Ensuring Access to Data and Information-

Capacity Building for Tropical Diseases

Lester ChitsuloSpecial Programme for Research and Training in Tropical Diseases (TDR)

World Health Organization, Geneva, Switzerland

Permanent Access to Scientific Information in Southern Africa

An International Workshop

5-7 September 2005, Pretoria, South Africa

• To give an overview of Tropical Diseases Research (TDR) programme

• To discuss capacity building efforts for ensuring that data and information from research are accurate, reproducible, robust and are disseminated

Purpose of this presentation

TDR Objectives

• To support research to improve and/or develop new tools for preventing, diagnosing, treating, and controlling neglected infectious diseases

• To strengthen the capacity of disease endemic countries to undertake the research required for disease control

TDR Disease Portfolio

• African trypanosomiasis• Chagas disease• Dengue• Leishmaniasis• Leprosy• Lymphatic filariasis• Malaria• Onchocerciasis• Schistosomiasis

• Tuberculosis.

Disease Coordinator 1

Disease Coordinator 2

Disease Coordinator 3

Disease Coordinator n

Director

PPM

SDR PDE IRM RCS

LDCs

“RCS-Plus”

TDR Structure

SSK

TDR Disease Strategic Emphases Matrix

DIR

SDR PDE IRM

SEB GDRPAGBCV CPR DRD IR

PDT 1 PDT 4 PDT 1 PDT 2 PDT 1 PDT 2

RCS

RSG

R&DProject

1

R&DProject

2 PDT 3PDT 2

MIM

Course1

MIM

TDR works through Committee Structures with External Advisors

Secretariat @ 20+ persons

Advisors @ 200+ persons

TDR Support

• Collaborative research grants – tenable globally

• Research capacity strengthening grants for disease endemic countries

• Research training grants, including career development fellowships

• Re-entry grants• Project specific training, good practices

• Establishment of networks• Access to scientific literature and

communications – hardware, software and training• www.who.int/tdr

Institution

Regionalapproaches

N-S & S-S partnerhips

`

Degree trainingGroup trainingRe-entry

Individual

R&D-driven projectsProgramme-based

Regional networks Small grants

Global networks

MIM/TDRPartnership grants

Capacity Building Support

Resea

rch

self-r

elian

ce

mapping grants

(supply

and demand)Approach

Resea

rch

syst

ems

Capacity building approaches

SampleCollection

Recruitment

Study Preparation

Data Analysis

Field Stafftraining

Report

PostDoc,PhD & M.Sc

Training

Protocoldevelopment

Field study

Workshops Hb GenotypeMSP1 ELISAs

MSP1 PI&comp.ELISA

Epitope mapping

T cellwork

MSP1 AllelesPCR

Grant Approval

Jun 02

1st year fundingAug 02

Contribution to

MSP-1Vaccine

Development

Characteristics and dynamics of antibodies to MSP-1 ofPlasmodium falciparum in humans naturally exposed to

malaria

2002-2005 PERT CHART

Aug -Sep t‘02

Jul ‘02

Dec ‘05

Aug 0 2 Aug-Sep02

Nov ‘0 3–Jan ‘05

Aug 0 2- Jan 04

Mar 03-May 05

Oct 02 –Dec 0 4

Nov 0 3-Aug 04

WHO

Local

EthicalClearance

SampleCollection

Recruitment

Cross-sectional

Longitudinal

LaboratoryWork

Aug 0 2–Nov ‘05

Jun – Jul ’0 2

Oct ’04-Ju n ‘05

Oct ’02-Oct‘04

Capacity building &

Collaboration

Visits by N. Partner

Sep t ’02-Oct ‘05

Training in project planning and management

Capacity building in Research EthicsCapacity building in Research Ethics

is a global network for developing ethical review and promote ethical and scientific values in biomedical research

FERCAPFERCAPFLACEISFLACEIS

FECCISFECCIS

PABINPABIN

FOCUSFOCUS

SIDCERSIDCER

http://www.sidcer.org

Quality Practice in basic biomedical research

• Data from basic research must be reliable in order to ensure a solid basis for decision making

• Fully described experimental conditions and properly collected and recorded data will ensure reproducibility and avoid controversies• QPBBR is concerned with the way the research work is organised, performed, reported and supervised• It is a non-regulatory quality guidance for researchers in basic biomedical research

Good Laboratory Practices

Laboratory Assessment

SOPs TrainingSOPs Training

Good Clinical Practices

CLINICAL DATA MANAGEMENT

• Training in clinical data management • 8 Clinical data management centres

– China, Colombia, Ethiopia, India (2), Japan (2), and Thailand

– To ensure production of high quality databases that meet clinical and regulatory requirements

• WHO/TDR Annual Meeting on Clinical Data Management, Second Military Medical University, Shanghai, September 26-28, 2005.  

• http://www.cdmtdr.org/

Strengthening of DEC medical journals

FAME - fame@who.int

Improving access to scientific informationImproving access to scientific information

Disease Watch

Multilateral Initiative on Malaria (MIM).

Reagents

CommunicationResearch grants

Coordination

Biggest global

malaria conference

Major participation of

African scientists (>

1500)

Strong interface with

malaria control

Important malaria

advocacy event

TDR sponsored

symposia on R & D

innovation in Africa

Partnerships for MSc programmes

L'UniversiteD'Abomey-CalaviI

Centers of excellence for applied genomicsCenters of excellence for applied genomics

Latin American Course on Bioinformaticsfor Tropical Disease Research South African National

Bioinformatics Institute

FIOCRUZ

• We should build capacity that insures that data and information from tropical diseases research are accurate, reproducible and accessible.

• Thank you for the opportunity to share ideas with you.

Conclusion