Versatile X-ray scattering platform

• USAXS • SAXS • bio-SAXS • WAXS • PDF

EMPYREAN NANO EDITION

NANOMATERIAL ANALYSIS ON MULTIPLE LENGTH SCALES

SAXS / WAXS and more

The Empyrean Nano edition is a hybrid laboratory instrument that enables for a variety of X-ray scattering techniques. It is based on a compact, high-resolution goniometer platform. It is based on a compact, high-resolution goniometer platform.

The Empyrean Nano edition off ers the combination of SAXS / WAXS with the ultra-SAXS and total scattering techniques. Structures with Bragg spacings ranging from sub-Angstrom to almost two microns can be probed.

Typical samples• nanoparticles• colloids• polymers• protein solutions• surfactants• lipids• nanocomposites• nanopowders• porous materials• crystalline, semi-crystalline and

amorphous materials

Typical applications• particle size distribution• shape of nano-objects• surface area• interparticle interactions• nano-structure• hierarchical structures• liquid crystalline phases• phase transitions• atomic order & disorder

SAXS

USAXS

almost 5 orders of magnitude; no gaps

WAXS

Total scattering

0.005 1700 0.0036

superstructures,particles > 100 nm

nanoscale structures& dimensions

atomic order& disorder

0.1 100 0.07

5 2 3.6

80 0.1 53

160 0.03 220

2θdBragg

q

[deg][nm][nm-1]

Cu radiation Ag or Mo radiation

2θ: Scattering angle, the angle between the incident and scattered beam

q: Scattering vector, q = 4πλ-1 sin(θ)d: Bragg spacing, d = 2π/q

HIGH-PERFORMANCE SAXS AND WAXS

Sample temperature controlSoft matter analysis

Bio-SAXSInvestigate size, shape, oligomerization and stability of dilute protein solutions

2D SAXS and 2D WAXSDual sample position concept and switchable beam stop

2D SAXS 2D WAXS

SAXS / WAXS features

• Compact setup• Easy to use• Patented vacuum path (ScatterX78)• Semi-transparent beam stop• High sensitivity• 1D and 2D collimation

HIGH-PERFORMANCE SAXS AND WAXSIn

tens

ity [a

.u.]

Inte

nsity

[a.u

.]

q [Å-1]

q [Å-1]

SAXS

WAXS

q [Å-1]

Inte

nsity

[a.u

.]Re

d. S

truc

ture

Fct

. F(Q

) [a.

u.]

Q [Å-1]

T = 5 °CT = 70 °C

Dilute protein solutiont = 15 min

irreversible aggregationat elevated temperature

2θ = 0.08 - 78 deg

q = 0.06 - 51.4 nm-1

*Figure reproduced from J. Bolze, V. Kogan, D. Beckers, M. Fransen, ‘High-performance small- and wide-angle X-ray scattering (SAXS/WAXS) experiments on a multi-functional laboratory goniometer platform with easily exchangeable X-ray modules’. Review of Scientifi c Instruments 89, 085115 (2018), with the permission of AIP Publishing. Open access: https://doi.org/10.1063/1.5041949

Colloidal gold nanorods

Colloidal crystal; 2D SAXS*

Polymer fi ber; 2D WAXS*

Silver behenate*Liposomes (DPPC)*

Commercial insulin (Novorapid®, 3.5 mg/ml)*

Sample stage

EXTEND THE MEASUREMENT RANGE UNIQUE FLEXIBILITY

USAXS option - based on high-resolution optics

PDF (total scattering) option - using Ag or Mo radiation

Classical X-ray diff raction Computed tomography

HIGH-RESOLUTION HYBRID PIXEL AREA DETECTORS

Several additional options upon request, also as later upgrades

Inte

nsity

[a.u

.]In

tens

ity [a

.u.]

q [Å-1]

q [Å-1]

SAXS

WAXS

q [Å-1]

Inte

nsity

[a.u

.]Re

d. S

truc

ture

Fct

. F(Q

) [a.

u.]

Q [Å-1]

T = 5 °CT = 70 °C

Dilute protein solutiont = 15 min

irreversible aggregationat elevated temperature

Inte

nsity

[a.u

.]In

tens

ity [a

.u.]

q [Å-1]

q [Å-1]

SAXS

WAXS

q [Å-1]

Inte

nsity

[a.u

.]Re

d. S

truc

ture

Fct

. F(Q

) [a.

u.]

Q [Å-1]

T = 5 °CT = 70 °C

Dilute protein solutiont = 15 min

irreversible aggregationat elevated temperature

2θmin = 0.0050° qmin = 0.00036 Å-1

2θmax = 160°Qmax = 22 Å-1

based on high-resolution optics

using Ag or Mo radiation

The Empyrean Nano edition can be used with a variety of hardware modules that can be easily exchanged.Changing between diff erent experimental setups only takes a few minutes and does not require re-alignment.

2-circle goniometer

Theta arm

Incident beam optics Area detector

2Theta arm

PIXcel3D (Si sensor)GaliPIX3D (CdTe sensor)

Silica particles (D = 560 nm)

Powder of zinc cyanide

NaSrVO4 powder**Blister-packaged drug capsules

** Reprinted by permission from Springer Nature Customer Service Centre GmbH: Springer Nature. Crystal structure and polymorphism of NaSrVO4 (...). Phys Chem Minerals, G. Nenert et al. 44:455-463(2017).

Sample stage

UNIQUE FLEXIBILITY

HIGH-RESOLUTION HYBRID PIXEL AREA DETECTORS

The Empyrean Nano edition can be used with a variety of hardware modules that can be easily exchanged.Changing between diff erent experimental setups only takes a few minutes and does not require re-alignment.

2-circle goniometer

Theta arm

Incident beam optics Area detector

2Theta arm

PIXcel3D (Si sensor)GaliPIX3D (CdTe sensor)

The performance of the Empyrean Nano edition is largely driven by our detector technologies.

• high spatial resolution• very low noise• high linearity• light and compact• maintenance-free• 100% effi ciency for hard radiation

MALVERN PANALYTICALGrovewood Road, Malvern, Worcestershire, WR14 1XZ, United Kingdom

Tel. +44 1684 892456Fax. +44 1684 892789

Lelyweg 1, 7602 EA Almelo, The Netherlands

Tel. +31 546 534 444Fax. +31 546 534 598

info@malvernpanalytical.comwww.malvernpanalytical.com

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WHY CHOOSEMALVERN PANALYTICAL?

SERVICE & SUPPORT Malvern Panalytical provides the global training, service and support you need to continuously drive your analytical processes at the highest level. We help you increase the return on your investment with us, and ensure that as your laboratory and analytical needs grow, we are there to support you.

Our worldwide team of specialists adds value to your business processes by ensuring applications expertise, rapid response and maximum instrument uptime.

• Local and remote support• Full and fl exible range of support agreements• Compliance and validation support• Onsite or classroom-based training courses• e-Learning training courses and web seminars• Sample and application consultancy

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