endobiogeny a global overview

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(c) 2013 American Society of Endobiogenic Medicine and Integrative Physiology

Endobiogeny: A global approach to systems biology

Kamyar M. Hedayat, MDPresident, American Society of Endobiogenic

Medicine and Integrative Physiology

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INTRODUCTION

““Living systems are organized in such a way that they form multi-leveled structures, each level consisting of subsytems which are wholes in regard to their parts, and parts with respect to the larger wholes ”--Fritjof Capra, The turning point: science, society and the rising culture, p. 43

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Differing views

REDUCTIONISM HOLISM

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Systems Theory“Systems theory looks at the world in terms of the interrelatedness and interdependence of all phenomenon, and in this framework an integrated whole whose properties cannot be reduced to those of its parts is called a system.” Fritjof Capra, The turning point: science, society and the rising culture, p. 43

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Determining level of study


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OVERVIEW OF ENDOBIOGENY

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A false dichotomy

ReductionismQuantitative

Function of the partsHierarchy

CategoricalSeparate

IndependentStatic

Control

HolismQualitative

Function of the SystemRelationshipsIndividualized

InterconnectedInterdependence

DynamicCreative chaos

ENDOBIOGENY

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Endobiogeny: A theory of terrain

• Terrain: functional expression of structural constitution in its internal equilibrium– Constitution: Genetic heritage, potential capacity

of the structure– Structure: materialized constitutive elements that

assure life. The achievement of constitution– Function: all the biologic and metabolic mechanics

that assure functioning of structure and dynamics of the organism

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Manager of the System

• In order to ensure the integrity of the system, the manager must possess 3 qualities: 1) Ubiquity of interaction with each structural

element2) Constancy of relationship with those elements3) Auto-regulation.

• The Endocrine system is the manager of the terrain and the system most worthy of study

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Towards an Integrative Physiology

METABOLISM

CATABOLISM ANABOLISMANABOLISM CATABOLISM

CRH

ACTH

ADRENALS

LHRH

FSH LH

GONADS

TRH

TSH

THYROID

GHRH

GH PL

PANCREASπΣ

αΣ

βΣ

Corticotropic Gonadotropic Thyrotropic Somatotropic

ANS

ENDOCRINE MANAGEMENT

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Inte

grati

ve P

hysi

olog

y

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Elements of the Endobiogenic Method

• Theory of Terrain• History• Physical Exam• Systems-based biomarker interpretation• Treatment– Rational clinical phytotherapy– Alimentation– Lifestyle

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THE BIOLOGY OF FUNCTIONS

"The new mathematics...is one of relationships and patterns. It is qualitative rather than quantitative and thus embodies the shift of emphasis that is characteristic of systems thinking—from objects to relationships, from quantity to quality, from substance to pattern." Fritjof Capra

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Need to use blood-based biomarkers

Advantages• Objective• Quantitative• Accurate• Reproducible• Minimally invasive

Short-comings• Binary• Reductionist• Confusion of

– Cause vs. Effect– Cause vs. Effect vs.

Mechanism

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Wisdom of using blood

Blood and Physiology• The life of the flesh is in the

blood (Lev. 17:10)• The blood is the life (Deut

12:23)

Blood, Thought and Emotions• And indeed We have

created man, and We know whatever thoughts his inner self develops, and We are closer to him than (his) jugular vein. (50:16)

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Cellular Elements

Image 2: (left to right) Erythrocytes, Thrombocytes, Leukocytes

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Table 1: BiomarkersOrigin Biomarker

Bone Marrow

Red blood cell

White blood cell, total

Neutrophil

Lymphocytes

Eosinophils

Monocytes

Basophils

Hemoglobin

Platelets

Marrow-Blood interaction Erythrocyte sedimentation rate

Bone Stroma EnzymesOsteocalcin

Alkaline phosphatase bone isoenzyme

General Enzymes Lactate dehydrogenase

Creatine phosphokinase

Endocrine: Pituitary Thyroid stimulating hormone

ElectrolytesPotassium

Calcium, total serum

70% bone and blood

30% other

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Direct and Indirect ratios

Direct Indices• Direct relationship of

biomarkers• Genital Ratio (GR)

– RBC/WBC

• Adaptation Index – Eosinophils/Monocytes

Indirect Indices• Indirect relationship of

direct indexes and other indirect indexes

• Genital ratio corrected=(RBC/PMI) / (WBC/LMI)

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CASE STUDIES IN PINEAL PHYSIOLOGY

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Pineal physiology:Seasonal entrainment

• Seasonal entrainment– Shorter duration of light, greater production of

melatonin– Pineal adapts adrenal gland to increase activity

during the winter months– Pineal adapts thyroid in similar fashion

• Cosmobiology: evaluates the effects of cosmologic events such as solar flares and lunar cycles on human physiology

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Pineal Physiology:Other

• Nocturnal– Anti-oxidant: most powerful endogenous– Anti-inflammatory, free radical scavenger– Anti-tumoral– Reorganizes cerebral connections

• Diurnal– Protects skin against UV damage– Stimulates pancreatic enzymes– Gastric motility– Adrenal adaptability– Thyroid adaptability

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Pineal Physiology

πΣ Serotonin Melatonin

CRF ACTH Cortisol Adaptation, Alertness, Memory

Sleep

(-) βMSH

Dopamine TRH

Imagination, Rumination, Expansive, tangential thinking, emotional labiality, explosive energy

Executive thinking, Rational thought, pleasure and reward

Thyroid Drive, Energy, Cell turnover and “spring cleaning”

αΣ

Impulsivity, Extroversion

Hyperalertness, Increased perception and intake of stimuli

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Review of clinical studies of melatonin and neuropsychiatric disorders

Disorder Melatonin-AM Melatonin-PM

Mania -

Anorexia

Bulemia -

Schizophrenia - Blunted peak

Depression -

Seizures -

Aging -

Alzheimer’s -

Verster GC. Melatonin and its agonists, circadian rhythms and psychiatry. Afr J Psychiatry (Johannesbg). Feb 2009;12(1):42-46.

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Indices relevant to Pineal function

• Corticotropic– ACTH index– Corisol index– Adrenal cortex index

• Thyrotropic– Thyroid metabolic index– Thyroid yield– TRH/TSH index

• Somatotropic– Prolactin index– Peripheral Serotonin

• Pineal Gland– Adaptogen index: relative

level of participation of pineal gland in adaptation

– βMSH/αMSH: Relative level of participation of pineal vs. pituitary in adaptation

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Case 1: Insufficient pineal adaptation10 year old boy hearing voices, death wish

• 10 yo boy with anxiety, death wish from voices in head• H/O: Severe atopy: food allergies, environmental

allergies, asthma, arrested growth, < 5% for weight• Symptoms

– ANXIETY: mood swings, sad, but cannot express exactly what makes him feel that way; stated he wanted to kill himself due to feeling overwhelmed from hearing voices. Claims to have had visions since 2 years of age, telepathy, empathic

– Asthma: daily use with constant dyspnea– Fatigue: chronic, cannot play at recess, tired in school

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Case 1: Insufficient Pineal adaptation

• Treatment:– Mind blend: California poppy, Annual Mercury, Cassis buds,

Lithy tree buds, DOSE: 2.5 ml tid • 48 hours: Voices and death wish resolved

– Treatment for asthma started 2 weeks later after biology of functions performed

• 3 months: full energy, need for daily asthma inhaler resolved—went 6 months before requiring again

• 12 months: Happy, healthy boy, gaining weight (6 lbs), growing in height (5.5’’), expanding list of tolerable foods, mild asthma with colds

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Case 1: Biology of Functions

Index Value Low High

Adrenal cortex 1.62 2.7 3.3

Evoked Histamine 10,221 20 60

Thyroid metabolic 1.64 3.5 5.5

Thyroid yield 0.79 2 3

bMSH/aMSH 1.87 6 8

Prolactin 4.81 0.8 1.2

Peripheral Serotonin 0.22 1.5 7.5

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Case Study 2: Excessive Pineal activity Cyclic Dysthymia

• Chief Complaints: Hormonal and mood fluctuations• Symptoms

– EMOTIONS: Phases last for months at a time: • Depressed, chornic fatigue easily irritated, brain fog • Suddenly improves during ovulation

– 15: ADRENAL FATIGUE with late onset of puberty – 18-26: Anxiety attacks after caffeine or chocolate– 34: nearly died from traumatic birth with severe hemorrhaging became

hypersensitive to noise; – 36: 8th month of pregnancy: insomnia, anemia (Hg 10), anxiety, panic

attacks--started on Armor thyroid which worsened her situation; Child born with trisomy 21

– SLEEP: Variable: Cannot shut off mind when tries to sleep, hard to fall asleep; Dreams: Vivid, engaging, but not fatiguing

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Case Study 2 (cont): Pineal Over-adaptation

• Based on history, physical exam and biology of functions, started on following treatment

• #1: Nervous tension: California poppy, Salad burnett, Yarrow, White deadnettle, Artichoke leaf, 2.5 ml BID

• #2: Mood swings: Strawberry leaf, Gypsywort, Arnica, Buggleweed, Pichi, 2.5 ml bid

• Magnesium oligoelement: 20 drops qAM• 6 weeks: reduction in amplitude of swings• 7 months: increased functionality and delayed onset

of cyclic dysthymia and as above

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Case 2: Biology of functions10 months on treatment

Index 8/30/11 6/29/12 Low High

Adrenal Cortex 1.83 6.51 2.7 3.3

Thyroid index 8.93 7.94 3.5 5.5

Thyroid yield 4.85 2.93 2 3

TRH/TSH 31.13 0.19 0.33 1.7

bMSH/aMSH 9.72 9.37 6 8

Thyroid relaunching corrected

1.5 0.75 0.1 0.5

Insulin index 10.67 4.28 1.5 5

Insulin resistance 0.07 0.11 0.75 1.25

Summary of Pineal function

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RESEARCH, LEARNING AND PRACTICE

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Endobiogeny around the world

• Europe– France: Home of Endobiogeny– UK: taught in conjunction with Middlesex University– Lithuania: Taught through affiliation with medical school

(starting 2014)• Americas– US: Fellowship underway– Mexico: Official form of medicine, used by public health

system• North Africa– Tunisia: Masters degree in endobiogeny

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Areas of research

• Cancer• Autoimmune disorders• Neuro-psychiatric disorders• Cardiovascular disorders• Septic Shock• PTSD

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Conclusions

• Endobiogeny is a theory of terrain• Offers a Global systems approach to biology– Quantitative– Qualitative– Humanistic– Clinical solutions open to all forms of treatment,

prefers medicinal plants, diet, lifestyle

endobiogeny a global overview

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