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ENCYCLOPEDIA OF MEDICAL DEVICES AND INSTRUMENTATION Second Edition VOLUME 4 Hydrocephalus, Tools for Diagnosis and Treatment of – Monoclonal Antibodies

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  • ENCYCLOPEDIA OF

    MEDICAL DEVICES ANDINSTRUMENTATION

    Second Edition

    VOLUME 4

    Hydrocephalus, Tools for Diagnosis and Treatment of Monoclonal Antibodies

  • ENCYCLOPEDIA OF MEDICAL DEVICES AND INSTRUMENTATION, SECOND EDITION

    Editor-in-ChiefJohn G. WebsterUniversity of WisconsinMadison

    Editorial BoardDavid BeebeUniversity of WisconsinMadison

    Jerry M. CalkinsUniversity of Arizona College of Medicine

    Michael R. NeumanMichigan Technological University

    Joon B. ParkUniversity of Iowa

    Edward S. SternickTuftsNew England Medical Center

    Editorial StaffVice President, STM Books: Janet BaileyAssociate Publisher: George J. TeleckiEditorial Director: Sean PidgeonDirector, Book Production and Manufacturing:Camille P. CarterProduction Manager: Shirley ThomasIllustration Manager: Dean GonzalezSenior Production Editor: Kellsee ChuEditorial Program Coordinator: Surlan Murrell

  • ENCYCLOPEDIA OF

    MEDICAL DEVICES ANDINSTRUMENTATION

    Second EditionVolume 4

    Hydrocephalus, Tools for Diagnosis and Treatment of Monoclonal Antibodies

    Edited by

    John G. Webster

    University of WisconsinMadison

    The Encyclopedia of Medical Devices and Instrumentation is available online athttp://www.mrw.interscience.wiley.com/emdi

    A John Wiley & Sons, Inc., Publication

  • Copyright # 2006 by John Wiley & Sons, Inc. All rights reserved.

    Published by John Wiley & Sons, Inc., Hoboken, New Jersey

    Published simultaneously in Canada

    No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic,mechanical, photocopying, recording, scanning, or otherwise, except as permitted under Section 107 or 108 of the 1976 United StatesCopyright Act, without either the prior written permission of the Publisher, or authorization through payment of the appropriateper-copy fee to the Copyright Clearance Center, Inc., 222, Rosewood Drive, Danvers, MA 01923, (978) 750-8400, fax (978)750-4470, or on the web at www.copyright.com. Requests to the Publisher for permission should be addressed to the PermissionsDepartment, John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, (201) 748-6011, fax (201) 748-6008, or online athttp://www.wiley.com/go/permission.

    Limit of Liability/Disclaimer of Warranty: While the publisher and author have used their best efforts in preparing this book, theymake no representations or warrnaties with respect to the accuracy or completeness of the contents of this book and specifically disclaimany implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by salesrepresentatives or written sales materials. The advice and strategies contained herein may not be suitable for your situation. You shouldconsult with a professional where appropriate. Neither the publisher nor author shall be liable for any loss of profit or any other commercialdamages, including but not limited to special, incidental, consequential, or other damages.

    For general information on our other products and services or for technical support, please contact our Customer Care Departmentwithin the United States at (800) 762-2974, outside the United States at (317) 572-3993 or fax (317) 572-4002.

    Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available inelectronic formats. For more information about Wiley products, visit our web site at www.wiley.com.

    Library of Congress Cataloging-in-Publication Data:

    Library of Congress Cataloging-in-Publication DataEncylopedia of medical devices & instrumentation/by John G. Webster,

    editor in chief. 2nd ed.p. ; cm.

    Rev. ed. of: Encyclopedia of medical devices and instrumentation. 1988.Includes bibliographical references and index.ISBN-13 978-0-471-26358-6 (set : cloth)ISBN-10 0-471-26358-3 (set : cloth)ISBN-13 978-0-470-04069-0 (v. 4 : cloth)ISBN-10 0-470-04069-6 (v. 4 : cloth)

    1. Medical instruments and apparatusEncyclopedias. 2. Biomedical engineeringEncyclopedias. 3. Medical physicsEncyclopedias.4. MedicineData processingEncyclopedias. I. Webster, John G.,1932- . II. Title: Encyclopedia of medical devices and instrumentation.

    [DNLM: 1. Equipment and SuppliesEncyclopediasEnglish. W 13

    E555 2006]R856.A3E53 2006610.2803dc222005028946

    Printed in the United States of America

    10 9 8 7 6 5 4 3 2 1

  • CONTRIBUTOR LIST

    ABDEL HADY, MAZEN, McMaster University, Hamilton,Ontario Canada, Bladder Dysfunction, Neurostimulationof

    ABEL, L.A., University of Melbourne, Melbourne, Australia,Ocular Motility Recording and Nystagmus

    ABREU, BEATRIZ C., Transitional Learning Center at Gal-veston, Galveston, Texas, Rehabilitation, Computers inCognitive

    ALEXANDER, A.L., University of WisconsinMadison, Madi-son, Wisconsin, Magnetic Resonance Imaging

    ALI, ABBAS, University of Illinois, at Urbana-Champaign,Bioinformatics

    ALI, MUFTU, School of Dental Medicine, Boston, Massachu-setts, Tooth and Jaw, Biomechanics of

    ALPERIN, NOAM, University of Illinois at Chicago, Chicago,Illinois, Hydrocephalus, Tools for Diagnosis and Treat-ment of

    ANSON, DENIS, College Misericordia, Dallas, Pennsylvania,Environmental Control

    ARENA, JOHN C., VA Medical Center and Medical College ofGeorgia, Biofeedback

    ARIEL, GIDEON, Ariel Dynamics, Canyon, California, Biome-chanics of Exercise Fitness

    ARMSTRONG, STEVE, University of Iowa, Iowa City, Iowa,Biomaterials for Dentistry

    ASPDEN, R.M., University of Aberdeen, Aberdeen, UnitedKingdom, Ligament and Tendon, Properties of

    AUBIN, C.E., Polytechniquie Montreal, Montreal Quebec,Canada, Scoliosis, Biomechanics of

    AYRES, VIRGINIA M., Michigan State University, East Lan-sing, Michigan, Microscopy, Scanning Tunneling

    AZANGWE, G., Ligament and Tendon, Properties of

    BACK, LLOYD H., California Institute of Technology, Pasa-dena, California, Coronary Angioplasty and GuidewireDiagnostics

    BADYLAK, STEPHEN F., McGowan Institute for RegenerativeMedicine, Pittsburgh, Pennsylvania, Sterilization of Bio-logic Scaffold Materials

    BANDYOPADHYAY, AMIT, Washington State University, Pull-man, Washington, Orthopedic Devices, Materials andDesign for

    BANERJEE, RUPAK K., University of Cincinnati, Cincinnati,Ohio, Coronary Angioplasty and Guidewire Diagnostics

    BARBOUR, RANDALL L., State University of New York Down-state Medical Center, Brooklyn, New York, PeripheralVascular Noninvasive Measurements

    BARKER, STEVEN J., University of Arizona, Tucson, Arizona,Oxygen Monitoring

    BARTH, ROLF F., The Ohio State University, Columbus,Ohio, Boron Neutron Capture Therapy

    BECCHETTI, F.D., University of Michigan, Ann Arbor, Michi-gan, Radiotherapy, Heavy Ion

    BELFORTE, GUIDO, Politecnico di Torino Department ofMechanics, Laryngeal Prosthetic Devices

    BENKESER, PAUL, Georgia Institute of Technology, Atlanta,Georgia, Biomedical Engineering Education

    BENNETT, JAMES R., University of Iowa, Iowa City, Iowa,Digital Angiography

    BERSANO-BEGEY, TOMMASO, University of Michigan, AnnArbor, Michigan, Microbioreactors

    BIGGS, PETER J., Harvard Medical School, Boston, Massa-chusetts, Radiotherapy, Intraoperative

    BIYANI, ASHOK, University of Toledo, and Medical College ofOhio, Toledo, Ohio, Human Spine, Biomechanics of

    BLOCK, W.F., University of WisconsinMadison, Madison,Wisconsin, Magnetic Resonance Imaging

    BLUE, THOMAS E., The Ohio State University, Columbus,Ohio, Boron Neutron Capture Therapy

    BLUMSACK, JUDITH T., Disorders Auburn University,Auburn, Alabama, Audiometry

    BOGAN, RICHARD K., University of South Carolina, Colum-bia, South Carolina, Sleep Laboratory

    BOKROS, JACK C., Medical Carbon Research Institute, Aus-tin, Texas, Biomaterials, Carbon

    BONGIOANNINI, GUIDO, ENT Division Mauriziano Hospital,Torino, Italy, Laryngeal Prosthetic Devices

    BORAH, JOSHUA, Applied Science Laboratories, Bedford,Massachusetts, Eye Movement, Measurement Techni-ques for

    BORDEN, MARK, Director of Biomaterials Research, Irvine,California, Biomaterials, Absorbable

    BORTON, BETTIE B., Auburn University Montgomery, Mont-gomery, Alabama, Audiometry

    BORTON, THOMAS E., Auburn University Montgomery, Mont-gomery, Alabama, Audiometry

    BOSE SUSMITA,, Washington State University, Pullman,Washington, Orthopedic Devices, Materials and Designfor

    BOVA, FRANK J., M. D. Anderson Cancer Center Orlando,Orlando, FL, Radiosurgery, Stereotactic

    BRENNER, DAVID J., Columbia University Medical Center,New York, New York, Computed Tomography Screening

    BREWER, JOHN M., University of Georgia, Electrophoresis

    BRIAN, L. DAVIS, Lerner Research Institute, The ClevelandClinic Foundation, Cleveland, Ohio, Skin, Biomechanicsof

    BRITT, L.D., Eastern Virginia Medical School, Norfolk, Vir-ginia, Gastrointestinal Hemorrhage

    BRITT, R.C., Eastern Virginia Medical School, Norfolk,Virginia, Gastrointestinal Hemorrhage

    BROZIK, SUSAN M., Sandia National Laboratories, Albuquer-que, New Mexico, Microbial Detection Systems

    BRUNER, JOSEPH P., Vanderbilt University MedicalCenter, Nashville, Tennessee, Intrauterine SurgicalTechniques

    BRUNSWIG NEWRING, KIRK A., University of Nevada, Reno,Nevada, Sexual Instrumentatio n

    BRUYANT, PHILIPPE P., University of Massachusetts, NorthWorcester, Massachusetts, Nuclear Medicine, Computersin

    BUNNELL, BERT J., Bunnell Inc., Salt Lake City, Utah, HighFrequency Ventilation

    CALKINS, JERRY M., Defense Research Technologies, Inc.,Rockville, Maryland, Medical Gas Analyzers

    CANNON, MARK, Northwestern University, Chicago, Illinois,Resin-Based Composites

    v

  • CAPPELLERI, JOSEPH C., Pfizer Inc., Groton, Connecticut,Quality-of-Life Measures, Clinical Significance of

    CARDOSO, JORGE, University of Madeira, Funchal, Portugal,Office Automation Systems

    CARELLO, MASSIMILIANA, Politecnicodi Torino Departmentof Mechanics, Laryngeal Prosthetic Devices

    CASKEY, THOMAS C., Cogene Biotech Ventures, Houston,Texas, Polymerase Chain Reaction

    CECCIO, STEVEN, University of Michigan, Ann Arbor, Michi-gan, Heart Valve Prostheses, In Vitro Flow Dynamics of

    CHAN, JACKIE K., Columbia University, New York, NewYork, Photography, Medical

    CHANDRAN, K.B., University of Iowa, Iowa City, Iowa, HeartValve Prostheses

    CHATZANDROULIS, S., NTUA, Athens, Attiki, Greece, Capaci-tive Microsensors for Biomedical Applications

    CHAVEZ, ELIANA, University of Pittsburgh, Pittsburgh, Penn-sylvania, Mobility Aids

    CHEN, HENRY, Stanford University, Palo Alto, California,Exercise Stress Testing

    CHEN, JIANDE, University of Texas Medical Branch, Galves-ton, Texas, Electrogastrogram

    CHEN, YAN, Lerner Research Institute, The Cleveland ClinicFoundation, Cleveland, Ohio, Skin, Biomechanics of

    CHEYNE, DOUGLAS, Hospital for Sick Children ResearchInstitute, Biomagnetism

    CHUI, CHEN-SHOU, Memorial Sloan-Kettering Cancer Cen-ter, New York, New York, Radiation Therapy TreatmentPlanning, Monte Carlo Calculations in

    CLAXTON, NATHAN S., The Florida State University, Talla-hassee, Florida, Microscopy, Confocal

    CODERRE, JEFFREY A., Massachus etts Institute of Technol-ogy, Cambridge, Massachusetts, Boron Neutron CaptureTherapy

    COLLINS, BETH, University of Mississippi Medical Center,Jackson, Mississippi, Hyperbaric Medicine

    COLLINS, DIANE, University of Pittsburgh, Pittsburgh, Penn-sylvania, Mobility Aids

    CONSTANTINOU, C., Columbia University Radiation Oncol-ogy, New York, New York, Phantom Materials in Radi-ology

    COOK, ALBERT, University of Alberta, Edmonton, Alberta,Canada, Communication Devices

    COOPER, RORY, University of Pittsburgh, Pittsburgh, Penn-sylvania, Mobility Aids

    CORK, RANDALL C., Louisiana State University,Shreveport, Louisiana, Monitoring, Umbilical Arteryand Vein, Blood Gas Measurements; Transcuta neousElectrical Nerve Stimulation (TENS); AmbulatoryMonitoring

    COX, JOSEPHINE H., Walter Reed Army Institute of Research,Rockville, Maryland, Blood Collection and Processing

    CRAIG, LEONARD, Feinberg School of Medicine of Northwes-tern University, Chicago, Illinois, Ventilators, Acute Med-ical Care

    CRESS, CYNTHIA J., University of Nebraska, Lincoln,Nebraska, Communicative Disorders, Computer Applica-tions for

    CUMMING, DAVID R.S., University of Glasgow, Glasgow,United Kingdom, Ion-Sensitive Field-Effect Transistors

    CUNNINGHAM, JOHN R., Camrose, Alberta, Canada, Cobalt 60Units for Radiotherapy

    DALESSANDRO, DAVID, Montefiore Medical Center, Bronx,New York, HeartLung Machines

    DAMBRA, MICHAEL N., Harvard Medical School, Cambridge,Massachusetts, Cardiac Output, Thermodilution Mea-surement of

    DADSETAN, MAHROKH, Mayo Clinic, College of Medicine,Rochester, Minnesota, Microscopy, Electron

    DALEY, MICHAEL L., The University of Memphis, Memphis,Tennessee, Monitoring, Intracranial Pressure

    DAN, LOYD, Linkoping University, Linkoping, Sweden, Ther-mocouples

    DAS, RUPAK, University of Wisconsin, Madison, Wisconsin,Brachytherapy, High Dosage Rate

    DATTAWADKAR, AMRUTA M., University of Wisconsin,Madison, Madison, Wisconsin, Ocular Fundus Reflecto-metry

    DAVIDSON, MICHAEL W., The Florida State University, Tal-lahassee, Florida, Microscopy, Confocal

    DE LUCA, CARLO, Boston University, Boston, Massachusetts,Electromyography

    DE SALLES, ANTONIO A.F., UCLA Medical School, LosAngeles, California, Stereotactic Surgery

    DECAU, SABIN, University of Maryland, School of Medicine,Shock, Treatment of

    DECHOW, PAUL C., A & M University Health Science Center,Dallas, Texas, Strain Gages

    DELBEKE, JEAN, Catholique University of Louvain, Brussels,Belgium, Visual Prostheses

    DELLOSSO, LOUIS F., Case Western Reserve University,Cleveland, Ohio, Ocular Motility Recording and Nystag-mus

    DELORME, ARNAUD, University of San Diego, La Jolla, Cali-fornia, Statistical Methods

    DEMENKOFF, JOHN, Mayo Clinic, Scottsdale, Arizona, Pul-monary Physiology

    DEMIR, SEMAHAT S., The University of Memphis and TheUniversity of Tennessee Health Science Center, Memphis,Tennessee, Electrophysiology

    DEMLING, ROBERT H., Harvard Medical School, Skin Sub-stitute for Burns, Bioactive

    DENNIS, MICHAEL J., Medical University of Ohio, Toledo,Ohio, Computed Tomography

    DESANTI, LESLIE, Harvard Medical School, Skin Substitutefor Burns, Bioactive

    DEUTSCH, STEVEN, Pennsylvania State University, Univer-sity Park, Pennsylvania, Flowmeters

    DEVINENI, TRISHUL, Conemaugh Health System, Biofeedback

    DI BELLA EDWARD, V.R., University of Utah, Tracer Kinetics

    DIAKIDES, NICHOLAS A., Advanced Concepts Analysis, Inc.,Falls Church, Virginia, Thermography

    DOLAN, PATRICIA L., Sandia National Laboratories, Albu-querque, New Mexico, Microbial Detection Systems

    DONOVAN, F.M., University of South Alabama, Cardiac Out-put, Indicator Dilution Measurement of

    DOUGLAS, WILSON R., Childrens Hospital of Philadelphia,Philadelphia, Pennsylvania, Intrauterine Surgical Tech-niques

    DRAPER, CRISSA, University of Nevada, Reno, Nevada, Sex-ual Instrumentation

    DRZEWIECKI, TADEUSZ M., Defense Research Technologies,Inc., Rockville, Maryland, Medical Gas Analyzers

    DURFEE, W.K., University of Minnesota, Minneapolis, Min-nesota, Rehabilitation and Muscle Testing

    DYRO, JOSEPH F., Setauket, New York, Safety Program,Hospital

    vi CONTRIBUTOR LIST

  • DYSON, MARY, Herts, United Kingdom, Heat and Cold,Therapeutic

    ECKERLE, JOSEPH S., SRI International, Menlo Park, Cali-fornia, Tonometry, Arterial

    EDWARDS, BENJAMIN, University of Wisconsin-Madison,Madison, Wisconsin, Codes and Regulations: Radiation

    EDWARDS, THAYNE L., University of Washington, Seattle,Washington, Chromatography

    EKLUND, ANDERS, University of Illinois at Chicago, Chicago,Illinois, Hydrocephalus, Tools for Diagnosis and Treat-ment of

    EL SOLH, ALI A., Erie County Medical Center, Buffalo, NewYork, Sleep Studies, Computer Analysis of

    ELMAYERGI, NADER, McMaster University, Hamilton,Ontario, Canada, Bladder Dysfunction, Neurostimula-tion of

    ELSHARYDAH, AHMAD, Louisiana State University, BatonRouge, Louisiana, Ambulatory Monitoring; Monitoring,Umbilical Artery and Vein, Blood Gas Measurements

    FADDY, STEVEN C., St. Vincents Hospital, Sydney, Darlin-ghurst, Australia, Cardiac Output, Fick Technique for

    FAHEY, FREDERIC H., Childrens Hospital Boston, ComputedTomography, Single Photon Emission

    FAIN, S.B., University of WisconsinMadison, Madison,Wisconsin, Magnetic Resonance Imaging

    FELDMAN, JEFFREY, Childrens Hospital of Philadelphia,Philadelphia, Pennsylvania, Anesthesia Machines

    FELLERS, THOMAS J., The Florida State University, Talla-hassee, Florida, Microscopy, Confocal

    FERRARA, LISA, Cleveland Clinic Foundation, Cleveland,Ohio, Human Spine, Biomechanics of

    FERRARI, MAURO, The Ohio State University, Columbus,Ohio, Drug Delivery Systems

    FONTAINE, ARNOLD A., Pennsylvania State University, Uni-versity Park, Pennsylvania, Flowmeters

    FOUST, MILTON J., JR, Medical University of South CarolinaPsychiatry and Behavioral Sciences, Charleston, SouthCarolina, Electroconvulsive Therapy

    FRASCO, PETER, Mayo Clinic Scottsdale, Scottsdale, Arizona,Temperature Monitoring

    FRAZIER, JAMES, Louisiana State University, Baton Rouge,Louisiana, Ambulatory Monitoring

    FREIESLEBEN DE BLASIO, BIRGITTE, University of Oslo, Oslo,Norway, Impedance Spectroscopy

    FRESTA, MASSIMO, University of Catanzaro Magna Grcia,Germaneto (CZ), Italy, Drug Delivery Systems

    FREYTES, DONALD O., McGowan Institute for RegenerativeMedicine, Pittsburgh Pennsylvania, Sterilization of Bio-logic Scaffold Materials

    FROEHLICHER, VICTOR, VA Medical Center, Palo Alto, Cali-fornia, Exercise Stress Testing

    FUNG, EDWARD K., Columbia University, New York,New York, Photography, Medical

    GAGE, ANDREW A., State University of New York at Buffalo,Buffalo, New York, Cryosurgery

    GAGLIO, PAUL J., Columbia University College of Physiciansand Surgeons, Liver Transplantation

    GARDNER, REED M., LDS Hospital and Utah University, SaltLake City, Utah, Monitoring, Hemodynamic

    GEJERMAN, GLEN, Hackensack University Medical, Hacken-sack, New Jersey, Radiation Therapy, Quality Assurancein

    GEORGE, MARK S., Medical University of South CarolinaPsychiatry and Behavioral Sciences, Charleston, SouthCarolina, Electroconvulsive Therapy

    GHARIEB, R.R., Infinite Biomedical Technologies, Baltimore,Maryland, Neurological Monitors

    GLASGOW, GLENN P., Loyola University of Chicago, May-wood, Illinois, Radiation Protection Instrumentation

    GLASGOW, GLENN, University of Wisconsin-Madison, Madi-son, Wisconsin, Codes and Regulations: Radiation

    GOEL, VIJAY K., University of Toledo, and Medical College ofOhio, Toledo, Ohio, Human Spine, Biomechanics of

    GOETSCH, STEVEN J., San Diego Gamma Knife Center, LaJolla, California, Gamma Knife

    GOLDBERG, JAY R., Marquette University Milwaukee, Wis-consin, Minimally Invasive Surgery

    GOLDBERG, ZELENNA, Department of Radiation Oncology,Davis, California, Ionizing Radiation, Biological Effectsof

    GOPALAKRISHNAKONE, P., National University of Singapore,Singapore, Immunologically Sensitive Field-Effect Tran-sistors

    GOPAS, JACOB, Ben Gurion University of the Negev, BeerSheva, Israel, Monoclonal Antibodies

    GORGULHO, ALESSANDRA, UCLA Medical School, LosAngeles, California, Stereotactic Surgery

    GOUGH, DAVID A., University of California, La Jolla, Cali-fornia, Glucose Sensors

    GOUSTOURIDIS, D., NTUA, Athens, Attiki, Greece, CapacitiveMicrosensors for Biomedical Applications

    GRABER, HARRY L., State University of New York DownstateMedical Center, Brooklyn, New York, Peripheral VascularNoninvasive Measurements

    GRACA, M., Louisiana State University, Baton Rouge,Louisiana, Boron Neutron Capture Therapy

    GRANT, WALTER III, Baylor College of Medicine, Houston,Texas, Radiation Therapy, Intensity Modulated

    GRAYDEN, EDWARD, Mayo Health Center, Albertlea, Minne-sota, Cardiopulmonary Resuscitation

    GREEN, JORDAN R., University of Nebraska, Lincoln,Nebraska, Communicative Disorders, Computer Applica-tions for

    HAEMMERICH, DIETER, Medical University of South Carolina,Charleston, South Carolina, Tissue Ablation

    HAMAM, HABIB, Universite de Moncton, Moncton New Bruns-wick, Canada, Lenses, Intraocular

    HAMMOND, PAUL A., University of Glasgow, Glasgow, UnitedKingdom, Ion-Sensitive Field-Effect Transistors

    HANLEY, JOSEPH, Hackensack University Medical, Hacken-sack, New Jersey, Radiation Therapy, Quality Assurancein

    HARLEY, BRENDAN A., Massachusetts Institute of Technol-ogy, Skin Tissue Engineering for Regeneration

    HARPER, JASON C., Sandia National Laboratories, Albu-querque, New Mexico, Microbial Detection Systems

    HASMAN, ARIE, Maastricht, The Netherlands, Medical Edu-cation, Computers in

    HASSOUNA, MAGDY, Toronto Western Hospital, Toronto,Canada, Bladder Dysfunction, Neurostimulation of

    HAYASHI, KOZABURO, Okayama University of Science,Okayama, Japan, Arteries, Elastic Properties of

    HENCH, LARRY L., Imperial College London, London, UnitedKingdom, Biomaterials: Bioceramics

    HETTRICK, DOUGLAS A., Sr. Principal Scientist Medtronic,Inc., Minneapolis, Minnesota, Bioimpedance in Cardio-vascular Medicine

    HIRSCH-KUCHMA, MELISSA, University of Central FloridaNanoScience Technology Center, Orlando, Florida,Biosurface Engineering

    CONTRIBUTOR LIST vii

  • HOLDER, GRAHAM E., Moorfields Eye Hospital, London,United Kingdom, Electroretinography

    HOLMES, TIMOTHY, St. Agnes Cancer Center, Baltimore,Maryland, Tomotherapy

    HONEYMAN-BUCK, JANICE C., University of Florida, Gaines-ville, Florida, Radiology Information Systems

    HOOPER, BRETT A., Arete Associates, Arlington, Virginia,Endoscopes

    HORN, BRUCE, Kaiser Permanente, Los Angeles, California,X-Rays Production of

    HORNER, PATRICIA I., Biomedical Engineering SocietyLandover, Maryland, Medical Engineering Societiesand Organizations

    HOROWITZ, PAUL M., University of Texas, San Antonio,Texas, Fluorescence Measurements

    HOU, XIAOLIN, Ris National Laboratory, Roskilde, Den-mark, Neutron Activation Analysis

    HOVORKA, ROMAN, University of Cambridge, Cambridge,United Kingdom, Pancreas, Artificial

    HUANG, H.K., University of Southern California, Teleradiol-ogy

    HUNT, ALAN J., University of Michigan, Ann Arbor, Michi-gan, Optical Tweezers

    HUTTEN, HELMUT, University of Technology, Graz, Australia,Impedance Plethysmography

    IAIZZO, P.A., University of Minnesota, Minneapolis, Minne-sota, Rehabilitation and Muscle Testing

    IBBOTT, GEOFFREY S., Anderson Cancer Center, Houston,Texas, Radiation Dosimetry, Three-Dimensional

    INGHAM, E., University of Leeds, Leeds, United Kingdom,Hip Joints, Artificial

    ISIK, CAN, Syracuse University, Syracuse, New York, BloodPressure Measurement

    JAMES, SUSAN P., Colorado State University, Fort Collins,Colorado, Biomaterials: Polymers

    JENSEN, WINNIE, Aalborg University, Aalborg, Denmark,Electroneurography

    JIN, CHUNMING, North Carolina State University, Raleigh,North Carolina, Biomaterials, Corrosion and Wearof

    JIN, Z.M., University of Leeds, Leeds, United Kingdom, HipJoints, Artificial

    JOHNSON, ARTHUR T., University of Maryland College Park,Maryland, Medical Engineering Societies and Organiza-tions

    JONES, JULIAN R., Imperial College London, London, UnitedKingdom, Biomaterials: Bioceramics

    JOSHI, ABHIJEET, Abbott Spine, Austin, Texas, SpinalImplants

    JUNG, RANU, Arizona State University, Tempe, Arizona,Functional Electrical Stimulation

    JURISSON, SILVIA S., University of Missouri Columbia,Missouri, Radionuclide Production and RadioactiveDecay

    KAEDING, PATRICIA J., Godfrey & Kahn S.C., Madison,Wisconsin, Codes and Regulations: Medical Devices

    KAMATH, CELIA C., Mayo Clinic, Rochester, Minnesota,Quality-of-Life Measures, Clinical Significance of

    KANE, MOLLIE, Madison, Wisconsin, Contraceptive Devices

    KATHERINE, ANDRIOLE P., Harvard Medical School, Boston,Massachusetts, Picture Archiving and CommunicationSystems

    KATSAGGELOS, AGGELOS K., Northwestern University, Evan-ston, Illinois, DNA Sequencing

    KATZ, J. LAWRENCE, University of Missouri-Kansas City,Kansas City, Missouri, Bone and Teeth, Properties of

    KESAVAN, SUNIL, Akebono Corporation, Farmington Hills,Michigan, Linear Variable Differential Transformers

    KHANG, GILSON, Chonbuk National University, Biomaterials:Tissue Engineering and Scaffolds

    KHAODHIAR, LALITA, Harvard Medical School, Boston, Mas-sachusetts, Cutaneous Blood Flow, Doppler Measurementof

    KIM, MOON SUK, Korea Research Institutes of ChemicalTechnology, Biomaterials: Tissue Engineering and Scaf-folds

    KIM, YOUNG KON, Inje University, Kimhae City, Korea,Alloys, Shape Memory

    KINDWALL, ERIC P., St. Lukes Medical Center, Milwaukee,Wisconsin, Hyperbaric Oxygenation

    KING, MICHAEL A., University of Massachusetts, North Wor-cester, Massachusetts, Nuclear Medicine, Computers in

    KLEBE, ROBERT J., University of Texas, San Antonio, Texas,Fluorescence Measurements

    KLEIN, BURTON, Burton Klein Associates, Newton, Massa-chusetts, Gas and Vacuum Systems, Centrally PipedMedical

    KNOPER, STEVEN R., University of Arizona College of Med-icine, Ventilatory Monitoring

    KONTAXAKIS, GEORGE, Universidad Politecnica de Madrid,Madrid, Spain, Positron Emission Tomography

    KOTTKE-MARCHANT, KANDICE, The Cleveland Clinic Founda-tion, Cleveland, Ohio, Vascular Graft Prosthesis

    KRIPFGANS, OLIVER, University of Michigan, Ann Arbor,Michigan, Ultrasonic Imaging

    KULKARNI, AMOL D., University of WisconsinMadison,Madison, Wisconsin, Ocular Fundus Reflectometry,Visual Field Testing

    KUMARADAS, J. CARL, Ryerson University, Toronto, Ontario,Canada, Hyperthermia, Interstitial

    KUNICKA, JOLANTA, Bayer HealthCare LLC, Tarrytown, NewYork, Differential Counts, Automated

    KWAK, KWANJ JOO, University of Miami Miller School ofMedicine, Miami, Florida, Microscopy, Scanning Force

    LAKES, RODERIC, University of Wisconsin-Madison, Boneand Teeth, Properties of

    LAKKIREDDY, DHANUNJAYA, The Cleveland Clinic Founda-tion, Cleveland, Ohio, Hyperthermia, Ultrasonic

    LARSEN, COBY, Case Western Reserve University, Cleveland,Ohio, Vascular Graft Prosthesis

    LASTER, BRENDA H., Ben Gurion University of the Negev,Beer Sheva, Israel, Monoclonal Antibodies

    LATTA, LOREN, University of Miami, Coral Gables, Florida,Rehabilitation, Orthotics in

    LEDER, RON S., Universidad Nacional Autonoma de MexicoMexico, Distrito Federal, Continuous Positive AirwayPressure

    LEE, CHIN, Harvard Medical School, Boston, Massachusetts,Radiotherapy Treatment Planning, Optimization of;Hyperthermia, Interstitial

    LEE, HAI BANG, Korea Research Institutes of ChemicalTechnology, Biomaterials: Tissue Engineering andScaffolds

    LEE, SANG JIN, Korea Research Institutes of ChemicalTechnology, Biomaterials: Tissue Engineering andScaffolds

    LEI, LIU, Department of General Engineering, Urbana,Illinois, Bioinformatics

    viii CONTRIBUTOR LIST

  • LEI, XING, Stanford University, Stanford, California, Radia-tion Dose Planning, Computer-Aided

    LEWIS, MATTHEW C., Medical College of Wisconsin, Milwau-kee, Wisconsin, Hyperbaric Oxygenation

    LI, CHAODI, University of Notre Dame, Notre Dame, Indiana,Bone Cement, Acrylic

    LI, JONATHAN G., University of Florida, Gainesville, Florida,Radiation Dose Planning, Computer-Aided

    LI, QIAO, University of Michigan, Ann Arbor, Michigan,Immunotherapy

    LI, YANBIN, University of Arkansas, Fayetteville, Arkansas,Piezoelectric Sensors

    LIBOFF, A.R., Oakland University, Rochester, Michigan,Bone Ununited Fracture and Spinal Fusion, ElectricalTreatment of

    LIGAS, JAMES, University of Connecticut, Farmington, Con-necticut, Respiratory Mechanics and Gas Exchange

    LIMOGE, AIME, The Rene Descartes University of Paris, Paris,France, Electroanalgesia, Systemic

    LIN, PEI-JAN PAUL, Beth Israel Deaconess Medical Center,Boston, Massachusets, Mammography

    LIN, ZHIYUE, University of Kansas Medical Center, KansasCity, Kansas, Electrogastrogram

    LINEAWEAVER, WILLIAM C., Unive rsity of Mississippi Med-ical Center, Jackson, Mississippi, Hyperbaric Medicine

    LIPPING, TARMO, Tampere University of Technology, Pori,Finland, Monitoring in Anesthesia

    LIU, XIAOHUA, The University of Michigan, Ann Arbor,Michigan, Polymeric Materials

    LLOYD, J.J., Regional Medical Physics Department, New-castle-upon-Tyne, United Kingdom, Ultraviolet Radiationin Medicine

    LOEB, ROBERT, University of Arizona, Tuscon, Arizona,Anesthesia Machines

    LOPES DE MELO, PEDRO, State University of Rio de Janeiro,Terreo Salas, Maracana, Thermistors

    LOUDON, ROBERT G., Lung Sounds

    LOW, DANIEL A., Washington University School of Medicine,St. Louis, Missouri, Radiation Therapy Simulator

    LU, LICHUN, Mayo Clinic, College of Medicine, Rochester,Minnesota, Microscopy, Electron

    LU, ZHENG FENG, Columbia University, New York, NewYork, Screen-Film Systems

    LYON, ANDREW W., University of Calgary, Calgary, Canada,Flame Atomic Emission Spectrometry and AtomicAbsorption Spectrometry

    LYON, MARTHA E., University of Calgary, Calgary, Canada,Flame Atomic Emission Spectrometry and AtomicAbsorption Spectrometry

    MA, C-M CHARLIE, Fox Chase Cancer Center, Philadelphia,Pennsylvania, X-Ray Therapy Equipment, Low and Med-ium Energy

    MACIA, NARCISO F., Arizona State University at the Poly-technic Campus, Mesa, Arizona, Pneumotachometers

    MACKENZIE, COLIN F., University of Maryland, School ofMedicine, Shock, Treatment of

    MACKIE, THOMAS R., University of Wisconsin, Madison,Wisconsin, Tomotherapy

    MADNANI, ANJU, LSU Medical Centre, Shreveport, Louisi-ana, Transcutaneous Electrical Nerve Stimulation(TENS)

    MADNANI, SANJAY, LSU Medical Centre, Shreveport, Louisi-ana, Transcutaneous Electrical Nerve Stimulation(TENS)

    MADSEN, MARK T., University of Iowa, Iowa City, Iowa,Anger Camera

    MAGNANO, MAURO, ENT Division Mauriziano Hospital,Torino, Italy, Drug Delivery Systems

    MANDEL, RICHARD, Boston University School of Medicine,Boston, Massachusetts, Colorimetry

    MANNING, KEEFE B., Pennsylvania State University, Uni-versity Park, Pennsylvania, Flowmeters

    MAO, JEREMY J., University of Illinois at Chicago, Chicago,Illinois, Cartilage and Meniscus, Properties of

    MARCOLONGO, MICHELE, Drexel University, Philadelphia,Pennsylvania, Spinal Implants

    MAREK, MIROSLAV, Georgia Institute of Technology, Atlanta,Georgia, Biomaterials, Corrosion and Wear of

    MARION, NICHOLAS W., University of Illinois at Chicago,Chicago, Illinois, Cartilage and Meniscus, Properties of

    MASTERS, KRISTYN S., University of Wisconsin, Madison,Wisconsin, Tissue Engineering

    MAUGHAN, RICHARD L., Hospital of the University of Penn-sylvania, Neutron Beam Therapy

    MCADAMS, ERIC, University of Ulster at Jordanstown, New-townabbey, Ireland, Bioelectrodes

    MCARTHUR, SALLY L., University of Sheffield, Sheffield,United Kingdom, Biomaterials, Surface Properties of

    MCEWEN, MALCOM, National Research Council of Canada,Ontario, Canada, Radiation Dosimetry for Oncology

    MCGOWAN, EDWARD J., E.J. McGowan & Associates, Bio-feedback

    MCGRATH, SUSAN, Dartmouth College, Hanover, New Hamp-shire, Oxygen Analyzers

    MEEKS, SANFORD L., University of Florida, Gainesville,Florida, Radiosurgery, Stereotactic

    MELISSA, PETER, University of Central Florida NanoScienceTechnology Center, Orlando, Florida, Biosurface Engi-neering

    MENDELSON, YITZHAK, Worcester Polytechnic Institute,Optical Sensors

    METZKER, MICHAEL L., Baylor College of Medicine, Houston,Texas, Polymerase Chain Reaction

    MEYEREND, M.E., University of WisconsinMadison,Madison, Wisconsin, Magnetic Resonance Imaging

    MICHLER, ROBERT, Montefiore Medical Center, Bronx, NewYork, HeartLung Machines

    MICIC, MIODRAG, MP Biomedicals LLC, Irvine, California,Microscopy and Spectroscopy, Near-Field

    MILLER, WILLIAM, University of Missouri Columbia,Missouri, Radionuclide Production and RadioactiveDecay

    MITTRA, ERIK, Stony Brook University, New York, BoneDensity Measurement

    MODELL, MARK, Harvard Medical School, Boston, Massa-chusetts, Fiber Optics in Medicine

    MORE, ROBERT B., RBMore Associates, Austin, Texas Bio-materials Carbon

    MORE, ROBERT, Austin, Texas, Heart Valves, Prosthetic

    MORROW, DARREN, Royal Adelaide Hospital, Adelaide,Australia, Intraaortic Balloon Pump

    MOURTADA, FIRAS, MD Anderson Cancer Center, Houston,Texas, Brachytherapy, Intravascular

    MOY, VINCENT T., University of Miami, Miller School ofMedicine, Miami, Florida, Microscopy, Scanning Force

    MUFTU, SINAN, Northeastern University, Boston, Massachu-setts, Tooth and Jaw, Biomechanics of

    MURPHY, RAYMOND L.H., Lung Sounds

    CONTRIBUTOR LIST ix

  • MURPHY, WILLIAM L., University of Wisconsin, Madison,Wisconsin, Tissue Engineering

    MURRAY, ALAN, Newcastle University Medical Physics, New-castle upon Tyne, United Kingdom, Pace makers

    MUTIC, SASA, Washington University School of Medicine, St.Louis, Missouri, Radiation Therapy Simulator

    NARAYAN, ROGER J., University of North Carolina, ChapelHill, North Carolina, Biomaterials, Corrosion and Wear of

    NATALE, ANDREA, The Cleveland Clinic Foundation,Cleveland, Ohio, Hyperthermia, Ultrasonic

    NAZERAN, HOMER, The University of Texas, El Paso, Texas,Electrocardiography, Computers in

    NEUMAN, MICHAEL R., Michigan Technological University,Houghton, Houghton, Michigan, Fetal Monitoring, Neo-natal Monitoring

    NEUZIL, PAVEL, Institute of Bioengineering and Nanotech-nology, Singapore, Immunologically Sensitive Field-Effect Transistors

    NICKOLOFF, EDWARD L., Columbia University, New York,New York, X-Ray Quality Control Program

    NIEZGODA, JEFFREY A., Medical College of Wisconsin,Milwaukee, Wisconsin, Hyperbaric Oxygenation

    NISHIKAWA, ROBERT M., The University of Chicago,Chicago, Illinois, Computer-Assisted Detection and Diag-nosis

    NUTTER, BRIAN, Texas Tech University, Lubbock, Texas,Medical Records, Computers in

    ODONOHUE, WILLIAM, University of Nevada, Reno, Nevada,Sexual Instrumentation

    ORTON, COLIN, Harper Hospital and Wayne State University,Detroit, Michigan, Medical Physics Literature

    OZCELIK, SELAHATTIN, Texas A&M University, Kingsville,Texas, Drug Infusion Systems

    PANITCH, ALYSSA, Arizona State University, Tempe, Arizona,Biomaterials: An Overview

    PAOLINO, DONATELLA, University of Catanzaro MagnaGrcia, Germaneto (CZ), Italy, Drug Delivery Systems

    PAPAIOANNOU, GEORGE, University of Wisconsin, Milwaukee,Wisconsin, Joints, Biomechanics of

    PARK, GRACE E., Purdue University, West Lafayette, Indi-ana, Porous Materials for Biological Applications

    PARMENTER, BRETT A., State University of New York atBuffalo, Buffalo, New York, Sleep Studies, ComputerAnalysis of

    PATEL, DIMPI, The Cleveland Clinic Foundation, Cleveland,Ohio, Hyperthermia, Ultrasonic

    PEARCE, JOHN, The University of Texas, Austin, Texas,Electrosurgical Unit (ESU)

    PELET, SERGE, Massachusetts Institute of Technology, Cam-bridge, Massachusetts, Microscopy, Fluorescence

    PERIASAMY, AMMASI, University of Virginia, Charlottesville,Virginia, Cellular Imaging

    PERSONS, BARBARA L., University of Mississippi MedicalCenter, Jackson, Mississippi, Hyperbaric Medicine

    PIPER, IAN, The University of Memphis, Memphis,Tennessee, Monitoring, Intracranial Pressure

    POLETTO, CHRISTOPHER J., National Institutes of Health,Tactile Stimulation

    PREMINGER, GLENN M., Duke University Medical Center,Durham, North Carolina, Lithotripsy

    PRENDERGAST, PATRICK J., Trinity College, Dublin, Ireland,Orthopedics, Prosthesis Fixation for

    PREVITE, MICHAEL, Massachusetts Institute of Technology,Cambridge, Massachusetts, Microscopy, Fluorescence

    PURDY, JAMES A., UC Davis Medical Center, Sacramento,California, Radiotherapy Accessories

    QI, HAIRONG, Advanced Concepts Analysis, Inc., FallsChurch, Virginia, Thermography

    QIN, YIXIAN, Stony Brook University, New York, Bone Den-sity Measurement

    QUAN, STUART F., University of Arizona, Tucson, Arizona,Ventilatory Monitoring

    QUIROGA, RODRIGO QUIAN, University of Leicester, Leicester,United Kingdom, Evoked Potentials

    RAHAGHI, FARBOD N., University of California, La Jolla,California, Glucose Sensors

    RAHKO, PETER S., University of Wisconsin Medical School,Echocardiography and Doppler Echocardiography

    RALPH, LIETO, University of WisconsinMadison, Madison,Wisconsin, Codes and Regulations: Radiation

    RAMANATHAN, LAKSHMI, Mount Sinai Medical Center, Ana-lytical Methods, Automated

    RAO, SATISH S.C., University of Iowa College of Medicine,Iowa City, Iowa, Anorectal Manometry

    RAPOPORT, DAVID M., NYU School of Medicine, New York,New York, Continuous Positive Airway Pressure

    REBELLO, KEITH J., The Johns Hopkins University AppliedPhysics Lab, Laurel, Maryland, Micro surgery

    REDDY, NARENDER, The University of Akron, Akron, Ohio,Linear Variable Differential Transformers

    REN-DIH, SHEU, Memorial Sloan-Kettering Cancer Center,New York, New York, Radiation Therapy Treatment Plan-ning, Monte Carlo Calculations in

    RENGACHARY, SETTI S., Detroit, Michigan, Human Spine,Biomechanics of

    REPPERGER, DANIEL W., Wright-Patterson Air Force Base,Dayton, Ohio, Human Factors in Medical Devices

    RITCHEY, ERIC R., The Ohio State University, Columbus,Ohio, Contact Lenses

    RIVARD, MARK J., Tufts New England Medical Center, Bos-ton, Massachusetts, Imaging Devices

    ROBERTSON, J. DAVID, University of Missouri, Columbia,Missouri, Radionuclide Production and Radioactive Decay

    ROTH, BRADLEY J., Oakland University, Rochester, Michi-gan, Defibrillators

    ROWE-HORWEGE, R. WANDA, University of Texas MedicalSchool, Houston, Texas, Hyperthermia, Systemic

    RUMSEY, JOHN W., University of Central Florida, Orlando,Florida, Biosurface Engineering

    RUTKOWSKI, GREGORY E., University of Minnesota, Duluth,Minnesota, Engineered Tissue

    SALATA, O.V., University of Oxford, Oxford, United King-dom, Nanoparticles

    SAMARAS, THEODOROS, Aristotle University of ThessalonikiDepartment of Physics, Thessaloniki, Greece, Thermo-metry

    SANGOLE, ARCHANA P., Transitional Learning Center atGalveston, Galveston, Texas, Rehabilitation, Computersin Cognitive

    SARKOZI, LASZLO, Mount Sinai School of Medicine, Analy-tical Methods, Automated

    SCHEK, HENRY III, University of Michigan, Ann Arbor,Michigan, Optical Tweezers

    SCHMITZ, CHRISTOPH H., State University of New York Down-state Medical Center, Brooklyn, New York, PeripheralVascular Noninvasive Measurements

    SCHUCKERS, STEPHANIE A.C., Clarkson University, Potsdam,New York, Arrhythmia Analysis, Automated

    x CONTRIBUTOR LIST

  • SCOPE, KENNETH, Northwestern University, Chicago,Illinois, Ventilators, Acute Medical Care

    SCOTT, ADZICK N., University of Pennsylvania, Philadelphia,Pennsylvania, Intrauterine Surgical Techniques

    SEAL, BRANDON L., Arizona State University, Tempe,Arizona, Biomaterials: An Overview

    SEALE, GARY, Transitional Learning Center atGalveston, Galveston, Texas, Rehabilitation, Computersin Cognitive

    SEGERS, PATRICK, Ghent University, Belgium, Hemody-namics

    SELIM, MOSTAFA A., Cleveland Metropolitan General Hospi-tal, Palm Coast, Florida, Colposcopy

    SETHI, ANIL, Loyola University Medical Center, Maywood,Illinois, X-Rays: Interaction with Matter

    SEVERINGHAUS, JOHN W., University of California in SanFrancisco, CO2 Electrodes

    SHALODI, ABDELWAHAB D., Cleveland Metropolitan GeneralHospital, Palm Coast, Florida, Colposcopy

    SHANMUGASUNDARAM, SHOBANA, New Jersey Institute of Tech-nology, Newark, New Jersey, Polymeric Materials

    SHARD, ALEXANDER G., University of Sheffield, SheffieldUnited Kingdom, Biomaterials, Surface Properties of

    SHEN, LI-JIUAN, National Taiwan University School of Phar-macy, Taipei, Taiwan, Colorimetry

    SHEN, WEI-CHIANG,University of Southern California Schoolof Pharmacy, Los Angeles, California, Colorimetry

    SHERAR, MICHAEL D., London Health Sciences Centre andUniversity of Western Ontario, London, Ontario, Canada,Hyperthermia, Interstitial

    SHERMAN, DAVID, The Johns Hopkins University, Baltimore,Maryland, Electroencephalography

    SHI, DONGLU, University of Cincinnati, Cincinnati, Ohio,Biomaterials, Testing and Structural Properties of

    SHUCARD, DAVID W.M., State University of New York atBuffalo, Buffalo, New York, Sleep Studies, ComputerAnalysis of

    SIEDBAND, MELVIN P., University of Wisconsin, Madison,Wisconsin, Image Intensifiers and Fluoroscopy

    SILBERMAN, HOWARD, University of Southern California, LosAngeles, California, Nutrition, Parenteral

    SILVERMAN, GORDON, Manhattan College, Computers in theBiomedical Laboratory

    SILVERN, DAVID A., Medical Physics Unit, Rabin MedicalCenter, Petah Tikva, Israel, Prostate Seed Implants

    SINHA, PIYUSH, The Ohio State University, Columbus, Ohio,Drug Delivery Systems

    SINHA, ABHIJIT ROY, University of Cincinnati, Cin-cinnati, Ohio, Coronary Angioplasty and GuidewireDiagnostics

    SINKJR, THOMAS, Aalborg University, Aalborg, Denmark,Electroneurography

    SLOAN, JEFFREY A., Mayo Clinic, Rochester, Minnesota,Quality-of-Life Measures, Clinical Significance of

    SO, PETER T.C., Massachusetts Institute of Technology,Cambridge, Massachusetts, Microscopy, Fluorescence

    SOBOL, WLAD T., University of Alabama at BirminghamHealth System, Birmingham, Alabama, Nuclear Mag-netic Resonance Spectroscopy

    SOOD, SANDEEP, University of Illinois at Chicago, Chicago,Illinois, Hydrocephalus, Tools for Diagnosis and Treat-ment of

    SPECTOR, MYRON, Brigham and Womens Hospital, Boston,Massachusetts, Biocompatibility of Materials

    SPELMAN, FRANCIS A., University of Washington, CochlearProstheses

    SRINIVASAN, YESHWANTH, Texas Tech University, Lubbock,Texas, Medical Records, Computers in

    SRIRAM, NEELAMEGHAM, University of Buffalo, Buffalo, NewYork, Cell Counters, Blood

    STARKO, KENTON R., Point Roberts, Washington, Physiolo-gical Systems Modeling

    STARKSCHALL, GEORGE, The University of Texas, Radiother-apy, Three-Dimensional Conformal

    STAVREV, PAVEL, Cross Cancer Institute, Edmonton, Alberta,Canada, Radiotherapy Treatment Planning, Optimiza-tion of

    STENKEN, JULIE A., Rensselaer Polytechnic Institute, Troy,New York, Microdialysis Sampling

    STIEFEL, ROBERT, University of Maryland Medical Center,Baltimore, Maryland, Equipment Acquisition

    STOKES, I.A.F., Polytechniquie Montreal, Montreal Quebec,Canada, Scoliosis, Biomechanics of

    STONE, M.H., University of Leeds, Leeds, United Kingdom,Hip Joints, Artificial

    SU, XIAo-LI, BioDetection Instruments LLC, Fayetteville,Arkansas, Piezoelectric Sensors

    SUBHAN, ARIF, Masterplan Technology Management,Chatsworth, California, Equipment Maintenance,Biomedical

    SWEENEY, JAMES D., Arizona State University, Tempe,Arizona, Functional Electrical Stimulation

    SZETO, ANDREW Y.J., San Diego State University, San Diego,California, Blind and Visually Impaired, Assistive Tech-nology for

    TAKAYAMA, SHUICHI, University of Michigan, Ann Arbor,Michigan, Microbioreactors

    TAMUL, PAUL C., Northwestern University, Chicago, Illinois,Ventilators, Acute Medical Care

    TAMURA, TOSHIYO, Chiba University School of Engineering,Chiba, Japan, Home Health Care Devices

    TANG, XIANGYANG, GE Healthcare Technologies, Wankesha,Wisconsin, Computed Tomography Simulators

    TAYLOR, B.C., The University of Akron, Akron, Ohio, CardiacOutput, Indicator Dilution Measurement of

    TEMPLE, RICHARD O., Transitional Learning Center atGalveston, Galveston, Texas, Rehabilitation, Computersin Cognitive

    TEN, STANLEY, Salt Lake City, Utah, Electroanalgesia, Sys-temic

    TERRY, TERESA M., Walter Reed Army Institute ofResearch, Rockville, Maryland, Blood Collection andProcessing

    THAKOR, N.V., Johns Hopkins University, Baltimore, Mary-land, Neurological Monitors

    THIERENS, HUBERT M.A., University of Ghent, Ghent, Bel-gium, Radiopharmaceutical Dosimetry

    THOMADSEN, BRUCE, University of WisconsinMadison,Madison, Wisconsin, Codes and Regulations: Radiation

    TIPPER, J.L., University of Leeds, Leeds, United Kingdom,Hip Joints, Artificial

    TOGAWA, TATSUO, Waseda University, Saitama, Japan, Inte-grated Circuit Temperature Sensor

    TORNAI, MARTIN, Duke University, Durham, North Carolina,X-Ray Equipment Design

    TRAN-SON-TAY, ROGER, University of Florida, Gainesville,Florida, Blood Rheology

    CONTRIBUTOR LIST xi

  • TRAUTMAN, EDWIN D., RMF Strategies, Cambridge, Massa-chusetts, Cardiac Output, Thermodilution Measurementof

    TREENA, LIVINGSTON ARINZEH, New Jersey Institute of Tech-nology, Newark, New Jersey, Polymeric Materials

    TRENTMAN, TERRENCE L., Mayo Clinic Scottsdale, SpinalCord Stimulation

    TROKEN, ALEXANDER J., University of Illinois at Chicago,Chicago, Illinois, Cartilage and Meniscus, Properties of

    TSAFTARIS, SOTIRIOS A., Northwestern University, Evanston,Illinois, DNA Sequence

    TSOUKALAS, D., NTUA, Athens, Attiki, Greece, CapacitiveMicrosensors for Biomedical Applications

    TULIPAN, NOEL, Vanderbilt University Medical Center,Nashville, Tennessee, Intrauterine Surgical Techniques

    TUTEJA, ASHOK K., University of Utah, Salt Lake City, Utah,Anorectal Manometry

    TY, SMITH N., University of California, San Diego, Califor-nia, Physiological Systems Modeling

    TYRER, HARRY W., University of Missouri-Columbia, Colum-bia, Missouri, Cytology, Automated

    VALVANO, JONATHAN W., The University of Texas, Austin,Texas, Bioheat Transfer

    VAN DEN HEUVAL, FRANK, Wayne State University, Detroit,Michigan, Imaging Devices

    VEIT, SCHNABEL, Aalborg University, Aalborg, Denmark,Electroneurography

    VELANOVICH, VIC, Henry Ford Hospital, Detroit, Michigan,Esophageal Manometry

    VENKATASUBRAMANIAN, GANAPRIYA, Arizona StateUniversity, Tempe, Arizona, Functional ElectricalStimulation

    VERAART, CLAUDE, Catholique University of Louvain, Brus-sels, Belgium, Visual Prostheses

    VERDONCK, PASCAL, Ghent University, Belgium, Hemody-namics

    VERMARIEN, HERMAN, Vrije Universiteit Brussel, Brussels,Belgium, Phonocardiography, Recorders, Graphic

    VEVES, ARISTIDIS, Harvard Medical School, Boston, Mass-achusetts, Cutaneous Blood Flow, Doppler Measurementof

    VICINI, PAOLO, University of Washington, Seattle, Washing-ton, Pharmacokinetics and Pharmacodynamics

    VILLE, JANTTI, Tampere University of Technology, Pori,Finland, Monitoring in Anesthesia

    VRBA, JINI, VSM MedTech Ltd., Biomagnetism

    WAGNER, THOMAS, H., M. D. Anderson Cancer CenterOrlando, Orlando, Florida, Radiosurgery, Stereotactic

    WAHLEN, GEORGE E., Veterans Affairs Medical Center andthe University of Utah, Salt Lake City, Utah, AnorectalManometry

    WALKER, GLENN M., North Carolina State University,Raleigh, North Carolina, Microfluidics

    WALTERSPACHER, DIRK, The Johns Hopkins University, Bal-timore, Maryland, Electroencephalography

    WAN, LEO Q., Liu Ping, Columbia University, New York,New York, Cartilage and Meniscus, Properties of

    WANG, GE, University of Iowa, Iowa City, Iowa, ComputedTomography Simulators

    WANG, HAIBO, Louisiana State University Health CenterShreveport, Louisiana, Monitoring, Umbilical Arteryand Vein, Ambulatory Monitoring

    WANG, HONG, Wayne State University, Detroit, Michigan,Anesthesia, Computers in

    WANG, LE YI, Wayne State University, Detroit, Michigan,Anesthesia, Computers in

    WANG, QIAN, A & M University Health Science Center,Dallas, Texas, Strain Gages

    WARWICK, WARREN J., University of Minnesota MedicalSchool, Minneapolis, Minnesota, Cystic Fibrosis SweatTest

    WATANABE, YOICHI, Columbia University RadiationOncology, New York, New York, Phantom Materials inRadiology

    WAXLER, MORRIS, Godfrey & Kahn S.C., Madison, Wiscon-sin, Codes and Regulations: Medical Devices

    WEBSTER, THOMAS J., Purdue University, West Lafayette,Indiana, Porous Materials for Biological Applications

    WEGENER, JOACHIM, University of Oslo, Oslo, Norway, Impe-dance Spectroscopy

    WEI, SHYY, University of Michigan, Ann Arbor, Michigan,Blood Rheology

    WEINMEISTER, KENT P., Mayo Clinic Scottsdale, Spinal CordStimulation

    WEIZER, ALON Z., Duke University Medical Center, Durham,North Carolina, Lithotripsy

    WELLER, PETER, City University , London, United Kingdom,Intraaortic Balloon Pump

    WELLS, JASON, LSU Medical Centre, Shreveport, Louisiana,Transcutaneous Electrical Nerve Stimulation (TENS)

    WENDELKEN, SUZANNE, Dartmouth College, Hanover, NewHampshire, Oxygen Analyzers

    WHELAN, HARRY T., Medical College of Wisconsin, Milwau-kee, Wisconsin, Hyperbaric Oxygenation

    WHITE, ROBERT, Memorial Hospital, Regional NewbornProgram, South Bend, Indiana, Incubators, Infant

    WILLIAMS, LAWRENCE E., City of Hope, Duarte, California,Nuclear Medicine Instrumentation

    WILSON, KERRY, University of Central Florida, Orlando,Florida, Biosurface Engineering

    WINEGARDEN, NEIL, University Health Network MicroarrayCentre, Toronto, Ontario, Canada, Microarrays

    WOJCIKIEWICZ, EWA P., University of Miami Miller Schoolof Medicine, Miami, Florida, Microscopy, ScanningForce

    WOLBARST, ANTHONY B., Georgetown Medical School,Washington, DC, Radiotherapy Treatment Planning,Optimization of

    WOLF, ERIK, University of Pittsburgh, Pittsburgh, Pennsyl-vania, Mobility Aids

    WOOD, ANDREW, Swinburne University of Technology, Mel-bourne, Australia, Nonionizing Radiation, BiologicalEffects of

    WOODCOCK, BRIAN, University of Michigan, Ann Arbor,Michigan, Blood, Artificial

    WREN, JOAKIM, Linkoping University, Linkoping, Sweden,Thermocouples

    XIANG, ZHOU, Brigham and Womens Hospital, Boston, Mas-sachusetts, Biocompatibility of Materials

    XUEJUN, WEN, Clemson University, Clemson, SouthCarolina, Biomaterials, Testing and Structural Proper-ties of

    YAN, ZHOU, University of Notre Dame, Notre Dame, Indiana,Bone Cement, Acrylic

    YANNAS, IOANNIS V., Massachusetts Institute of Technology,Skin Tissue Engineering for Regeneration

    YASZEMSKI, MICHAEL J., Mayo Clinic, College of Medicine,Rochester, Minnesota, Microscopy, Electron

    xii CONTRIBUTOR LIST

  • YENI, YENER N., Henry Ford Hospital, Detroit, Michigan,Joints, Biomechanics of

    YLI-HANKALA, ARVI, Tampere University of Technology, Pori,Finland, Monitoring in Anesthesia

    YOKO, KAMOTANI, University of Michigan, Ann Arbor, Michi-gan, Microbioreactors

    YOON, KANG JI, Korea Institute of Science and Technology,Seoul, Korea, Micropower for Medical Applications

    YORKE, ELLEN, Memorial Sloan-Kettering Cancer Center,New York, New York, Radiation Therapy Treatment Plan-ning, Monte Carlo Calculations in

    YOSHIDA, KEN, Aalborg University, Aalborg, Denmark, Elec-troneurography

    YOUNGSTEDT, SHAWN D., University of South Carolina,Columbia, South Carolina, Sleep Laboratory

    YU, YIH-CHOUNG, Lafayette College, Easton, Pennsylvania,Blood Pressure, Automatic Control of

    ZACHARIAH, EMMANUEL S., University of Medicine and Den-tistry of New Jersey, New Brunswick, New Jersey, Immu-nologically Sensitive Field-Effect Transistors

    ZAIDER, MARCO, Memorial Sloan Kettering Cancer Center,New York, New York, Prostate Seed Implants

    ZAPANTA, CONRAD M., Penn State College of Medicine,Hershey, Pennsylvania, Heart, Artificial

    ZARDENETA, GUSTAVO, University of Texas, San Antonio,Texas, Fluorescence Measurements

    ZELMANOVIC, DAVID, Bayer HealthCare LLC, Tarrytown,New York, Differential Counts, Automated

    ZHANG, MIN, University of Washington, Seattle, Washington,Biomaterials: Polymers

    ZHANG, YI, University of Buffalo, Buffalo, New York, CellCounters, Blood

    ZHU, XIAOYUE, University of Michigan, Ann Arbor, Michi-gan, Microbioreactors

    ZIAIE, BABAK, Purdue University, W. Lafayette, Indiana,Biotelemetry

    ZIELINSKI, TODD M., Medtronic, Inc., Minneapolis, Minne-sota, Bioimpedance in Cardiovascular Medicine

    ZIESSMAN, HARVEY A., Johns Hopkins University, ComputedTomography, Single Photon Emission

    CONTRIBUTOR LIST xiii

  • PREFACE

    This six-volume work is an alphabetically organized compi-lation of almost 300 articles that describe critical aspects ofmedical devices and instrumentation.

    It is comprehensive. The articles emphasize the contri-butions of engineering, physics, and computers to each of thegeneral areas of anesthesiology, biomaterials, burns, cardi-ology, clinical chemistry, clinical engineering, communica-tive disorders, computers in medicine, critical caremedicine, dermatology, dentistry, ear, nose, and throat,emergency medicine, endocrinology, gastroenterology,genetics, geriatrics, gynecology, hematology, heptology,internal medicine, medical physics, microbiology, nephrol-ogy, neurology, nutrition, obstetrics, oncology, ophthalmol-ogy, orthopedics, pain, pediatrics, peripheral vasculardisease, pharmacology, physical therapy, psychiatry, pul-monary medicine, radiology, rehabilitation, surgery, tissueengineering, transducers, and urology.

    The discipline is defined through the synthesis of the coreknowledge from all the fields encompassed by the applica-tion of engineering, physics, and computers to problems inmedicine. The articles focus not only on what is now usefulbut also on what is likely to be useful in future medicalapplications.

    These volumes answer the question, What are thebranches of medicine and how does technology assist eachof them? rather than What are the branches of technologyand how could each be used in medicine? To keep this workto a manageable length, the practice of medicine that isunassisted by devices, such as the use of drugs to treatdisease, has been excluded.

    The articles are accessible to the user; each benefits frombrevity of condensation instead of what could easily havebeen a book-length work. The articles are designed not forpeers, but rather for workers from related fields who wish totake a first look at what is important in the subject.

    The articles are readable. They do not presume a detailedbackground in the subject, but are designed for any personwith a scientific background and an interest in technology.Rather than attempting to teach the basics of physiology orOhms law, the articles build on such basic concepts to showhow the worlds of life science and physical science meld toproduce improved systems. While the ideal reader might bea person with a Masters degree in biomedical engineering ormedical physics or an M.D. with a physical science under-graduate degree, much of the material will be of value toothers with an interest in this growing field. High schoolstudents and hospital patients can skip over more technicalareas and still gain much from the descriptive presentations.

    The Encyclopedia of Medical Devices and Instrumenta-tion is excellent for browsing and searching for those newdivergent associations that may advance work in a periph-eral field. While it can be used as a reference for facts, thearticles are long enough that they can serve as an educa-tional instrument and provide genuine understanding of asubject.

    One can use this work just as one would use a dictionary,since the articles are arranged alphabetically by topic. Crossreferences assist the reader looking for subjects listed underslightly different names. The index at the end leads thereader to all articles containing pertinent information onany subject. Listed on pages xxi to xxx are all the abbrevia-tions and acronyms used in the Encyclopedia. Because ofthe increasing use of SI units in all branches of science, theseunits are provided throughout the Encyclopedia articles aswell as on pages xxxi to xxxv in the section on conversionfactors and unit symbols.

    I owe a great debt to the many people who have con-tributed to the creation of this work. At John Wiley & Sons,Encyclopedia Editor George Telecki provided the idea andguiding influence to launch the project. Sean Pidgeon wasEditorial Director of the project. Assistant Editors RoseannZappia, Sarah Harrington, and Surlan Murrell handled themyriad details of communication between publisher, editor,authors, and reviewers and stimulated authors andreviewers to meet necessary deadlines.

    My own background has been in the electrical aspects ofbiomedical engineering. I was delighted to have the assis-tance of the editorial board to develop a comprehensiveencyclopedia. David J. Beebe suggested cellular topics suchas microfluidics. Jerry M. Calkins assisted in defining thechemically related subjects, such as anesthesiology.Michael R. Neuman suggested subjects related to sensors,such as in his own workneonatology. Joon B. Park haswritten extensively on biomaterials and suggested relatedsubjects. Edward S. Sternick provided many suggestionsfrom medical physics. The Editorial Board was instrumen-tal both in defining the list of subjects and in suggestingauthors.

    This second edition brings the field up to date. It isavailable on the web at http://www.mrw.interscience.wiley.com/emdi, where articles can be searched simultaneously toprovide rapid and comprehensive information on all aspectsof medical devices and instrumentation.

    JOHN G. WEBSTERUniversity of Wisconsin, Madison

    xv

  • LIST OF ARTICLES

    ALLOYS, SHAPE MEMORYAMBULATORY MONITORINGANALYTICAL METHODS, AUTOMATEDANESTHESIA MACHINESANESTHESIA, COMPUTERS INANGER CAMERAANORECTAL MANOMETRYARRHYTHMIA ANALYSIS, AUTOMATEDARTERIES, ELASTIC PROPERTIES OFAUDIOMETRYBIOCOMPATIBILITY OF MATERIALSBIOELECTRODESBIOFEEDBACKBIOHEAT TRANSFERBIOIMPEDANCE IN CARDIOVASCULAR MEDICINEBIOINFORMATICSBIOMAGNETISMBIOMATERIALS, ABSORBABLEBIOMATERIALS: AN OVERVIEWBIOMATERIALS: BIOCERAMICSBIOMATERIALS: CARBONBIOMATERIALS, CORROSION AND WEAR OFBIOMATERIALS FOR DENTISTRYBIOMATERIALS: POLYMERSBIOMATERIALS, SURFACE PROPERTIES OFBIOMATERIALS, TESTING AND STRUCTURAL

    PROPERTIES OFBIOMATERIALS: TISSUE ENGINEERING AND

    SCAFFOLDSBIOMECHANICS OF EXERCISE FITNESSBIOMEDICAL ENGINEERING EDUCATIONBIOSURFACE ENGINEERINGBIOTELEMETRYBLADDER DYSFUNCTION, NEUROSTIMULATION

    OFBLIND AND VISUALLY IMPAIRED, ASSISTIVE

    TECHNOLOGY FORBLOOD COLLECTION AND PROCESSINGBLOOD GAS MEASUREMENTSBLOOD PRESSURE MEASUREMENTBLOOD PRESSURE, AUTOMATIC CONTROL OFBLOOD RHEOLOGYBLOOD, ARTIFICIALBONE AND TEETH, PROPERTIES OFBONE CEMENT, ACRYLICBONE DENSITY MEASUREMENTBONE UNUNITED FRACTURE AND SPINAL FUSION,

    ELECTRICAL TREATMENT OFBORON NEUTRON CAPTURE THERAPYBRACHYTHERAPY, HIGH DOSAGE RATEBRACHYTHERAPY, INTRAVASCULARCAPACITIVE MICROSENSORS FOR BIOMEDICAL

    APPLICATIONS

    CARDIAC OUTPUT, FICK TECHNIQUE FORCARDIAC OUTPUT, INDICATOR DILUTION

    MEASUREMENT OFCARDIAC OUTPUT, THERMODILUTION

    MEASUREMENT OFCARDIOPULMONARY RESUSCITATIONCARTILAGE AND MENISCUS, PROPERTIES OFCELL COUNTERS, BLOODCELLULAR IMAGINGCHROMATOGRAPHYCO2 ELECTRODESCOBALT 60 UNITS FOR RADIOTHERAPYCOCHLEAR PROSTHESESCODES AND REGULATIONS: MEDICAL DEVICESCODES AND REGULATIONS: RADIATIONCOLORIMETRYCOLPOSCOPYCOMMUNICATION DEVICESCOMMUNICATIVE DISORDERS, COMPUTER

    APPLICATIONS FORCOMPUTED TOMOGRAPHYCOMPUTED TOMOGRAPHY SCREENINGCOMPUTED TOMOGRAPHY SIMULATORSCOMPUTED TOMOGRAPHY, SINGLE PHOTON

    EMISSIONCOMPUTER-ASSISTED DETECTION AND DIAGNOSISCOMPUTERS IN THE BIOMEDICAL LABORATORYCONTACT LENSESCONTINUOUS POSITIVE AIRWAY PRESSURECONTRACEPTIVE DEVICESCORONARY ANGIOPLASTY AND GUIDEWIRE

    DIAGNOSTICSCRYOSURGERYCUTANEOUS BLOOD FLOW, DOPPLER

    MEASUREMENT OFCYSTIC FIBROSIS SWEAT TESTCYTOLOGY, AUTOMATEDDEFIBRILLATORSDIFFERENTIAL COUNTS, AUTOMATEDDIGITAL ANGIOGRAPHYDNA SEQUENCEDRUG DELIVERY SYSTEMSDRUG INFUSION SYSTEMSECHOCARDIOGRAPHY AND DOPPLER

    ECHOCARDIOGRAPHYELECTROANALGESIA, SYSTEMICELECTROCARDIOGRAPHY, COMPUTERS INELECTROCONVULSIVE THERAPYELECTROENCEPHALOGRAPHYELECTROGASTROGRAMELECTROMYOGRAPHYELECTRONEUROGRAPHYELECTROPHORESIS

    xvii

  • ELECTROPHYSIOLOGYELECTRORETINOGRAPHYELECTROSURGICAL UNIT (ESU)ENDOSCOPESENGINEERED TISSUEENVIRONMENTAL CONTROLEQUIPMENT ACQUISITIONEQUIPMENT MAINTENANCE, BIOMEDICALESOPHAGEAL MANOMETRYEVOKED POTENTIALSEXERCISE STRESS TESTINGEYE MOVEMENT, MEASUREMENT TECHNIQUES FORFETAL MONITORINGFIBER OPTICS IN MEDICINEFLAME ATOMIC EMISSION SPECTROMETRY AND

    ATOMIC ABSORPTION SPECTROMETRYFLOWMETERSFLUORESCENCE MEASUREMENTSFUNCTIONAL ELECTRICAL STIMULATIONGAMMA KNIFEGAS AND VACUUM SYSTEMS, CENTRALLY PIPED

    MEDICALGASTROINTESTINAL HEMORRHAGEGLUCOSE SENSORSHEART VALVE PROSTHESESHEART VALVE PROSTHESES, IN VITRO FLOW

    DYNAMICS OFHEART VALVES, PROSTHETICHEART, ARTIFICIALHEARTLUNG MACHINESHEAT AND COLD, THERAPEUTICHEMODYNAMICSHIGH FREQUENCY VENTILATIONHIP JOINTS, ARTIFICIALHOME HEALTH CARE DEVICESHUMAN FACTORS IN MEDICAL DEVICESHUMAN SPINE, BIOMECHANICS OFHYDROCEPHALUS, TOOLS FOR DIAGNOSIS

    AND TREATMENT OFHYPERBARIC MEDICINEHYPERBARIC OXYGENATIONHYPERTHERMIA, INTERSTITIALHYPERTHERMIA, SYSTEMICHYPERTHERMIA, ULTRASONICIMAGE INTENSIFIERS AND FLUOROSCOPYIMAGING DEVICESIMMUNOLOGICALLY SENSITIVE FIELD-EFFECT

    TRANSISTORSIMMUNOTHERAPYIMPEDANCE PLETHYSMOGRAPHYIMPEDANCE SPECTROSCOPYINCUBATORS, INFANTINTEGRATED CIRCUIT TEMPERATURE SENSORINTRAAORTIC BALLOON PUMPINTRAUTERINE SURGICAL TECHNIQUESIONIZING RADIATION, BIOLOGICAL EFFECTS OFION-SENSITIVE FIELD-EFFECT TRANSISTORSJOINTS, BIOMECHANICS OFLARYNGEAL PROSTHETIC DEVICESLENSES, INTRAOCULARLIGAMENT AND TENDON, PROPERTIES OF

    LINEAR VARIABLE DIFFERENTIAL TRANSFORMERSLITHOTRIPSYLIVER TRANSPLANTATIONLUNG SOUNDSMAGNETIC RESONANCE IMAGINGMAMMOGRAPHYMEDICAL EDUCATION, COMPUTERS INMEDICAL ENGINEERING SOCIETIES

    AND ORGANIZATIONSMEDICAL GAS ANALYZERSMEDICAL PHYSICS LITERATUREMEDICAL RECORDS, COMPUTERS INMICROARRAYSMICROBIAL DETECTION SYSTEMSMICROBIOREACTORSMICRODIALYSIS SAMPLINGMICROFLUIDICSMICROPOWER FOR MEDICAL APPLICATIONSMICROSCOPY AND SPECTROSCOPY, NEAR-FIELDMICROSCOPY, CONFOCALMICROSCOPY, ELECTRONMICROSCOPY, FLUORESCENCEMICROSCOPY, SCANNING FORCEMICROSCOPY, SCANNING TUNNELINGMICROSURGERYMINIMALLY INVASIVE SURGERYMOBILITY AIDSMONITORING IN ANESTHESIAMONITORING, HEMODYNAMICMONITORING, INTRACRANIAL PRESSUREMONITORING, UMBILICAL ARTERY AND VEINMONOCLONAL ANTIBODIESNANOPARTICLESNEONATAL MONITORINGNEUROLOGICAL MONITORSNEUTRON ACTIVATION ANALYSISNEUTRON BEAM THERAPYNONIONIZING RADIATION, BIOLOGICAL EFFECTS OFNUCLEAR MAGNETIC RESONANCE SPECTROSCOPYNUCLEAR MEDICINE INSTRUMENTATIONNUCLEAR MEDICINE, COMPUTERS INNUTRITION, PARENTERALOCULAR FUNDUS REFLECTOMETRYOCULAR MOTILITY RECORDING AND NYSTAGMUSOFFICE AUTOMATION SYSTEMSOPTICAL SENSORSOPTICAL TWEEZERSORTHOPEDIC DEVICES, MATERIALS AND

    DESIGN FORORTHOPEDICS, PROSTHESIS FIXATION FOROXYGEN ANALYZERSOXYGEN MONITORINGPACEMAKERSPANCREAS, ARTIFICIALPERIPHERAL VASCULAR NONINVASIVE

    MEASUREMENTSPHANTOM MATERIALS IN RADIOLOGYPHARMACOKINETICS AND PHARMACODYNAMICSPHONOCARDIOGRAPHYPHOTOGRAPHY, MEDICALPHYSIOLOGICAL SYSTEMS MODELING

    xviii LIST OF ARTICLES

  • PICTURE ARCHIVING AND COMMUNICATIONSYSTEMS

    PIEZOELECTRIC SENSORSPNEUMOTACHOMETERSPOLYMERASE CHAIN REACTIONPOLYMERIC MATERIALSPOROUS MATERIALS FOR BIOLOGICAL

    APPLICATIONSPOSITRON EMISSION TOMOGRAPHYPROSTATE SEED IMPLANTSPULMONARY PHYSIOLOGYQUALITY-OF-LIFE MEASURES, CLINICAL

    SIGNIFICANCE OFRADIATION DOSE PLANNING, COMPUTER-AIDEDRADIATION DOSIMETRY FOR ONCOLOGYRADIATION DOSIMETRY, THREE-DIMENSIONALRADIATION PROTECTION INSTRUMENTATIONRADIATION THERAPY, INTENSITY MODULATEDRADIATION THERAPY SIMULATORRADIATION THERAPY TREATMENT PLANNING,

    MONTE CARLO CALCULATIONS INRADIATION THERAPY, QUALITY ASSURANCE INRADIOLOGY INFORMATION SYSTEMSRADIONUCLIDE PRODUCTION AND

    RADIOACTIVE DECAYRADIOPHARMACEUTICAL DOSIMETRYRADIOSURGERY, STEREOTACTICRADIOTHERAPY ACCESSORIESRADIOTHERAPY, HEAVY IONRADIOTHERAPY, INTRAOPERATIVERADIOTHERAPY, THREE-DIMENSIONAL CONFORMALRADIOTHERAPY TREATMENT PLANNING,

    OPTIMIZATION OFRECORDERS, GRAPHICREHABILITATION AND MUSCLE TESTINGREHABILITATION, COMPUTERS IN COGNITIVEREHABILITATION, ORTHOTICS INRESIN-BASED COMPOSITESRESPIRATORY MECHANICS AND GAS EXCHANGESAFETY PROGRAM, HOSPITALSCOLIOSIS, BIOMECHANICS OFSCREEN-FILM SYSTEMS

    SEXUAL INSTRUMENTATIONSHOCK, TREATMENT OFSKIN SUBSTITUTE FOR BURNS, BIOACTIVESKIN TISSUE ENGINEERING FOR REGENERATIONSKIN, BIOMECHANICS OFSLEEP LABORATORYSLEEP STUDIES, COMPUTER ANALYSIS OFSPINAL CORD STIMULATIONSPINAL IMPLANTSSTATISTICAL METHODSSTEREOTACTIC SURGERYSTERILIZATION OF BIOLOGIC SCAFFOLD

    MATERIALSSTRAIN GAGESTACTILE STIMULATIONTELERADIOLOGYTEMPERATURE MONITORINGTHERMISTORSTHERMOCOUPLESTHERMOGRAPHYTHERMOMETRYTISSUE ABLATIONTISSUE ENGINEERINGTOMOTHERAPYTONOMETRY, ARTERIALTOOTH AND JAW, BIOMECHANICS OFTRACER KINETICSTRANSCUTANEOUS ELECTRICAL NERVE

    STIMULATION (TENS)ULTRASONIC IMAGINGULTRAVIOLET RADIATION IN MEDICINEVASCULAR GRAFT PROSTHESISVENTILATORS, ACUTE MEDICAL CAREVENTILATORY MONITORINGVISUAL FIELD TESTINGVISUAL PROSTHESESX-RAY EQUIPMENT DESIGNX-RAY QUALITY CONTROL PROGRAMX-RAY THERAPY EQUIPMENT, LOW AND

    MEDIUM ENERGYX-RAYS: INTERACTION WITH MATTERX-RAYS, PRODUCTION OF

    LIST OF ARTICLES xix

  • ABBREVIATIONS AND ACRONYMS

    AAMI Association for the Advancement ofMedical Instrumentation

    AAPM American Association of Physicists inMedicine

    ABC Automatic brightness controlABET Accreditation board for engineering

    trainingABG Arterial blood gasesABLB Alternative binaural loudness balanceABS Acrylonitrilebutadienestyreneac Alternating currentAC Abdominal circumference; Affinity

    chromatographyACA Automated clinical analyzerACES Augmentative communication evaluation

    systemACL Anterior chamber lensACLS Advanced cardiac life supportACOG American College of Obstetrics and

    GynecologyACR American College of RadiologyACS American Cancer Society; American

    College of SurgeonsA/D Analog-to-digitalADC Agar diffusion chambers; Analog-to-

    digital converterADCC Antibody-dependent cellular

    cytotoxicityADCL Accredited Dosimetry Calibration

    LaboratoriesADP Adenosine diphosphateA-D-T Admission, discharge, and transferAE Anion exchange; Auxiliary electrodeAEA Articulation error analysisAEB Activation energy barrierAEC Automatic exposure controlAED Automatic external defibrillatorAEMB Alliance for Engineering in Medicine

    and BiologyAES Auger electron spectroscopyAESC American Engineering Standards

    CommitteeAET Automatic exposure terminationAFO Ankle-foot orthosisAGC Automatic gain controlAHA American Heart AssociationAI Arterial insufficiencyAICD Automatic implantable cardiac

    defibrillatorAID Agency for International DevelopmentAIDS Acquired immune deficiency syndromeAL Anterior leafletALG Antilymphocyte globulin

    ALS Advanced life support; Amyotropiclateral sclerosis

    ALT Alanine aminotransferaseALU Arithmetic and logic unitAM Amplitude modulationAMA American Medical Associationamu Atomic mass unitsANOVA Analysis of varianceANSI American National Standards InstituteAP Action potential; Alternative pathway;

    AnteroposteriorAPD Anterioposterior diameterAPL Adjustable pressure limiting valve;

    Applied Physics LaboratoryAPR Anatomically programmed radiographyAR Amplitude reduction; Aortic

    regurgitation; AutoregressiveAra-C ArabinosylcytosineARD Absorption rate densityARDS Adult respiratory distress syndromeARGUS Arrhythmia guard systemARMA Autoregressive-moving-average modelARMAX Autoregressive-moving-average model

    with external inputsAS Aortic stenosisASA American Standards AssociationASCII American standard code for information

    interchangeASD Antisiphon deviceASHE American Society for Hospital EngineeringASTM American Society for Testing and

    MaterialsAT Adenosine-thiamide; Anaerobic threshold;

    AntithrombinATA Atmosphere absoluteATLS Advanced trauma life supportATN Acute tubular necrosisATP Adenosine triphosphateATPD Ambient temperature pressure dryATPS Ambient temperature pressure

    saturatedATR Attenuated total reflectionAUC Area under curveAUMC Area under moment curveAV AtrioventricularAZT Azido thymidineBA Biliary atresiaBAEP Brainstem auditory evoked potentialBAPN Beta-amino-proprionitrylBAS Boston anesthesis systemBASO BasophilBB Buffer baseBBT Basal body temperature

    xxi

  • BCC Body-centered cubicBCD Binary-coded decimalBCG BallistocardiogramBCLS Basic cardiac life supportBCRU British Commitee on Radiation Units

    and MeasurementsBDI Beck depression inventoryBE Base excess; Binding energyBET Brunauer, Emmett, and Teller methodsBH His bundleBI Biological indicatorsBIH Beth Israel HospitalBIPM International Bureau of Weights and

    MeasurementsBJT Bipolar junction transistorBMDP Biomedical ProgramsBME Biomedical engineeringBMET Biomedical equipment technicianBMO Biomechanically optimizedBMR Basal metabolic rateBOL Beginning of lifeBP Bereitschafts potential; Break pointBR PolybutadieneBRM Biological response modifierBRS Bibliographic retrieval servicesBSS Balanced salt solutionBTG Beta thromboglobulinBTPS Body temperature pressure saturatedBUN Blood urea nitrogenBW Body weightCA Conductive adhesivesCABG Coronary artery by-pass graftingCAD/CAM Computer-aided design/computer-aided

    manufacturingCAD/D Computer-aided drafting and designCADD Central axis depth doseCAI Computer assisted instruction;

    Computer-aided instructionCAM Computer-assisted managementcAMP Cyclic AMPCAPD Continuous ambulatory peritoneal

    dialysisCAPP Child amputee prosthetic projectCAT Computerized axial tomographyCATS Computer-assisted teaching system;

    Computerized aphasia treatment systemCAVH Continuous arteriovenous hemofiltrationCB Conjugated bilirubin; Coulomb barrierCBC Complete blood countCBF Cerebral blood flowCBM Computer-based managementCBV Cerebral blood volumeCC Closing capacityCCC Computer Curriculum CompanyCCD Charge-coupled deviceCCE Capacitance contact electrodeCCF Cross-correlation functionCCL Cardiac catheterization laboratoryCCM Critical care medical servicesCCPD Continuous cycling peritoneal

    dialysis

    CCTV Closed circuit television systemCCU Coronary care unit; Critical care unitCD Current densityCDR Complimentary determining regionCDRH Center for Devices and Radiological

    HealthCEA Carcinoembryonic antigenCF Conversion factor; Cystic fibrosisCFC Continuous flow cytometerCFR Code of Federal RegulationsCFU Colony forming unitsCGA Compressed Gas AssociationCGPM General Conference on Weights and

    MeasuresCHO CarbohydrateCHO Chinese hamster ovaryCI Combination indexCICU Cardiac intensive care unitCIF Contrast improvement factorCIN Cervical intraepithelial neoplasiaCK Creatine kinaseCLAV ClavicleCLSA Computerized language sample analysisCM Cardiomyopathy; Code modulationCMAD Computer managed articulation diagnosisCMI Computer-managed instructionCMRR Common mode rejection ratioCMV Conventional mechanical ventilation;

    CytomegalovirusCNS Central nervous systemCNV Contingent negative variationCO Carbon monoxide; Cardiac outputCOBAS Comprehensive Bio-Analysis SystemCOPD Chronic obstructive pulmonary diseaseCOR Center of rotationCP Cerebral palsy; Closing pressure; Creatine

    phosphateCPB Cardiopulmonary bypassCPET Cardiac pacemaker electrode tipsCPM Computerized probe measurementsCPP Cerebral perfusion pressure;

    Cryoprecipitated plasmaCPR Cardiopulmonary resuscitationcps Cycles per secondCPU Central Processing unitCR Center of resistance; Conditioned response;

    Conductive rubber; CreatinineCRBB Complete right bundle branch blockCRD Completely randomized designCRL Crown rump lengthCRT Cathode ray tubeCS Conditioned stimulus; Contrast scale;

    Crown seatCSA Compressed spectral arrayCSF Cerebrospinal fluidCSI Chemical shift imagingCSM Chemically sensitive membraneCT Computed tomography; Computerized

    tomographyCTI Cumulative toxicity response indexCV Closing volume

    xxii ABBREVIATIONS AND ACRONYMS

  • C.V. Coefficient of variationCVA Cerebral vascular accidentCVP Central venous pressureCVR Cardiovascular resistanceCW Continuous waveCWE Coated wire electrodesCWRU Case Western Reserve UniversityDAC Digital-to-analog converterDAS Data acquisition systemdB DecibelDB Direct bodyDBMS Data base management systemDBS Deep brain stimulationdc Direct currentDCCT Diabetes control and complications trialDCP Distal cavity pressureDCS Dorsal column stimulationDDC Deck decompression chamberDDS Deep diving systemDE Dispersive electrodeDEN Device experience networkDERS Drug exception ordering systemDES Diffuse esophageal spasmd.f. Distribution functionDHCP Distributed Hospital Computer ProgramDHE Dihematoporphyrin etherDHEW Department of Health Education and

    WelfareDHHS Department of Health and Human ServicesDHT Duration of hypothermiaDI Deionized waterDIC Displacement currentDIS Diagnostic interview scheduleDL Double layerDLI Difference lumen for intensityDM Delta modulationDME Dropping mercury electrodeDN Donation numberDNA Deoxyribonucleic acidDOF Degree of freedomDOS Drug ordering systemDOT-NHTSA Department of Transportation Highway

    Traffic Safety AdministrationDPB Differential pencil beamDPG DiphosphoglycerateDQE Detection quantum efficiencyDRESS Depth-resolved surface coil spectroscopyDRG Diagnosis-related groupDSA Digital subtraction angiographyDSAR Differential scatter-air ratioDSB Double strand breaksDSC Differential scanning calorimetryD-T Deuterium-on-tritiumDTA Differential thermal analysisd.u. Density unitDUR DurationDVT Deep venous thrombosisEA Esophageal accelerogramEB Electron beamEBCDIC Extended binary code decimal interchange

    code

    EBS Early burn scarEBV EpsteinBarr VirusEC Ethyl celluloseECC Emergency cardiac care; Extracorporeal

    circulationECCE Extracapsular cataract extinctionECD Electron capture detectorECG ElectrocardiogramECM Electrochemical machiningECMO Extracorporeal membrane oxygenationECOD Extracranial cerebrovascular occlusive

    diseaseECRI Emergency Care Research InstituteECS Exners Comprehensive SystemECT Electroconvulsive shock therapy;

    Electroconvulsive therapy; Emissioncomputed tomography

    EDD Estimated date of deliveryEDP Aortic end diastolic pressureEDTA Ethylenediaminetetraacetic acidEDX Energy dispersive X-ray analysisEEG ElectroencephalogramEEI Electrode electrolyte interfaceEELV End-expiratory lung volumeEER Electrically evoked responseEF Ejection fractionEF Electric field; Evoked magnetic fieldsEFA Estimated fetal ageEGF Epidermal growth factorEGG ElectrogastrogramEIA Enzyme immunoassayEIU Electrode impedance unbalanceELF Extra low frequencyELGON Electrical goniometerELISA Enzyme-linked immunosorbent assayELS Energy loss spectroscopyELV Equivalent lung volumeEM ElectromagneticEMBS Engineering in Medicine and Biology

    Societyemf Electromotive forceEMG ElectromyogramEMGE Integrated electromyogramEMI Electromagnetic interferenceEMS Emergency medical servicesEMT Emergency medical technicianENT Ear, nose, and throatEO Elbow orthosisEOG ElectrooculographyEOL End of lifeEOS EosinophilEP Elastoplastic; Evoked potentiateEPA Environmental protection agencyER Evoked responseERCP Endoscopic retrograde

    cholangiopancreatographyERG Electron radiography;

    ElectroretinogramERMF Event-related magnetic fieldERP Event-related potentialERV Expiratory reserve volume

    ABBREVIATIONS AND ACRONYMS xxiii

  • ESCA Electron spectroscopy for chemicalanalysis

    ESI Electrode skin impedanceESRD End-stage renal diseaseesu Electrostatic unitESU Electrosurgical unitESWL Extracorporeal shock wave lithotripsyETO, Eto Ethylene oxideETT Exercise tolerance testingEVA Ethylene vinyl acetateEVR Endocardial viability ratioEW Extended wearFAD Flavin adenine dinucleotideFARA Flexible automation random analysisFBD Fetal biparietal diameterFBS Fetal bovine serumfcc Face centered cubicFCC Federal Communications CommissionFct FluorocritFDA Food and Drug AdministrationFDCA Food, Drug, and Cosmetic ActFE Finite elementFECG Fetal electrocardiogramFEF Forced expiratory flowFEL Free electron lasersFEM Finite element methodFEP Fluorinated ethylene propyleneFES Functional electrical stimulationFET Field-effect transistorFEV Forced expiratory volumeFFD Focal spot to film distanceFFT Fast Fourier transformFGF Fresh gas flowFHR Fetal heart rateFIC Forced inspiratory capacityFID Flame ionization detector; Free-induction

    decayFIFO First-in-first-outFITC Fluorescent indicator tagged polymerFL Femur lengthFM Frequency modulationFNS Functional neuromuscular stimulationFO Foramen ovaleFO-CRT Fiber optics cathode ray tubeFP Fluorescence polarizationFPA Fibrinopeptide AFR Federal RegisterFRC Federal Radiation Council; Functional

    residual capacityFSD Focus-to-surface distanceFTD Focal spot to tissue-plane distanceFTIR Fourier transform infraredFTMS Fourier transform mass spectrometerFU FluorouracilFUDR FloxuridineFVC Forced vital capacityFWHM Full width at half maximumFWTM Full width at tenth maximumGABA Gamma amino buteric acidGAG GlycosaminoglycanGBE Gas-bearing electrodynamometer

    GC Gas chromatography; Guanine-cytosineGDT Gas discharge tubeGFR Glomerular filtration rateGHb Glycosylated hemoglobinGI GastrointestinalGLC Gasliquid chromatographyGMV General minimum varianceGNP Gross national productGPC Giant papillary conjunctivitisGPH Gas-permeable hardGPH-EW Gas-permeable hard lens extended wearGPO Government Printing OfficeGSC Gas-solid chromatographyGSR Galvanic skin responseGSWD Generalized spike-wave dischargeHA HydroxyapatiteHAM Helical axis of motionHb HemoglobinHBE His bundle electrogramHBO Hyperbaric oxygenationHC Head circumferenceHCA Hypothermic circulatory arrestHCFA Health care financing administrationHCL Harvard Cyclotron Laboratoryhcp Hexagonal close-packedHCP Half cell potentialHDPE High density polyethyleneHECS Hospital Equipment Control SystemHEMS Hospital Engineering Management

    SystemHEPA High efficiency particulate air filterHES HydroxyethylstarchHETP Height equivalent to a theoretical plateHF High-frequency; Heating factorHFCWO High-frequency chest wall oscillationHFER High-frequency electromagnetic radiationHFJV High-frequency jet ventilationHFO High-frequency oscillatorHFOV High-frequency oscillatory ventilationHFPPV High-frequency positive pressure

    ventilationHFV High-frequency ventilationHHS Department of Health and Human

    ServicesHIBC Health industry bar codeHIMA Health Industry Manufacturers

    AssociationHIP Hydrostatic indifference pointHIS Hospital information systemHK HexokinaseHL Hearing levelHMBA Hexamethylene bisacetamideHMO Health maintenance organizationHMWPE High-molecular-weight polyethyleneHOL Higher-order languagesHP Heating factor; His-PurkinjeHpD Hematoporphyrin derivativeHPLC High-performance liquid chromatographyHPNS High-pressure neurological syndromeHPS His-Purkinje systemHPX High peroxidase activity

    xxiv ABBREVIATIONS AND ACRONYMS

  • HR Heart rate; High-resolutionHRNB Halstead-Reitan Neuropsychological

    BatteryH/S Hard/softHSA Human serum albuminHSG HysterosalpingogramHTCA Human tumor cloning assayHTLV Human T cell lymphotrophic virusHU Heat unit; Houndsfield units; HydroxyureaHVL Half value layerHVR Hypoxic ventilatory responseHVT Half-value thicknessIA Image intensifier assembly; Inominate

    arteryIABP Intraaortic balloon pumpingIAEA International Atomic Energy AgencyIAIMS Integrated Academic Information

    Management SystemIASP International Association for the Study

    of PainIC Inspiratory capacity; Integrated circuitICCE Intracapsular cataract extractionICD Intracervical deviceICDA International classification of diagnosesICL Ms-clip lensICP Inductively coupled plasma;

    Intracranial pressureICPA Intracranial pressure amplitudeICRP International Commission on

    Radiological ProtectionICRU International Commission on Radiological

    Units and MeasurementsICU Intensive care unitID Inside diameterIDDM Insulin dependent diabetes mellitusIDE Investigational device exemptionIDI Index of inspired gas distributionI:E Inspiratory: expiratoryIEC International Electrotechnical

    Commission; Ion-exchangechromatography

    IEEE Institute of Electrical and ElectronicsEngineers

    IEP Individual educational programBETS Inelastic electron tunneling spectroscopyIF ImmunofluorescentIFIP International Federation for Information

    ProcessingIFMBE International Federation for Medical and

    Biological EngineeringIGFET Insulated-gate field-effect transistorIgG Immunoglobulin GIgM Immunoglobulin MIHP Inner Helmholtz planeIHSS Idiopathic hypertrophic subaortic stenosisII Image intensifierIIIES Image intensifier input-exposure

    sensitivityIM IntramuscularIMFET Immunologically sensitive field-effect

    transistor

    IMIA International Medical InformaticsAssociation

    IMS Information management systemIMV Intermittent mandatory ventilationINF InterferonIOL Intraocular lensIPC Ion-pair chromatographyIPD Intermittent peritoneal dialysisIPG Impedance plethysmographyIPI Interpulse intervalIPPB Intermittent positive pressure breathingIPTS International practical temperature scaleIR Polyisoprene rubberIRB Institutional Review BoardIRBBB Incomplete right bundle branch blockIRPA International Radiation Protection

    AssociationIRRAS Infrared reflection-absorption

    spectroscopyIRRS Infrared reflection spectroscopyIRS Internal reflection spectroscopyIRV Inspiratory reserve capacityIS Image size; Ion-selectiveISC Infant skin servo controlISDA Instantaneous screw displacement axisISE Ion-selective electrodeISFET Ion-sensitive field effect transistorISIT Intensified silicon-intensified target tubeISO International Organization for

    StandardizationISS Ion scattering spectroscopyIT IntrathecalITEP Institute of Theoretical and Experimental

    PhysicsITEPI Instantaneous trailing edge pulse

    impedanceITLC Instant thin-layer chromatographyIUD Intrauterine deviceIV IntravenousIVC Inferior vena cavaIVP Intraventricular pressureJCAH Joint Commission on the Accreditation

    of HospitalsJND Just noticeable differenceJRP Joint replacement prosthesisKB Kent bundleKerma Kinetic energy released in unit massKO Knee orthosisKPM Kilopond meterKRPB Krebs-Ringer physiological bufferLA Left arm; Left atriumLAD Left anterior descending; Left axis

    deviationLAE Left atrial enlargementLAK Lymphokine activated killerLAL Limulus amoebocyte lysateLAN Local area networkLAP Left atrial pressureLAT Left anterior temporalisLBBB Left bundle branch blockLC Left carotid; Liquid chromatography

    ABBREVIATIONS AND ACRONYMS xxv

  • LCC Left coronary cuspLCD Liquid crystal displayLDA Laser Doppler anemometryLDF Laser Doppler flowmetryLDH Lactate dehydrogenaseLDPE Low density polyethyleneLEBS Low-energy brief stimulusLED Light-emitting diodeLEED Low energy electron diffractionLES Lower esophageal sphincterLESP Lower esophageal sphincter pressureLET Linear energy transferLF Low frequencyLH Luteinizing hormoneLHT Local hyperthermiaLL Left legLLDPE Linear low density polyethyleneLLPC Liquid-liquid partition chromatographyLLW Low-level wasteLM Left masseterLNNB Luria-Nebraska Neuropsychological

    BatteryLOS Length of stayLP Late potential; LumboperitonealLPA Left pulmonary arteryLPC Linear predictive codingLPT Left posterior temporalisLPV Left pulmonary veinsLRP Late receptor potentialLS Left subclavianLSC Liquid-solid adsorption chromatographyLSI Large scale integratedLSV Low-amplitude shear-wave

    viscoelastometryLTI Low temperature isotropicLUC Large unstained cellsLV Left ventricleLVAD Left ventricular assist deviceLVDT Linear variable differential transformerLVEP Left ventricular ejection periodLVET Left ventricular ejection timeLVH Left ventricular hypertrophyLYMPH LymphocyteMAA Macroaggregated albuminMAC Minimal auditory capabilitiesMAN ManubriumMAP Mean airway pressure; Mean arterial

    pressureMAST Military assistance to safety and trafficMBA Monoclonal antibodyMBV Maximum breathing ventilationMBX Monitoring branch exchangeMCA Methyl cryanoacrylateMCG MagnetocardiogramMCI Motion Control IncorporatedMCMI Millon Clinical Multiaxial InventoryMCT Microcatheter transducerMCV Mean corpuscular volumeMDC Medical diagnostic categoriesMDI Diphenylmethane diisocyanate;

    Medical Database Informatics

    MDP Mean diastolic aortic pressureMDR Medical device reportingMDS Multidimensional scalingME MyoelectricMED Minimum erythema doseMEDPAR Medicare provider analysis and reviewMEFV Maximal expiratory flow volumeMEG MagnetoencephalographyMeSH Medline subject headingMETS Metabolic equivalentsMF Melamine-formaldehydeMFP Magnetic field potentialMGH Massachusetts General HospitalMHV Magnetic heart vectorMI Myocardial infarctionMIC Minimum inhibitory concentrationMIFR Maximum inspiratory flow rateMINET Medical Information NetworkMIR Mercury-in-rubberMIS Medical information system;

    Metal-insulator-semiconductorMIT Massachusetts Institute of TechnologyMIT/BIH Massachusetts Institute of Technology/

    Beth Israel HospitalMMA Manual metal arc weldingMMA Methyl methacrylateMMECT Multiple-monitored ECTMMFR Maximum midexpiratory flow ratemm Hg Millimeters of mercuryMMPI Minnesota Multiphasic Personality

    InventoryMMSE Minimum mean square errorMO Membrane oxygenationMONO MonocyteMOSFET Metal oxide silicon field-effect

    transistorMP Mercaptopurine; Metacarpal-phalangealMPD Maximal permissible doseMR Magnetic resonanceMRG MagnetoretinogramMRI Magnetic resonance imagingMRS Magnetic resonance spectroscopyMRT Mean residence timeMS Mild steel; Multiple sclerosisMSR Magnetically shielded roomMTBF Mean time between failureMTF Modulation transfer functionMTTR Mean time to repairMTX MethotroxateMUA Motor unit activityMUAP Motor unit action potentialMUAPT Motor unit action potential trainMUMPI Missouri University Multi-Plane

    ImagerMUMPS Massachusetts General Hospital utility

    multiuser programming systemMV Mitral valveMVO2 Maximal oxygen uptakeMVTR Moisture vapor transmission rateMVV Maximum voluntary ventilationMW Molecular weight

    xxvi ABBREVIATIONS AND ACRONYMS

  • NAA Neutron activation analysisNAD Nicotinamide adenine dinucleotideNADH Nicotinamide adenine dinucleotide,

    reduced formNADP Nicotinamide adenine dinucleotide

    phosphateNAF Neutrophil activating factorNARM Naturally occurring and accelerator-

    produced radioactive materialsNBB Normal buffer baseNBD Neuromuscular blocking drugsN-BPC Normal bonded phase chromatographyNBS National Bureau of StandardsNCC Noncoronary cuspNCCLS National Committee for Clinical

    Laboratory Standards; NationalCommittee on Clinical LaboratoryStandards

    NCRP National Council on Radiation ProtectionNCT Neutron capture theoryNEEP Negative end-expiratory pressureNEMA National Electrical Manufacturers

    AssociationNEMR Nonionizing electromagnetic radiationNEQ Noise equivalent quantaNET NorethisteroneNEUT NeutrophilNFPA National Fire Protection AssociationNH Neonatal hepatitisNHE Normal hydrogen electrodeNHLBI National Heart, Lung, and Blood InstituteNIR Nonionizing radiationNIRS National Institute for Radiologic ScienceNK Natural killerNMJ Neuromuscular junctionNMOS N-type metal oxide siliconNMR Nuclear magnetic resonanceNMS Neuromuscular stimulationNPH Normal pressure hydrocephalusNPL National Physical LaboratoryNR Natural rubberNRC Nuclear Regulatory CommissionNRZ Non-return-to-zeroNTC Negative temperature coefficientNTIS National Technical Information ServiceNVT Neutrons versus timeNYHA New York Heart Associationob/gyn Obstetrics and gynecologyOCR Off-center ratio; Optical character

    recognitionOCV Open circuit voltageOD Optical density; Outside diameterODC Oxyhemoglobin dissociation curveODT Oxygen delivery truckODU Optical density unitOER Oxygen enhancement ratioOFD Object to film distance; Occiputo-frontal

    diameterOHL Outer Helmholtz layerOHP Outer Helmholtz planeOIH Orthoiodohippurate

    OPG Ocular pneumoplethysmographyOR Operating roomOS Object of known size; Operating systemOTC Over the counterOV Offset voltagePA Posterioanterior; Pulmonary artery;

    Pulse amplitudePACS Picture archiving and communications

    systemsPAD Primary afferent depolarizationPAM Pulse amplitude modulationPAN PolyacrylonitrilePAP Pulmonary artery pressurePAR Photoactivation ratioPARFR Program for Applied Research on

    Fertility RegulationPARR Poetanesthesia recovery roomPAS Photoacoustic spectroscopyPASG Pneumatic antishock garmentPBI Penile brachial indexPBL Positive beam limitationPBT