt at a moving part of the body Diagnosis should be made on the basis of the clinicianrsquos ability to interpret these symptoms and signs Among treatment options diagnostic injection with local anesthetic drug is a good choice is the following conditions 1 When the examiner is not certain about a diagnosis or when the examiner want

positive confirmation of a tentative diagnosis the induction of local anesthetic may help

2 For lesion is the extremities infiltration is particularly helpful 3 In difficult cases this approach maybe the final diagnosis method Application of ultrasound in pain medicine is a rapidly growing field of interventional pain management and in the recent few years US guidance for chronic pain practice has been noticed With the help of ultrasound we can target our treatment goal precisely If the pain is completely or partly negative the exact site of lesion has clearly been reached confirming the diagnosis When the pain is still as painful or as limited as before the diagnosis is wrong Combine clinical evaluation and ultrasound guided intervention made treatment more effective and less suffer

8

中華民國風濕病醫學會 2014 年會

Meet the Master 時間103 年 12 月 05 日(星期五)1200~1330 Time1200~1330 05-Dec-2013 地點台中日月千禧酒店 5 樓 Vee5 主講人高雄醫學大學附設中和紀念醫院 劉宏文教授中國醫藥大學附設

醫院藍忠亮教授 主持人社團法人中華民國風濕病醫學會 陳得源 理事長

您hellip想要了解『醫界大師』是如何產生的嗎

邀請了 2 位榮獲中華民國風濕病醫學會大師獎蒞臨現場

劉宏文教授藍忠亮教授

此活動將與重量級大師對談

2 位大師將自我介紹談論一生經歷並分享生涯規劃

9

中華民國風濕病醫學會 2014 年會

超音波研討會及實際操作 時間103 年 12 月 05 日(星期五) 1330~1900 地點台中日月千禧酒店 5 樓 Vee1+Vee2 (1) 主辦單位社團法人中華民國風濕病醫學會TRUST Team (2) 協辦單位瑞士商艾伯維藥品有限公司衛采製藥股份有限公司 (3) 本次年會超音波研討會及實際操作 分三個主題進行研討 (1)晶體性關節

炎及退化性關節炎(2) 類風濕性關節炎僵直性脊椎炎及乾癬性關節炎(3)乾燥症硬皮症血管炎 每個主題研討完 Speaker 將進行患者超音波實際

檢查學員分組輪流進行操作練習 時間 講題 主講人

1320-1330 Registration

Section 1 座長 陳英州蔡文展

1330-1350 Ultrasound in OA 高雄醫學大學附設醫院

林育志醫師

1350-1410 Ultrasound in CPPD 嘉義長庚醫院風濕免疫科

林靖麒醫師

1410-1430 Ultrasound in Gout 奇美醫院風濕免疫科

林永章醫師

1430-1510 Hands-on practice section All 1510-1525 Break

Section 2 座長 張棋楨羅淑芬

1525-1545 Ultrasound in RA

台北醫學大學附設醫院

風濕免疫科

蔡凱倫醫師

1545-1605 Ultrasound in AS 林口長庚醫院風濕免疫科

方耀凡醫師

1605-1625 Ultrasound in PSA

台灣大學附設醫院

風濕免疫科

李克仁醫師

1625-1705 Hands-on practice section All 1705~1720 Break

Section 3 座長 陳得源黃春明

10

1720~1740 Ultrasound in SS 中國醫藥大學附設醫院

免疫風濕科 黃柏豪醫師

1740~1800 Ultrasound in SSc 台中榮民總醫院

醫學研究部臨床試驗科 陳信華醫師

1800~1820 Ultrasound in Vasculitis 台中榮民總醫院 免疫風濕科 賴國隆醫師

1820~1900 Hands-on practice section All

1900 晚餐

11

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

應用幹細胞移植治療自體免疫疾病 (Stem cell transplantation for autoimmune diseases)

時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點 台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

0840~0920 Stem cell transplantation in scleroderma

Prof Dr Jacob M van Laar

(Dutch)

台北榮民總醫院

蔡長祐教授

0920~0940 Preliminary experience in stem cell transplantation for systemic sclerosis

台大醫院 謝松洲主任

12

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Gout 時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 贊助單位台灣安斯泰來製藥股份有限公司

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

0840~0900 Epidemiology of gout An update 林口長庚紀念醫院

郭昶甫醫師

林口長庚紀念

醫院

羅淑芬教授

花蓮慈濟醫院

蔡世滋教授

0900~0920 Severe Allopurinol Hypersensitivity Syndrome and HLA-B5801

林口長庚紀念醫院

余光輝主任

0920~0940 Taiwan guideline for the management of gout and hyperuricemia are we on the trend

台北榮民總醫院

林孝義主任

申請學分台灣內科醫學會學分台灣家庭醫學會學分申請中

13

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Thomas Bardin PhD 時間103 年 12 月 06 日(星期六)0945-1035 Time0945~1035 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 周昌德 教授 ModeratorProf Chung-Tei Chou Taipei Veterans General Hospital

The new EULAR recommendations in the management of gout

Thomas Bardin PhD

14

中華民國風濕病醫學會 2014 年會

風濕病友教育講座 時間103 年 12 月 06 日(星期六)1055~1215 Time1055~1215 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1055-1100 開場簡介 中山醫學大學附設醫院

魏正宗主任

中山醫學大

學附設醫院

魏正宗主任

1100-1130 風濕病人的疫苗接種 花蓮慈濟醫院 蔡世滋主任

1130-1200 風濕病人的生活保健 台中榮民總醫院

謝祖怡主任

1200-1215 問與答

大林慈濟醫院 賴寧生院長 花蓮慈濟醫院 蔡世滋主任 台中榮民總醫院 謝祖怡主任

中山醫學大學附設醫院 魏正宗主任

15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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抵或搭乘計程車約 20 分鐘即抵

2

2014 社團法人中華民國風濕病醫學會會員大會暨學術演講會

會員注意事項

1 社團法人中華民國風濕病醫學會會員(以下簡稱本會會員)欲住宿者請與

惠康旅行社 Sophie 張小姐連絡洽詢住宿及費用相關事宜行動電話

0927-115512 (07)285-0067

2 報到時間12 月 06 日(星期六)0730~1700

12 月 07 日(星期日)0730~1500

3 報到處設於台中日月千禧酒店 B2 宴會廳電梯出口

4 本會會員於報到時請繳交參加費 NT$500 元非本會會員繳交參加費

NT$5000 元並領取大會資料

5 今年度常年會費與參加費可經以下兩種方式繳納

(1) 郵政劃撥劃撥帳號07641125 號

(2) 超商繳納

本次年會盡可能不接受現場繳費請於 11 月 25 日前完成繳費以免造成

報到處壅擠

6 今年度年會繼續教育學分可以以身份證條碼或健保卡登錄請會員擕帶身

份證或健保卡非會員仍比照往年簽名於紙本

7 壁報論文注意事項

(1)壁報規格寬 90 times 高 150

(2) 12 月 06 日(星期六)上午 900 開放海報張貼

(3) 12 月 07 日(星期日)下午 1500 後才可撤下壁報

(4)海報論文作者應在 Poster section 時間內在其海報論文前現場備詢以

便評選優秀壁報獎

(5)Poster view and discussion 共有二個時段

(a)12 月 06 日(六)下午 1320~1410

由謝松洲主任帶領請有興趣者於規定時間至 P001 集合

NoP001P002P003P004P005P006P007P008P009P010P011P012

P013P014P015P016P017P018P019P020P021

特別指定 5 篇為 P004P005P012P016P019當天需準備在海報前與主持人做

3

討論亦即被指定之 poster 負責人需在 poster 前面向主持人及觀眾作口頭報告研究成

果(報告時間為六分鐘討論四分鐘)每人不可超過 10 分鐘其他未被指定之 poster

則 poster 之負責人不用主動向主持人報告有觀眾來看時有須要再討論

(b)12 月 07 日(日)下午 1400~1450

由顏正賢教授帶領請有興趣者於規定時間至 P022 集合

No P022P023P024P025P026P027P028P029P030P031P032P033

P034P035P036P037P038P039P040P041P042

特別指定 5 篇為 P041P034P036P037P033當天需準備在海報前與主持人

做討論亦即被指定之 poster 負責人需在 poster 前面向主持人及觀眾作口頭報告研

究成果(報告時間為六分鐘討論四分鐘)每人不可超過 10 分鐘其他未被指定之

poster 則 poster 之負責人不用主動向主持人報告有觀眾來看時有須要再討論

8 午餐06 日(星期六)於 B2 宴會廳有 lunch symposium07 日(星期日)B2

宴會廳有 lunch symposium

9 大會晚宴12 月 06 日(星期六)晚上 1900 於 B2 宴會廳

4

主持人注意事項

1 請準時開始準時結束

2 主持人請於節目開始前 10 分鐘到現場

3 請每時段之座長事先準備介紹及討論(我們將寄上摘要內容)

4 提醒會議進行時請會員將手機轉為震動

演講者注意事項

1 本會提供單槍投影機Notebook演講者請使用 PowerPoint 檔案

2 演講內容請先於演講前 1 小時至報到處之試片處儲存於大會電腦恕無法

接受自備手提電腦轉接

3 簡報內容請以 Microsoft PowerPoint 2003 版本儲存勿使用 2007 版本以免

發生播放困難

4 口頭論文報告演講時間以8分鐘為限2分鐘討論時間結束前2分鐘按一

次鈴時間到按兩次鈴並開燈結束報告報告完畢後一併做討論

5

中華民國風濕病醫學會2014年年會節目時間地點一覽表

6

中華民國風濕病醫學會 2014 年會

Review Course

SLEVasculitisSjoumlgrenrsquos 時間103 年 12 月 05 日(星期五)0830~1100 Time0830~1100 05-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5

時間 講題 主講人 主持人

0840-0920 SLE-review 洪維廷 醫師

台中榮民總醫院 過敏免疫風濕科

社團法人中華民

國風濕病醫學會

理事長 陳得源

0920-1000 Vasculitis-review 黃建中 醫師

中國醫藥大學附設醫院 風濕免疫過敏科

1000-1040 Sjoumlgrenrsquos-review

翁孟玉 醫師 成大醫院

過敏免疫風濕科

1040-1100 Coffee break

7

中華民國風濕病醫學會 2014 年會

Sono-guided pain control in rheumatology 時間103 年 12 月 5 日(星期五)1100~1200 地點台中日月千禧酒店 5 樓 Vee5 主辦單位社團法人中華民國風濕病醫學會 主講人陳建行醫師 主持人中國醫藥大學附設醫院 藍忠亮教授

Soft tissue lesions From clinical presentation to ultrasound guided intervention

A non-osseous orthopedic disorders are one of the major causes of human suffering The manifest themselves with symptoms felt at a moving part of the body Diagnosis should be made on the basis of the clinicianrsquos ability to interpret these symptoms and signs Among treatment options diagnostic injection with local anesthetic drug is a good choice is the following conditions 1 When the examiner is not certain about a diagnosis or when the examiner want

positive confirmation of a tentative diagnosis the induction of local anesthetic may help

2 For lesion is the extremities infiltration is particularly helpful 3 In difficult cases this approach maybe the final diagnosis method Application of ultrasound in pain medicine is a rapidly growing field of interventional pain management and in the recent few years US guidance for chronic pain practice has been noticed With the help of ultrasound we can target our treatment goal precisely If the pain is completely or partly negative the exact site of lesion has clearly been reached confirming the diagnosis When the pain is still as painful or as limited as before the diagnosis is wrong Combine clinical evaluation and ultrasound guided intervention made treatment more effective and less suffer

8

中華民國風濕病醫學會 2014 年會

Meet the Master 時間103 年 12 月 05 日(星期五)1200~1330 Time1200~1330 05-Dec-2013 地點台中日月千禧酒店 5 樓 Vee5 主講人高雄醫學大學附設中和紀念醫院 劉宏文教授中國醫藥大學附設

醫院藍忠亮教授 主持人社團法人中華民國風濕病醫學會 陳得源 理事長

您hellip想要了解『醫界大師』是如何產生的嗎

邀請了 2 位榮獲中華民國風濕病醫學會大師獎蒞臨現場

劉宏文教授藍忠亮教授

此活動將與重量級大師對談

2 位大師將自我介紹談論一生經歷並分享生涯規劃

9

中華民國風濕病醫學會 2014 年會

超音波研討會及實際操作 時間103 年 12 月 05 日(星期五) 1330~1900 地點台中日月千禧酒店 5 樓 Vee1+Vee2 (1) 主辦單位社團法人中華民國風濕病醫學會TRUST Team (2) 協辦單位瑞士商艾伯維藥品有限公司衛采製藥股份有限公司 (3) 本次年會超音波研討會及實際操作 分三個主題進行研討 (1)晶體性關節

炎及退化性關節炎(2) 類風濕性關節炎僵直性脊椎炎及乾癬性關節炎(3)乾燥症硬皮症血管炎 每個主題研討完 Speaker 將進行患者超音波實際

檢查學員分組輪流進行操作練習 時間 講題 主講人

1320-1330 Registration

Section 1 座長 陳英州蔡文展

1330-1350 Ultrasound in OA 高雄醫學大學附設醫院

林育志醫師

1350-1410 Ultrasound in CPPD 嘉義長庚醫院風濕免疫科

林靖麒醫師

1410-1430 Ultrasound in Gout 奇美醫院風濕免疫科

林永章醫師

1430-1510 Hands-on practice section All 1510-1525 Break

Section 2 座長 張棋楨羅淑芬

1525-1545 Ultrasound in RA

台北醫學大學附設醫院

風濕免疫科

蔡凱倫醫師

1545-1605 Ultrasound in AS 林口長庚醫院風濕免疫科

方耀凡醫師

1605-1625 Ultrasound in PSA

台灣大學附設醫院

風濕免疫科

李克仁醫師

1625-1705 Hands-on practice section All 1705~1720 Break

Section 3 座長 陳得源黃春明

10

1720~1740 Ultrasound in SS 中國醫藥大學附設醫院

免疫風濕科 黃柏豪醫師

1740~1800 Ultrasound in SSc 台中榮民總醫院

醫學研究部臨床試驗科 陳信華醫師

1800~1820 Ultrasound in Vasculitis 台中榮民總醫院 免疫風濕科 賴國隆醫師

1820~1900 Hands-on practice section All

1900 晚餐

11

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

應用幹細胞移植治療自體免疫疾病 (Stem cell transplantation for autoimmune diseases)

時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點 台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

0840~0920 Stem cell transplantation in scleroderma

Prof Dr Jacob M van Laar

(Dutch)

台北榮民總醫院

蔡長祐教授

0920~0940 Preliminary experience in stem cell transplantation for systemic sclerosis

台大醫院 謝松洲主任

12

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Gout 時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 贊助單位台灣安斯泰來製藥股份有限公司

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

0840~0900 Epidemiology of gout An update 林口長庚紀念醫院

郭昶甫醫師

林口長庚紀念

醫院

羅淑芬教授

花蓮慈濟醫院

蔡世滋教授

0900~0920 Severe Allopurinol Hypersensitivity Syndrome and HLA-B5801

林口長庚紀念醫院

余光輝主任

0920~0940 Taiwan guideline for the management of gout and hyperuricemia are we on the trend

台北榮民總醫院

林孝義主任

申請學分台灣內科醫學會學分台灣家庭醫學會學分申請中

13

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Thomas Bardin PhD 時間103 年 12 月 06 日(星期六)0945-1035 Time0945~1035 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 周昌德 教授 ModeratorProf Chung-Tei Chou Taipei Veterans General Hospital

The new EULAR recommendations in the management of gout

Thomas Bardin PhD

14

中華民國風濕病醫學會 2014 年會

風濕病友教育講座 時間103 年 12 月 06 日(星期六)1055~1215 Time1055~1215 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1055-1100 開場簡介 中山醫學大學附設醫院

魏正宗主任

中山醫學大

學附設醫院

魏正宗主任

1100-1130 風濕病人的疫苗接種 花蓮慈濟醫院 蔡世滋主任

1130-1200 風濕病人的生活保健 台中榮民總醫院

謝祖怡主任

1200-1215 問與答

大林慈濟醫院 賴寧生院長 花蓮慈濟醫院 蔡世滋主任 台中榮民總醫院 謝祖怡主任

中山醫學大學附設醫院 魏正宗主任

15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

飯店位置圖 飯店名稱台中日月千禧酒店

飯店地址40756 台中市市政路 77 號

飯店電話(04)3900-8889

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交通資訊 【自行開車】

國道一號台中交流道往台中方向下rarr行中港路三段rarr右轉朝富路rarr左轉市政路即抵

【大眾運輸】

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即抵

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高鐵高鐵烏日站出站轉程 7507 路公車於黎明新村站(黎明路)下步行約 11 分鐘即

抵或搭乘計程車約 20 分鐘即抵

3

討論亦即被指定之 poster 負責人需在 poster 前面向主持人及觀眾作口頭報告研究成

果(報告時間為六分鐘討論四分鐘)每人不可超過 10 分鐘其他未被指定之 poster

則 poster 之負責人不用主動向主持人報告有觀眾來看時有須要再討論

(b)12 月 07 日(日)下午 1400~1450

由顏正賢教授帶領請有興趣者於規定時間至 P022 集合

No P022P023P024P025P026P027P028P029P030P031P032P033

P034P035P036P037P038P039P040P041P042

特別指定 5 篇為 P041P034P036P037P033當天需準備在海報前與主持人

做討論亦即被指定之 poster 負責人需在 poster 前面向主持人及觀眾作口頭報告研

究成果(報告時間為六分鐘討論四分鐘)每人不可超過 10 分鐘其他未被指定之

poster 則 poster 之負責人不用主動向主持人報告有觀眾來看時有須要再討論

8 午餐06 日(星期六)於 B2 宴會廳有 lunch symposium07 日(星期日)B2

宴會廳有 lunch symposium

9 大會晚宴12 月 06 日(星期六)晚上 1900 於 B2 宴會廳

4

主持人注意事項

1 請準時開始準時結束

2 主持人請於節目開始前 10 分鐘到現場

3 請每時段之座長事先準備介紹及討論(我們將寄上摘要內容)

4 提醒會議進行時請會員將手機轉為震動

演講者注意事項

1 本會提供單槍投影機Notebook演講者請使用 PowerPoint 檔案

2 演講內容請先於演講前 1 小時至報到處之試片處儲存於大會電腦恕無法

接受自備手提電腦轉接

3 簡報內容請以 Microsoft PowerPoint 2003 版本儲存勿使用 2007 版本以免

發生播放困難

4 口頭論文報告演講時間以8分鐘為限2分鐘討論時間結束前2分鐘按一

次鈴時間到按兩次鈴並開燈結束報告報告完畢後一併做討論

5

中華民國風濕病醫學會2014年年會節目時間地點一覽表

6

中華民國風濕病醫學會 2014 年會

Review Course

SLEVasculitisSjoumlgrenrsquos 時間103 年 12 月 05 日(星期五)0830~1100 Time0830~1100 05-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5

時間 講題 主講人 主持人

0840-0920 SLE-review 洪維廷 醫師

台中榮民總醫院 過敏免疫風濕科

社團法人中華民

國風濕病醫學會

理事長 陳得源

0920-1000 Vasculitis-review 黃建中 醫師

中國醫藥大學附設醫院 風濕免疫過敏科

1000-1040 Sjoumlgrenrsquos-review

翁孟玉 醫師 成大醫院

過敏免疫風濕科

1040-1100 Coffee break

7

中華民國風濕病醫學會 2014 年會

Sono-guided pain control in rheumatology 時間103 年 12 月 5 日(星期五)1100~1200 地點台中日月千禧酒店 5 樓 Vee5 主辦單位社團法人中華民國風濕病醫學會 主講人陳建行醫師 主持人中國醫藥大學附設醫院 藍忠亮教授

Soft tissue lesions From clinical presentation to ultrasound guided intervention

A non-osseous orthopedic disorders are one of the major causes of human suffering The manifest themselves with symptoms felt at a moving part of the body Diagnosis should be made on the basis of the clinicianrsquos ability to interpret these symptoms and signs Among treatment options diagnostic injection with local anesthetic drug is a good choice is the following conditions 1 When the examiner is not certain about a diagnosis or when the examiner want

positive confirmation of a tentative diagnosis the induction of local anesthetic may help

2 For lesion is the extremities infiltration is particularly helpful 3 In difficult cases this approach maybe the final diagnosis method Application of ultrasound in pain medicine is a rapidly growing field of interventional pain management and in the recent few years US guidance for chronic pain practice has been noticed With the help of ultrasound we can target our treatment goal precisely If the pain is completely or partly negative the exact site of lesion has clearly been reached confirming the diagnosis When the pain is still as painful or as limited as before the diagnosis is wrong Combine clinical evaluation and ultrasound guided intervention made treatment more effective and less suffer

8

中華民國風濕病醫學會 2014 年會

Meet the Master 時間103 年 12 月 05 日(星期五)1200~1330 Time1200~1330 05-Dec-2013 地點台中日月千禧酒店 5 樓 Vee5 主講人高雄醫學大學附設中和紀念醫院 劉宏文教授中國醫藥大學附設

醫院藍忠亮教授 主持人社團法人中華民國風濕病醫學會 陳得源 理事長

您hellip想要了解『醫界大師』是如何產生的嗎

邀請了 2 位榮獲中華民國風濕病醫學會大師獎蒞臨現場

劉宏文教授藍忠亮教授

此活動將與重量級大師對談

2 位大師將自我介紹談論一生經歷並分享生涯規劃

9

中華民國風濕病醫學會 2014 年會

超音波研討會及實際操作 時間103 年 12 月 05 日(星期五) 1330~1900 地點台中日月千禧酒店 5 樓 Vee1+Vee2 (1) 主辦單位社團法人中華民國風濕病醫學會TRUST Team (2) 協辦單位瑞士商艾伯維藥品有限公司衛采製藥股份有限公司 (3) 本次年會超音波研討會及實際操作 分三個主題進行研討 (1)晶體性關節

炎及退化性關節炎(2) 類風濕性關節炎僵直性脊椎炎及乾癬性關節炎(3)乾燥症硬皮症血管炎 每個主題研討完 Speaker 將進行患者超音波實際

檢查學員分組輪流進行操作練習 時間 講題 主講人

1320-1330 Registration

Section 1 座長 陳英州蔡文展

1330-1350 Ultrasound in OA 高雄醫學大學附設醫院

林育志醫師

1350-1410 Ultrasound in CPPD 嘉義長庚醫院風濕免疫科

林靖麒醫師

1410-1430 Ultrasound in Gout 奇美醫院風濕免疫科

林永章醫師

1430-1510 Hands-on practice section All 1510-1525 Break

Section 2 座長 張棋楨羅淑芬

1525-1545 Ultrasound in RA

台北醫學大學附設醫院

風濕免疫科

蔡凱倫醫師

1545-1605 Ultrasound in AS 林口長庚醫院風濕免疫科

方耀凡醫師

1605-1625 Ultrasound in PSA

台灣大學附設醫院

風濕免疫科

李克仁醫師

1625-1705 Hands-on practice section All 1705~1720 Break

Section 3 座長 陳得源黃春明

10

1720~1740 Ultrasound in SS 中國醫藥大學附設醫院

免疫風濕科 黃柏豪醫師

1740~1800 Ultrasound in SSc 台中榮民總醫院

醫學研究部臨床試驗科 陳信華醫師

1800~1820 Ultrasound in Vasculitis 台中榮民總醫院 免疫風濕科 賴國隆醫師

1820~1900 Hands-on practice section All

1900 晚餐

11

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

應用幹細胞移植治療自體免疫疾病 (Stem cell transplantation for autoimmune diseases)

時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點 台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

0840~0920 Stem cell transplantation in scleroderma

Prof Dr Jacob M van Laar

(Dutch)

台北榮民總醫院

蔡長祐教授

0920~0940 Preliminary experience in stem cell transplantation for systemic sclerosis

台大醫院 謝松洲主任

12

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Gout 時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 贊助單位台灣安斯泰來製藥股份有限公司

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

0840~0900 Epidemiology of gout An update 林口長庚紀念醫院

郭昶甫醫師

林口長庚紀念

醫院

羅淑芬教授

花蓮慈濟醫院

蔡世滋教授

0900~0920 Severe Allopurinol Hypersensitivity Syndrome and HLA-B5801

林口長庚紀念醫院

余光輝主任

0920~0940 Taiwan guideline for the management of gout and hyperuricemia are we on the trend

台北榮民總醫院

林孝義主任

申請學分台灣內科醫學會學分台灣家庭醫學會學分申請中

13

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Thomas Bardin PhD 時間103 年 12 月 06 日(星期六)0945-1035 Time0945~1035 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 周昌德 教授 ModeratorProf Chung-Tei Chou Taipei Veterans General Hospital

The new EULAR recommendations in the management of gout

Thomas Bardin PhD

14

中華民國風濕病醫學會 2014 年會

風濕病友教育講座 時間103 年 12 月 06 日(星期六)1055~1215 Time1055~1215 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1055-1100 開場簡介 中山醫學大學附設醫院

魏正宗主任

中山醫學大

學附設醫院

魏正宗主任

1100-1130 風濕病人的疫苗接種 花蓮慈濟醫院 蔡世滋主任

1130-1200 風濕病人的生活保健 台中榮民總醫院

謝祖怡主任

1200-1215 問與答

大林慈濟醫院 賴寧生院長 花蓮慈濟醫院 蔡世滋主任 台中榮民總醫院 謝祖怡主任

中山醫學大學附設醫院 魏正宗主任

15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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交通資訊 【自行開車】

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即抵

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抵或搭乘計程車約 20 分鐘即抵

4

主持人注意事項

1 請準時開始準時結束

2 主持人請於節目開始前 10 分鐘到現場

3 請每時段之座長事先準備介紹及討論(我們將寄上摘要內容)

4 提醒會議進行時請會員將手機轉為震動

演講者注意事項

1 本會提供單槍投影機Notebook演講者請使用 PowerPoint 檔案

2 演講內容請先於演講前 1 小時至報到處之試片處儲存於大會電腦恕無法

接受自備手提電腦轉接

3 簡報內容請以 Microsoft PowerPoint 2003 版本儲存勿使用 2007 版本以免

發生播放困難

4 口頭論文報告演講時間以8分鐘為限2分鐘討論時間結束前2分鐘按一

次鈴時間到按兩次鈴並開燈結束報告報告完畢後一併做討論

5

中華民國風濕病醫學會2014年年會節目時間地點一覽表

6

中華民國風濕病醫學會 2014 年會

Review Course

SLEVasculitisSjoumlgrenrsquos 時間103 年 12 月 05 日(星期五)0830~1100 Time0830~1100 05-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5

時間 講題 主講人 主持人

0840-0920 SLE-review 洪維廷 醫師

台中榮民總醫院 過敏免疫風濕科

社團法人中華民

國風濕病醫學會

理事長 陳得源

0920-1000 Vasculitis-review 黃建中 醫師

中國醫藥大學附設醫院 風濕免疫過敏科

1000-1040 Sjoumlgrenrsquos-review

翁孟玉 醫師 成大醫院

過敏免疫風濕科

1040-1100 Coffee break

7

中華民國風濕病醫學會 2014 年會

Sono-guided pain control in rheumatology 時間103 年 12 月 5 日(星期五)1100~1200 地點台中日月千禧酒店 5 樓 Vee5 主辦單位社團法人中華民國風濕病醫學會 主講人陳建行醫師 主持人中國醫藥大學附設醫院 藍忠亮教授

Soft tissue lesions From clinical presentation to ultrasound guided intervention

A non-osseous orthopedic disorders are one of the major causes of human suffering The manifest themselves with symptoms felt at a moving part of the body Diagnosis should be made on the basis of the clinicianrsquos ability to interpret these symptoms and signs Among treatment options diagnostic injection with local anesthetic drug is a good choice is the following conditions 1 When the examiner is not certain about a diagnosis or when the examiner want

positive confirmation of a tentative diagnosis the induction of local anesthetic may help

2 For lesion is the extremities infiltration is particularly helpful 3 In difficult cases this approach maybe the final diagnosis method Application of ultrasound in pain medicine is a rapidly growing field of interventional pain management and in the recent few years US guidance for chronic pain practice has been noticed With the help of ultrasound we can target our treatment goal precisely If the pain is completely or partly negative the exact site of lesion has clearly been reached confirming the diagnosis When the pain is still as painful or as limited as before the diagnosis is wrong Combine clinical evaluation and ultrasound guided intervention made treatment more effective and less suffer

8

中華民國風濕病醫學會 2014 年會

Meet the Master 時間103 年 12 月 05 日(星期五)1200~1330 Time1200~1330 05-Dec-2013 地點台中日月千禧酒店 5 樓 Vee5 主講人高雄醫學大學附設中和紀念醫院 劉宏文教授中國醫藥大學附設

醫院藍忠亮教授 主持人社團法人中華民國風濕病醫學會 陳得源 理事長

您hellip想要了解『醫界大師』是如何產生的嗎

邀請了 2 位榮獲中華民國風濕病醫學會大師獎蒞臨現場

劉宏文教授藍忠亮教授

此活動將與重量級大師對談

2 位大師將自我介紹談論一生經歷並分享生涯規劃

9

中華民國風濕病醫學會 2014 年會

超音波研討會及實際操作 時間103 年 12 月 05 日(星期五) 1330~1900 地點台中日月千禧酒店 5 樓 Vee1+Vee2 (1) 主辦單位社團法人中華民國風濕病醫學會TRUST Team (2) 協辦單位瑞士商艾伯維藥品有限公司衛采製藥股份有限公司 (3) 本次年會超音波研討會及實際操作 分三個主題進行研討 (1)晶體性關節

炎及退化性關節炎(2) 類風濕性關節炎僵直性脊椎炎及乾癬性關節炎(3)乾燥症硬皮症血管炎 每個主題研討完 Speaker 將進行患者超音波實際

檢查學員分組輪流進行操作練習 時間 講題 主講人

1320-1330 Registration

Section 1 座長 陳英州蔡文展

1330-1350 Ultrasound in OA 高雄醫學大學附設醫院

林育志醫師

1350-1410 Ultrasound in CPPD 嘉義長庚醫院風濕免疫科

林靖麒醫師

1410-1430 Ultrasound in Gout 奇美醫院風濕免疫科

林永章醫師

1430-1510 Hands-on practice section All 1510-1525 Break

Section 2 座長 張棋楨羅淑芬

1525-1545 Ultrasound in RA

台北醫學大學附設醫院

風濕免疫科

蔡凱倫醫師

1545-1605 Ultrasound in AS 林口長庚醫院風濕免疫科

方耀凡醫師

1605-1625 Ultrasound in PSA

台灣大學附設醫院

風濕免疫科

李克仁醫師

1625-1705 Hands-on practice section All 1705~1720 Break

Section 3 座長 陳得源黃春明

10

1720~1740 Ultrasound in SS 中國醫藥大學附設醫院

免疫風濕科 黃柏豪醫師

1740~1800 Ultrasound in SSc 台中榮民總醫院

醫學研究部臨床試驗科 陳信華醫師

1800~1820 Ultrasound in Vasculitis 台中榮民總醫院 免疫風濕科 賴國隆醫師

1820~1900 Hands-on practice section All

1900 晚餐

11

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

應用幹細胞移植治療自體免疫疾病 (Stem cell transplantation for autoimmune diseases)

時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點 台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

0840~0920 Stem cell transplantation in scleroderma

Prof Dr Jacob M van Laar

(Dutch)

台北榮民總醫院

蔡長祐教授

0920~0940 Preliminary experience in stem cell transplantation for systemic sclerosis

台大醫院 謝松洲主任

12

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Gout 時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 贊助單位台灣安斯泰來製藥股份有限公司

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

0840~0900 Epidemiology of gout An update 林口長庚紀念醫院

郭昶甫醫師

林口長庚紀念

醫院

羅淑芬教授

花蓮慈濟醫院

蔡世滋教授

0900~0920 Severe Allopurinol Hypersensitivity Syndrome and HLA-B5801

林口長庚紀念醫院

余光輝主任

0920~0940 Taiwan guideline for the management of gout and hyperuricemia are we on the trend

台北榮民總醫院

林孝義主任

申請學分台灣內科醫學會學分台灣家庭醫學會學分申請中

13

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Thomas Bardin PhD 時間103 年 12 月 06 日(星期六)0945-1035 Time0945~1035 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 周昌德 教授 ModeratorProf Chung-Tei Chou Taipei Veterans General Hospital

The new EULAR recommendations in the management of gout

Thomas Bardin PhD

14

中華民國風濕病醫學會 2014 年會

風濕病友教育講座 時間103 年 12 月 06 日(星期六)1055~1215 Time1055~1215 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1055-1100 開場簡介 中山醫學大學附設醫院

魏正宗主任

中山醫學大

學附設醫院

魏正宗主任

1100-1130 風濕病人的疫苗接種 花蓮慈濟醫院 蔡世滋主任

1130-1200 風濕病人的生活保健 台中榮民總醫院

謝祖怡主任

1200-1215 問與答

大林慈濟醫院 賴寧生院長 花蓮慈濟醫院 蔡世滋主任 台中榮民總醫院 謝祖怡主任

中山醫學大學附設醫院 魏正宗主任

15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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飯店地址40756 台中市市政路 77 號

飯店電話(04)3900-8889

飯店網址httpwwwmillenniumhotelscomzh-twmillenniumveehoteltaichung

交通資訊 【自行開車】

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即抵

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抵或搭乘計程車約 20 分鐘即抵

5

中華民國風濕病醫學會2014年年會節目時間地點一覽表

6

中華民國風濕病醫學會 2014 年會

Review Course

SLEVasculitisSjoumlgrenrsquos 時間103 年 12 月 05 日(星期五)0830~1100 Time0830~1100 05-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5

時間 講題 主講人 主持人

0840-0920 SLE-review 洪維廷 醫師

台中榮民總醫院 過敏免疫風濕科

社團法人中華民

國風濕病醫學會

理事長 陳得源

0920-1000 Vasculitis-review 黃建中 醫師

中國醫藥大學附設醫院 風濕免疫過敏科

1000-1040 Sjoumlgrenrsquos-review

翁孟玉 醫師 成大醫院

過敏免疫風濕科

1040-1100 Coffee break

7

中華民國風濕病醫學會 2014 年會

Sono-guided pain control in rheumatology 時間103 年 12 月 5 日(星期五)1100~1200 地點台中日月千禧酒店 5 樓 Vee5 主辦單位社團法人中華民國風濕病醫學會 主講人陳建行醫師 主持人中國醫藥大學附設醫院 藍忠亮教授

Soft tissue lesions From clinical presentation to ultrasound guided intervention

A non-osseous orthopedic disorders are one of the major causes of human suffering The manifest themselves with symptoms felt at a moving part of the body Diagnosis should be made on the basis of the clinicianrsquos ability to interpret these symptoms and signs Among treatment options diagnostic injection with local anesthetic drug is a good choice is the following conditions 1 When the examiner is not certain about a diagnosis or when the examiner want

positive confirmation of a tentative diagnosis the induction of local anesthetic may help

2 For lesion is the extremities infiltration is particularly helpful 3 In difficult cases this approach maybe the final diagnosis method Application of ultrasound in pain medicine is a rapidly growing field of interventional pain management and in the recent few years US guidance for chronic pain practice has been noticed With the help of ultrasound we can target our treatment goal precisely If the pain is completely or partly negative the exact site of lesion has clearly been reached confirming the diagnosis When the pain is still as painful or as limited as before the diagnosis is wrong Combine clinical evaluation and ultrasound guided intervention made treatment more effective and less suffer

8

中華民國風濕病醫學會 2014 年會

Meet the Master 時間103 年 12 月 05 日(星期五)1200~1330 Time1200~1330 05-Dec-2013 地點台中日月千禧酒店 5 樓 Vee5 主講人高雄醫學大學附設中和紀念醫院 劉宏文教授中國醫藥大學附設

醫院藍忠亮教授 主持人社團法人中華民國風濕病醫學會 陳得源 理事長

您hellip想要了解『醫界大師』是如何產生的嗎

邀請了 2 位榮獲中華民國風濕病醫學會大師獎蒞臨現場

劉宏文教授藍忠亮教授

此活動將與重量級大師對談

2 位大師將自我介紹談論一生經歷並分享生涯規劃

9

中華民國風濕病醫學會 2014 年會

超音波研討會及實際操作 時間103 年 12 月 05 日(星期五) 1330~1900 地點台中日月千禧酒店 5 樓 Vee1+Vee2 (1) 主辦單位社團法人中華民國風濕病醫學會TRUST Team (2) 協辦單位瑞士商艾伯維藥品有限公司衛采製藥股份有限公司 (3) 本次年會超音波研討會及實際操作 分三個主題進行研討 (1)晶體性關節

炎及退化性關節炎(2) 類風濕性關節炎僵直性脊椎炎及乾癬性關節炎(3)乾燥症硬皮症血管炎 每個主題研討完 Speaker 將進行患者超音波實際

檢查學員分組輪流進行操作練習 時間 講題 主講人

1320-1330 Registration

Section 1 座長 陳英州蔡文展

1330-1350 Ultrasound in OA 高雄醫學大學附設醫院

林育志醫師

1350-1410 Ultrasound in CPPD 嘉義長庚醫院風濕免疫科

林靖麒醫師

1410-1430 Ultrasound in Gout 奇美醫院風濕免疫科

林永章醫師

1430-1510 Hands-on practice section All 1510-1525 Break

Section 2 座長 張棋楨羅淑芬

1525-1545 Ultrasound in RA

台北醫學大學附設醫院

風濕免疫科

蔡凱倫醫師

1545-1605 Ultrasound in AS 林口長庚醫院風濕免疫科

方耀凡醫師

1605-1625 Ultrasound in PSA

台灣大學附設醫院

風濕免疫科

李克仁醫師

1625-1705 Hands-on practice section All 1705~1720 Break

Section 3 座長 陳得源黃春明

10

1720~1740 Ultrasound in SS 中國醫藥大學附設醫院

免疫風濕科 黃柏豪醫師

1740~1800 Ultrasound in SSc 台中榮民總醫院

醫學研究部臨床試驗科 陳信華醫師

1800~1820 Ultrasound in Vasculitis 台中榮民總醫院 免疫風濕科 賴國隆醫師

1820~1900 Hands-on practice section All

1900 晚餐

11

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

應用幹細胞移植治療自體免疫疾病 (Stem cell transplantation for autoimmune diseases)

時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點 台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

0840~0920 Stem cell transplantation in scleroderma

Prof Dr Jacob M van Laar

(Dutch)

台北榮民總醫院

蔡長祐教授

0920~0940 Preliminary experience in stem cell transplantation for systemic sclerosis

台大醫院 謝松洲主任

12

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Gout 時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 贊助單位台灣安斯泰來製藥股份有限公司

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

0840~0900 Epidemiology of gout An update 林口長庚紀念醫院

郭昶甫醫師

林口長庚紀念

醫院

羅淑芬教授

花蓮慈濟醫院

蔡世滋教授

0900~0920 Severe Allopurinol Hypersensitivity Syndrome and HLA-B5801

林口長庚紀念醫院

余光輝主任

0920~0940 Taiwan guideline for the management of gout and hyperuricemia are we on the trend

台北榮民總醫院

林孝義主任

申請學分台灣內科醫學會學分台灣家庭醫學會學分申請中

13

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Thomas Bardin PhD 時間103 年 12 月 06 日(星期六)0945-1035 Time0945~1035 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 周昌德 教授 ModeratorProf Chung-Tei Chou Taipei Veterans General Hospital

The new EULAR recommendations in the management of gout

Thomas Bardin PhD

14

中華民國風濕病醫學會 2014 年會

風濕病友教育講座 時間103 年 12 月 06 日(星期六)1055~1215 Time1055~1215 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1055-1100 開場簡介 中山醫學大學附設醫院

魏正宗主任

中山醫學大

學附設醫院

魏正宗主任

1100-1130 風濕病人的疫苗接種 花蓮慈濟醫院 蔡世滋主任

1130-1200 風濕病人的生活保健 台中榮民總醫院

謝祖怡主任

1200-1215 問與答

大林慈濟醫院 賴寧生院長 花蓮慈濟醫院 蔡世滋主任 台中榮民總醫院 謝祖怡主任

中山醫學大學附設醫院 魏正宗主任

15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

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高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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6

中華民國風濕病醫學會 2014 年會

Review Course

SLEVasculitisSjoumlgrenrsquos 時間103 年 12 月 05 日(星期五)0830~1100 Time0830~1100 05-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5

時間 講題 主講人 主持人

0840-0920 SLE-review 洪維廷 醫師

台中榮民總醫院 過敏免疫風濕科

社團法人中華民

國風濕病醫學會

理事長 陳得源

0920-1000 Vasculitis-review 黃建中 醫師

中國醫藥大學附設醫院 風濕免疫過敏科

1000-1040 Sjoumlgrenrsquos-review

翁孟玉 醫師 成大醫院

過敏免疫風濕科

1040-1100 Coffee break

7

中華民國風濕病醫學會 2014 年會

Sono-guided pain control in rheumatology 時間103 年 12 月 5 日(星期五)1100~1200 地點台中日月千禧酒店 5 樓 Vee5 主辦單位社團法人中華民國風濕病醫學會 主講人陳建行醫師 主持人中國醫藥大學附設醫院 藍忠亮教授

Soft tissue lesions From clinical presentation to ultrasound guided intervention

A non-osseous orthopedic disorders are one of the major causes of human suffering The manifest themselves with symptoms felt at a moving part of the body Diagnosis should be made on the basis of the clinicianrsquos ability to interpret these symptoms and signs Among treatment options diagnostic injection with local anesthetic drug is a good choice is the following conditions 1 When the examiner is not certain about a diagnosis or when the examiner want

positive confirmation of a tentative diagnosis the induction of local anesthetic may help

2 For lesion is the extremities infiltration is particularly helpful 3 In difficult cases this approach maybe the final diagnosis method Application of ultrasound in pain medicine is a rapidly growing field of interventional pain management and in the recent few years US guidance for chronic pain practice has been noticed With the help of ultrasound we can target our treatment goal precisely If the pain is completely or partly negative the exact site of lesion has clearly been reached confirming the diagnosis When the pain is still as painful or as limited as before the diagnosis is wrong Combine clinical evaluation and ultrasound guided intervention made treatment more effective and less suffer

8

中華民國風濕病醫學會 2014 年會

Meet the Master 時間103 年 12 月 05 日(星期五)1200~1330 Time1200~1330 05-Dec-2013 地點台中日月千禧酒店 5 樓 Vee5 主講人高雄醫學大學附設中和紀念醫院 劉宏文教授中國醫藥大學附設

醫院藍忠亮教授 主持人社團法人中華民國風濕病醫學會 陳得源 理事長

您hellip想要了解『醫界大師』是如何產生的嗎

邀請了 2 位榮獲中華民國風濕病醫學會大師獎蒞臨現場

劉宏文教授藍忠亮教授

此活動將與重量級大師對談

2 位大師將自我介紹談論一生經歷並分享生涯規劃

9

中華民國風濕病醫學會 2014 年會

超音波研討會及實際操作 時間103 年 12 月 05 日(星期五) 1330~1900 地點台中日月千禧酒店 5 樓 Vee1+Vee2 (1) 主辦單位社團法人中華民國風濕病醫學會TRUST Team (2) 協辦單位瑞士商艾伯維藥品有限公司衛采製藥股份有限公司 (3) 本次年會超音波研討會及實際操作 分三個主題進行研討 (1)晶體性關節

炎及退化性關節炎(2) 類風濕性關節炎僵直性脊椎炎及乾癬性關節炎(3)乾燥症硬皮症血管炎 每個主題研討完 Speaker 將進行患者超音波實際

檢查學員分組輪流進行操作練習 時間 講題 主講人

1320-1330 Registration

Section 1 座長 陳英州蔡文展

1330-1350 Ultrasound in OA 高雄醫學大學附設醫院

林育志醫師

1350-1410 Ultrasound in CPPD 嘉義長庚醫院風濕免疫科

林靖麒醫師

1410-1430 Ultrasound in Gout 奇美醫院風濕免疫科

林永章醫師

1430-1510 Hands-on practice section All 1510-1525 Break

Section 2 座長 張棋楨羅淑芬

1525-1545 Ultrasound in RA

台北醫學大學附設醫院

風濕免疫科

蔡凱倫醫師

1545-1605 Ultrasound in AS 林口長庚醫院風濕免疫科

方耀凡醫師

1605-1625 Ultrasound in PSA

台灣大學附設醫院

風濕免疫科

李克仁醫師

1625-1705 Hands-on practice section All 1705~1720 Break

Section 3 座長 陳得源黃春明

10

1720~1740 Ultrasound in SS 中國醫藥大學附設醫院

免疫風濕科 黃柏豪醫師

1740~1800 Ultrasound in SSc 台中榮民總醫院

醫學研究部臨床試驗科 陳信華醫師

1800~1820 Ultrasound in Vasculitis 台中榮民總醫院 免疫風濕科 賴國隆醫師

1820~1900 Hands-on practice section All

1900 晚餐

11

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

應用幹細胞移植治療自體免疫疾病 (Stem cell transplantation for autoimmune diseases)

時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點 台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

0840~0920 Stem cell transplantation in scleroderma

Prof Dr Jacob M van Laar

(Dutch)

台北榮民總醫院

蔡長祐教授

0920~0940 Preliminary experience in stem cell transplantation for systemic sclerosis

台大醫院 謝松洲主任

12

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Gout 時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 贊助單位台灣安斯泰來製藥股份有限公司

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

0840~0900 Epidemiology of gout An update 林口長庚紀念醫院

郭昶甫醫師

林口長庚紀念

醫院

羅淑芬教授

花蓮慈濟醫院

蔡世滋教授

0900~0920 Severe Allopurinol Hypersensitivity Syndrome and HLA-B5801

林口長庚紀念醫院

余光輝主任

0920~0940 Taiwan guideline for the management of gout and hyperuricemia are we on the trend

台北榮民總醫院

林孝義主任

申請學分台灣內科醫學會學分台灣家庭醫學會學分申請中

13

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Thomas Bardin PhD 時間103 年 12 月 06 日(星期六)0945-1035 Time0945~1035 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 周昌德 教授 ModeratorProf Chung-Tei Chou Taipei Veterans General Hospital

The new EULAR recommendations in the management of gout

Thomas Bardin PhD

14

中華民國風濕病醫學會 2014 年會

風濕病友教育講座 時間103 年 12 月 06 日(星期六)1055~1215 Time1055~1215 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1055-1100 開場簡介 中山醫學大學附設醫院

魏正宗主任

中山醫學大

學附設醫院

魏正宗主任

1100-1130 風濕病人的疫苗接種 花蓮慈濟醫院 蔡世滋主任

1130-1200 風濕病人的生活保健 台中榮民總醫院

謝祖怡主任

1200-1215 問與答

大林慈濟醫院 賴寧生院長 花蓮慈濟醫院 蔡世滋主任 台中榮民總醫院 謝祖怡主任

中山醫學大學附設醫院 魏正宗主任

15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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飯店電話(04)3900-8889

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國道一號台中交流道往台中方向下rarr行中港路三段rarr右轉朝富路rarr左轉市政路即抵

【大眾運輸】

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即抵

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7

中華民國風濕病醫學會 2014 年會

Sono-guided pain control in rheumatology 時間103 年 12 月 5 日(星期五)1100~1200 地點台中日月千禧酒店 5 樓 Vee5 主辦單位社團法人中華民國風濕病醫學會 主講人陳建行醫師 主持人中國醫藥大學附設醫院 藍忠亮教授

Soft tissue lesions From clinical presentation to ultrasound guided intervention

A non-osseous orthopedic disorders are one of the major causes of human suffering The manifest themselves with symptoms felt at a moving part of the body Diagnosis should be made on the basis of the clinicianrsquos ability to interpret these symptoms and signs Among treatment options diagnostic injection with local anesthetic drug is a good choice is the following conditions 1 When the examiner is not certain about a diagnosis or when the examiner want

positive confirmation of a tentative diagnosis the induction of local anesthetic may help

2 For lesion is the extremities infiltration is particularly helpful 3 In difficult cases this approach maybe the final diagnosis method Application of ultrasound in pain medicine is a rapidly growing field of interventional pain management and in the recent few years US guidance for chronic pain practice has been noticed With the help of ultrasound we can target our treatment goal precisely If the pain is completely or partly negative the exact site of lesion has clearly been reached confirming the diagnosis When the pain is still as painful or as limited as before the diagnosis is wrong Combine clinical evaluation and ultrasound guided intervention made treatment more effective and less suffer

8

中華民國風濕病醫學會 2014 年會

Meet the Master 時間103 年 12 月 05 日(星期五)1200~1330 Time1200~1330 05-Dec-2013 地點台中日月千禧酒店 5 樓 Vee5 主講人高雄醫學大學附設中和紀念醫院 劉宏文教授中國醫藥大學附設

醫院藍忠亮教授 主持人社團法人中華民國風濕病醫學會 陳得源 理事長

您hellip想要了解『醫界大師』是如何產生的嗎

邀請了 2 位榮獲中華民國風濕病醫學會大師獎蒞臨現場

劉宏文教授藍忠亮教授

此活動將與重量級大師對談

2 位大師將自我介紹談論一生經歷並分享生涯規劃

9

中華民國風濕病醫學會 2014 年會

超音波研討會及實際操作 時間103 年 12 月 05 日(星期五) 1330~1900 地點台中日月千禧酒店 5 樓 Vee1+Vee2 (1) 主辦單位社團法人中華民國風濕病醫學會TRUST Team (2) 協辦單位瑞士商艾伯維藥品有限公司衛采製藥股份有限公司 (3) 本次年會超音波研討會及實際操作 分三個主題進行研討 (1)晶體性關節

炎及退化性關節炎(2) 類風濕性關節炎僵直性脊椎炎及乾癬性關節炎(3)乾燥症硬皮症血管炎 每個主題研討完 Speaker 將進行患者超音波實際

檢查學員分組輪流進行操作練習 時間 講題 主講人

1320-1330 Registration

Section 1 座長 陳英州蔡文展

1330-1350 Ultrasound in OA 高雄醫學大學附設醫院

林育志醫師

1350-1410 Ultrasound in CPPD 嘉義長庚醫院風濕免疫科

林靖麒醫師

1410-1430 Ultrasound in Gout 奇美醫院風濕免疫科

林永章醫師

1430-1510 Hands-on practice section All 1510-1525 Break

Section 2 座長 張棋楨羅淑芬

1525-1545 Ultrasound in RA

台北醫學大學附設醫院

風濕免疫科

蔡凱倫醫師

1545-1605 Ultrasound in AS 林口長庚醫院風濕免疫科

方耀凡醫師

1605-1625 Ultrasound in PSA

台灣大學附設醫院

風濕免疫科

李克仁醫師

1625-1705 Hands-on practice section All 1705~1720 Break

Section 3 座長 陳得源黃春明

10

1720~1740 Ultrasound in SS 中國醫藥大學附設醫院

免疫風濕科 黃柏豪醫師

1740~1800 Ultrasound in SSc 台中榮民總醫院

醫學研究部臨床試驗科 陳信華醫師

1800~1820 Ultrasound in Vasculitis 台中榮民總醫院 免疫風濕科 賴國隆醫師

1820~1900 Hands-on practice section All

1900 晚餐

11

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

應用幹細胞移植治療自體免疫疾病 (Stem cell transplantation for autoimmune diseases)

時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點 台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

0840~0920 Stem cell transplantation in scleroderma

Prof Dr Jacob M van Laar

(Dutch)

台北榮民總醫院

蔡長祐教授

0920~0940 Preliminary experience in stem cell transplantation for systemic sclerosis

台大醫院 謝松洲主任

12

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Gout 時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 贊助單位台灣安斯泰來製藥股份有限公司

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

0840~0900 Epidemiology of gout An update 林口長庚紀念醫院

郭昶甫醫師

林口長庚紀念

醫院

羅淑芬教授

花蓮慈濟醫院

蔡世滋教授

0900~0920 Severe Allopurinol Hypersensitivity Syndrome and HLA-B5801

林口長庚紀念醫院

余光輝主任

0920~0940 Taiwan guideline for the management of gout and hyperuricemia are we on the trend

台北榮民總醫院

林孝義主任

申請學分台灣內科醫學會學分台灣家庭醫學會學分申請中

13

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Thomas Bardin PhD 時間103 年 12 月 06 日(星期六)0945-1035 Time0945~1035 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 周昌德 教授 ModeratorProf Chung-Tei Chou Taipei Veterans General Hospital

The new EULAR recommendations in the management of gout

Thomas Bardin PhD

14

中華民國風濕病醫學會 2014 年會

風濕病友教育講座 時間103 年 12 月 06 日(星期六)1055~1215 Time1055~1215 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1055-1100 開場簡介 中山醫學大學附設醫院

魏正宗主任

中山醫學大

學附設醫院

魏正宗主任

1100-1130 風濕病人的疫苗接種 花蓮慈濟醫院 蔡世滋主任

1130-1200 風濕病人的生活保健 台中榮民總醫院

謝祖怡主任

1200-1215 問與答

大林慈濟醫院 賴寧生院長 花蓮慈濟醫院 蔡世滋主任 台中榮民總醫院 謝祖怡主任

中山醫學大學附設醫院 魏正宗主任

15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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8

中華民國風濕病醫學會 2014 年會

Meet the Master 時間103 年 12 月 05 日(星期五)1200~1330 Time1200~1330 05-Dec-2013 地點台中日月千禧酒店 5 樓 Vee5 主講人高雄醫學大學附設中和紀念醫院 劉宏文教授中國醫藥大學附設

醫院藍忠亮教授 主持人社團法人中華民國風濕病醫學會 陳得源 理事長

您hellip想要了解『醫界大師』是如何產生的嗎

邀請了 2 位榮獲中華民國風濕病醫學會大師獎蒞臨現場

劉宏文教授藍忠亮教授

此活動將與重量級大師對談

2 位大師將自我介紹談論一生經歷並分享生涯規劃

9

中華民國風濕病醫學會 2014 年會

超音波研討會及實際操作 時間103 年 12 月 05 日(星期五) 1330~1900 地點台中日月千禧酒店 5 樓 Vee1+Vee2 (1) 主辦單位社團法人中華民國風濕病醫學會TRUST Team (2) 協辦單位瑞士商艾伯維藥品有限公司衛采製藥股份有限公司 (3) 本次年會超音波研討會及實際操作 分三個主題進行研討 (1)晶體性關節

炎及退化性關節炎(2) 類風濕性關節炎僵直性脊椎炎及乾癬性關節炎(3)乾燥症硬皮症血管炎 每個主題研討完 Speaker 將進行患者超音波實際

檢查學員分組輪流進行操作練習 時間 講題 主講人

1320-1330 Registration

Section 1 座長 陳英州蔡文展

1330-1350 Ultrasound in OA 高雄醫學大學附設醫院

林育志醫師

1350-1410 Ultrasound in CPPD 嘉義長庚醫院風濕免疫科

林靖麒醫師

1410-1430 Ultrasound in Gout 奇美醫院風濕免疫科

林永章醫師

1430-1510 Hands-on practice section All 1510-1525 Break

Section 2 座長 張棋楨羅淑芬

1525-1545 Ultrasound in RA

台北醫學大學附設醫院

風濕免疫科

蔡凱倫醫師

1545-1605 Ultrasound in AS 林口長庚醫院風濕免疫科

方耀凡醫師

1605-1625 Ultrasound in PSA

台灣大學附設醫院

風濕免疫科

李克仁醫師

1625-1705 Hands-on practice section All 1705~1720 Break

Section 3 座長 陳得源黃春明

10

1720~1740 Ultrasound in SS 中國醫藥大學附設醫院

免疫風濕科 黃柏豪醫師

1740~1800 Ultrasound in SSc 台中榮民總醫院

醫學研究部臨床試驗科 陳信華醫師

1800~1820 Ultrasound in Vasculitis 台中榮民總醫院 免疫風濕科 賴國隆醫師

1820~1900 Hands-on practice section All

1900 晚餐

11

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

應用幹細胞移植治療自體免疫疾病 (Stem cell transplantation for autoimmune diseases)

時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點 台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

0840~0920 Stem cell transplantation in scleroderma

Prof Dr Jacob M van Laar

(Dutch)

台北榮民總醫院

蔡長祐教授

0920~0940 Preliminary experience in stem cell transplantation for systemic sclerosis

台大醫院 謝松洲主任

12

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Gout 時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 贊助單位台灣安斯泰來製藥股份有限公司

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

0840~0900 Epidemiology of gout An update 林口長庚紀念醫院

郭昶甫醫師

林口長庚紀念

醫院

羅淑芬教授

花蓮慈濟醫院

蔡世滋教授

0900~0920 Severe Allopurinol Hypersensitivity Syndrome and HLA-B5801

林口長庚紀念醫院

余光輝主任

0920~0940 Taiwan guideline for the management of gout and hyperuricemia are we on the trend

台北榮民總醫院

林孝義主任

申請學分台灣內科醫學會學分台灣家庭醫學會學分申請中

13

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Thomas Bardin PhD 時間103 年 12 月 06 日(星期六)0945-1035 Time0945~1035 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 周昌德 教授 ModeratorProf Chung-Tei Chou Taipei Veterans General Hospital

The new EULAR recommendations in the management of gout

Thomas Bardin PhD

14

中華民國風濕病醫學會 2014 年會

風濕病友教育講座 時間103 年 12 月 06 日(星期六)1055~1215 Time1055~1215 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1055-1100 開場簡介 中山醫學大學附設醫院

魏正宗主任

中山醫學大

學附設醫院

魏正宗主任

1100-1130 風濕病人的疫苗接種 花蓮慈濟醫院 蔡世滋主任

1130-1200 風濕病人的生活保健 台中榮民總醫院

謝祖怡主任

1200-1215 問與答

大林慈濟醫院 賴寧生院長 花蓮慈濟醫院 蔡世滋主任 台中榮民總醫院 謝祖怡主任

中山醫學大學附設醫院 魏正宗主任

15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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9

中華民國風濕病醫學會 2014 年會

超音波研討會及實際操作 時間103 年 12 月 05 日(星期五) 1330~1900 地點台中日月千禧酒店 5 樓 Vee1+Vee2 (1) 主辦單位社團法人中華民國風濕病醫學會TRUST Team (2) 協辦單位瑞士商艾伯維藥品有限公司衛采製藥股份有限公司 (3) 本次年會超音波研討會及實際操作 分三個主題進行研討 (1)晶體性關節

炎及退化性關節炎(2) 類風濕性關節炎僵直性脊椎炎及乾癬性關節炎(3)乾燥症硬皮症血管炎 每個主題研討完 Speaker 將進行患者超音波實際

檢查學員分組輪流進行操作練習 時間 講題 主講人

1320-1330 Registration

Section 1 座長 陳英州蔡文展

1330-1350 Ultrasound in OA 高雄醫學大學附設醫院

林育志醫師

1350-1410 Ultrasound in CPPD 嘉義長庚醫院風濕免疫科

林靖麒醫師

1410-1430 Ultrasound in Gout 奇美醫院風濕免疫科

林永章醫師

1430-1510 Hands-on practice section All 1510-1525 Break

Section 2 座長 張棋楨羅淑芬

1525-1545 Ultrasound in RA

台北醫學大學附設醫院

風濕免疫科

蔡凱倫醫師

1545-1605 Ultrasound in AS 林口長庚醫院風濕免疫科

方耀凡醫師

1605-1625 Ultrasound in PSA

台灣大學附設醫院

風濕免疫科

李克仁醫師

1625-1705 Hands-on practice section All 1705~1720 Break

Section 3 座長 陳得源黃春明

10

1720~1740 Ultrasound in SS 中國醫藥大學附設醫院

免疫風濕科 黃柏豪醫師

1740~1800 Ultrasound in SSc 台中榮民總醫院

醫學研究部臨床試驗科 陳信華醫師

1800~1820 Ultrasound in Vasculitis 台中榮民總醫院 免疫風濕科 賴國隆醫師

1820~1900 Hands-on practice section All

1900 晚餐

11

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

應用幹細胞移植治療自體免疫疾病 (Stem cell transplantation for autoimmune diseases)

時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點 台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

0840~0920 Stem cell transplantation in scleroderma

Prof Dr Jacob M van Laar

(Dutch)

台北榮民總醫院

蔡長祐教授

0920~0940 Preliminary experience in stem cell transplantation for systemic sclerosis

台大醫院 謝松洲主任

12

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Gout 時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 贊助單位台灣安斯泰來製藥股份有限公司

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

0840~0900 Epidemiology of gout An update 林口長庚紀念醫院

郭昶甫醫師

林口長庚紀念

醫院

羅淑芬教授

花蓮慈濟醫院

蔡世滋教授

0900~0920 Severe Allopurinol Hypersensitivity Syndrome and HLA-B5801

林口長庚紀念醫院

余光輝主任

0920~0940 Taiwan guideline for the management of gout and hyperuricemia are we on the trend

台北榮民總醫院

林孝義主任

申請學分台灣內科醫學會學分台灣家庭醫學會學分申請中

13

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Thomas Bardin PhD 時間103 年 12 月 06 日(星期六)0945-1035 Time0945~1035 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 周昌德 教授 ModeratorProf Chung-Tei Chou Taipei Veterans General Hospital

The new EULAR recommendations in the management of gout

Thomas Bardin PhD

14

中華民國風濕病醫學會 2014 年會

風濕病友教育講座 時間103 年 12 月 06 日(星期六)1055~1215 Time1055~1215 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1055-1100 開場簡介 中山醫學大學附設醫院

魏正宗主任

中山醫學大

學附設醫院

魏正宗主任

1100-1130 風濕病人的疫苗接種 花蓮慈濟醫院 蔡世滋主任

1130-1200 風濕病人的生活保健 台中榮民總醫院

謝祖怡主任

1200-1215 問與答

大林慈濟醫院 賴寧生院長 花蓮慈濟醫院 蔡世滋主任 台中榮民總醫院 謝祖怡主任

中山醫學大學附設醫院 魏正宗主任

15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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交通資訊 【自行開車】

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即抵

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抵或搭乘計程車約 20 分鐘即抵

10

1720~1740 Ultrasound in SS 中國醫藥大學附設醫院

免疫風濕科 黃柏豪醫師

1740~1800 Ultrasound in SSc 台中榮民總醫院

醫學研究部臨床試驗科 陳信華醫師

1800~1820 Ultrasound in Vasculitis 台中榮民總醫院 免疫風濕科 賴國隆醫師

1820~1900 Hands-on practice section All

1900 晚餐

11

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

應用幹細胞移植治療自體免疫疾病 (Stem cell transplantation for autoimmune diseases)

時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點 台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

0840~0920 Stem cell transplantation in scleroderma

Prof Dr Jacob M van Laar

(Dutch)

台北榮民總醫院

蔡長祐教授

0920~0940 Preliminary experience in stem cell transplantation for systemic sclerosis

台大醫院 謝松洲主任

12

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Gout 時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 贊助單位台灣安斯泰來製藥股份有限公司

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

0840~0900 Epidemiology of gout An update 林口長庚紀念醫院

郭昶甫醫師

林口長庚紀念

醫院

羅淑芬教授

花蓮慈濟醫院

蔡世滋教授

0900~0920 Severe Allopurinol Hypersensitivity Syndrome and HLA-B5801

林口長庚紀念醫院

余光輝主任

0920~0940 Taiwan guideline for the management of gout and hyperuricemia are we on the trend

台北榮民總醫院

林孝義主任

申請學分台灣內科醫學會學分台灣家庭醫學會學分申請中

13

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Thomas Bardin PhD 時間103 年 12 月 06 日(星期六)0945-1035 Time0945~1035 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 周昌德 教授 ModeratorProf Chung-Tei Chou Taipei Veterans General Hospital

The new EULAR recommendations in the management of gout

Thomas Bardin PhD

14

中華民國風濕病醫學會 2014 年會

風濕病友教育講座 時間103 年 12 月 06 日(星期六)1055~1215 Time1055~1215 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1055-1100 開場簡介 中山醫學大學附設醫院

魏正宗主任

中山醫學大

學附設醫院

魏正宗主任

1100-1130 風濕病人的疫苗接種 花蓮慈濟醫院 蔡世滋主任

1130-1200 風濕病人的生活保健 台中榮民總醫院

謝祖怡主任

1200-1215 問與答

大林慈濟醫院 賴寧生院長 花蓮慈濟醫院 蔡世滋主任 台中榮民總醫院 謝祖怡主任

中山醫學大學附設醫院 魏正宗主任

15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

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Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

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Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

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中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

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Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

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中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

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Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

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1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

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中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

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Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

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中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

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高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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11

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

應用幹細胞移植治療自體免疫疾病 (Stem cell transplantation for autoimmune diseases)

時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點 台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

0840~0920 Stem cell transplantation in scleroderma

Prof Dr Jacob M van Laar

(Dutch)

台北榮民總醫院

蔡長祐教授

0920~0940 Preliminary experience in stem cell transplantation for systemic sclerosis

台大醫院 謝松洲主任

12

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Gout 時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 贊助單位台灣安斯泰來製藥股份有限公司

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

0840~0900 Epidemiology of gout An update 林口長庚紀念醫院

郭昶甫醫師

林口長庚紀念

醫院

羅淑芬教授

花蓮慈濟醫院

蔡世滋教授

0900~0920 Severe Allopurinol Hypersensitivity Syndrome and HLA-B5801

林口長庚紀念醫院

余光輝主任

0920~0940 Taiwan guideline for the management of gout and hyperuricemia are we on the trend

台北榮民總醫院

林孝義主任

申請學分台灣內科醫學會學分台灣家庭醫學會學分申請中

13

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Thomas Bardin PhD 時間103 年 12 月 06 日(星期六)0945-1035 Time0945~1035 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 周昌德 教授 ModeratorProf Chung-Tei Chou Taipei Veterans General Hospital

The new EULAR recommendations in the management of gout

Thomas Bardin PhD

14

中華民國風濕病醫學會 2014 年會

風濕病友教育講座 時間103 年 12 月 06 日(星期六)1055~1215 Time1055~1215 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1055-1100 開場簡介 中山醫學大學附設醫院

魏正宗主任

中山醫學大

學附設醫院

魏正宗主任

1100-1130 風濕病人的疫苗接種 花蓮慈濟醫院 蔡世滋主任

1130-1200 風濕病人的生活保健 台中榮民總醫院

謝祖怡主任

1200-1215 問與答

大林慈濟醫院 賴寧生院長 花蓮慈濟醫院 蔡世滋主任 台中榮民總醫院 謝祖怡主任

中山醫學大學附設醫院 魏正宗主任

15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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12

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Gout 時間103 年 12 月 06 日(星期六)0840~0940 Time0840~0940 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 贊助單位台灣安斯泰來製藥股份有限公司

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

0840~0900 Epidemiology of gout An update 林口長庚紀念醫院

郭昶甫醫師

林口長庚紀念

醫院

羅淑芬教授

花蓮慈濟醫院

蔡世滋教授

0900~0920 Severe Allopurinol Hypersensitivity Syndrome and HLA-B5801

林口長庚紀念醫院

余光輝主任

0920~0940 Taiwan guideline for the management of gout and hyperuricemia are we on the trend

台北榮民總醫院

林孝義主任

申請學分台灣內科醫學會學分台灣家庭醫學會學分申請中

13

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Thomas Bardin PhD 時間103 年 12 月 06 日(星期六)0945-1035 Time0945~1035 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 周昌德 教授 ModeratorProf Chung-Tei Chou Taipei Veterans General Hospital

The new EULAR recommendations in the management of gout

Thomas Bardin PhD

14

中華民國風濕病醫學會 2014 年會

風濕病友教育講座 時間103 年 12 月 06 日(星期六)1055~1215 Time1055~1215 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1055-1100 開場簡介 中山醫學大學附設醫院

魏正宗主任

中山醫學大

學附設醫院

魏正宗主任

1100-1130 風濕病人的疫苗接種 花蓮慈濟醫院 蔡世滋主任

1130-1200 風濕病人的生活保健 台中榮民總醫院

謝祖怡主任

1200-1215 問與答

大林慈濟醫院 賴寧生院長 花蓮慈濟醫院 蔡世滋主任 台中榮民總醫院 謝祖怡主任

中山醫學大學附設醫院 魏正宗主任

15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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13

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Thomas Bardin PhD 時間103 年 12 月 06 日(星期六)0945-1035 Time0945~1035 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 周昌德 教授 ModeratorProf Chung-Tei Chou Taipei Veterans General Hospital

The new EULAR recommendations in the management of gout

Thomas Bardin PhD

14

中華民國風濕病醫學會 2014 年會

風濕病友教育講座 時間103 年 12 月 06 日(星期六)1055~1215 Time1055~1215 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1055-1100 開場簡介 中山醫學大學附設醫院

魏正宗主任

中山醫學大

學附設醫院

魏正宗主任

1100-1130 風濕病人的疫苗接種 花蓮慈濟醫院 蔡世滋主任

1130-1200 風濕病人的生活保健 台中榮民總醫院

謝祖怡主任

1200-1215 問與答

大林慈濟醫院 賴寧生院長 花蓮慈濟醫院 蔡世滋主任 台中榮民總醫院 謝祖怡主任

中山醫學大學附設醫院 魏正宗主任

15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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14

中華民國風濕病醫學會 2014 年會

風濕病友教育講座 時間103 年 12 月 06 日(星期六)1055~1215 Time1055~1215 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1055-1100 開場簡介 中山醫學大學附設醫院

魏正宗主任

中山醫學大

學附設醫院

魏正宗主任

1100-1130 風濕病人的疫苗接種 花蓮慈濟醫院 蔡世滋主任

1130-1200 風濕病人的生活保健 台中榮民總醫院

謝祖怡主任

1200-1215 問與答

大林慈濟醫院 賴寧生院長 花蓮慈濟醫院 蔡世滋主任 台中榮民總醫院 謝祖怡主任

中山醫學大學附設醫院 魏正宗主任

15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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15

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Glucocorticoid Induced Osteoporosis (GIOP)

From Bench to Clinical Practice 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄長庚紀念醫院鄭添財醫師台北榮民總醫院林孝義醫師 ModeratorDr Tien-Tsai Cheng Kaohsiung Chang Gung Memorial HospitalDr Hsiao-Yi Lin Taipei Veterans General Hospital

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410~1435 微型核糖核酸分子與骨關節

免疫反應 高雄長庚醫院 王逢興教授

高雄長庚醫院

鄭添財醫師

1435~1500

Understanding glucocorticoid induced osteoporosis beyond bone density - bone quality

and strength

香港風濕病學學

會理事長 譚麗珊醫師

台北榮民總醫院

林孝義醫師

1500~1510 Discussion All

16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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16

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SLE 時間103 年 12 月 06 日(星期六)1410~1510 Time1410~1510 06-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resortsTaichung 主持人成大醫院 劉明煇教授 ModeratorProf Ming Fei Liu Medical College National Cheng Kung University

時間Time 講題Topic 主講人 Speaker 主持人

Moderator

1410-1440 Recent advance of innate

immunity in the pathogenesis of systemic lupus erythematosus

林口長庚紀念醫院 陳基益 醫師

成大醫院 劉明煇 教授

1440-1510 Update of antiphospholipid

antibody and antiphospholipid syndrome

高雄榮民總醫院 呂聆音 醫師

17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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17

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

余家利教授 時間103 年 12 月 06 日(星期六)1530-1620 Time1530~1620 06-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人中山醫學大學附設醫院 蔡嘉哲 教授 ModeratorProf Gregory J TsayChung Shan Medical University Hospital

Highlight and the unsolved problems of lupus research Chia-Li Yu MD PhD

Honorary Professor Department of Internal Medicine National Taiwan University Hospital

Taipei Taiwan Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disorder

characterized by the presence of a number of autoantibodies in the serum Immunologically

Th1Th2Th17Treg cytokine dysregulation is evident However the underlying etiopathogenetic

mechanisms remain undiscovered In these years we characterized the properties of SLE

neutrophils (SLE-PMN) and found that at least 13 defects exist These defects can alter Th1Th2

cytokine expression probably via enhanced lactoferrin transfer from PMN to MNC compared to

normal controls In the aspect of SLE-T cell dysfuctions decreased miR-145 whereas increased

miR-224 and miR-524-5-P expression may accelerate Ca2+-influx regulation and

activation-induced cell death by suppressing API5 expression in SLE-T cells

It is conceivable that two unique properties of auto-antibodies including polyreactivity

(cross-reactivity) and cell penetration ability render many important autoantibodies

immunopathologic in patients with SLE These autoantibodies such as anti-Smanti-RNP

anti-SSB ANCA and anti-dsDNA were proved penetrating into cell interior We further

demonstrated that positively charged arginines in the CDR of anti-dsDNA autoantibodies

facilitate cell-internalization via electrostatic interactions Recently many authors focused on

the study of excessive neutrophil extracellular traps (NETosis) in inducing endothelial damage

tissues infiltration and exposure of immunostimulatory molecules to the immune systems in

patients with SLE

Despite of these advances many enigmata still remain in lupus pathogenesis We list

18

below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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below for readersrsquo references

(1) What is the nature of auto-antigens The importance of degenerated nucleosomes

(2) What is the role of genetic susceptibility epigenetic regulation and environ- mental factors

(3) The importance of endogenous viral infection and molecular mimicry with microbial

infections

(4) Is SLE an autoimmune aberrant signal-induced or endocrinological disorder

(5) Is SLE a unique disease with different spectrum Or a syndrome contains diverse

heterogeneous diseases

(6) What is the molecular basis for opportunistic SLE

(7) What is the role of miRNAs and autophagy in lupus pathogenesis

(8) What is the optimal therapeutic strategy for SLE

Chemical DMARDs

Biological DMARDs or combination therapy

Cell therapy bone marrow stem cell transplantation

Other novel therapy

19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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19

中華民國風濕病醫學會 2014 年會

RMP 生物製劑風險管理計畫 時間103 年 12 月 06 日(星期六)1530~1620 Time1530~1620 06-Dec-2014 地點台中日月千禧酒店 5 樓 Vee5 Place5F Vee5 millennium hotels and resorts Taichung 主持人台中榮民總醫院 陳怡行主任彰化基督教醫院 邱瑩明主任 ModeratorDr Yi-Hsing Chen Taichung Veterans General HospitalDr Ying-Ming Chiu Changhua Christian Hospital

時間Time 講題Topic 主講人 Speaker

主持人 Moderator

1530-1535 會議引言 台中榮民總醫院 過敏免疫風濕科 陳怡行醫師

1535-1545 台灣藥物風險管理計畫現況簡介與國際趨

成功大學藥理研

究所 鄭靜蘭助理教授 台中榮民總醫院

過敏免疫風濕科

陳怡行醫師 1545-1555 台灣生物製劑使用者 B 肝復發之研究 彰化基督教醫院 過敏免疫風濕科 邱瑩明醫師

1555-1605 風險管理計畫對生物製劑使用者 TB 感染

之影響--台中榮總經驗

台中榮民總醫院 過敏免疫風濕科 陳一銘醫師

彰化基督教醫院

過敏免疫風濕科

邱瑩明醫師

1605-1620

討 論 12012學會版RMP建議各醫院執行現況與

困難 2 2012 學會版 RMP 建議不足點 3未來學會 RMP 建議改版之制定方向

全體參加者

20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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20

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

Song Guo Zheng MDamp PhD 時間103 年 12 月 07 日(星期日)0830-0920 Time0830~0920 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 張德明副院長 ModeratorProf Deh Ming Chang Taipei Veterans General Hospital

Therapeutic effects of Foxp3+ regulatory T cells on the established autoimmune and inflammatory diseases

Song Guo Zheng MD PhD Professor of Medicine and Director

Division of Rheumatology Rheumatology Research Department of Medicine Penn State University Hershey College of Medicine Hershey PA 17033

While it has been well recognized that both natural Foxp3+ regulatory T (nTreg) cells and TGF-β-induced Treg (iTreg) cells can prevent autoimmune diseases in animal models recent studies reveled that injection of nTregs has less therapeutic effects on established autoimmune diseases It is less clear if iTregs can treat the established autoimmune diseases We now provide evidence that unlike nTregs injection of iTreg cells can markedly ameliorate the established autoimmune asthma arthritis and lupus We observed that adoptive transfer of either nTreg or iTreg significantly suppressed airway and peri-vascular inflammation However inflammatory suppression by iTreg cells was more effective than that of nTreg cells particularly in the lung tissues surrounding airways Interestingly adoptively transferred iTreg cells but not nTreg cells significantly inhibited the elevation of Th2 cytokines in peripheral lymphatic tissues as demonstrated by the level of IL-5 produced in CD4+ cells of adjacent draining lymph nodes Both antigen-specific and polyclonally induced iTregs also suppressed established collagen-induced arthritis (CIA) although antigen-specific iTregs had a superior therapeutic effect CIA mice given iTregs have a significantly lower incidence of disease and lower clinic scores than mice given nTregs Teff cells or no cells We found while nTregs were converted into Th1Th17 cells in vitro and in vivo in the inflammatory milieu iTregs were resistant to T effector cell conversion in the similar condition Injection of iTregs to naiumlve mice and immune deficient mice displayed

21

similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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similar levels of Foxp3 stability as comparing with nTregs Of note the stability of Foxp3 expression was only found in iTreg cells during established CIA iTregs suppressed Th17 cell and osteoclast differentiation that paralleled with improved clinical scores CII-specific IgG production and bone erosion Injection of iTregs to the established lupus mice significantly decreased the levels of anti-dsDNA and proteinuria and markedly prolonged the survival of lupus Blocking of TGF-βTGF-βR pathway using anti-TGF-β antibody or TGF-βRI (ALK5) inhibitor or anti-IL-10R antibody almost completely abolished the therapeutic effects of iTregs on lupus suggesting that TGF-β andor IL-10 secreted by iTregs play a crucial role in the cell therapy We further observed that DC isolated from lupus mice received iTregs but not control cells expressed lower levels of CD80 and CD86 and adoptive transfer of these DCs to another lupus mouse can suppress the disease development Moreover we also observed that pre-treatment of nTreg with all-trans retinoic acid (atRA) is able to resort the stability and functionality of nTreg in the inflammatory condition atRA regulates epigenetic effect on Foxp3 promoter by nTregs We therefore suggest that the manipulation of iTregs or atRA-nTreg has a potential effect on treating or even curing patients with autoimmune diseases

Supported by NIH R01 AR059103 P30 DK048522 R43 AI 084359 the National MS Society (RG 4646A11) ACR within our reach the Alliance for Lupus Research the Department of Veterans Affairs the Arthritis Foundation the Outstanding Youth Scientist Investigator Award from National Nature Science of Foundation of China the Sun Yat-sen University Key Major Project Fund and the PSU Starting-up fund

22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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22

中華民國風濕病醫學會 2014 年會

Plenary Lecture

Taiwan Rheumatology Association Keynote Speech

譚澤華教授 時間103 年 12 月 07 日(星期日)0940-1030 Time0940~1030 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resortsTaichung 主辦單位社團法人中華民國風濕病醫學會 主持人中國醫藥大學附設醫院 藍忠亮 副院長 ModeratorProf Joung Liang Lan China Medical University Hospital

MAPK kinases and phosphatases in autoimmunity and inflammation

Tse-Hua Tan Immunology Research Center National Health Research Institutes Zhunan Taiwan

The c-Jun N-terminal kinases (JNKs) belong to the mitogen-activated protein kinase (MAPK) superfamily JNKs play crucial roles in cell proliferation differentiation stress responses and apoptosis JNK kinase activity can be activated by diverse stimuli including growth factors cytokines environmental stresses and apoptotic stimuli MAP kinase kinase kinase kinases (MAP4Ks) are a subfamily of mammalian Ste20-like serinethreonine protein kinases that activate the JNK kinase cascade In addition MAPKs are also regulated by various MAP kinase phosphatases (MKPs) which belong to a subfamily of dual-specificity phosphatases (DUSPs) We have cloned and characterized the roles of three MAP4Ks namely HPK1 (MAP4K1) GLK (MAP4K3) and HGK (MAP4K4) in various signal transduction pathways in the immune system We generated HPK1 knockout mice and revealed that HPK1 is a negative regulator of T cell signaling by phosphorylating the T-cell adaptor SLP-76 leading to SLP-76 degradation and attenuation of lymphocyte signaling In addition we have generated GLK (MAP4K3)-deficient mice and demonstrated that GLK (MAP4K3) directly activates PKC during TCR      signaling Systemic lupus erythematosus (SLE) patients show dramatically enhanced GLK expression and PKC- -IKK activation in Th17 cells and the percentage of GLK-overexpressing T cells is correlated with disease severity Thus GLK (MAP4K3) can be used as a novel diagnostic biomarker and therapeutic target for various IL-17-mediated autoimmune diseases The role of GLK in IL-17-mediated autoimmune diseases will be discussed I will also present our recent findings on the roles of HGK (MAP4K4) and the dual-specificity phosphatase 22 (DUSP22 also named JKAP) in autoimmune diseases and inflammation

23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

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結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

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中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

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Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

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中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

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Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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23

中華民國風濕病醫學會 2014 年會

基層醫師繼續教育演講 時間102 年 12 月 07 日(星期日)1030~1200 Time1030~1200 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 主辦單位社團法人中華民國風濕病醫學會 時間 講題 主講人 主持人

1030-1035 Opening 中華民國

風濕病醫學會 陳得源 理事長

1035-1100 基層醫師如何快速診

斷肌纖維疼痛症

台中榮民總醫院 過敏免疫風濕科

陳信華醫師

台中榮民總醫院 過敏免疫風濕科主任

陳怡行醫師

大林慈濟醫院 過敏免疫風濕科主任

黃光永醫師

1100-1125 肌纖維疼痛症的治療

中國醫藥大學附設醫院

過敏免疫風濕科 陳俊宏醫師

1125-1150 免疫風濕疾病之眼睛

表徵 台中榮民總醫院眼科

梁巧盈醫師 1150-1200 問題與討論 所有參加者

教育學分台灣內科醫學會中華民國風濕病醫學會中華民國免疫學會

台灣家庭醫學會醫師公會全國聯合會

24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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24

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

SpA- Assessment of Treatment efficacy 時間103 年 12 月 07 日(星期日)1450~1550 Time1450~1550 07-Dec-2014 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主持人高雄醫學大學附設中和紀念醫院 蔡文展教授 ModeratorProf Wen-Chan Tsai Kaohsiung Medical University Hospital

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1450-1455 Introduction 高雄醫學大學附

設中和紀念醫院 蔡文展 教授

高雄醫學大學附設

中和紀念醫院 蔡文展 教授

1455-1520 Clinical assessment of efficacy

in spondyloarthritis 台北榮民總醫院 周昌德 教授

1520-1545 Image assessment of efficacy

in spondyloarthritis

中山醫學大學附

設醫院 魏正宗 主任

25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

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中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

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Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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25

中華民國風濕病醫學會 2014 年會

Concurrent Symposium

Pediatric Rheumatology Session 時間103 年 12 月 07 日(星期日)1500~1615 Time1500~1615 07-Dec-2014 地點 台中日月千禧酒店 5 樓 Vee1+Vee2 Place5F Vee1+Vee2 millennium hotels and resorts Taichung 主持人林口長庚紀念醫院 黃璟隆教授 ModeratorProf Jing-Long Huang Chang Gung Memorial Hospital Lin Kou

時間Time 講題Topic 主講人 Speaker 主持人 Moderator

1500-1505 Introduction 林口長庚紀念醫院

黃璟隆 教授

林口長庚紀念醫院

黃璟隆 教授

1505-1535 Recent progresses of

systemic juvenile idiopathic arthritis

Prof Shumpei Yokota Japan

1535-1605 Current status of

Pediatric Rheumatology in China

Prof Cai-Fen Li China

1605-1615 Discussion

26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

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結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

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中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

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Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

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中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

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Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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26

中華民國風濕病醫學會 2014 年會

Special Lecture

Taiwan Rheumatology Association Keynote Speech

王振源醫師 時間103 年 12 月 07 日(星期日)1610-1650 Time1610~1650 07-Dec-2013 地點台中日月千禧酒店 B2 宴會廳 PlaceB2 millennium hotels and resorts Taichung 主辦單位社團法人中華民國風濕病醫學會 主持人台北榮民總醫院 林孝義主任 ModeratorDr Hsiao-Yi Lin Taipei Veterans General Hospital

Latent TB ndash How to know and how to treat

王振源 臨床副教授 臺大醫院內科部胸腔科臺大醫學院醫學系內科

結核病一直是世界上最重要的傳染性疾病臺灣地區自從政府開始大力推

動十年減半國家結核病計畫結核病的發生率已經由 2005 年的每十萬人

口 725 人逐年降低至 2012 年的每十萬人口 530 人這樣的疫情資訊意

味著我們即將由結核病高度盛行地區想要進一步控制結核疫情公共衛生

上的策略也就必須要進入了另外一個階段 研究證實在結核病發生率較低的地區或國家中大部分結核病新個案發

病的途徑大多是因為宿主的免疫力降低而活化造成活動性結核病前者因

此隨著一個地區結核病的發生率逐漸降低如何能讓原本蟄伏的結核菌不

活化不發病就逐漸變成重要的防疫工作所以找出潛伏結核感染的個

案並進一步投予治療將是未來臺灣地區公共衛生政策上控制甚至根除

結核病很重要的一環 找出潛伏結核感染個案只能倚靠免疫檢測的方法目前最普遍使用的便是

「結核菌素皮膚試驗」結核菌素皮膚試驗在臨床上使用已經有超過一百年

的歷史醫護公衛人員對它都相當的熟悉結果也很容易判讀另外一種

免疫檢測方法稱為丙型干擾素釋放試驗(interferon-gamma release assay)包括有 QuantiFERON TB-Gold 和 T-SPOTTB 等兩種商業化的檢測試劑優

點是特意度高操作方便但相關的成效仍需要更多研究的確認 目前治療潛伏結核感染的藥物處方大多採用持續九個月每天給予單一種抗

27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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27

結核藥物治療的時間較長是最大的不方便但若能按規服藥就能避免

掉百分之八十五至九十左右的活動性結核病發生國外已有每週服用一次

總共服用 12 次的處方相較之下方便了許多不過因為接受潛伏結核感

染治療的對象都是沒有病的健康人因此治療之前必須謹慎評估發生副作

用的風險而治療當中必須格外注意有無副作用的發生 藉由潛伏結核的診斷治療結核病已經是可以預防的疾病了等到發病才

使用多種藥物合併治療不如當機立斷在疾病將發而未發之際接受簡單

的藥物治療保障自己的健康守護家人朋友的安全

28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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28

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1055-1215

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1055-1135 類型 座長張德明副院長鄭賀雄副院長

1055-1105 Sjogrenrsquos

Growth ArrestndashSpecific 6 (GAS6) Protein in Patients With Sjoumlgren Syndrome Determination of Plasma Levels and expression in labial salivary gland biopsies Chen-Hung Chen12 Hsiang-Cheng Chen3 Chi-Ching Chang2 Yi-Jen Hung4 Yuh-Feng Lin2 陳政宏 12 陳相成 3張棋楨 2洪乙仁 4林裕峰 2 1Division of Allergy Immunology and Rheumatology Taipei Tzu Chi Hospital 臺北慈濟醫院風濕免疫過敏科 2Graduate institute of clinical medicine Taipei medical university 臺北醫學大學臨床醫學研究所 3Division of Allergy Immunology and Rheumatology Tri-Service General Hospital 三軍總醫院風濕免疫過敏科 4Division of Endocrinology and Metabolism Tri-Service General Hospital 三軍總醫院風新陳代謝科

1105-1115 SLE

Analysis of Tim-1 Tim-3 and Tim-4 Expression on CD4 Lymphocytes in Systemic Lupus Erythematosus Patients with Active Nephritis or Heavy Proteinuria Jeng-Ting Tsao1 Song-Chou Hsieh2 Po-Chang Wu3 Li-Jing Lin4 Chia-Chen Kuo4 Shih-Chang Lin145 曹正婷謝松洲吳柏樟林立菁郭家禎林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2Division of Rheumatology and Immunology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 臺大醫學院附設醫院內科部風濕免疫科 3Division of Rheumatology and Immunology Department of Internal Medicine China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院內科部風濕免疫科 4The Laboratory of Allergy and Immunology Cathay Medical

29

Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 5Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

1115-1125 SLE

Aberrant T-cell expression of Ca2+ influx regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis Ming-Chi Lu1 Hua-Chien Chen2 Chia-Li Yu3 Ning-Sheng Lai1

1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Chia-Yi Taiwan 2 Department of Biomedical Sciences Chang Gung University Tao-Yuan Taiwan 3 Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan 系統性紅斑性狼瘡患者的 T 細胞中鈣離子湧入所調控的微

小核糖核酸表現異常並且參與了系統性紅斑性狼瘡的致病機

轉 呂明錡 1陳華鍵 2余家利 3賴寧生 1 佛教大林慈濟醫院 過敏免疫風濕科 1 長庚大學生物醫學系 2 臺大醫院免疫風濕科 3

1125-1135 SLE

Suicidal drug overdose in patients with systemic lupus erythematosus a nationwide population-based case-control study 紅斑性狼瘡病患藥物過量企圖自殺的全國性病例對照研究 Kuo-Tung Tang1 Ching-Heng Lin2 Der-Yuan Chen1345 譚國棟 1 林敬恆 2 陳得源 1345 1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung ROC 台中榮民總醫院過敏免疫風濕科 2Department of Medical Research Taichung Veterans General Hospital ROC 台中榮總醫學研究部 3Faculty of Medicine School of Medicine National Yang-Ming University Taipei ROC 國立陽明大學醫學院 4Institute of Microbiology and Immunology Chung Shan Medical University Taichung ROC 中山醫學大學微生物免疫研究所 5Institute of Biomedical Science National Chung Hsing University Taichung ROC 國立中興大學生物醫學研究所

1135-1215 類型 座長蔡嘉哲教授曾瑞成主任

1135-1145 RA Disease Activity Affects All Domains of Quality of Life in Patients with Rheumatoid Arthritis and is Modified by Disease Duration

30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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30

Ying-Ming Chiu1 Hsiao-Yi Lin2 Hui-Chu Lang3 Jung-Der Wang4 邱瑩明 林孝義 郎慧珠 王榮德 1Department of Allergy Immunology and Rheumatology Changhua Christian Hospital Changhua Taiwan 彰化基督教醫院過敏免疫風濕科 2Department of Allergy Immunology and Rheumatology Taipei Veteran General Hospital Taipei Taiwan 台北榮民總醫院過敏免疫風濕科 3Institute of Hospital and Health Care Administration National Yang-Ming University Taipei Taiwan 陽明大學醫務管理所 4Department of Public Health National Cheng Kung University College of Medicine 成功大學醫學院公衛所

1145-1155 RA

Apolipoprotein E gene polymorphisms are linked with inflammation in rheumatoid arthritis Yi-Ming Chen1 2 Chi-Chen Lin3 Yung-Jung Lin1 Yi-Hsing Chen1 2 Chao-Liang Wu4 Der-Yuan Chen1 2 3 5 陳一銘 林季千 林詠容 陳怡行 吳昭良 陳得源 1Division of allergy immunology and rheumatology Taichung Veterans General Hospital Taiwan 2School of medicine National Yang-Ming University Taiwan 3Institute of Biomedical Science National Chung Hsing University Taiwan 4Department of Biochemistry and Molecular Biology National Cheng Kung University Medical College Taiwan 5Institute of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan

1155-1205 RA

Trends in prescription of traditional and biologic disease modifying antirheumatic drugs among patients with early rheumatoid arthritis a national population cohort in Taiwan 台灣類風濕性關節炎病患早期使用傳統及生物製劑

DMARDs 之處方型態與趨勢 翁孟玉 薛亘佑 吳俊欣 翁嘉澤 劉明煇 Meng-Yu Weng Hsuan-You Hsueh Chun-Hsin Wu Chia-Tse Weng Ming-Fu Liu Section of Allergy Immunology and Rheumatology Department of Internal Medicine National Cheng-Kung University Medical College and Hospital Tainan Taiwan 成功大學醫學院附設醫院 內科部 過敏免疫風濕科

1205-1215 RA

Detection of Serum Concentration of Adalimumab by Different Methods Feng So Yang Tsan Teng Ou Cheng-Chin Wu Jeng-Hsien Yen Wen-Chan Tsai Department of Internal Medicine Department of Laboratory Medicine Kaohsiung Medical University Hospital

31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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31

楊豐碩 歐燦驣 吳正欽 顏正賢 蔡文展 高雄醫學大學 檢驗醫學部 內科部

32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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32

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 5 樓 Vee 5

主辦單位社團法人中華民國風濕病醫學會

1320-1410 類型 座長魏正宗主任張棋楨主任

1320-1330 AS

Semaphorin 3A (Sema 3A) in Ankylosing Spondylitis Patients Hsien-Tzung Liao1 Chung-Tei Chou2 廖顯宗 1 周昌德 2 1Division of Allergy-Immunology-Rheumatology Wan Fang Hospital Taipei 2Division of Allergy-Immunology-Rheumatology Taipei Veterans General Hospita 1 台北醫學大學-萬芳醫院過敏免疫風濕科 2 台北榮民總醫院過敏免疫風濕科

1330-1340 PsA

GCK-like kinase and HPKGCK-like kinase had a positive correlation with inflammatory status in patients with psoriatic arthritis GCK-like kinase 及 HPKGCK-like kinase 和乾癬性關節炎的

疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1340-1350 AS

HPKGCK-like kinase and dual-specificity phosphatases 6 had a positive correlation with disease activity of ankylosing spondylitis HPKGCK-like kinase 及 dual-specificity phosphatases 6 和僵

直性脊椎炎的疾病活性有正相關 Ming-Han Chen12 Huai-Chia Chuang3 Chang-Youh Tsai12 Tse-Hua Tan3 Chung-Tei Chou12 陳明翰 12 莊懷佳 3蔡長祐 12譚澤華 3周昌德 12 1 Division of Allergy Immunology and Rheumatology

33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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33

Department of Medicine Taipei Veterans General Hospital 台北榮民總醫院 過敏免疫風濕科 2 Faculty of Medicine National Yang-Ming University Taipei Taiwa 陽明大學附設醫院 內科 3 Immunology Research Center National Health Research Institutes Zhunan Taiwan 國家衛生研究院 免疫醫學研究中心

1350-1400 Sono

Evidence of ultrasound single joint evaluation Comparison of efficacy by ultrasound between seven joints in rheumatoid arthritis Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 單一關節超音波評估之證據 以超音波比較七組關節在類風

濕性關節炎病患生物製劑治療 12 月之評估 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

1400-1410 Sono

No difference between mild and moderate tapering etanercept evaluate by wrist ultrasound after adjusting time sequence Jia-Feng Chen Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Wen-Chan Chiu Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 考量時間因素下 恩博輕度或中度減量對手腕關節組合分數

無差異 陳嘉夆 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 高雄長庚醫院風濕過敏免疫科

34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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34

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1030-1150

地點台中日月千禧酒店 B2 宴會廳

主辦單位社團法人中華民國風濕病醫學會

1030-1110 類型 座長陳堃宏主任鄭添財主任

1030-1040 OP

Fracture site and 10-year probability of fracture in Rheumatoid Arthritis associated osteoporosis ndash A population study in Taiwan Cheng Tien-Tsai12 Yu San-Fu12 Chen Jia-Feng1 Chiu Wen-Chan1 鄭添財 尤珊富 陳嘉夆 邱文燦 1Division of Rheumatology Allergy and Immunology Kaohsiung Chang Gung Memorial Hospital 2Chang-Gung University College of Medicine Kaohsiung Taiwan 1 高雄長庚紀念醫院風濕過敏免疫科 2 長庚大學醫學院

1040-1050 OP

驅蟲藥物抑制噬骨細胞之生成與分化 The Antihelminth Compound Inhibits Osteoclast Formation and Differentiation Fei-Lan Liu1 Chun-Liang Chen2 Ruo-Yu Wang1 Chia-Chung Lee2 Cheng-Chi Wu1 Hsu-Shan Huang2 Deh-Ming Chang1 劉斐蘭 陳俊良 王若羽 李佳駿 吳正啟 黃旭山 張德明 1 臺北榮民總醫院風濕免疫科 2 台北醫學大學 醫學科技院 癌症生物學與藥物研發博士學位學程1Allergy immunology rheumatology Taipei veterans general hospital 2Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University

1050-1100 OA

Ginkgo biloba Extract Individually Inhibits JNK Activation and Induces c-Jun Degradation in Human Chondrocytes Potential Therapeutics for Osteoarthritis Ling-Jun Ho12 Li-Feng Hung1 Feng-Cheng Liu3 Tsung-Yun Hou3 Leou-Chyr Lin4 Chuan-Yueh Huang1 Jenn-Haung Lai56 何令君 洪儷鳳 劉峰誠 侯宗昀 林柳池 黃荃約 賴振宏 1 Institute of Cellular and System Medicine National Health Research Institute Zhunan Taiwan ROC 2 Graduate Institute of Basic Medical Science PhD Program of Aging China Medical University Taichung Taiwan ROC 3 RheumatologyImmunology and Allergy Department of Medicine Tri-Service General Hospital National Defense

35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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交通資訊 【自行開車】

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35

Medical Center Taipei Taiwan ROC 4 Department of Orthopaedics Tri-Service General Hospital National Defense Medical Center Taipei Taiwan ROC 5 Graduate Institute of Medical Science National Defense Medical Center Taipei Taiwan ROC 6Division of Allergy Immunology and Rheumatology Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Tao-Yuan Taiwan ROC 國防醫學院三軍總醫院內科部風濕免疫過敏科

1100-1110 OA

The Walking Patterns of Lumbar Spine Pelvis amp Lower Limbs 下半身肢體的走路模式 Ying-Yang Tsai Lu-Chin Wei Yin-Tzu Huang Chi-Ju Li Tzu-yin Lin 蔡瀛陽魏呂瑾黃音慈李奇儒林姿吟 Chien-Sheng Clinics Taipei Taiwan 潔生診所 台北 台灣

1110-1150 類型 座長林孝義主任陳政宏主任

1110-1120 gout

ALPK1 affects the flares of gout by regulating SLC22A12URAT1 Hung-Pin Tu1 Tzer-Min Kuo2 Chung-Ming Huang3 and Ying-Chin Ko2 杜鴻賓 1 郭澤民 2 黃春明 3 葛應欽 2 1Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan 高雄醫學大學醫學系公共衛學科 2Environment-Omics-Disease Research Centre China Medical University Hospital Taichung Taiwan 中國醫藥大學附設醫院環境質體疾病研究中心 3Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan 中國醫藥大學中西整合研究所

1120-1130 Comorbidity

纖維肌痛症的病人罹患冠心症的風險研究 Increased Risk of Coronary Heart Diseases in Patients with Fibromyalgia--A Nationwide Population-based Cohort Study Jiunn-Horng Chen 陳俊宏 12 Joung-Liang Lan 藍忠亮 12 Chien-Chung Huang 黃建中 1 Chung-Ming Huang 黃春明 1 Po-Hao Huang 黃柏豪 1 Wei-Jhe Hong 洪偉哲 1 1 中國附醫風濕免疫科2 中國醫藥大學醫學系

36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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36

1130-1140 Comorbidity

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan

3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗

性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信

華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫

學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫免疫風濕

科 5

1140-1150 Como idiot

DELAY IN DIAGNOSIS OF RHEUMATOID ARTHRITIS IN MEMBERS OF THE TAIWAN RHEUMATOID ARTHRITIS AID GROUP Horng-Ming Yeh1 Hung-An Chen2 Wei-Sen Lin3 Department of Medicine Tainan Municipal Hospital1 Division of Allergy-Immunology-Rheumatology Department of Medicine Chi Mei Medical Center 2 Department of Hospital and Health Care Administration Chan-Nan University of Pharmacy and Science Taiwan ROC3

37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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37

中華民國風濕病醫學會 2014 年會

Free Paper Presentation 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 5 樓 Vee1+Vee2

主辦單位社團法人中華民國風濕病醫學會

1400-1450 類型 座長羅淑芬教授黃春明主任

1400-1410 Basic

Der p 2 can induce bystander activation of B cells derived from patients with systemic lupus erythematosus Sheng-Jie Yu12 En-Chih Liao2 Jaw-Ji Tsai13 1 Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan 2 Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan 3 Section of Allergy Immunology and Rheumatology of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 1國立中興大學生物醫學研究所 2台中榮民總醫院醫學研究部 3台中榮民總醫院風濕免疫科

1410-1420 Basic

Activation of p73 by Modulation of iASPP to Induce Apoptosis in Synovial Fibroblasts by the Experimental Model and Clinical Samples as a Novel Therapeutic Strategy in Rheumatoid Joint Chrong-Reen Wang Shih-Yao Chen Ai-Li Shiau I-Ming Jou Ming-Fei Liu Chao-Liang Wu Departments of Internal Medicine Microbiology and Immunology Biochemistry and Molecular Biology and Orthopedics National Cheng Kung University Medical College 利用實驗模型及臨床檢體來研究以調控 iASPP 活化轉錄因子

p73 來誘導滑膜纖母細胞之凋亡作為治療類風濕性關節的嶄

新策略 王崇任陳世堯蕭璦莉周一鳴劉明煇吳昭良 國立成功大學醫學院內科部微免所生化所骨科部

1420-1430 Basic

Fetal Microchimerism Cells Suppress Disease Progression in Collagen-Induced Arthritis Mice during Pregnancy Cheng-Chi Wu12 Fei-Lan Liu2 Deh-Ming Chang12 1Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan Republic of China 2Taipei Veterans General Hospital Taipei Taiwan Republic of China

1430-1440 Basic Effect of IL-17 and IL-23 serum levels and gene polymorphisms on the risk for rheumatoid arthritis Chung-Ming Huang13 Joung-Liang Lan 1 Jonathan Chen 1

38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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38

Po-hao Huang1 Chien-Chung Huang1 Shih-Yin Chen24Fuu-Jen Tsai24 Division of Immunology and Rheumatology Department of Internal Medicine1 and Genetic Center Department of Medical Research2 China Medical University Hospital Taichung Taiwan Graduate Institute of Integrated Medicine3 College of Chinese Medicine China Medical University4 Taichung Taiwan 黃春明13 藍忠亮1 陳俊宏1黃柏豪1 黃建中1 洪偉哲1陳世殷24 蔡輔仁24 中國醫藥大學附設醫院 內科部免疫風濕科1 醫研部2 中國醫藥大學 中醫學院 4 中西整合研究所 3

1440-1450 Basic

Methylation and Gene Expression of HDAC6 in Systemic Lupus Erythematosus 林原兆方姿蓉林嘉慧曾家駿宋婉瑜吳正欽歐燦

騰蔡文展顏正賢 高雄醫學大學 過敏免疫風濕科

39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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39

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 06 日(星期六) 1320-1410

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人謝松洲主任

NO 摘要說明

P001

Clinical image Herpetic esophagitis in a patient with systemic sclerosis Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P002

Clinical image Extra-nodal NKT-cell lymphoma manifested with

granulomatous Mei-Ping Liu 留美萍

Changhua Christian Hospital Taiwan

財團法人彰化基督教醫院

P003

Clinical Images Orbital Apex Syndrome due to aspergilosis in a Rheumatoid arthritis patient with MTX related pancytopenia Mei-Ping Liu 留美萍 Changhua Christian Hospital Taiwan 財團法人彰化基督教醫院

P004

痛風引起深部靜脈血栓與肺栓塞之風險研究 An independent risk of gout on the development of deep vein thrombosis and pulmonary embolism a nationwide population-based cohort study Jiunn-Horng Chen陳俊宏12 Joung-Liang Lan藍忠亮12 Chien-Chung Huang黃建中1 Chung-Ming Huang黃春明1 Po-Hao Huang黃柏豪1 Wei-Jhe Hong洪偉哲1 1中國附醫風濕免疫科2中國醫藥大學醫學系

P005

The Mechanism of Peripheral Blood Leukocyte Apoptosis and Its Association with Disease Activity in Systemic Lupus Erythematosus Patients 紅斑性狼瘡患者的周邊血液中細胞凋亡機轉探討和疾病活性的相關性 Yu-Jih Su12 蘇昱日 12 1Department of Biological Science National Sun Yat-Sen University Kaohsiung Taiwan 中山大學生物科學系 2Department of Rheumatology Kaohsiung Chang-Gung Memorial Hospital

40

高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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高雄長庚醫院風濕免疫科

P006

Glucocorticoid use as a risk factor for mortality in osteoporotic vertebral fracture Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 使用類固醇是骨鬆合併脊椎骨折死亡的危險因素 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P007

Hypertrophic Osteoarthropathy with Pigmented Villonodular Synovitis Yen-Po Tsao Chung-Tei Chou Wei-Sheng Chen 曹彥博 周昌德 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 臺北榮民總醫院 內科部過敏免疫風濕科

P008

Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 無心血管危險因子之 Churg-strauss syndrome 併發出血性中風 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

P009

Clinical Images Percutaneous transluminal angioplasty in Takayasursquos arteritis Ya-Chi Li MD 黎亞綺 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P010

Image Maffucci Syndrome Yen-Po Tsao Wei-Sheng Chen 曹彥博 陳瑋昇 Division of Allergy Immunology and Rheumatology Department of Medicine Taipei Veterans General Hospital Taiwan 台北榮民總醫院 內科部過敏免疫風濕科

P011 Clinical Images Chronic Lupus Peritonitis and Enteritis Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy

41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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41

Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P012

Dermatomyositis and Polymyositis are Associated with An Increased Risk of Active Tuberculosis Disease Yi-Ting Lin1 Yi-Hsin Yang2 Yi-Ching Lin345 Yu-Chih Lin6 林憶婷 1楊奕馨 2林宜靜 345林育志 6 1Department of Family Medicine Kaohsiung Municipal HsiaondashKang Hospital Taiwan 2School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 3Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 4Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 5Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 6Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄市立小港醫院家庭醫學科 2高雄醫學大學藥學系 3高雄醫學大學醫學

系實驗診斷學科4 高雄醫學大學附設醫院檢驗醫學部5 高雄醫學大學附設

醫院兒科部 6 高雄醫學大學附設醫院內科部一般醫學內科

P013

Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Presented a Rapid Progression and Fatal Course A Case Report Shih-Kai Wang Ling-Rong Yan Li-Fong Wang Ruei-Jie Hu Ling-Yin Lyu Ruei-Cheng Zeng 王仕凱顏伶容王立峰胡瑞潔呂聆音曾瑞成 Division of Allergy Immunology and Rheumatology Kaohsiung Veterans General Hospital Taiwan 高雄榮民總醫院過敏免疫風濕科

P014

Multiple hepatic artery aneurysms An unusual manifestation of systemic lupus erythematosus Yi-Da Wu 1 Chih-Wei Tseng 1 Kuo-Lung Lai12 Yi-Hsing Chen12

1Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan 2School of Medicine National Yang-Ming University Taipei Taiwan 吳沂達 1曾智偉 1賴國隆 12陳怡行 12

1 臺中榮民總醫院過敏風濕免疫科 2 國立陽明大學醫學系 Corresponding author Yi-Hsing Chen MD PhD Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung

P015

Calcium Pyrophosphate Deposition (CPPD) Disease Min-Chung Shen MD12 沈明忠 12 1Division of Internal Medicine Taoyuan Armed Forces General Hospital Taoyuan

42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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42

Taiwan 2Division of Rheumatology Immunology and Allergy Department of Internal medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 1 桃園國軍總醫院內科部 2 三軍總醫院風濕免疫過敏科

P016

JAK2 but not JAK1 or JAK3 is involved in urate crystal-induced inflammation Jia-Hau Yen1 Lin Ling-Chun1 Meng-Chi Chen1 Gregory J Tsay1 2 1Institute of Microbiology amp Immunology 2Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan 顏加豪林怜君陳孟琦蔡嘉哲 中山醫學大學微生物免疫學研究所 中山醫學大學附設醫院內科部

P017

Extensive pneumatosis intestinalis and pneumoperitoneum in a patient with dermatomyositis Ting-Syuan Lin1 Song-Chou Hsieh2 Ko-Jen Li2 林廷軒 1 謝松洲 2 李克仁 2 1Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Taiwan 2Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taiwan 1 台大雲林分院內科部免疫風濕過敏科 2 台大醫院內科部免疫風濕過敏科

P018

A Wegeners Granulomatosis Patient Unresponsive to Traditional Cyclophosphamide Treatment Successfully Treated With Rituximab A Case Report Hung-an Chen Yung-chang Lin Chun-yu Lin Chih-Sheng Chen Chao-yu Chen 陳宏安 林永章 林峻宇 陳之盛 陳昭宇 Division of allergy Immunology and Rheumatology Chi-mei medical center Taiwan 私立財團法人奇美醫學中心

P019

The expression of advanced glycation end-products in the patients with rheumatoid arthritis 最終糖化產物在類風濕性關節炎病人之表現 Deng-Ho Yang 1 2 MD PhD 楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P020 Scrotal pyoderma gangrenosum associated with Evans syndrome 伊凡斯症候群合併陰囊壞疽性膿皮症 Deng-Ho Yang 1 2 MD PhD

43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

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43

楊登和 1 2 1 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Taichung Armed-Forces General Hospital 2 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center 1 國軍台中總醫院 風濕免疫科 2 三軍總醫院 國防醫學院 風濕免疫科

P021

The Reactivation of JC Polyomavirus was Associated with Joint Manifestation in Patients with Systemic Lupus Erythematosus Jui-Mei Hus3 Ming-Chi Lu12 Ning-Sheng Lai12 許瑞美 呂明錡 賴寧生 1Division of Allergy Immunology and Rheumatology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院免疫風濕中心 2 School of Medicine Tzu Chi University Hualien Taiwan 慈濟大學 3Department of Medical Research Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan 佛教慈濟醫療財團法人大林慈濟醫院醫學研究部

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

飯店位置圖 飯店名稱台中日月千禧酒店

飯店地址40756 台中市市政路 77 號

飯店電話(04)3900-8889

飯店網址httpwwwmillenniumhotelscomzh-twmillenniumveehoteltaichung

交通資訊 【自行開車】

國道一號台中交流道往台中方向下rarr行中港路三段rarr右轉朝富路rarr左轉市政路即抵

【大眾運輸】

台鐵台中火車站出站搭乘 75 路公車於第六分局站下即抵或搭乘計程車約 20 分鐘

即抵

客運台中朝馬站下步行約 18 分鐘即抵或搭乘計程車約 5 分鐘即抵

高鐵高鐵烏日站出站轉程 7507 路公車於黎明新村站(黎明路)下步行約 11 分鐘即

抵或搭乘計程車約 20 分鐘即抵

44

中華民國風濕病醫學會 2014 年會

海報目錄 時間103 年 12 月 07 日(星期日) 1400-1450

地點台中日月千禧酒店 B2 宴會廳

主辦單位中華民國風濕病醫學會 主持人顏正賢教授

NO 摘要說明

P022

Hypertrophic osteoarthropathy a warning sign of underlying malignancy 肥厚性骨關節病變需警覺潛在惡性病的重要表徵 Chien-Kai Kau 高堅凱 Division of Allergy Immunology and Rheumatology Chung-Hua Hospital Ministry of Health and Welfare 行政院衛生福利部彰化醫院過敏免疫風濕科

P023

Takayasu arteritis in a young woman Tzu-Min Lin1Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1 Yu-Sheng Chang3 1Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 林子閔1張棋楨12 邱啟勝1蔡凱倫1郭佩邑1張又升3 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科

P024

Significant Effects of Biologic Therapy on Lipid Profiles and Insulin Resistance in Patients with Rheumatoid Arthritis Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12Chia-Wei Hsieh24 Wei-Ting Hung23 Hsin-Hua Chen23 and Joung-Liang Lan5 1Department of Medical Education Taichung Veterans General Hospital Taiwan 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taiwan 5Division of Immunology and Rheumatology China Medical University Hospital Taiwan 類風濕關節炎患者使用之生物製劑對於血脂肪及胰島素阻抗性之影響 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 洪維廷 23 陳信華 23 藍忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學醫學系 3 中興

大學 生醫研究所 4 中國醫藥大學附醫免疫風濕科 5

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

飯店位置圖 飯店名稱台中日月千禧酒店

飯店地址40756 台中市市政路 77 號

飯店電話(04)3900-8889

飯店網址httpwwwmillenniumhotelscomzh-twmillenniumveehoteltaichung

交通資訊 【自行開車】

國道一號台中交流道往台中方向下rarr行中港路三段rarr右轉朝富路rarr左轉市政路即抵

【大眾運輸】

台鐵台中火車站出站搭乘 75 路公車於第六分局站下即抵或搭乘計程車約 20 分鐘

即抵

客運台中朝馬站下步行約 18 分鐘即抵或搭乘計程車約 5 分鐘即抵

高鐵高鐵烏日站出站轉程 7507 路公車於黎明新村站(黎明路)下步行約 11 分鐘即

抵或搭乘計程車約 20 分鐘即抵

45

P025

Serum drug trough levels could predict sustained therapeutic responses after dose reduction of adalimumab in rheumatoid arthritis patients during 24 weeks of follow-up Der-Yuan Chen1234 Yi-Ming Chen234 Tsu-Yi Hsieh12 Chia-Wei Hsieh24 Hsin-Hua Chen23 Kuo-Lung Lai2 Wei-Ting Hung23 Joung-Liang Lan5 1Department of Medical Education 2Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taiwan 3Faculty of Medicine National Yang-Ming University Taiwan 4Institute of Biomedical Science National Chung Hsing University Taichung Taiwan School of Medicine Chung Shan Medical University Taiwan 5 Division of Immunology and Rheumatology China Medical University Hospital Taiwan 血清藥物濃度可預測類風濕關節炎病人接受復邁藥量減半治療 24 週後之

療效反應 陳得源 1234 陳一銘 234 謝祖怡 12 謝佳偉 24 陳信華 23 賴國隆 2 洪維廷 23 藍

忠亮 5 台中榮民總醫院教學部 1 過敏免疫風濕科 2 國立陽明大學 醫學系 3 中興大學 生醫研究所 4 中國醫藥大學附醫 免疫風濕科 5

P026

Amelioration of Collagen-induced Arthritis by Water-soluble Fullerene C60(OH)36 Nanoparticles through the Inhibition of Angiogenesis 以水溶性富勒烯(碳六十)治療大鼠之膠原誘導關節炎 Chia-Tse Weng1 Shih-Yao Chen2 Yu-Hung Chen2 Chao-Liang Wu2 Ming-Fei Liu1 Ai-Li Shiau3 Chrong-Reen Wang1 翁嘉澤 1陳世堯 2陳毓宏 2吳昭良 2劉明煇 1蕭璦莉 3王崇任 1 1Division of Rheumatology and Immunology Department of Internal Medicine National Cheng Kung University Hospital 2Department of Biochemistry and Molecular Biology 3Department of Microbiology and Immunology College of Medicine National Cheng Kung University

P027

Erythema multiforme-before and after shortly high-dose intravenous steroid therapy Jeng-Ting Tsao1 Shih-Chang Lin123 曹正婷林世昌 1Division of Allergy and Immunology Department of Internal Medicine Cathay General Hospital Taipei Taiwan 國泰醫療財團法人國泰綜合醫院內科部過敏免疫科 2The Laboratory of Allergy and Immunology Cathay Medical Research Institute New Taipei Taiwan 國泰醫療財團法人國泰綜合醫院過敏免疫室 3Department of Medicine School of Medicine Fu Jen Catholic University New Taipei Taiwan 輔仁大學醫學院醫學系

P028

Changes at Gray Scale Synovitis Composite Scores at One Month as a Predictor of Radiological Progression in Patients with Rheumatoid Arthritis Receiving TNF Antagonists Therapy Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

飯店位置圖 飯店名稱台中日月千禧酒店

飯店地址40756 台中市市政路 77 號

飯店電話(04)3900-8889

飯店網址httpwwwmillenniumhotelscomzh-twmillenniumveehoteltaichung

交通資訊 【自行開車】

國道一號台中交流道往台中方向下rarr行中港路三段rarr右轉朝富路rarr左轉市政路即抵

【大眾運輸】

台鐵台中火車站出站搭乘 75 路公車於第六分局站下即抵或搭乘計程車約 20 分鐘

即抵

客運台中朝馬站下步行約 18 分鐘即抵或搭乘計程車約 5 分鐘即抵

高鐵高鐵烏日站出站轉程 7507 路公車於黎明新村站(黎明路)下步行約 11 分鐘即

抵或搭乘計程車約 20 分鐘即抵

46

University College of Medicine Kaohsiung Taiwan 以第一個月灰階超音波的滑囊炎組合分數變化作為預測類風濕性關節炎病

患接受抗腫瘤壞死藥物 X 光關節惡化的依據 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭 陳嘉夆 高雄長庚醫院風濕過敏免疫科

P029

Clinical Images Ruptured Bakerrsquos Cyst Mimicking Tennis Leg Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P030

Clinical Images Heliotrope rash as a manifestation of Sjoumlgrenrsquos Syndrome with rapid deterioration of anti-Ro titer Fu-Chiang Yeh MD 葉富強 Division of RheumatologyImmunologyAllergy Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 三軍總醫院 內科部 風濕免疫過敏科

P031

The effectiveness of patient management system in health promotion for autoimmune disease patient 病患管理系統用于自體免疫疾病病患的健康促進的成效 Chien-Hsueh Tung1 Miao-Chiu Lin1 Kuang-Yung Huang1 Ming-Chi Lu1 Bao-Bao Hsu1 Ning-Sheng Lai1 1Division of Allergy Immunology and Rheumatology Buddhist Dalin Tzu Chi Hospital Dalin Chia-Yi Taiwan Republic of China 童建學1 林妙秋1 黃光永1 呂明錡1 許寶寶1 賴寧生1 佛教大林慈濟醫院免疫風濕科 1

P032

The Risk of Gastrointestinal Bleeding in Patients with Systemic Sclerosis - A Nationwide Cohort Study Ping-Hsun Wu123 Yi-Hsin Yang4 Yi-Ching Lin567 Yu-Chih Lin8 吳秉勳123楊奕馨4林宜靜56林育志7 1Division of Nephrology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 2Department of Emergency Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 3Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Taiwan 4School of Pharmacy College of Pharmacy Kaohsiung Medical University Taiwan 5Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Taiwan 6Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan 7Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

飯店位置圖 飯店名稱台中日月千禧酒店

飯店地址40756 台中市市政路 77 號

飯店電話(04)3900-8889

飯店網址httpwwwmillenniumhotelscomzh-twmillenniumveehoteltaichung

交通資訊 【自行開車】

國道一號台中交流道往台中方向下rarr行中港路三段rarr右轉朝富路rarr左轉市政路即抵

【大眾運輸】

台鐵台中火車站出站搭乘 75 路公車於第六分局站下即抵或搭乘計程車約 20 分鐘

即抵

客運台中朝馬站下步行約 18 分鐘即抵或搭乘計程車約 5 分鐘即抵

高鐵高鐵烏日站出站轉程 7507 路公車於黎明新村站(黎明路)下步行約 11 分鐘即

抵或搭乘計程車約 20 分鐘即抵

47

Medical University Taiwan 8Division of General Internal Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Taiwan1高雄醫學大學附設醫院內科部腎臟內科 2高雄醫學大學附設醫院急診醫學

部3高雄醫學大學醫學研究所4高雄醫學大學藥學系5高雄醫學大學醫學系

實驗診斷學科6高雄醫學大學附設醫院檢驗醫學部7高雄醫學大學附設醫院

兒科部 8高雄醫學大學附設醫院內科部一般醫學內科

P033

Nonlupus nephritides in patients with systemic lupus erythematosusthree case reports 全身性紅斑狼瘡患者表現非狼瘡腎炎腎病變三個病例報告 Ting-Hui Chang Chien-Sheng Wu Division of Allergy Immunology and Rheumatology Department of Internal Medicine Far Eastern Memorial Hospital Taipei 張婷惠 吳建陞 亞東紀念醫院內科部過敏免疫風濕科

P034

Idiopathic Granulomatous Mastitis A Case Series From Northern Taiwan 自發性肉芽腫乳腺炎來自北台灣的系列病例報告 Hui-Ching Hsu1 Song-Chou Hsieh2 Cheng-Han Wu2 Ko-Jen Li2 許惠晴1謝松洲2吳政翰2李克仁2 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taipei Medical University-Municipal Wan Fang Hospital Taipei Taiwan 2 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan 1臺北市立萬芳醫院-委託財團法人臺北醫學大學辦理 內科部 過敏免疫風

濕科 2國立台灣大學醫學院附設醫院 內科部 過敏免疫風濕科

P035

自身免疫性蛋白S缺乏症以視神經炎為初始表現 Autoimmune protein S deficiency presented with optic neuritis 呂政勳1 陳達慶2 謝松洲3 吳政翰3 Cheng-Hsun Lu MD 1 Ta-Ching Chen MD2 Song-Chou Hsieh PhD3 Cheng-Han Wu MD3 1臺大醫院雲林分院內科部過敏免疫風濕科 2臺大醫院眼科部 3臺大醫院內科部過敏免疫風濕科 1 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin Taiwan 2 Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan 3 Division of Allergy Immunology and Rheumatology Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

P036

Calcium-containing crystals enhance RANKLM-CSF-mediated osteoclastogenesis via MAPK pathways Chi-Ching Chang12 Chi-Sheng Chiou1 Kai-Len Tsai1 Pei-I Kuo1Tzu-Min Lin1 Yu-Sheng Chang3 Shyr-Yi Lin24 Yu-Chih Liang5 1Division of Rheumatology Immunology and Allergy Taipei Medical

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

飯店位置圖 飯店名稱台中日月千禧酒店

飯店地址40756 台中市市政路 77 號

飯店電話(04)3900-8889

飯店網址httpwwwmillenniumhotelscomzh-twmillenniumveehoteltaichung

交通資訊 【自行開車】

國道一號台中交流道往台中方向下rarr行中港路三段rarr右轉朝富路rarr左轉市政路即抵

【大眾運輸】

台鐵台中火車站出站搭乘 75 路公車於第六分局站下即抵或搭乘計程車約 20 分鐘

即抵

客運台中朝馬站下步行約 18 分鐘即抵或搭乘計程車約 5 分鐘即抵

高鐵高鐵烏日站出站轉程 7507 路公車於黎明新村站(黎明路)下步行約 11 分鐘即

抵或搭乘計程車約 20 分鐘即抵

48

University Hospital 2Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University 3Division of Rheumatology Immunology and Allergy Taipei Medical University Shuang Ho Hospital 4Department of General Medicine School of Medicine College of Medicine Taipei Medical University 5School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University 含鈣晶體促進蝕骨分化的機制 張棋楨12 邱啟勝1蔡凱倫1郭佩邑1林子閔1張又升3林時宜24梁有志5 台北醫學大學附設醫院風濕免疫過敏科1 台北醫學大學臨床醫學研究所2 台北醫學大學衛生署雙和醫院過敏免疫風濕科3 台北醫學大學醫學系一般醫學科24 台北醫學大學醫技系5

P037

Addition of lidocaine injection immediately before physiotherapy for frozen shoulder 物理治療之前肩關節注射lidocaine止痛劑對於冰凍肩之療效 Lin-Fen Hsieh12 Wei-Chun Hsu3 Tao-Liang Wang4 Yi-Jia Lin 5 謝 霖 芬12 許 維 君3 汪作良4 林儀佳5 1Department of Physical Medicine amp Rehabilitation Shin Kong Wu Ho-Su Memorial Hospital Taipei 新光醫療財團法人新光吳火獅紀念醫院 2School of Medicine Fu Jen Catholic University New Taipei City 輔仁大學 3Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei 國立台灣科技大學醫學工程研究所 4Somategrity Clinic Taipei 全衡診所 5Taipei City University Taipei Taiwan 國立台北醫學大學

P038

Repair of Abrasion of Supraspinatus Tendon using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復棘上肌肌腱磨損 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源 Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P039

Repair of Tendon Tear in Tennis Elbow using Dextrose Prolotherapy with Ultrasound Guidance 以超音波導引增生療法修復網球肘的肌腱裂傷 Kuo-Lung Lai Hsin-Hua Chen Der-Yuan Chen 賴國隆 陳信華 陳得源

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

飯店位置圖 飯店名稱台中日月千禧酒店

飯店地址40756 台中市市政路 77 號

飯店電話(04)3900-8889

飯店網址httpwwwmillenniumhotelscomzh-twmillenniumveehoteltaichung

交通資訊 【自行開車】

國道一號台中交流道往台中方向下rarr行中港路三段rarr右轉朝富路rarr左轉市政路即抵

【大眾運輸】

台鐵台中火車站出站搭乘 75 路公車於第六分局站下即抵或搭乘計程車約 20 分鐘

即抵

客運台中朝馬站下步行約 18 分鐘即抵或搭乘計程車約 5 分鐘即抵

高鐵高鐵烏日站出站轉程 7507 路公車於黎明新村站(黎明路)下步行約 11 分鐘即

抵或搭乘計程車約 20 分鐘即抵

49

Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Taiwan 台中榮民總醫院內科部過敏免疫風濕科

P040

Heavy Proteinuria in A Patient Receiving Treatment with Etanercept for Severe Rheumatoid Arthritis KS Tseng Tao-Yuan General Hospital Division of Rheumatology Immunology amp Allergy類風濕關節炎患者使用恩博併發蛋白尿 曾國森 衛生福利部桃園醫院 風濕免疫過敏科

P041

Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells 維生素C可增強Methotrexate對於Hep3B肝癌細胞的抗癌活性 Pei-Lun Chou12 Yu-Ting Hung3 Chyou-Wei Wei3 周貝倫 洪鈺婷 魏秋偉 1Division of Allergy-Immunology-Rheumatology Department of Internal Medicine Min-Sheng General Hospital Taoyuan 2Saint Maryrsquos Hospital Luodong Yilan 桃園敏盛經國總院 天主教靈醫會羅東聖母醫院 內科部風濕免疫過敏科 3Institute of Clinical Nutrition HungKuang University Taichung Taiwan 弘光科技大學營養醫學研究所

P042

Head-to-head comparison of abatacept versus adalimumab for rheumatoid arthritis 6 month efficacy by ultrasound evaluation Ying-Chou Chen Tien-Tsai Cheng Han-Ming Lai Yu-Jih Su Shan-Fu Yu Chung-Jen Chen Wen-Chan Chiu Chung-Yuan Hsu Ching-Lan Chou Jia-Feng Chen Division of Rheumatology Allergy and Immunology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan 以超音波評恩瑞舒及復邁在類風濕性關節炎病患療效之6個月比較 陳英州 鄭添財 賴漢明 蘇昱日 尤珊富 陳忠仁 邱文燦 許鐘元 周靜蘭

陳嘉夆 高雄長庚醫院風濕過敏免疫科

50

飯店位置圖 飯店名稱台中日月千禧酒店

飯店地址40756 台中市市政路 77 號

飯店電話(04)3900-8889

飯店網址httpwwwmillenniumhotelscomzh-twmillenniumveehoteltaichung

交通資訊 【自行開車】

國道一號台中交流道往台中方向下rarr行中港路三段rarr右轉朝富路rarr左轉市政路即抵

【大眾運輸】

台鐵台中火車站出站搭乘 75 路公車於第六分局站下即抵或搭乘計程車約 20 分鐘

即抵

客運台中朝馬站下步行約 18 分鐘即抵或搭乘計程車約 5 分鐘即抵

高鐵高鐵烏日站出站轉程 7507 路公車於黎明新村站(黎明路)下步行約 11 分鐘即

抵或搭乘計程車約 20 分鐘即抵

50

飯店位置圖 飯店名稱台中日月千禧酒店

飯店地址40756 台中市市政路 77 號

飯店電話(04)3900-8889

飯店網址httpwwwmillenniumhotelscomzh-twmillenniumveehoteltaichung

交通資訊 【自行開車】

國道一號台中交流道往台中方向下rarr行中港路三段rarr右轉朝富路rarr左轉市政路即抵

【大眾運輸】

台鐵台中火車站出站搭乘 75 路公車於第六分局站下即抵或搭乘計程車約 20 分鐘

即抵

客運台中朝馬站下步行約 18 分鐘即抵或搭乘計程車約 5 分鐘即抵

高鐵高鐵烏日站出站轉程 7507 路公車於黎明新村站(黎明路)下步行約 11 分鐘即

抵或搭乘計程車約 20 分鐘即抵