Encapsulation of liquids in micro-organisms

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  • encoding calmodulin. Transgenic potato plants carrying sense nucleic acid constructs of pPCM-1, a cDNA clone of potato cal- modulin, exhibit unexpected increased shoot and tuber growth, whereas plants carrying antisense nucleic acid constructs exhibit decreased shoot and tuber growth.

    Immunology

    Chimeric Antibody with Specificity to Human B Cell Surface Antigen Liu et al. Xoma Corporation US 5500362; March 19, 1996 A chimeric IgGl antibody molecule having two heavy chains and two light chains, each of the chains having a human constant region and a variable region, the antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody.

    Blood-Coagulation Factor XIIa Beta Monoclonal Antibody and Immunoassay Esnouf Coagen Ltd. US 5500349; March 19, 1996 A monoclonal antibody which binds to Factor Beta XII and which shows substantially no binding to Factor XII. This antibody may be used in immunoassays to measure Factor Beta XIIA levels in blood, for example, for studies of blood coagulation systems and of thrombotic disorders.

    Recombinant Subunit Vaccine Against Porcine Parvovirus Casal et al. Immunologia y Genetica S A US 5498413; March 12, 1996 Method for the production of a subunit vaccine against porcine parvovirus (PPV). The method is comprised of a first step wherein a recombinant protein VP2 of PPV is obtained by using the rep- lication of a recombinant baculovirus wherein the gene corre- sponding to VP2 has been previously inserted in cells of a per- missive host. The protein VP2 obtained in this invention has the capacity of forming empty chimeric capsids with high immuno- genicity and can be provided as a vaccine formulation for protect- ing pigs against PPV infection. The recombinant baculovirus AcMNPV.pPPVEx8 expresses the VP2 of PPV in conditions mak- ing possible the formulation of pseudo-viral capsids.

    Genetics

    Hepatic Parenchymal Cell Growth Factor Gene Encoding the Same Daikuhara et al. Mitsubishi Kasei Corporation US 5500354; March 19, 1996 Hepatic parenchymal cell growth factor obtained by recombinant DNA technology; a gene coding for the factor; an expression vec- tor capable of expressing the gene; a cell, in particular animal cell transformed with the expression vector; and a process for produc- ing the hepatic parenchymal cell growth factor.

    Peptide Library and Screening Method Cull et al. AfSymax Technologies N V US 5498530; March 12, 1996 A random peptide library constructed by transforming host cells with a collection of recombinant vectors that encode a fusion pro-

    Pa tent Reports

    tein of a DNA binding protein and a random peptide and also contain a binding site for the DNA binding protein that can be used to screen for novel ligands.

    Genes Encoding Platelet Aggregation Inhibitors Charo et al. Cor Therapeutics, Inc. US 5496724; March 5, 1996 An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and char- acterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PA1 from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but con- taining K*-(G/&r)-D wherein K* is a modified lysyl residue of the formula R12N(CH2)4CHNHCO wherein each Rl is indepen- dently H, alkyl(l-6C) or at most one Rl is R2-C = NR3 wherein R2 is H, alkyl( l-6C) or is NR42 in which each R4 is independently H or alkyl(l-6C) and R3 is H, alkyl(l6C), phenyl or benzyl, or R2-C = NR3 is a radical.

    Pharmaceuticals

    Bispecific Monoclonal Antibodies, Thrombolytic Agent and Method of Cell Lysis Iwasa et al. Takeda Chemical Industries Ltd. US 5496549; March 5, 1996 Disclosed are a bispecific hybrid MoAb having specificity for both an activated platelet and a substance having thrombolytic activity, and a thrombolytic agent comprising the above bispecific MoAB and a substance having thrombolytic activity immunologically bound thereto, whereby efficient, rapid thrombolysis is possible.

    Fungi

    Encapsulation of Liquids in Micro-Organisms Hardy et al. Procter & Gamble Company Us 5496728; March 5, 1996 Yeast or other micro-organism cells for use in the encapsulation of liquids (e.g. liquid bleach activators for use in laundry detergent compositions) are deodorised by treatment with a peroxygen bleach, e.g. hydrogen peroxide.

    Applications

    Allelic Association of the Human Dopamine(D2) Receptor Gene in Compulsive Disorders Blum et al. University of California and University of Texas US 5500343; March 19, 1996 A method for detecting compulsive disorder susceptibility of a human. The method involves initially obtaining a DNA sample of the human and then determining the presence or absence of a particular human D2 receptor gene allele in the sample. Detection of the allele in the sample is indicative of susceptibility to com- pulsive disorder.

    Enzyme Microb. Technol., 1997, vol. 20, May 15 559