eijkman graduate school for immunology & infectious diseases report 2003.pdf · 1 annual report...

1

Annual report

2003

Eijkman Graduate School for

Immunology & Infectious Diseases

2

Colophon annual report Eijkman Graduate School 2003 Editors E.J.G. van Wilsem, PhD Professor J.J.M. Marx, MD, PhD Lay out Annette Lengkeek Printer Brouwer Uithof, Utrecht Address Eijkman Graduate School for Immunology & Infectious Diseases UMC Utrecht, AZU Room F 03.821 Heidelberglaan 100 3584 CX Utrecht Telephone ++ 31 30 2504967 Fax ++ 31 30 2517107 Email: [email protected]

3

CONTENTS

5 MISSION STATEMENT

7 PREFACE

11 FACTS Organization charts

Number of PhD students according to financial sources

Number of PhD students male/female

PhD training programme

Eijkman Seminar Series 2003

Research groups

21 PUBLICATIONS

PROGRAMME: INFECTION

Subprogramme: Molecular epidemiology, prevention and treatment of infection

23 Mechanisms of microbiol resistance and virulence 26 Molecular epidemiology of hospital infection

28 Epidemiology and therapy of infection in general practice 32 Pathogenesis and epidemiology of viral infection in humans

35 Prevention of pulmonary infection 36 Parasitology and tropical veterinary medicine

39 Molecular infection biology 41 Molecular microbiology

42 Pathobiology and molecular epidemiology of veterinary virus 44 Pathogenesis and prevention of pediatric infectious and immune

diseases 54 Molecular epidemiology, immune-response and prevention of

infection 56 Population oriented virology

58 Vaccine development for bacterial and viral infection 61 Infectious diseases

Subprogramme:

Inflammation and tissue damage

4

63 Inflammation, iron and tissue damage 65 Microbial virulence and innate immunity

67 Infection and inflammation in the immunocompromised host 70 Inflammation of the inner eye

71 Effects of exogenous factors on the immune system

PROGRAMME: IMMUNITY

Subprogramme: Physiology and ontogeny of the immune system

74 Regulation of immune cell function 75 Fc Receptors and immuno therapy

Subprogramme: Pathogenesis and therapy of immune mediated diseases

78 Cutaneous and food allergy 81 Immuno gene therapy

83 Multiple myeloma 87 Immunology of transplantation

91 Immunopharmacology 94 Pharmaco-epidemology of pulmonary diseases

95 Chronic inflammatory pulmonary diseases 98 Inflammatory joint diseases 102 Psychoneuroimmunology

104 Regulation of antigen specific defense mechanisms, fundamental aspects with application in human and veterinary medicine

108 Drug design for immune intervention 110 Liposomes for immune intervention

113 Immunotoxicology 114 Immunology and immunopathology pathobiology of large farm

animals

5

MISSION OF THE EIJKMAN GRADUATE SCHOOL

(2003)

To train graduate students in the broad field of infection and

immunity within a high quality multidisciplinary scientific

environment, and to understand, prevent and cure (re)emerging

infections and chronic inflammatory diseases.

7

PREFACE

9

Dear reader, Accreditation of the Eijkman Graduate School (EGS) by the Royal Netherlands Academy of Arts and Sciences (KNAW) was first obtained in 1994. This was renewed in 1999. In 2003 we decided that we should try to obtain accreditation for a third period. This was not an easy task, which demanded a lot of work and energy from many members of the EGS. The situation in 2003, however, was completely different from 1993. After reshaping the scientific landscape in The Netherlands in the 80’s by – for the first time – quality-based selection of research groups for continuation of financial support, another government had decided in the early 90’s for selectively founding of large, high quality research schools. Such “graduate schools” should offer an ideal environment for PhD training. They should also cross borders of departments, faculties and even universities, which required a new and strong management structure. It was expected that the accredited graduate schools would receive preferential and independent financial support, enabling them to design and control their own research programs. It was a matter of survival for research groups in 1993 to belong to a graduate school, and universities were motivated to squeeze as many as possible of their research groups into designated graduate schools. Ten years later it is obvious that the promises and expectations of 1993 did not come true. The schools received just enough money to run their own organization and to coordinate PhD training. But all finances for research continued to flow through the established institutional and funding channels, and decisions on research priorities, and selection of employees and research leaders, remained with the parent institutions. The reality of 2003 was not supportive for investing much effort in the tedious procedure for reaccreditation. The members of the board of the EGS had to convince themselves, the leaders of EGS research groups and the participating institutions that it was worthwhile to strive for continuation of the EGS. During several meetings, and when working on the application report for renewal of accreditation, we realized that there was much achieved during the last 10 years. Our PhD training programme and our research output appeared to be of very good quality, and many more investigators than expected cooperated productively with other EGS-groups. Due to the EGS a regional but world-class scientific network in infection and immunity research was available that deserved to be invented if it would not exist already. When the International Review Committee visited Utrecht on 2-4 September in 2003 we knew that the school was not perfect but that we could present a research institute of international standing. The excellent scientific presentations by our junior and senior scientists, and the critical interviews with PhD students and postdocs were highly appreciated. The very positive initial judgment by the Committee was followed by an extensive written evaluation that contained many valuable suggestions for improvement and supported our ambitions. This must stimulate all our members to use the great opportunities that are offered by the mere existence of the Eijkman Graduate School. As the School has nothing to offer financially, and has hardly any power in formal research management, future success depends on the efforts of all of us to demonstrate that in the Utrecht area a strong and coherent conglomerate of infection and immunity research exists. This must be visible to the national and international scientific community, as we have to compete with an increasing number of such conglomerates, being the kind of cooperation that is demanded by an increasing number of funding organizations. Jo Marx Chairman of the Eijkman Graduate School

11

FACTS

12

23. Organization Chart of the Eijkman Graduate School in 2003

Eijkman Graduate School for Immunology and Infectious Diseases 2003

Board of Deans Medicine UU (chair), Veterinary Medicine UU, Pharmacy UU, Biology UU, Animal Sciences Group Lelystad, RIVM, NIV

Eijkman Graduate School (EGS) Director (chairman of the board), Board

Utrecht Institute for Infection and Immunity (UIFII) Director UIFII (= directorr EGS)

RIVM Boardmember EGS

Animal Sciences Group, LelystadBoardmember EGS

UMCU Institute Infection and Immunity Director (= director EGS), boardmember EGS Boardmembers from participating divisions UMCU

Office Managing directorsecretary

External Advisory Council

Committees Training PhD students (Boardmember EGS) Coordination vaccine research Coordination genomics and proteomics Communication (Newsletter, Website) Retreats PhD students, postdocs, senior staff Eijkman lectures

Veterinary Medicine UU Boardmember EGS

Pharmacy UU Boardmember EGS

Committee: Biomedical Masters Infection and Immunity

Biology UU Boardmember EGS

NVI Boardmember EGS

13

ORGANIZATION CHART EIJKMAN GRADUATE SCHOOL FOR IMMUNOLOGY & INFECTIOUS DISEASES 2003 Board of Deans Eijkman Graduate School

Prof.dr. J.C. Stoof (chairman) (UMCU) Prof.dr. A.W.C.A. Cornelissen (VET MED) Prof.dr. D.J.A. Crommelin (FAR) Prof.dr. H.W. de Vries (ID-Lelystad) Dr. Ir. A.M. Henken (RIVM) Prof. dr. P.J. Weisbeek (BIO) Prof. dr. B.A.M. v.d. Zeijst (NVI)

Board Eijkman Graduate School

Prof. dr. J.J.M. Marx (chairman) (UMCU) Prof. dr. L. Koenderman (vice-chairman) (UMCU) Prof.dr. J. Verhoef (UMCU) Prof. dr. W. Kuis (UMCU) Prof.dr. J.P.M. v. Putten (VET MED) Prof.dr. H.G.M. Leufkens (FAR) Prof. dr. E.W. Brascamp (ID-Lelystad) Prof. dr. J.P.M. Tommassen (BIO) Dr. L. van Alphen (NVI) Dr. E.J.G. van Wilsem Managing Director

External Advisory Council

Prof.dr. E.J. Ruitenberg Drs. C. van Winzum († 2004) Prof.dr. B.J.M. Zegers Prof. dr. L. van der Eb Prof. dr. T. Logtenberg

Executive Committee

Prof.dr. J.J.M. Marx, (director) Dr. E.J.G. van Wilsem, (managing director) Mw. A.J. Lengkeek, (secretary)

Editorial Board Newsletter

Dr. G. Rijkers (chairman) (UMCU) Dr. L. van Alphen (RIVM) Prof. dr. W. Boersma (ID-Lelystad) Dr. P. Coffer (UMCU) Dr. K. Denzer (UMCU) Dr. V.P.M.G. Rutten (VET MED) Dr. J.A.G. van Strijp (UMCU) Dr. L. Taams (UMCU) Dr. J. Wilting (FAR) Dr. E.J.G. van Wilsem Managing Director Mw. A.J. Lengkeek secretary

PhD Training Committee

Prof. dr. L. Koenderman (chairman) (UMCU) Dr. G.v.d.Dobbelsteen (RIVM) Dr. P.A.J. Hendricks (FAR) Dr. H. Snippe (UMCU) Drs. C. Lindemans (UMCU) Mw. Drs. D.L. Valstar (FAR) Dr. M. Wauben (VET MED) Drs. L. van Alphen (VET MED) Dr. A. Rebel (ASG Lelystad)

14

Drs. P. Jochemsen (ASG Lelystad) Dr. E.J.G. van Wilsem Managing Director Mw. A.J. Lengkeek secretary

Master Training Committee Prof.Dr. J. Marx (chairman) (UMCU)

Dr. K. Denzer (coordinator) (UMCU) Genomics and Proteomics Committee

Dr. M. Oosterwegel (chairperson) (UMCU) Dr. M. Tilanus (UMCU) Dr. P. Coffer (UMCU) Dr. A. Fluit (UMCU) Dr. S. Ebeling (UMCU)

15

NUMBER OF PHD STUDENTS ACCORDING TO FINANCIAL SOURCES (Reference date 31.12.2003)

1*

2*

3*

4*

5*

Total

Faculty of Medicine

27

14

14

21

11

87

Faculty of Veterinary Sciences

8

2

-

1

1

12

Faculty of Pharmacy

2

-

2

-

-

4

Faculty of Biology

-

-

-

-

-

-

Animal Science Group Wageningen, Lelystad

1

1

-

1

2

5

National Institute Of Public Health and the Environment,

1

-

-

3

1

5

Netherland Vaccine Institute

-

1

-

-

-

1

Institute for Risk Assessment

4

-

-

-

-

4

Fungal Biodiversity Centre

-

-

-

-

1

1

Total

43

18

16

26

16

119

* 1 = Faculty of VET - PHAR - MED (UMCU)

2 = NWO 3 = Charity fund 4 = Industry - EU ministry - Econ. Aff. or WVS – contract research 5 = Others

16

NUMBER OF PHD STUDENTS MALE/FEMALE (Reference date 31.12.2003)

Male

Female

Total

Faculty of Medicine

25

62

87

Faculty of Veterinary Sciences

5

7

12

Faculty of Pharmacy

1

3

4

Faculty of Biology

1

-

1

Animal Science Group Wageningen, Lelystad

3

2

5

National Institute Of Public Health and the Environment, Bilthoven

3

1

4

Netherland Vaccine Institute

1

-

1

Institute for Risk Assessment

2

2

4

Fungal Biodiversity Centre

-

1

1

Total

41

78

119

The discrepancy between tables in number of students per faculty is due to double appointments

17

PHD TRAINING PROGRAMME Post Graduate Course Immunology (every year) January 6 – 10, 2003 Place: UMC Utrecht – WKZ, AZU and Stratenum Organization: dr. E.J.G. van Wilsem Participants: 37 Post Graduate Course Infection Biology (every year) January 13 – 16, 2003 Place: UMC Utrecht – Stratenum; Faculty of Veterinary Sciences, ID – Lelystad Organization: dr. P.W. van Olm, dr. H. Snippe, dr. E.J.G. van Wilsem Participants: 42 Course Immunogenetics (every two years) March 11 – 13, 2003 Place: UMC Utrecht – AZU; Faculty of Veterinay Sciences Organization: dr. H. Otten Participants: 18 Course Clinical Immunology (every two years) March 21 and 28, April 4 and 11, 2003 Place: UMC Utrecht – Stratenum Organization: dr. F.H.J. Gmelig Meyling Participants: 22 Course Epidemiological Principles of Infectious Diseases (every year) April 22 – 25, 2003 Place: UMC Utrecht - Stratenum Organization: dr. M. Bonten, dr. C. Boucher, dr. E. Hak, dr. D. van de Vijver Participants: 12 Pathogenesis, diagnosis and treatment of infectious diseases – part II (every two years) October 27 – 31, 2004-06-09 Place: Faculty of Veterinary Sciences, RIVM Organization: dr. H. Snippe Participants: 19 PhD Students Retreat (every year) November 13 – 14, 2003 Place: Hotel Zuiderduin, Egmond aan Zee Organization: Nina van Sorge, Bent Postma (PhD students), dr. J. van Strijp Participants: 42 Course Psycho Neuro Immunology (every two years) November: 17 – 19, 2003 Place: UMC Utrecht – WKZ Organization: Prof. C. Heijnen, dr. A. Kavelaars Participants: 16 Staff Retreat May 15, 2003 Place:Hotel/restaurant ‘Oud London’, Woudenbergseweg 52, Zeist Organization: prof. dr. J.J.M. Marx, dr. P.J.Boot Participants: 43

18

EIJKMAN SEMINAR SERIES 2003 January 8, 2003 Jos van der Meer UMC Sint Radboud – Nijmegen “Recognition of microbes and cytokine responses” February 5, 2003 Arne Akbar Royal Free and University College Medical School - London "The persistence of memory T-cells in humans" February 20, 2003 (combined with the ABC Seminar) Göran Hansson Karolinska Hospital Stockholm “Good or bad? How does the immune system modulate atherosclerosis?” April 2, 2003 Randolph Noelle Dartmouth Medical School, Lebanon, New Hampshire, U.S.A. "Terminal B cell differentiation" May 28, 2003 Fiona Powrie Sir William Dunn School for Pathology, University of Oxford, UK “Control of immune pathology by regulatory T cells” September 3, 2003 Martin Glennie Cancer Sciences Division, University of Southampton, UK "Developing Antibodies for the Treatment of Cancer" October 1, 2003 Jim Woodgett Ontario Cancer Institute Toronto - Canada "Physiological functions of Protein Kinase B and Glycogen Synthase Kinase-3" November 5, 2003 Gosse Adema University of Nijmegen UMC St Radboud Nijmegen Center for Molecular Life Sciences "Dendritic cells: from bench to bedside"

19

RESEARCH GROUPS OF THE EIJKMAN GRADUATE SCHOOL FOR IMMUNOLOGY AND INFECTIOUS DISEASES Programme: INFECTION Subprogramme: Molecular Epidemiology, Prevention and Treatment of Infection Research Group Page Group Leaders Institution

Mechanisms of microbial resistance and virulence 23 J. Verhoef, A.C. Fluit UMCU Molecular epidemiology of hospital infection 26 M. Bonten, I.M. Hoepelman UMCU, RIVM Epidemiology and therapy of infection in general practice 28 M. Bonten, A.W. Hoes UMCU Pathogenesis and epidemiology of viral infection in humans 32 C.A.B. Boucher, J. van

Hattum UMCU

Prevention of pulmonary infection 35 H. Snippe UMCU Parasitology and tropical veterinary medicine 36 A.W.C.A. Cornelissen,

F. Jongejan UU-Vet

Molecular infection biology 39 J.P.M. van Putten UU-Vet Molecular microbiology 41 J.P.M. Tommassen UU-Bio Pathobiology and molecular epidemiology of veterinary virus 42 P.J.M. Rottier Pathogenesis and prevention of pediatric infectious and immune diseases

44 J.L.L. Kimpen, W. Kuis UMCU

Molecular epidemiology, immune-response and prevention of infection

54 T.G. Kimman RIVM

Population oriented virology

56 Ms. M. Koopmans RIVM

Vaccine development for bacterial and viral infection 58 A.J.W. van Alphen RIVM Infectious diseases 61 J.A. Wagenaar ASG Wageningen Programme: INFECTION Subprogramme: Inflammation and tissue damage

Research Group Page Group Leaders Institution Inflammation, iron and tissue damage 63 J.J.M. Marx, J. Van Strijp,

J. Verhoef UMCU

Microbial virulence and innate immunity 65 H. van Dijk, A. Fleer UMCU Infection and inflammation in the immunocompromised host 67 I.M. Hoepelman UMCU Inflammation of the inner eye 70 A. Rothova UMCU Effects of exogenous factors on the immune system 71 H. Van Loveren RIVM Programme: IMMUNITY Subprogramme: Physiology and ontogeny of the immune system

Research Group Page Group Leaders Institution Regulation of immune cell function 74 L. Meyaard UMCU Fc receptors and immuno therapy 75 J.G.J. van de Winkel,

J.H.W. Leusen UMCU

Programme: IMMUNITY Subprogramme: Pathogenesis and therapy of immune mediated diseases Research Group Page Group Leaders Institution Cutaneous and food allergy 78 C.A.F.M. Btruijnzeel-

Koomen UMCU

Immuno gene therapy 81 A. Hagenbeek UMCU Multiple myeloma 83 A.C. Bloem, H.M. Lokhorst UMCU Immunology of transplantation 87 R. de Weger, M. Tilanus,

N. de Jonge, F. Gmelig Meyling

UMCU

Immunopharmacology 91 F.P. Nijkamp UU-Pharm Pharmaco-epidemology of pulmonary diseases 94 H.G.M. Leufkens, M. Bracke UU-Pharm Chronic inflammatory pulmonary diseases 95 J-W.J. Lammers,

L. Koenderman, P. Coffer UMCU

Inflammatory joint diseases 98 J.W.J. Bijlsma UMCU Psychoneuroimmunology 102 C.J. Heijnen UMCU Regulation of antigen specific defense mechanisms, fundamental aspects with application in human and veterinary medicine

104 W. van Eden UU-Vet

Drug design for immune intervention 108 R.M.J. Liskamp UU-Pharm Liposomes for immune intervention 110 D.J.A. Crommelin,

W.E. Hennink, G. Storm UU-Pharm

Immunotoxicology 113 R.H.H. Pieters UU-IRAS Immunology and immunopathology pathobiology of large farm animals

114 W.J.A. Boersma ASG Wageningen

21

PUBLICATIONS

23

University Medical Center Utrecht Eijkman Winkler Institute

Research Group

Mechanisms of microbial resistance and virulence (UU UMC 2.1.2)

Leader

A.C. Fluit J. Verhoef

Staff

A.W. Dekker D. Milatovic M.R. Visser

M. Leverstein-van Hall A. Troelstra

E.M. Mascini M.Rozenberg-Arska

A.J.L. Weersink

Post docs J.T. van de Bruggen

W.T.M. Jansen G. Andriesse

PhD students

M. Ekkelenkamp H.J. van Loon B. Vlaminckx B.U. Ridwan

Ms. R. Ikawati

Titles of PhD project M. Ekkelkamp: New antimicrobial peptides to fight resistance Ms. R. Ikawati: Fighting antimicrobial resistant organisms H.J. van Loon: Understanding epidemicity and colonization of bacteria in an ICU. B.U. Ridwan: Probiotics and resistance B. Vlaminckx: Streptococcal virulence factors - in vivo and in vitro studies Thesis

Leeuwen, H.J. van (25-11-2003). Lipoproteins and sepsis. UU Universiteit Utrecht (183 pag.). (Utrecht: Drukkerij Zuidam & Uithof). Prom./coprom.: Verhoef, J., Hoepelman, I.M., Strijp, J.A.G. van, & Kessel, C.P.M. van Sutanti Subekti, D. (21-11-2003). Patients with Diarrhea in Indonesia: Microbiological and Public Health Aspects UU Universiteit Utrecht (265 pag.). (Enschede: Febodruk BV). Prom./coprom.: Verhoef, J., Roord, J.J., Oyofo, B.A., & Punjabi, N.H. International publications Ballemans, C.A.J.M., Blok, H.E.M., Swennenhuis, J., Troelstra, A., & Mascini, E.M. (2003). Dry cleaning or wet mopping: comparison of bacterial colony counts in the hospital environment The journal of hospital infection 53, 150-152. Berkhout, J., Visser, L.G., Broek, P.J. van den, Klundert, J.A.M. van der, & Mattie, H. (2003). Clinical Pharmacokinetics of Cefamandole and Ceftazidime Administered by Continuous Intravenous Infusion Antimicrobial Agents and Chemotherapy 47 (6), 1862-1866. Blok, H.E.M., Troelstra, A., Kamp-Hopmans, T.E.M., Gigengack-Baars, A.C.M., Vandenbroucke-Grauls, C.M.J.E., Weersink, A.J.L., Verhoef, J., & Mascini, E.M. (2003). Role of Healthcare Workers in outbreaks of methicillin-resistant Staphylococcus aureus: a 10-year Evaluation from a Dutch University Hospita Infection control and hospital epidemiology 24 (9), 679-685. Bogo Jensen, L., Willems, R.J.L., & Bogaard, A.E.J.M. van den (2003). Genetic characterization of glycopeptide-resistant enterococci of human and animal origin from mixed pig and poultry farms APMIS 111, 669-672.

24

Borst, A., & Fluit, A.C. (2003). High levels of hydrolytic enzymes secreted by Candida albicans isolates involved in respiratory infections Journal of Medical Microbiology 52 (Pt 11), 971-974. Borst, A., Theelen, B., Reinders, E., Boekhout, T., Fluit, A.C., & Savelkoul, P.H. (2003). Use of amplified fragment length polymorphism analysis to identify medically important Candida spp., including C. dubliniensis Journal of Clinical Microbiology 41 (4), 1357-1362. Felius, I.D., Akkermans, L.M.A., Bosscha, K., Verheem, A., Harmsen, W.C.M., Visser, M.R., & Gooszen, H.G. (2003). Interdigestive small bowel motility and duodenal bacterial overgrowth in experimental acute pancreatitis Neurogastroenterology and Motility 15 (3), 267-276. Fluit, A.C., Florijn, A., Verhoef, J., & Schmitz, F.J. (2003). High-level gentamicin resistance in Enterococcus faecium and Enterococcus faecalis blood culture isolates from 23 European university hospitals International journal of antimicrobial agents 21 (4), 357-359. Fluit, A.C., Schmitz, F.J., & Milatovic, D. (2003). The presence of ermB in Streptococcus pneumoniae has no influence on AZD2563 MIC values Journal of Antimicrobial Chemotherapy 51 (1), 184-185. Higgins, P.G., Fluit, A.C., & Schmitz, F.J. (2003). Fluoroquinolones: structure and target sites Current Drug Targets 4 (2), 181-190. Higgins, P.G., Fluit, A.C., Milatovic, D., Verhoef, J., & Schmitz, F.J. (2003). Mutations in GyrA, ParC, MexR and NfxB in clinical isolates of Pseudomonas aeruginosa International journal of antimicrobial agents 21 (5), 409-413. Kamp-Hopmans, T.E.M., Blok, H.E.M., Troelstra, A., Gigengack-Baars, A.C.M., Weersink, A.J.L., Vandenbroucke-Grauls, C.M.J.E., Verhoef, J., & Mascini, E.M. (2003). Surveillance of hospital acquired infections on surgical wards in a Dutch university hospital Infection control and hospital epidemiology 24, 585-590. Laevis, H.L., Willems, R.J.L., Top, J., Spalburg, E., Mascini, E.M., Fluit, A.C., Hoepelman, I.M., Neeling, A.J. de, & Bonten, M.J.M. (2003). Epidemic and nonepidemic multidrug-resistant Enterococcus faecium Emerging Infectious Diseases 9, 1108-1115. Leverstein-van Hall, M.A., Blok, H.E.M., Donders, A.R.T., Paauw, A., Fluit, A.C., & Verhoef, J. (2003). Multidrug resistance among Enterobacteriaceae is strongly associated with the presence of integrons and is independent of species or isolate origin Journal of Infectious Diseases 187 (2), 251-259. Mascini, E.M., Jalink, K.P., Kamp-Hopmans, T.E.M., Blok, H.E.M., Verhoef, J., Bonten, M.J.M., & Troelstra, A. (2003). Acquisition and duration of vancomycin-resistant enterococcal carriage in relation to strain type Journal of Clinical Microbiology 41, 5377-5383. Milatovic, D., Schmitz, F.J., Verhoef, J., & Fluit, A.C. (2003). Activities of the glycylcycline tigecycline (GAR-936) against 1,924 recent European clinical bacterial isolates Antimicrobial Agents and Chemotherapy 47 (1), 400-404. Nijssen, S., Bonten, M.J.M., Nathan, C., Rice, T., Franklin, C., Verhoef, J., Hoepelman, I.M., & Weinstein, R.A. (2003). Relative importance of nurses and physiacins in transmission of microorganisms in intensive care units Archives of Internal Medicine 163, 2785-2786. Schmitz, F.J., Beyer, A., Charpentier, E., Normark, B.H., Schade, M., Fluit, A.C., Hafner, D., & Novak, R. (2003). Toxin-gene profile heterogeneity among endemic invasive European group A streptococcal isolates Journal of Infectious Diseases 188 (10), 1578-1586. Schurink, C.A.M., Nieuwenhoven, C. van, Buskens, E., Joore, J.C.A., Rozenberg-Arska, M., Hoepelman, I.M., & Bonten, M.J.M. (2003). Clinical Pulmonary Infection Score for Ventilator Associated Pneumonia: accuracy and inter-observer variability Intensive Care Medicine. Tzouvelekis, L.S., Lukova, V., Tassios, P.T., Fluit, A.C., Jones, R.N., & Legakis, N.J. (2003). Resistance to beta-lactams among blood isolates of Salmonella spp. in European hospitals: results from the SENTRY Antimicrobial Surveillance Program 1997-98 Clinical Microbiology Infections 9 (2), 149-152. Vlaminckx, B.J.M., Mascini, E.M., Schellekens, J., Schouls, L.M., Paauw, A., Fluit, A.C., Novak, R., Verhoef, J., & Schmitz, F.J. (2003). Site-specific manifestations of invasive group A streptococcal disease: type-distribution and corresponding patterns of virulence determinants Journal of Clinical Microbiology 41, 4941-4949. Westreenen, M. van, Paauw, A., Fluit, A.C., Brisse, S., Dijk, W. van, & Verhoef, J. (2003). Occurrence and spread of SHV extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates in Curacao Journal of Antimicrobial Chemotherapy 52 (3), 530-532. National Publications

Blom, J.R., Andriesse, G.I., & Hoorntje, J.C.A. (2003). Transient cardiac failure due to infectious myocarditis Nederlands Tijdschrift voor Geneeskunde 147 (34), 1621-1624.

Dietz, V., Derks, J., Mascini, E.M., & Bruinse, H.W. (2003). Infecties door groep A haemolytische streptokokken in het kraambed; een pseudo-epidemie op de kraamafdeling in het UMC-Utrecht Nederlands Tijdschrift voor Geneeskunde 147, 2505-2508.

Duijkeren, E. van, Box, A.T.A., Mulder, J., Wannet, W.J.B., Fluit, A.C., & Houwers, D.J. (2003). Een meticilline-resistente Staphylococcus aureus (MRSA)-infectie bij een hond in Nederland Tijdschrift voor diergeneeskunde 128 (10), 314-315.

25

Kluytmans, J., Arends, J., Bonten, M.J.M., Buiting, A., Endtz, H.P., Keulen, P. van, Kluytmans-van den Bergh, M., Mascini, E.M., Vandenbroucke-Grauls, C.M.J.E., & Voss, A. (2003). Infecties geassocieerd met intravasculaire katheters: een ander standpunt Nederlands Tijdschrift voor Geneeskunde 11, 55-56. Book, book chapters & proceedings Fluit, A.C., & Schmitz, F.J. (2003). MRSA: Current perspectives Wymondham, Norfolk, UK: Caister Academic Press. Andriesse, G.I. (2003). Pneumocystis carinii In Jonathan Cohen & William Powderly (Eds.), Infectious Diseases Mosby. Cookson, B., Schmitz, F.J., & Fluit, A.C. (2003). Introduction In A.C. Fluit & F.-J. Schmitz (Eds.), MRSA: Current perspectives (pp. 1-10). Wymondham, Norfolk, UK: Caister Academic Press. Fluit, A.C., & Schmitz, F.J. (2003). Concluding remarks In A.C. Fluit & F.-J. Schmitz (Eds.), MRSA: Current perspectives (pp. 337-342). Wymondham, Norfolk, UK: Caister Academic Press. Fluit, A.C., & Schmitz, F.J. (2003). Population structure of MRSA In A.C. Fluit & F.-J. Schmitz (Eds.), MRSA: Current perspectives (pp. 159-186). Wymondham, Norfolk, UK: Caister Academic Press. Verhoef, J. (2003). Antibiotic Resistance: the Pandemic In S. Marzuki, J. Verhoef & H. Snippe (Eds.), Tropical Diseases: From Molecule To Bedside (Advances in Experimental Medicine and Biology, 531, pp. 301-314). New York: Kluwer Academic / Plenum Publishers.

26


Research group Molecular epidemiology of hospital infection

Leader

M.J.M. Bonten I.M. Hoepelman

Staff

Ms. M.M.E. Schneider W. van Wamel

R.J. Willems

PhD students Ms. M. Koeman

Ms. S. Nijssen Ms. C.A.M. Schurink

Ms. J. Top

Titles PhD projects M. Bootsma: Mathematical modelling of hospital infections I. Jongerden: Implementation of nursing guidelines in Intensive Care Units M. Koeman: Prevention of ventilator-associated pneumonia S. Nijssen: Clinical epidemiology of antibiotic resistance J.J. Oosterheert: Treatment issues in community-acquired pneumonia C.A.M. Schurink: The development of a Baysian model for diagnosis and treatment of

ventilator-associated pneumonia J. Top : Vancomycin-resistant enterococcus faecium International publications

Bonten, M.J.M., Joore, H.C.A., Jongh, B.M. de, Kluytmans, J., Kuijper, E.J., Leeuwen, H.J. van, Smet, A.M. de, & Vandenbroucke-Grauls, C.M.J.E. (2003). Selective decontamination of the digestive tract: All questions answered? Critical Care Medicine 7, 203-205.

Bonten, M.J.M., Brun-Buisson, C., & Weinstein, R.A. (2003). Selective Decontamination of the Digestive Tract: to stimulate or stifle? Intensive Care Medicine 29, 672-676.

Bonten, M.J.M., & Grundmann, H. (2003). Selective Digestive Decontamination and antibiotic resistance: A balancing act Critical Care Medicine 31, 2239-2240.

Bonten, M.J.M., & Mascini, E.M. (2003). The hidden faces of the epidemiology of antibiotic resistance Intensive Care Medicine 29, 1-2.

Bonten, M.J.M. (2003). Prevention of hospital-acquired pneumonia: European perspective. Infectious Disease Clinics of North America 17, 773-784

Bonten, M.J.M. (2003). Selective decontamination of digestive tract in intensive care. Lancet 20, 2118-2120.

Koeman, M., & Bonten, M.J.M. (2003). When can empiric therapy for intensive care unit-acquired pneumonia be withheld or withdrawn? Seminars in respiratory infections 18, 122-128.

Leavis, H.L., Willems, R.J.L., Top, J., Spalburg, E., Mascini, E.M., Fluit, A.C., Hoepelman, I.M., Neeling, A.J. de, & Bonten, M.J.M. (2003). Epidemic and nonepidemic multidrug-resistant Enterococcus faecium Emerging Infectious Diseases 9, 1108-1115.

Mascini, E.M., Jalink, K.P., Kamp-Hopmans, T.E.M., Blok, H.E.M., Verhoef, J., Bonten, M.J.M., & Troelstra, A. (2003). Acquisition and duration of vancomycin-resistant enterococcal carriage in relation to strain type Journal of Clinical Microbiology 41, 5377-5383.

Nijssen, S., Bonten, M.J.M., Nathan, C., Rice, T., Franklin, C., Verhoef, J., Hoepelman, I.M., & Weinstein, R.A. (2003). Relative importance of nurses and physicians in transmission of microorganisms in intensive care units. Archives of Internal Medicine 163, 2785-2786.

Nijssen, S., Bonten, M.J., Franklin, C., Verhoef, J., Hoepelman, A.I., & Weinstein, R.A. Relative risk of physicians and nurses to transmit pathogens in a medical care unit. Archives of Internal Medicine 163, 2785-2786.

Routsi, C., Platsouka, E., Willems, R.J.L., Bonten, M.J.M., Paniara, O., Saroglou, G., & Roussos, C. (2003). Detection of enterococcal surface protein, esp gene, and amplified fragment length polymorphism (AFLP) typing in glycopeptide-resistant Enterococcus faecium during its emergence in a Greek ICU Journal of Clinical Microbiology 41, 5742-5746.

Schurink, C.A.M., Nieuwenhoven, C. van, Buskens, E., Joore, J.C.A., Rozenberg-Arska, M.,

27

Hoepelman, I.M., & Bonten, M.J.M. (2003). Clinical Pulmonary Infection Score for Ventilator Associated Pneumonia: accuracy and inter-observer variability Intensive Care Medicine.

Vincent, J.L., Opal, S., Torres, A., Bonten, M.J.M., Cohen, J., & Wunderink, R. (2003). The PIRO concept: I is for infection (meeting report) Critical Care Medicine 7, 252-255. National publications

Hoepelman, I.M., & Wolfs, T.F.W. (2003). Splenectomie en pneumokokkenvaccinatie. Nederlands Tijdschrift voor Geneeskunde 147 (23), 1143-1143.

Kluytmans, J., Arends, J., Bonten, M.J.M., Buiting, A., Endtz, H.P., Keulen, P. van, Kluytmans-van den Bergh, M., Mascini, E.M., Vandenbroucke-Grauls, C.M.J.E., & Voss, A. (2003). Infecties geassocieerd met intravasculaire katheters: een ander standpunt Nederlands Tijdschrift voor Miedische Microbiologie 11, 55-56.

Oosterheert, J.J., Bonten, M.J.M., Schneider, M.M.E., & Hoepelman, I.M. (2003). Toegevoegde waarde van empirische antibiotische behandeling van atypische verwekkers bij patiënten die in het ziekenhuis worden opgenomen met pneumonie Nederlands Tijdschrift voor Geneeskunde 147, 381-386. Book, book chapters & proceedings

Bonten, M.J.M., Austin, D.J., & Lipsitch, M. (2003). Modeling endemic and epidemic infections. In R.P. Wenzel (Ed.), Prevention and Control of Nosocomial Infections 4th edition (pp. 136-144). Lippincott Williams & Wilkins.

28

University Medical Center Utrecht Julius Center for Health Sciences and Primary Care

Research group Epidemiology and therapy of infection in general practice

(UU UMC 2.1.9)

Leader M.J.M. Bonten

A.W. Hoes

Staff Ms. M.M. Kuyvenhoven

Th.J.M. Verheij

Post docs E. Hak

M. Rovers A. Sachs N. de Wit

PhD students

Ms. E. van Dam – van Isselt Ms. S. van Loon Ms I. Welschen

Titles PhD projects Ms E.H. van den Akker: Natan: cost-effectiveness of adenotonsillectomy in children Ms A.E. Akkerman: Art-II study: Antibiotic prescription in primary care patients with upper

respiratory tract infusion, asthma and COPD Ms J. Bont: Cello-study: Complications in elderly with lower respiratory tract infections Ms C.N.M. Brouwer: Health related quality of life in children with recurrent acute otitis media Ms J.E. Brussee: Piama: The natural history of asthma children Ms. E. van Dam-van Isselt: Diagnostiek en beloopvan longfunctie-afwijkignen bij rokers H.J. van Duijn: Views on respiratory tract symptoms; similarities and differences between

doctors and patients R. Geijer: Diagnosis and clinical course of pulmonary function in smokers Ms B. de Jong: Whistler study: Wheezing in de Leidsche Rijn Ms N. Katier: Whistler study: Wheezing in de Leidsche Rijn Ms. S. van Loon: PRUNA-study: prevention of influenza, surveillance and management Ms I. Koomen: Educational and behavorial problems in schoolage survivors of bacterial

meningitis Ms L.M.A.J. Muller: Delphi: Diabetes and infections, Education learing in program for Health

Improvement W. Opstelten: Pine: Prevention by epidural injection of posthermic neuralgia in elderly D. Posthouwer: Optimizing treatment strategies for patients infected with hepatitis C: an international

cohort study Ms Y. Schönbeck: Primakid-study: Prevention of respiratory infections and management in

children Ms B.K. van Staaij: Natan: cost-effectiveness of adenotonsillectomy in children Ms S.C.J.M. Vervoort: Factors influencing therapy-fidelity in the view of HIV infected patients Ms I. Welschen: Arti-I study: Optimalisation of antibiotic prescription for respiratory tract

infections in primary care B. van Wijk: Pine: Prevention by epidural injection of posthermic neuralgia in the elderly Thesis Brouwer, C.N.M. (15-04-2003). Health related quality of life in children with recurrent acute otitis media. UU Universiteit Utrecht.. Prom./coprom.: Grobbee, D.E., Maillé, A.R., Sanders, E.A.M., Schilder, A.G.M., & Kuis, W. Koomen, I. (21-02-2003). Educational and behavioral problems in schoolage survivors of bacterial meningitis. UU Universiteit Utrecht.. Prom./coprom.: Grobbee, D.E., Roord, J.J., & Furth, A.M. van

29

International publications Akker, E.H. van den, Schilder, A.G.M., Kemps, Y., Balen, F.A.M. van, Hordijk, G.J., & Hoes, A.W. (2003). Current indications for (adeno)tonsillectomy in children: a survey in The Netherlands. International Journal of Pediatric Otorhinolaryngology 67, 603-607. Akker, E.H. van den, Rovers, M.M., Staaij, B.K. van, Hoes, A.W., & Schilder, A.G.M. (2003). Representativeness of trial populations: an example from a trial of adenotonsillectomy in children. Acta Oto-Laryngologica 123, 297-301. Balen, F.A.M. van, Smit, w.m., Zuithoff, N.P., & Verheij, Th.J.M. (2003). Clinical efficacy of three common treatments in acute otitis externa in primary care: randomised controlled trial. BMJ - British Medical Journal 327, 1201-1205. Beelen, R.M.J., Smit, H.A., Strien, R.T. van, Koopman, L.P., Brussee, J.E., Brunekreef, B., Gerritsen, W.B.M., & Merkus, P.J.F.M. (2003). Short and long term variability of the interrupter technique under field and standerdised condition in 3-6 year old children. Thorax 58, 761-764. Bijkerk, CJ, Wit, NJ de, Stalman, WA, Knottnerus, JA, Hoes, A.W., & Muris, JW (2003). Irritable bowel syndrome in primary care: the patients'and doctors'views on symptomes, etiology and management. Canadian Journal of Gastroenterology 17, 363-368. Bijkerk, CJ, Wit, NJ de, Muris, JW, Jones, R.H., Knottnerus, JA, & Hoes, A.W. (2003). Outcome measures in irritable bowel syndrome: comparison of psychometric and methodological characteristics. American Journal of Gastroenterology 98, 122-127. Bollen, C.W., Uiterwaal, C.S.P.M., & Vught, A.J. van (2003). Cumulative metaanalysis of high-frequency versus conventional ventilation in premature neonates. American Journal of Respiratory and Critical Care Medicine 168 (10), 1150-1155.

Bonten, M.J.M., Kluytmans, J., Smet, A.M. de, Bootsma, M.C., & Hoes, A.W. (2003). Selective decontamination of digestive tract in intensive care. Lancet 362 (20/27), 2118-2119.

Duijn, H. van, Kuyvenhoven, M.M., Jones, R.T., Butler, C., Coenen, S., & Royen, P van (2003). Patients' views on respiratory tract symptoms and antibiotics. British Journal of General Practice 53, 491-492. Essen, G.A. van, Palache, A.M., Forleo, E., & Fedson, D.S. (2003). Influenza vaccination in 2000: recommendations and vaccine use in 50 developed and rapidly developing countries. Vaccine 21, 1780-1785. Goudswaard, A.N., Lam, K., Stolk, R.P., & Rutten, G.E.H.M. (2003). Quality of recording of data from patients with type 2 diabetes is not a valid indicator of quality of care. Family Practice 20, 173-177.

Hak, E., Bonten, M.J.M., & Hoes, A.W. (2003). Pneumococcal vaccination in older adults. New England Journal of Medicine 349, 712. Hak, E., Hoes, A.W., Grobbee, D.E., Lammers, J.W.J., Essen, G.A. van, Loon, A.M. van, & Verheij, Th.J.M. (2003). Conventional influenza vaccination is not associated with complications in working-age patients with asthma or chronic obstructive pulmonary disease. American Journal of Epidemiology 157 (8), 692-700. Hak, E., Loon, S. van, Buskens, E., Essen, G.A. van, Bakker, D., Tacken, M.A., Hout, B.A. van, Grobbee, D.E., & Verheij, Th.J.M. (2003). Design of the Dutch Prevention of Influenza, Surveillance and Management (Prisma) study. Vaccine 21 (15), 1719-1724. Hak, E., Rovers, M.M., Sachs, A.P.E., Stalman, W.A., & Verheij, Th.J.M. (2003). Is asthma in 2-12 year-old children associated with physician-attended recurrent upper respiratory tract infections? European Journal of Epidemiology 18, 899-902. Kamps, A.W.A., Brand, P.L.P., Kimpen, J.L.L., Maille, A.R., Overgoor-van de Groes, A.W., Helsdingen, L.C.J.A.M., & Roorda, R.J. (2003). Outpatient management of childhood asthma by padiatrician or asthma nurse: randomised controlled study with one year follow up. Thorax 58, 968-973. Koomen, I., Grobbee, D.E., Roord, J.J., Donders, R.C.J.M., Jennekens-Schinkel, A., & Furth, A.M. van (2003). Hearing loss at school age in survivors of bacterial meningitis: assessment,. Pediatrics 112 (5), 1049-1053. Koomen, I., Grobbee, D.E., Jennekens-Schinkel, A., Roord, J.J., & Furth, A.M. van (2003). Parental perception of educational, behavioural and general health problems in school-age survivors of bacterial meningitis. Acta Paediatrica 92 (2), 177-185. Kuyvenhoven, M.M., Balen, F.A.M. van, & Verheij, Th.J.M. (2003). Outpatient antibiotic prescriptions from 1992 to 2001 in The Netherlands. Journal of Antimicrobial Chemotherapy 52, 675-678. Loon, S. van, Bart, A., Hertog, E. den, Nikkels, P.G.J., Houwen, R.H.J., Schrijver, J.E.A.R., & Oudshoorn, J.H. (2003). Helicobacter heilmannii gastritis caused by cat to child transmission. Journal of Pediatric Gastroenterology and Nutrition 36, 407-409. Numans, M.E., & Wit, N.J. de (2003). Reflux symptoms in general practice: diagnostic evaluation of the Carlsson-Dent gastro-oesophageal reflux disease questionnaire. Alimentary Pharmacology & Therapeutics 17, 1049-1055. Oosterheert, J.J., Buskens, E., Hak, E., Schneider, M.M.E., Hoepelman, I.M., & Bonten, M.J.M. (2003). An algorithm to determine cost-savings of targeting antimicrobial therapy based on the results of rapid diagnostic testing. Journal of Clinical Microbiology 41, 4708-4713. Oosterheert, J.J., Bonten, M.J.M., Hak, E., Schneider, M.M.E., & Hoepelman, I.M. (2003). How

30

good is the evidence for the recommended empirical antimicrobial treatment of patients hospitalized because of community-acquired pneumonia? A systematic review. Journal of Antimicrobial Chemotherapy 52, 555-563. Oosterheert, J.J., Bonten, M.J.M., Hak, E., Schneider, M.M.E., & Hoepelman, I.M. (2003). Severe community-acquired pneumonia: What's in a name? Current Opinion in Infectious Diseases 16, 153-159. Pinxteren, B. van, Numans, M.E., Lau, J., Wit, N.J. de, Hungin, A.P., & Bonis, P.A. (2003). Short-term treatment of gastroesophageal reflux disease. Journal of general internal medicine 18, 755-763. Poels, P.J.P., Schilder, A.G.M., Berg, S. van den, Hoes, A.W., & Joosten, K.F.M. (2003). Evaluation of a new device for home cardiorespiratory recording in children. Archives of Otolaryngology, Head and Neck Surgery 129, 1281-1284. Quartero, A.O., Smeets, H., & Wit, N.J. de (2003). Trends and determinants of pharmacotherapy for dyspepsia: analysis of 3-year prescription data in The Netherlands. Scandinavian Journal of Gastroenterology 38, 676-677. Rovers, M.M., Bij, S. van der, Ingels, K.J.A.O., Wilt, G.J. van der, & Zielhuis, G.A. (2003). Does a trial on the effects of ventilation tubes influence clinical practice? Clinical Otolaryngology 28, 355-359. Rutten, F.H., Hak, E., Stalman, W.A.B., Verheij, Th.J.M., & Hoes, A.W. (2003). Is treatment of atrial fibrillation in primary care based on thromboembolic risk assessment? Family Practice 20, 16-21. Schurink, C.A.M., Nieuwenhoven, C. van, Buskens, E., Joore, J.C.A., Rozenberg-Arska, M., Hoepelman, I.M., & Bonten, M.J.M. (2003). Clinical Pulmonary Infection Score for Ventilator Associated Pneumonia: accuracy and inter-observer variability. Intensive Care Medicine. Staaij, B.K. van, Rovers, M.M., Schilder, A.G.M., & Hoes, A.W. (2003). Accuracy and feasibility of daily infrared tympanic membrane temperature measurements in the identification of fever in children. International Journal of Pediatric Otorhinolaryngology 67, 1091-1097. Staaij, B.K. van, Akker, E.H. van den, Haas de-van Dorsser, E.H.M., Fleer, A., Hoes, A.W., & Schilder, A.G.M. (2003). Does the tonsillar surface flora differ in children with and without tonsillar disease? Acta Oto-Laryngologica 123, 873-878. Terreehorst, I, Hak, E., & van Wijk, G. (2003). Clinical effectiveness of bedding encasings in patients with allergic rhinitis and asthma (correspondence). New England Journal of Medicine 349, 1668-71. Terreehorst, I, Hak, E., Oosting, A.J., Tempels-Pavlica, Z, Monchy, J.G.R. de, Bruijnzeel-Koomen, C.A.F.M., Aalberse, R.C., & Gerth van Wijk, R (2003). Evaluation of impermeable covers for bedding in patients with allergic rhinitis. New England Journal of Medicine 17 (349), 237-246. Vincent, J.L., Opal, S., Torres, A., Bonten, M.J.M., Cohen, J., & Wunderink, R. (2003). The PIRO concept: I is for infection (meeting report). Critical Care Medicine 7, 252-255. Zwart, S., Rovers, M.M., Melker, R.A. de, & Hoes, A.W. (2003). Penicillin for acute sore throat in children: randomised, double blind trial. BMJ - British Medical Journal 327, 1324-1324. National publications

Ernst-Kruis, M.R. drs., Rutgers, M.I.L., Révész, T., Wolfs, T.F.W., Fleer, A., & Geelen, S.P.M. (2003). Invasieve infectie met Moraxella catarrhalis bij twee kinderen met lymfatische leukemie en granulocytopenie. Nederlands Tijdschrift voor Geneeskunde 147 (23), 1126-1128.

Flier, M. van der, Dijk, N.B. van, Fluit, A.C., Fleer, A., Wolfs, T.F.W., & Gestel, J.P.J. van (2003). Fatale pneumonie bij een adolescent door thuis opgelopen meticillineresistente Staphylococcus aureus positief voor Panton-Valentine-leukocidine. Nederlands Tijdschrift voor Geneeskunde 147 (22), 1076-1079.

Folmer, H., Wit, N.J. de, Festen, H.P.M., Balen, F.A.M. van, & de Boer, W.A. (2003). Landelijke Transmurale Afspraak Maagklachten. Huisarts en Wetenschap 46 (12), 701-706.

Gerrits, J.A., Wolfs, T.F.W., & Geelen, S.P.M. (2003). Drie peuters met een zwelling in de hals. Nederlands Tijdschrift voor Geneeskunde 147 (6), 225-229.

Hak, E., & Sachs, A.P.E. (2003). Influenza en astma. Nederlands Tijdschrift voor Geneeskunde 2, 47-53.

Koomen, I., Raat, H., Jennekens-Schinkel, A., Grobbee, D.E., Roord, J.J., & Furth, A.M. van (2003). Leer- en gedragsproblemen en kwaliteit van leven van kinderen na bacteriële meningitis: waakzaamheid geboden. Tijdschrift voor Kindergeneeskunde 71 (3), 109-118.

Kroneman, M., Paget, WJ, & Essen, G.A. van (2003). Influenza vaccination in Europe: an inventory of strategies to reach target populations and optimise vaccination uptake. Euro surveillance 8, 130-138.

Lammers, J.J., & Sachs, A.P.E. (2003). Diagnostiek en therapie. In (Ed.), Elsevier science LTD Mosby.

Numans, M.E., Wit, N.J. de, Dirven, J.A.M., Hurenkamp, G.J.B., Meijer, Q.C.M., Muris, J.W.M., van der Laan, J.R., & Balen, F.A.M. van (2003). NHG/Standaard Maagklachten (tweede herziening). Huisarts en Wetenschap 12 (46), 690-700.

Rutten, G.E.H.M. (2003). Zorg voor diabetes type 2 in de huisartspraktijk. In R.J. Heine (Ed.), Diabetes mellitus in vogelvlucht - aspecten van multidisciplinaire diabeteszorg (Diabetes mellitus in vogelvlucht - aspecten van multidisciplinaire diabeteszorg, pp. 93-107). Van Zuiden Communications

31

BV. Verheij, Th.J.M., Salome, Ph.L, Bindels, P.J.E., Chavannes, A.W., Ponsioen, B.P., Sachs,

A.P.E., Thiadens, HA, Romeijneders, A.C.M., & Balen, J.A.M. (2003). NHG-standaard acuut hoesten. Huisarts en Wetenschap 46 (9), 496-506. Book, book chapters & proceedings

Bernelot Moens, H.J., Croonenburg, J.J. van, Al, M.J., Bemt, P.M.L.A. van den, Folmer, H., Janssen, M., Lourens, J., Rutten, W.J.M.J., & Numans, M.E. (2003). CBO-richtlijn NSAID-gebruik en maagschade. Alphen aan den Rijn: van zuiden communications bv.

Govaert, T.M.E., & Essen, G.A. van (2003). Influenza. In R et al Jones (Ed.), Oxford Textbook of Primary Medical Care (Volume 2 Clinical management). Oxford: Oxford University Press.

Numans, M.E. (2003). Chronic abdominal complaints. In R.H. Jones & L. Culpepper (Eds.), Oxford Textbook of Primary Care Oxford University Press.

Quiroga, L.E., & Verheij, Th.J.M. (2003). Lower respiratory tract infections. In R. Jones, N. Britten, L Culpepper & et al (Eds.), Oxford textbook of primary medical care (pp. 675-677). Oxford: Oxford University Press.

Rutten, G.E.H.M. (2003). (Serie) Diabetes. Kennis en zorg in de huisartspraktijk. . Mark Two Communications bv: . Mark Two Communications bv.

Sachs, A.P.E., & Dekhuijzen, P.N.R. (2003). Obstructieve longziekten. Schriftelijke nascholing voor huisartsen. Benecke: Pulmo Plus.

Schilder, A.G.M., & Rovers, M.M. (2003). International Perspective on Management. In R.M. Rosenfeld & C.D. Bluestone (Eds.), Evidence-Based Otitis Media (pp. 325-332). Hamilton: B.C. Decker. Verheij, Th.J.M. (2003). Upper respiratory tract infections. In R. Jones, N. Britten, L. Culpepper & et al (Eds.), Oxford textbook of primary medical care (pp. 673-675). Oxford: Oxford University Press.

32


Research group Pathogenesis and epidemiology of viral infection in humans

(UU UMC 2.1.7 & UU UMC 2.1.8)

Leader C.A.B. Boucher

J. van Hattum A.M. van Loon

Staff

Ms G.J. Boland Ms. M. Nijhuis R. Schuurman

A.J.L. Weersink

Post docs D.A.M.C. van de Vijver

PhD students

Ms L. van Elden Ms. C.D.G. Huigen

Ms N.M. van Maarseveen Ms. A. Sleijffers

Ms. H. van Soest Ms R. Strànská

Titles PhD projects Ms. L. van Elden: Therapy and changes in susuptibility of influenza viruses to therapy in vitro

and in vivo Ms. C.D.G. Huigen: HIV-I reverse transcriptase inhibitor resistance and its consequences for viral virulence Ms N.M. van Maarseveen: Rational approach towards understandig and overcoming

HIV protease inhibitor resistance Ms R. Strànská: Antivirale resistentie bij herpes simplex virus Ms A. Sleijffers: Ultraviolet B-induced immunomodulation of hepatitis B vaccination responses Ms. H. van Soest: Treatment of hepatitis C Ms A.M.J. Wensing: Pathogenesis and epidemiology of viral infection Thesis Elden, L.J.K. van (03-10-2003). Molecular Diagnostics for the Detection of Respiratory Viruses and Clinical Value UU Universiteit Utrecht (140 pag.). . Prom./coprom.: Hoepelman, I.M., Loon, A.M. van, & Nijhuis, M. Kraaij, M.G.J. van (07-10-2003). New developments in the diagnosis and the prevention of infections in stem cell transplant recipients UU Universiteit Utrecht (176 pag.). (Enschede: PrintPartners Ipskamp B.V.). Prom./coprom.: Hagenbeek, A., Dekker, A.W., & Loon, A.M. van International publications Caliendo, A.M., Yen-Lieberman, B., Baptista, J., Andersen, J., Crumpacker, C., Schuurman, R., Spector, S.A., Bremer, J., & Lurain, N.S. (2003). Comparison of molecular tests for detection and quantification of cell-associated cytomegalovirus DNA Journal of Clinical Microbiology 41 (8), 3509-3513. Davis, C., Heath, A., Best, S., Hewlett, I., Lelie, N., Schuurman, R., & Holmes, H. (2003). Calibration of HIV-1 working reagents for nucleic acid amplification techniques against the 1st international standard for HIV-1 RNA Journal of virological methods 107 (1), 37-44. Elden, L.J.K. van, Loon, A.M. van, Beek, A. van der, Hendriksen, K.A., Hoepelman, I.M., Kraaij, M.G.J. van, Schipper, P., & Nijhuis, M. (2003). Applicability of a real-time quantitative PCR assay for diagnosis of respiratory syncytial virus infection in immunocompromised adults Journal of Clinical Microbiology 41 (9), 4378-4381. Hak, E., Hoes, A.W., Grobbee, D.E., Lammers, J.W.J., Essen, G.A. van, Loon, A.M. van, &

33

Verheij, Th.J.M. (2003). Conventional Influenza Vaccination Is Not Associated with Complications in Working-Age Patients with Asthma or Chronic Obstructive Pulmonary Disease American Journal of Epidemiology 157, 692-700. Kooij, B. van, Thijsen, S.F.T., Niesters, H.G.M., Meyer, E., Verdonck, L.F., & Loon, A.M. van (2003). Sequence analysis of EBV DNA isolated from mouth washings and PBMC¿s of health individuals and blood of EBV-LPD patients Journal of clinical virology 28 (1), 85-92. Lutter, R., Wissen, M., Roger, T., Bresser, P., Sluijs, K.F. van der, Nijhuis, M., & Jansen, H.M. (2003). Mechanisms that potentially underlie virus-induced exaggerated inflammatory responses by airway epithelial cells Chest 123 (3 Suppl), 391S. Martinez-Picado, J., Negredo, E., Ruiz, L., Fumaz, C.R., Shintani, A., Zala, C., Domingo, P., Vilaro, J., Llibre, J.M., Viciana, P., Hertogs, K., Boucher, C.A.B., D'aquila, R.T., Clotet, B., & Swatch Study Team, Swatch (2003). A Multi-center, ramdomized trial of proactive switching and alternation of antiretroviral drug regimens for HIV infection Annals of Internal Medicine 139, 81-89. Meijer, E., Boland, G.J., & Verdonck, L.F. (2003). Prevention of cytomegalovirus disease in recipients of allogeneic stem cell transplants Clinical Microbiology Reviews 16 (4), 647-657. Pereira, C.F. da Fonseca, Bovenkamp, M. van de, Middel, J., Verhoef, J., & Nottet, H.S.L.M. (2003). APHS can act synergically with clinically available HIV-1 reverse transcriptase and protease inhibitors and is active against several drug-resistant HIV-1 strains in vitro Journal of Antimicrobial Chemotherapy 51 (5), 1181-1189. Pereira, C.F. da Fonseca, Paridaen, J.T., Rutten, K., Huigen, C.D.G., Bovenkamp, M. van de, Middel, J., Beerens, N., Berkhout, B., Schuurman, R., Marnett, L.J., & Verhoef, J. (2003). Aspirin-like molecules that inhibit human immunodeficiency virus 1 replication Antiviral Research 58 (3), 253-263. Reddy, Y.S., Kashuba, A., Gerber, J., Miller, V., & Boucher, C.A.B. (2003). Importance of antiretroviral drug concentrations in sanctuary sites and viral reservoirs AIDS Research and Human Retroviruses 19 (3), 167-176. Schloss, L., Loon, A.M. van, Cinque, P., Cleator, G.M., Echevarria, J-M., Falk, K., Klapper, P.E., Schirm, J., Faber Vestergaard, B., Niesters, H.G.M., Popow-Kraupp, P., Quint, W., & Linde, A. van der (2003). An international external quality assessment of nucleic acid amplification of herpes simplex virus Journal of clinical virology 28, 175-185. Sluijs, K. van der, Elden, L.J.K. van, Nijhuis, M., Schuurman, R., Florquin, S., Jansen, H.M., Lutter, R., & Poll, T. van der (2003). Toll-like receptor 4 is not involved in host defence against respiratory tract infections with Sendai virus Immunology Letters 89 (2-3), 201-206. Torti, C., Quiros-Roldan, E., Keulen, W., Scudeller, L., Lo Caputo, S., Boucher, C.A.B., Castelli, F., Mazzotta, F., Pierotti, P., Been-Tiktak, A.M.M., Buccoliero, G., Gennaro, M. De, Carosi, G., Tinelli, C., Study Group, GenPherex, & Cohort, MaSTeR (2003). Comparison between rules-based human immunodeficiency virus type 1 genotype interpretations and real or virtual phenotype: concordance analysis and correlation with clinical outcome in heavily treated patients Journal of Infectious Diseases 188 (2), 194-201. Woensel, J.B.M. van, Lutter, R., Biezeveld, M., Dekker, T., Nijhuis, M., Aalderen, W.M.C van, & Kuijpers, T.W. (2003). Effect of dexamethasone on tracheal viral load and interleukin-8 tracheal concentration in children with respiratory syncytial virus infection Pediatric Infectious Disease Journal 22 (8), 721-726. National publications

Bartels, M., Weersink, A.J.L., Wolfs, T.F.W., Bierings, M.B., & Révész, T. (2003). De behandeling van een Epstein-Barr-virus-gerelateerde lymfoproliferatieve ziekte na een allogene stamceltransplantatie: het gebruik van monoklonale anti-CD20-antilichamen Tijdschrift voor kindergeneeskunde 71 (2), 63-66. Manten, G.T.R., Derks, J.B., Loon, A.M. van, Gerards, L.J., & Bruinse, H.W. (2003). Waterpokken bij een zwangere met ernstige gevolgen voor moeder en kind Nederlands Tijdschrift voor Geneeskunde 147 (41), 2029-2032. Vijver, D.A.M.C. van der, & Laer, T. (2003). De ziekte van Parkinson I. Behandeling van motorische complicaties Geneesmiddelenbulletin 37, 63-70. Books, book chapters & proceedings Schuurman, R. (2003). Antiviral Drugs [Bespreking van het boek Antiviral Drugs]. Antivir.Ther., 8, 259.

34


Research group Prevention of pulmonary infection

(UU UMC 2.1.5)

Leader H. Snippe

Staff

C.A. Kraaijeveld

PhD students Ms. M.C.A. Blans

Titles PhD projects Ms. M.C.A. Blans: Aspects of Immunity against mycobacterium tuberculosis International publications

Lefeber, D.J., Benaissa-Trouw, B.J., Vliegenthart, J.F.G., Kamerling, J.P., Jansen, W.T.M., Kraaijeveld, C.A., & Snippe, H. (2003). Influence of adjuvants on the immunogenicity of oligosaccharide-protein conjugate vaccines related to Streptococcus pneumoniae type 3. Infection and Immunity 71 (12), 6915-6920. Book, book chapters & proceedings

S. Marzuki, J. Verhoef & H. Snippe (Eds.), Tropical Diseases: From Molecule To Bedside (Advances in Experimental Medicine and Biology, 531, pp. 301-314). New York: Kluwer Academic / Plenum Publishers.

35

Faculty of Veterinary Medicine, Utrecht University Department of Infectious Diseases and Immunology

Research group

Parasitology and tropical veterinary medicine (UU VET 07.04)

Leader

A.W.C.A. Cornelissen F. Jongejan

Staff

M. Eysker H.W. Ploeger

E. de Vries

Post docs C.P.J. Bekker

T. Mes Mrs. A.P. Yatsuda

PhD students

Mrs F.R. Gaffar Ms. K.U. Kanobana

F. Kooyman Ms. N. van Poppel

Ms. M. van der Veer

Titles PhD projects Mrs F.R. Gaffar: Characterization of the pathways leading to red blood cell invasion by Babesiabovis merozoites M-J. Gubbels: Application of recombinant DNA technology to vaccination, diagnosis and epidemiology of tropical theileriosis Ms K.U. Kanobana: The role of excretory products of Coopria oncophora in the induction of acquired immunity F. Kooyman: Immune response in calves infected with Dictyocaulus viviparus Ms. N. van Poppel: Phenotypic analysis of essential gene products in Toxoplasma gondii Ms M. van der Veer: Population genetics van cooperia oncophora and ostertagia ostertag during the parasitic phase in cattle

Thesis Kanobana, K.U. (18-09-2003). Experimental Cooperia oncophora infections in calves: an insight into host-parasite interactions UU Universiteit Utrecht (168 pag.). . Prom./coprom.: Cornelissen, A.W.C.A., Ploeger, H.W., Vervelde, L., & Eysker, M. Veer, M. van der (06-11-2003). Studies on the genetic population structure of Cooperia oncophora UU Universiteit Utrecht (120 pag.). . Prom./coprom.: Cornelissen, A.W.C.A., Vries, E. de, & Ploeger, H.W. International publications Bell-Sakyi, L., Koney, E.B.M., Dogbey, O., Sumption, K.J., Walker, A.R., Bath, A., & Jongejan, F. (2003). Detection by two enzyme-linked immunosorbent assays of antibodies to Ehrlichia ruminantium in field sera collected from sheep and cattle in Ghana Clinical and Diagnostic Laboratory Immunology 10, 917-925. Centeno-Lima, S., Rosario, V. do, Parreira, R., Maia, A.J., Freudenthal, A.M., Nijhof, A.M., & Jongejan, F. (2003). A fatal case of human babesiosis in Portugal: molecular and phylogenetic analysis Tropical medicine & international health 8, 760-764.

Coles, G.C., Eysker, M., Hodgkinson, J., Matthews, J.B., Kaplan, R.M., Klei, T.R., & Sangster, N. (2003). Anthelmintic resistance and use of anthelmintics in horses Veterinary Record 153, 636.

Dijkstra, T., Barkema, H.W., Eysker, M., Beiboer, M.L., & Wouda, W. (2003). Evaluation of a single serological screening of dairy herds for Neospora caninum antibodies Veterinary parasitology

36

110, 161-169. Franssen, F.F., Gaffar, F.R., Yatsuda, A.P., & Vries, E. de (2003). Characterisation of erythrocyte invasion by Babesia bovis merozoites efficiently released from their host cell after high-voltage pulsing Microbes and Infection 5, 365-372. Gaffar, F.R., Franssen, F.F., & Vries, E. de (2003). Babesia bovis merozoites invade human, ovine, equine, porcine and caprine erythrocytes by a sialic acid-dependent mechanism followed by developmental arrest after a single round of cell fission International Journal for Parasitology 33, 1595-1603. Hulst, R.G.M. van der, Mes, T.H.M., Falque, M., Stam, P., Nijs, J.C.M. den, & Bachmann, K. (2003). Genetic structure of a population sample of apomictic dandelions Heredity 90, 326-335. Kanobana, K.U., Koets, A.P., Kooyman, F.N.J., Bakker, N., Ploeger, H.W., & Vervelde, L. (2003). B cells and antibody response in calves primary-infected or re-infected with Cooperia oncophora: influence of priming dose and host responder types International Journal for Parasitology 33 (13), 1487-1502. Kanobana, K.U., Koets, A.P., Bakker, N., Ploeger, H.W., & Vervelde, L. (2003). T-cell mediated immune responses in calves primary-infected or re-infected with Cooperia oncophora: similar effector cells but different timing International Journal for Parasitology 33 (13), 1503-1514. Kirschner, J., Stepanek, J., Mes, T.H.M., Nijs, J.C.M. den, Oosterveld, P., Storchova, H., & Kuperus, P. (2003). Principal features of the cpDNA evolution in Taraxacum (Asteraceae, Lactuceae): a conflict with taxonomy Plant systematics and evolution 239, 231-255. Maldonado San Martin, A.P., Adamec, L., Suda, J., Mes, T.H.M., & Storchova, H. (2003). Genetic variation within the endangered species Aldrovanda vesiculosa (Droseraceae) as revealed by RAPD analysis Aquatic botany 75, 159-172. Mes, T.H.M. (2003). Demographic expansion of parasitic nematoed of livestock based on mitochondrial DNA regions that conflict with the infinite-sites model Molecular ecology 12, 1555-1566. Mes, T.H.M. (2003). Technical variability and required sample size of helminth egg isolation procedures Veterinary parasitology 115, 311-320. Moyo, D.Z., Hendrikx, W.M.L., Obwolo, M.J., & Eysker, M. (2003). The effect of treatment with a 1% injectable formulation of moxidectin during the rainy season and at the beginning of the dry season on gastrointestinal nematodes in cattle from communal areas in Zimbabwe Tropical animal health and production 35, 1-16. Nijhof, A.M., Penzhorn, B.L., Lynen, G., Mollel, J.O., Morkel, P., Bekker, C.P.J., & Jongejan, F. (2003). Babesia bicornis sp.nov. and Theileria bicornis sp.nov.: tick-borne parasites associated with mortality in the black rhinoceros (Diceros bicornis) Journal of Clinical Microbiology 41, 2249-2254. Osterman Lind, E., Eysker, M., Nilsson, O., Uggla, A., & Hoglund, J. (2003). Expulsion of small strongyle nematodes (cyathostomin spp) following deworming of horses on a stud farm in Sweden Veterinary parasitology 115, 289-299. Schnittger, L., Yin, H., Gubbels, M.-J., Beyer, D., Niemann, S., Jongejan, F., & Ahmed, J.S. (2003). Phylogeny of sheep and goat Theileria and Babesia parasites Parasitology research 91, 398-406. Veer, M. van der, Kanobana, K.U., Ploeger, H.W., & Vries, E. de (2003). Cytochrome oxidase c subunit 1 polymorphisms show significant differences in distribution between a laboratory maintained population and a field isolate of Cooperia oncophora Veterinary parasitology 116, 231-238. Veer, M. van der, & Vries, E. de (2003). Genetic intrapopulation variation, revealed by amplified fragment length polymorphism, within a population of the trichostrongylid nematode Cooperia oncohora Experimental Parasitology 104, 70-73. Vervelde, L., Bakker, N., Kooyman, F.N.J., Cornelissen, A.W.C.A., Bank, C.M.C., Nyame, A.K., Cummings, R.D., & Die, A. van (2003). Vaccination-induced protection of lambs against the parasitic nematode Haemonchus contortus correlates with high IgG antibody responses to the LDNF glycan antigen Glycobiology 13 (11), 795-804. Woods, P.S.A., Wynne, H.J., Ploeger, H.W., & Leonard, D.K. (2003). Path analysis of subsistence farmers' use of veterinary services in Zimbabwe Preventive veterinary medicine 61, 339-358. Yatsuda, A.P., Krijgsveld, J., Cornelissen, A.W.C.A., Heck, A.J.R., & Vries, E. de (2003). Comprehensive analysis of the secreted proteins of the parasite Haemonchus contortus reveals extensive sequence variation and differential immune recognition Journal of Biological Chemistry 278 (19), 16941-16951. National publications Holzhauer, M., Ploeger, H.W., & Verhoeff, J. (2003). Longwormproblemen bij melkkoeien: symptomatologie, diagnostiek en pathogenese aan de hand van een viertal cases Tijdschrift voor diergeneeskunde 128, 174-178. Mesu, S.J., Pellicaan, C.H.P., & Hendrikx, W.M.L. (2003). Anti-ectoparasitica juni 2002 Tijdschrift voor diergeneeskunde 127, 523-526.

37

Book, book chapters & proceedings Jongejan, F., & Kaufman, W.R. (Eds.). (2003). Ticks and tick-borne pathogens Dordrecht: Kluwer Academic Publishers.

38


Research group

Molecular infection biology (UU VET 07.02)

Leader

J.P.M. van Putten

Staff W. Gaastra

Post docs

R.A.M.H. van Aubel Ms. N. Bleumink - Pluym

M.M.S.M. Wösten

PhD students Ms. L. van Alphen Ms. S. van Selm

M.R. de Zoete

Titles PhD projects Ms. L. van Alphen Invasion strategies of Campylobacter jejuni Ms. S. van Selm: The capsule synthesis of streptococcus pneumoniae and the use of s. pneumoniae enzymes in carbohydrate synthesis M.R. de Zoete: Campylobacter vaccine development Thesis Selm, S. van (19-06-2003). Generation of capsule diversity in Streptococcus pneumoniae UU Universiteit Utrecht (104 pag.). . Prom./coprom.: Putten, J.P.M. van, Zeijst, B.A.M. van der, & Kolkman, M.A.B. Starcic Erjavec, M. (07-03-2003). Mosaic structure and regulation of conjugal transfer of the Escherichia coli plasmid pRK100 UU Universiteit Utrecht (112 pag.). . Prom./coprom.: Putten, J.P.M. van, Zgur-Bertok, D., & Grabnar, M. Verkaar, E.L.C. (23-10-2003). Structure and evolution of the Y-chromosomal and mitochondrial DNA of cattle UU Universiteit Utrecht (149 pag.). . Prom./coprom.: Putten, J.P.M. van, & Lenstra, J.A. Agbo, E.C. (27-03-2003). Genome analysis and DNA marker-based characterisation of pathogenic trypanosomes UU Universiteit Utrecht (189 pag.). . Prom./coprom.: Claassen, E., Putten, J.P.M. van, Büscher, P., & Pas, M.F.W. te Boekema, B.K.H.L. (19-06-2003). Pathogenesis of Actinobacillus pleuropneumoniae: role of toxins and fimbriae Utrecht University, Faculty of Veterinary Medicine (133 pag.). . Prom./coprom.: Verheijden, J.H.M., Putten, J.P.M. van, & Smith, H. International publications

Boekema, B.K.H.L., Stockhofe-Zurwieden, N., Smith, H.E., Kamp, E.M., Putten, J.P.M. van, & Verheijden, J.H.M. (2003). Adherence of Actinobacillus pleuropneumoniae to primary cultures of porcine lung epithelial cells Veterinary microbiology 93 (2), 133-144. Duijkeren, E. van, Wannet, W.J.B., Houwers, D.J., & Pelt, W. van (2003). Antimicrobial susceptibilities of Salmonella strains isolated from humans, cattle, pigs, and chickens in the Netherlands from 1984 to 2001 Journal of Clinical Microbiology 41 (8), 3574-3578. Ensink, J.M., Smit, J.A.H., & Duijkeren, E. van (2003). Clinical efficacy of trimethoprim/sulfadiazine and procaine penicillin G in a Streptococcus equi subsp. zooepidemicus infection model in ponies Journal of Veterinary Pharmacology and Therapeutics 26, 247-252. Selm, S. van, Cann, L.M. van, Kolkman, M.A.B., Zeijst, B.A.M. van der, & Putten, J.P.M. van (2003). Genetic basis for the structural difference between Streptococcus pneumoniae serotype 15B and 15C capsular polysaccharides Infection and Immunity 71 (11), 6192-6198. Soethout, E.C., Rutten, V.P.M.G., Houwers, D.J., Groot, H.S. de, Antonis, A.F.G, Niewold, D.J.H., & Müller, K.E. (2003). Alpha(4)-Integrin (CD49d) expression on bovine peripheral blood neutrophils is related to inflammation of the respiratory system Veterinary Immunology and Immunopathology 93 (1-2), 21-29. Starcic Erjavec, M., Putten, J.P.M. van, Gaastra, W., Jordi, B.J.A.M., Grabnar, M, & Zgur-

39

Bertok, D. (2003). H-NS and Lrp serve as positive modulators of traJ expression from the Escherichia coli plasmid pRK100 Molecular genetics and genomics 270 (1), 94-102. Starcic Erjavec, M., Gaastra, W., Putten, J.P.M. van, & Zgur-Bertok, D. (2003). Identification of the origin of replications and partial characterization of plasmid pRK100 Science Direct - Plasmid 50, 102-112. Starcic Erjavec, M., Zgur-Bertok, D., Jordi, B.J.A.M., Wösten, M.M.S.M., Gaastra, W., & Putten, J.P.M. van (2003). The cyclic AMP-cyclic AMP receptor protein complex regulates activity of the traJ promoter of the Escherichia coli conjugative plasmid pRK100. Journal of Bacteriology 185 (5), 1616-1623. Steinsland, H., Valentiner-Branth, P., Grewal, H.M.S., Gaastra, W., Molbak, K., & Sommerfelt, H. (2003). Development and evaluation of genotypic assays for the detection and characterization of enterotoxigenic Escherichia coli Diagnostic Microbiology and Infectious Disease 45, 97-105. National publications

Duijkeren, E. van, & Sloet van Oldruitenborgh, M.M. (2003). Droes Veehouder en Dierenarts 1, 4-5. Duijkeren, E. van, Box, A.T.A., Mulder, J., Wannet, W.J.B., Fluit, A.C., & Houwers, D.J. (2003). Een meticilline-resistente Staphylococcus aureus (MRSA)-infectie bij een hond in Nederland Tijdschrift voor diergeneeskunde 128 (10), 314-315.

40

Faculty of Biology, Utrecht University Department of microbiology

Research group

Molecular microbiology (UU BIO 0.12)

Leader

J.P.M. Tommassen

Post docs J.P. van Ulsen

PhD students

J.J.G. Geurtsen International publications Adams, H., Teertstra, W.R., Demmers, J.A.A., Boesten, R., & Tommassen, J.P.M. (2003). Interactions between phage-shock proteins in Escherichia coli. Journal of Bacteriology 185, 1174-1180. Khattabi, M. El, Gelder, P. van, Bitter, W., & Tommassen, J.P.M. (2003). Role of the calcium ion and the disulfide bond in the Burkholderia glumae lipase. Journal of Molecular Catalysis B-Enzymatic 22, 329-338. Llamas, M.A., Rodriguez-Herva, J.J., Hancock, R.E.W., Bitter, W., Tommassen, J.P.M., & Ramos, J.L. (2003). Role of Pseudomonas putida tol-oprL gene products in uptake of solutes through the cytoplasmic membrane. Journal of Bacteriology 185, 4707-4716.

P. van Ulsen, L. van Alphen, J. ten Hove, F. Fransen, P. van der Ley, J. Tommassen. 2003. A neisserial autotransporter NalP modulating the processing of other autotransporters. Molecular Microbiology 50, 1017-1030. Vandeputte-Rutten, L., Bos, M.P., Tommassen, J.P.M., & Gros, P. (2003). Crystal structure of neisserial surface protein A (NspA), a conserved outer membrane protein with vaccine potential. Journal of Biological Chemistry 278 (27), 24825-24830. Voulhoux, J.R., Bos, M.P., Geurtsen, J.J.G., Mols, M., & Tommassen, J.P.M. (2003). Role of a highly conserved bacterial protein in outer membrane protein assembly. Science 299, 262-265. Vrind, J. de, Groot, A. de, Brouwers, G.J., Tommassen, J.P.M., & Vrind-de Jong, E. de (2003). Identification of a novel Gsp-related pathway required for secretion of the manganese-oxidizing factor of Pseudomonas putida strain GB-1. Molecular Microbiology 47, 993-1006. Book, book chapters & proceedings

Tommassen, J.P.M., & Voulhoux, J.R. (2003). Biogenesis of outer membrane proteins. In B. Oudega (Ed.), Protein secretion pathways in bacteria, Chapter 5 Dordrecht: Kluwer Academic publishers.

41

Faculty of Veterinary Medicine, Utrecht University Department of Infectious Diseases and Immunology Virology Division

Research group Pathobiology and molecular epidemiology of veterinary virus

(UU VET 07.01)

Leader P.J.M. Rottier

Staff

H.F. Egberink R.J. de Groot

C.A.M. de Haan

Post docs E. Vogel

B.J. Haijema J.R.F. Mijnes M.H. Verheije

I.M. van der Lubben

PhD students E.E.C. Agbo

Ms. P. Jochemsen Ms. T. Lauterslager

Ms. M. Oostra F. Simons

Ms. M.G.J. Tacken Ms. M. de Wit

Titles PhD projects E.E.C. Agbo: Genome analysis and DNA marker-based characterisation of pathogenic trypanosomes Ms. P. Jochemsen: Infectious bursal disease virus; in ovo vaccination Ms. T. Lauterslager: Oral immunisation with LTB-based edible vaccines Ms. M. Oostra: Trojan horse vaccines F. Simons: Epidemiology and diagnosis of feline infectious peritonitis Ms. M.G.J. Tacken: Infectious bursal disease virus and protein-protein interactions Ms. M. de Wit: Immunopotentiation of endogenous cytokines in vaccine-induced immunity evoked by co-delivery of microbial components Thesis Lauterslager, T.G.M. (10-01-2003). Feasibility of oral immunisation with LTB-based edible vaccines Utrecht University, Faculty of Veterinary Medicine (120 pag.). (Amsterdam: Printpartners Ipskamp). Prom./coprom.: Rottier, P.J.M., Meloen, R.H., & Hilgers, L.A.Th. Tacken, M.G.J. (13-11-2003). Molecular interactions of the infectious bursal disease virus proteins Utrecht University, Faculty of Veterinary Medicine (215 pag.). (Enschede: Printpartners Ipskamp). Prom./coprom.: Rottier, P.J.M., Peeters, B.P.H., & Boot, H.J. Wieringa, R. (18-06-2003). The envelope proteins of Equine arteritis virus Utrecht University, Faculty of Veterinary Medicine (143 pag.). (Wageningen: Ponsen & Looijen b.v.). Prom./coprom.: Rottier, P.J.M., & Vries, A.A.F. Martina, B.E.E. (28-04-2003). Seal herpesviruses. Characterisation, host susceptibility and vaccine development UU Universiteit Utrecht (144 pag.). . Prom./coprom.: Osterhaus, A.D.M.E.

International publications Bosch, B.J., Zee, R. van der, Haan, C.A.M. de, & Rottier, P.J.M. (2003). The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex Journal of Virology 77, 8801-8811. Castillo-Olivares, J., Wieringa, R., Bakonyi, T., Vries, A.A.F. de, Davis-Poynter, N.J., & Rottier,

42

P.J.M. (2003). Generation of a condidate live marker vaccine for equine arteritis virus by deletion of the major virus neutralization domain Journal of Virology 77, 8470-8480. Haagmans, B.L., Hoogerbrugge, J.W., Themmen, A.P.N., & Tjeerds, K.J. (2003). Rat testicular germ cells and sertoli cells release different types of bioactive transforming growth factor beta in vitro Reproductive Biology and Endocrinology 1, 3-9. Haan, C.A.M. de, Genne, L. van, Stoop, J.N., Volders, H., & Rottier, P.J.M. (2003). Coronaviruses as vectors: position dependence of foreign gene expression Journal of Virology 77, 11312-11323. Haan, C.A.M. de, Wit, M.C. de, Kuo, L., Montalto-Morrison, C., Haagmans, B.L., Weiss, S.R., Masters, P.S., & Rottier, P.J.M. (2003). The glycosylation status of the murine hepatitis coronavirus M protein affects the interferogenic capacity of the virus in vitro and its ability to replicate in the liver but not the brain Virology 312, 395-406. Haijema, B.J., Volders, H., & Rottier, P.J.M. (2003). Switching species tropism an effective way to manipulate the feline coronavirus genome Journal of Virology 77, 4528-4538. Smits, S.L., Lavazza, A., Matiz, K., Horzinek, M.C., Koopmans, M.P.G., & Groot, R.J. de (2003). Phylogenetic and evolutionary relationships among torovirus field variants: evidence for multiple intertypic recombination events Journal of Virology 77, 9567-9677. Tacken, M.G.J., Beuken, P.A. van den, Peeters, B.P.H., Thomas, A.A.M., Rottier, P.J.M., & Boot, H.J. (2003). Homotypic interactions of the infectious bursal disease virus proteins VP3, pVP2, VP4 and VP5: mapping of the interacting domains Virology 312, 306-319. Wieringa, R., Vries, A.A.F., & Rottier, P.J.M. (2003). Formation of disulfide-linked complexes between the three minor envelope glycoproteins (GP(2b), GP(3) and GP(4)) of Equine Arteritis Virus Journal of Virology 77, 6216-6226. Wieringa, R., Vries, A.A.F., Post, S.M., & Rottier, P.J.M. (2003). Intra- and intermolecular disulfide bonds of the GP(2b) glycoprotein of equine arteritis virus: relevance for virus assembly and enfectivity Journal of Virology 77 (16), 12996-13004. Wissink, E.H.J., Wijk, H.A. van, Pol, J.M.A., Godeke, G.J., Rijn, P.A. van, Rottier, P.J.M., & Meulenberg, J. (2003). Identification of porcine alveolar macrophage glycoproteins involved in infection of porcine respiratory and reproductive syndrome virus Archives of virology 148, 177-187. Wissink, E.H.J., Wijk, H.A.R. van, Kroese, M.V., Weiland, E., Meulenberg, J.J.M., Rottier, P.J.M., & Rijn, P.A. van (2003). The major envelope protein, Gp5, of aEuropean porcine reproductive and respiratory syndrome virus contains a neutralization epitope in its N-terminal ectodomain The journal of general virology 84, 1535-1543.

43

University Medical Center Utrecht Department of Immunology and Pediatrics

Research group Pathogenesis and prevention of pediatric infectious and immune diseases

(UU UMC 2.5)

Leaders J.L.L. Kimpen

W. Kuis

Staff H.G.M. Arets G. van Bleek

C.K. van der Ent J. Frenkel

M.O. Hoekstra N.J.G. Jansen

A.B.J. Prakken T.T. Révész G.T. Rijkers

E.A.M. Sanders A.J. van Vught

T.F.W. Wolfs N.M. Wulffraat

PhD students W. Balemans

Ms. M. Ermers B. van Ewijk M. v.d. Flier P. de Graaff

L.M. Haveman Ms. I.M. Hament Ms. J. Heidema

E. Huijssoon Ms. B. de Jong

H. de Jong Ms. S.S.M. Kamphuis

Ms. B. Kapitein Ms. N. Katier

Ms. I.M. de Kleer Ms. C.A. Lindemans

L.E.M. Niers Ms. M. van Pel

Ms. A. van Royen Ms. S.T.A. Roord

M.G. Slieker T.J. Steenhuis

M. van Summeren S.W.J. Terheggen - Lagro

B. Vastert Ms. H.A.E. Vreugdenhil

S.P. Wiertsema Titles PhD projects W. Balemans: Role of early infections and genetics into development of asthma in adults a

prospective study (KNOOPsGAT) M.v.d.Flier: Analyse van de rol van vascular permeability factor (VPF/VEGF) en

substance-P in de verhoogde vaatpermeabiliteit bij sepses en de verhoogde doorlaatbaarheid van de bloedhersenbarriere bij bacteriele meningitis

44

Ms. M. Ermers: Local anti inflammatory treatment in the prevention of long-term airway morbidity following RSV infection: clinical efficacy and immunological correlations

B. van Ewijk: The respiratory epithelial cell, a key player in custic fibrosis Ms. P. de Graaff: Role of DC's in RSV infections Ms. I.M. Hament: Role of virus infections with pneumococcus adhesion Ms. L. Haveman: Identification of MHC class II restricted T-cell epitopes of adenovirus

serotype 5; the first step towards immunotherapy in pediatric allergeneic hematopoietic stem cell recipients

Ms. J. Heidema: De rol van T-cellen in infecties met RSV E. Huijssoon: To correct the fault within ourselves Ms. B. de Jong: Wheezing illness study Leidsche Rijn (Whistler) H. de Jong: Self peptide responses in reumatoid arthritis Ms. S. Kamphuis: Heat shock proteins; targets for immunotherapy Ms. B. Kapitein: Early differentiation between heterogeneous infant wheezing phonotypes by

using gene expression profiles in peripheral blood derived T-lymphocytes Ms. N. Katier: Wheezing Illnesses study Leidsche Rijn (Whistler) Ms. I. de Kleer: Developing immunotherapy in juvenile idioathic arthritis Ms. C.A. Lindemans Wheezing in infants: identification of the allergic asthma phenotype Ms. T. Niers: The influence of prolonged perinatal administration of probiotics on

sensitisation in high risk neonates; a clinical and immunological study. Ms. M. van Pel Role of facilitating cells and hematopoietic growth factors in the induction of

donor-specific tolerance with donor derived stem cells Ms. A. van Royen: Fc-receptor mediated immunomodulation S.T.A. Roord: Nasal immunomodulation in experimental arthritis M. Slieker: Fenotype and genotype in cystic fibrosis; the role of modifier genes M. van Summeren: Vit K-afhankelijke eiwitten Ms. S. Terheggen - Lagro: Cystic fibrosis: a hereditary inflammatory process B. Vasterd: To correct the fault within ourselves Ms. H.A.E. Vreugdenhil: Biotrauma: pro- and anti inflammation in disbalance? S.P. Wiertsema: Recurrent otitis media with effusion in children Thesis Brouwer, C.N.M. (15-04-2003). Health related quality of life in children with recurrent acute otitis media UU Universiteit Utrecht.. Prom./coprom.: Grobbee, D.E., Maillé, A.R., Sanders, E.A.M., Schilder, A.G.M., & Kuis, W.

Demmink, J.H. (08-04-2003). Therapeutic Ultrasound: theoretical backgrounds and clinical applications UU Faculteit Geneeskunde (144 pag.). . Prom./coprom.: Helders, P.J.M., Hobaek, H., Prevo, A.J.H., Kuis, W., Oostendorp, R.A.B., & Wijer, A. de

Flier, M. van der (28-11-2003). VEGF in meningitis and sepsis. UU Universiteit Utrecht (148 pag.). (Enschede: Febodruk). Prom./coprom.: Kimpen, J.L.L., Hoepelman, I.M., & Geelen, S.P.M.

Genderingen, H.R. van (07-03-2003). Quest for optimal lung volume during high-frequency oscillatory ventilation Vrije Universiteit Amsterdam.. Prom./coprom.: Heethaar, R.M., Vught, A.J. van, & Jansen, J.R.C. Hament, J.M. (21-11-2003). The pathogenesis of S. pneumoniae infections. UU Universiteit Utrecht. (Enschede: Febodruk BV). Prom./coprom.: Kimpen, J.L.L., Dijk van, H., Wolfs, T.F.W., Fleer, A., & Sanders, E.A.M.

Kamps, A.W.A. (02-10-2003). Management of childhood asthma. Reappraisal of current practice and implementation of nurse-led care. UU Universiteit Utrecht. (Enschede: Febodruk BV). Prom./coprom.: Kimpen, J.L.L., Brand, P.L.P., & Roorda, R.J. Klijn, P.H.C. (13-05-2003). Physical fitness and quality of life in children with cystic fibrosis UU Faculteit Geneeskunde (1-112 pag.). . Prom./coprom.: Helders, P.J.M., Kimpen, J.L.L., Ent, C.K. van der, & Net, J.J. van der Nolte-'t Hoen, E.N.M. Drs. (01-12-2003). Tuning of T cell responses by regulatory T cells UU Universiteit Utrecht. (Enschede: PrintPartners Ipskamp BV). Prom./coprom.: Prakken, A.B.J. Pel, M. van (03-06-2003). Induction and maintenance of mixed chimerism and donor-specific tolerance in a murine model UU Universiteit Utrecht.. Prom./coprom.: Kuis, W., Boog, C.J.P., Eden, W. van, Hagenbeek, A., Ploemacher, R.E., Kimpen, J.L.L., & Claas, F. Schoenmakers, M.A.G.C. (09-09-2003). Functional Aspects of Spina Bifida in Childhood UU Universiteit Utrecht.. Prom./coprom.: Helders, P.J.M., Prevo, A.J.H., Gooskens, R.H.J.M., & Gulmans, V.A.M.

Snepvangers, D.A.C.M. (27-11-2003). Respiratory mechanics in ventilated preterm infants: early determinants and outcome. UU Universiteit Utrecht (163 pag.). . Prom./coprom.: Bel, F. van, Kimpen, J.L.L., Ent, C.K. van der, & Winter, J.P. Takken, T. (21-01-2003). Studies on physical performance and functional ability in juvenile idiopathic arthritis UU Faculteit Geneeskunde (1-124 pag.). (Alphen aan de Rijn: T. Takken).

45

Prom./coprom.: Helders, P.J.M., Kuis, W., & Net, J.J. van der Vreugdenhil, H.A.E. (28-11-2003). Mechanical ventilation and immune function. UU

Universiteit Utrecht.. Prom./coprom.: Vught, A.J. van, Heijnen, C.J., Lachmann, B., & Jansen, N.J.G. International publications Annels, N.E., Willemze, A.J., van der Velden, V.H., Faaij, C.M., Wering, E.R. van, Sie-Go, D.M.D.S., Egeler, R.M., Tol, M.J. van, & Révész, T. (2003). Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL. Blood. Antoine, Corinne, Müller, Susanna, Cant, A., Cavazzana-Calvo, Marina, Veys, Paul, Vossen, J.M.J., Fasth, A., Heilmann, Carsten, Wulffraat, N.M., Seger, R.A., Blanche, S., Friedrich, W.N., Abinun, Mario, Davies, G.A., Bredius, R.G., Schulz, Ansgar, Landais, P., & Fischer, A. (2003). Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968-99. Lancet 361, 553-560. Arets, H.G.M., Brackel, H.J.L., & Ent, C.K. van der (2003). Applicability of interrupter resistance measurements using the Micro Rint in daily practice Respiratory Medicine 97, 366-374. Bergshoeff, A.S., Fraaij, P.L.A., Rossum, AMC van, Wolfs, T.F.W., Geelen, S.P.M., Groot, R de, & Burger, D.M. (2003). Pharmacokinetics of nelfinavir in children: influencing factors and dose implications Antiviral Therapy 8, 215-222. Bergshoeff, A.S., Wolfs, T.F.W., Geelen, S.P.M., & Burger, D.M. (2003). Ritonavir-enhanced pharmacokinetics of Nelfinavir/M8 during Rifampin use Annals of Pharmacotherapy 37 (4), 521-525. Boer, J.H. de, Wulffraat, N.M., & Rothova, A. (2003). Visual loss in uveitis of childhood British Journal of Ophthalmology 87, 879-884. Bollen, C.W., Uiterwaal, C.S.P.M., & Vught, A.J. van (2003). Cumulative metaanalysis of high-frequency versus conventional ventilation in premature neonates American Journal of Respiratory and Critical Care Medicine 168 (10), 1150-1155. Bom, J.G. van der, Fischer, K., & Berg, H.M. van den (2003). Meta-analysis on the effectiveness of B-domain deleted factor VIII fot prophylaxis Haemophilia 9, 744-750. Custers, J.W.H., Wassenberg, J.E., Net, J.J. van der, Hoijtink, H.J.A., Vermeer, A., & Helders, P.J.M. (2003). Dutch adaptation of the pediatric evaluation of disability inventory Dutch Journal of Physical Therapy 113, 33-36. Demmink, J.H., & Helders, P.J.M. (2003). The effect of moving an ultrasound transducer on tissue heating Advances in Physiotherapy 2003 (5), 50-56. Demmink, J.H., Helders, P.J.M., Hobaek, H., & Enwemeka, C. (2003). The variation of heating depth with therapeutic ultrasound frequency in physiotherapy Ultrasound in Medicine and Biology 29 (1), 113-118. Eden, W. van, Koets, A.P., Kooten, P. van, Prakken, A.B.J., & Zee, R. van der (2003). Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity Vaccine 14, 897-901. Elst, E.F., Kamphuis, S.S.M., Prakken, A.B.J., Wulffraat, N.M., Net, J.J. van der, Peters, A.C.B., & Kuis, W. (2003). Case report: severe central nervous system involvement in juvenile dermatomyositis Journal of Rheumatology 30 (9), 2059-2063.

Engelbert, R.H.H., Uiterwaal, C.S.P.M., Hulst, A. van der, Witjes, B., Helders, P.J.M., & Pruijs, J.E.H. (2003). Scoliosis in children with osteogenesis imperfecta: influence of severity of disease and age of reaching motor milestones. European Spine Journal 12, 130-134. Flier, M. van der, Geelen, S.P.M., Kimpen, J.L.L., Hoepelman, I.M., & Tuomanen, E. (2003). Reprogramming the host response in bacterial meningitis: how best to improve outcome? Clinical Microbiology Reviews 16 (3), 415-429. Frosch, M., Vogl, T., Seeliger, S., Wulffraat, N.M., Kuis, W., Viemann, D., Foell, D., Sorg, C., Sunderkotter, C., & Roth, J. (2003). Expression of Myeloid-Related Proteins 8 and 14 in Systemic-Onset Juvenile Rheumatoid Arthritis. Arthritis and Rheumatism 48 (9), 2622-2626. Geelen, S.P.M., Lange, J.M., Borleffs, J.C.C., Wolfs, T.F.W., Weersink, A.J.L., & Schuurman, R. (2003). Failure to detect a non-B HIV-1 subtype by the HIV-1 Amplicor Monitor test, version 1.5: a case of unexpected vertical transmission AIDS 17 (5), 781-782. Genderingen, H.R. van, Vught, A.J. van, & Jansen, J.R. (2003). Estimation of regional lung volume changes by electrical impedance pressures tomography during a pressure-volume maneuver Intensive Care Medicine 29 (2), 233-240. Gennery, A.R., Khawaja, K., Veys, Paul, Bredius, R.G., Notarangelo, L.D., Mazzolari, E., Fischer, A., Landais, P., Cavazzana-Calvo, Marina, Friedrich, W., Fasth, A., Wulffraat, N.M., Matthes-Martin, S., Bordigoni, P., Lange, A. de, Pagliuca, A., Andolina, M., Cant, A.J., & Davies, EG (2003). Treatment of CD40 ligand deficiency by hematopoietic stem cell transplantation: a survey of the European experience 1993-2002 Blood. Goulden, N., Bader, P., van der Velden, V.H., Moppett, J., Schilham, M.W., Masden, H.O., Krejci, O., Kreyenberg, H., Lankester, A., Révész, T., Klingebiel, T., & Dongen, JJ van (2003). Minimal residual disease prior to stem cell transplant for childhood acute lymphoblastic leukaemia. British Journal of Haematology 122 (1), 27-29.

46

Gracchi, V. Drs., Boel, M, Laag, J. van der, & Ent, C.K. van der (2003). Spirometry in young children: should computer animation programs be used during testing? European Respiratory Journal 21, 872-875. Hacein-Bey-Abina, Salima, von Kalle, Christof, Schmidt, M., Deist, Françoise le, Wulffraat, N.M., McIntyre, Elisabeth, Radford, Isabelle, Villeval, Jean-Luc, Fraser, Christophe, Cavazzana-Calvo, Marina, & Fischer, A. (2003). A serious Adverse Event after Successful Gene Therapy for X-linked Severe Combined Immunodeficiency New England Journal of Medicine 348 (3), 255-256. Hacein-Bey-Abina, Salima, von Kalle, Christof, Schmidt, M., McCormack, M.P., Wulffraat, N.M., Leboulch, P., Lim, A., Osborne, C.S., Pawliuk, R., Morillon, E, Sorensen, Ricardo, Forster, A, Fraser, P, Cohen, J., Saint Basile, G. de, Alexander, I, Wintergerst, U, Frebourg, T., Aurias, A., Stoppa-Lyonnet, D., Romana, S., Radford-Weiss, I., Gross, F., Valensi, F., Delabesse, E., Macintyre, E., Sigaux, F., Soulier, J, Leiva, L.E., Wissler, M., Prinz, C., Rabbitts, T.H., Le Deist, F., Fischer, A., & Cavazzana-Calvo, Marina (2004). LMO2-associated clonal T cell Proliferation in two patients after gene therapy for SCID-X1 Science 17 (302 (5644)), 415-419. Hament, J.M., Dijk, H. van, Fleer, A., Aerts, P.C., Schoenmakers, M., Snoo, M. de, Dekker, B.H., Kimpen, J.L.L., & Wolfs, T.F.W. (2003). Pneumococcal immune adherence to human erythrocytes European Journal of Clinical Investigation 33 (2), 169-175. Helders, P.J.M., Engelbert, R.H.H., Custers, J.W.H., Gorter, J.W., Takken, T., & Net, J.J. van der (2003). Creating and being created: the changing panorama of paediatric rehabilitation. Pediatric rehabilitation 6 (1), 5-12. Helders, P.J.M. (2003). Improving Care Advances in Physiotherapy, 1-2. Hoebee, B., Rietveld, E., Bont, L.J., Oosten, M. van, Hodemaekers, H.M., Nagelkerke, N.J.D., Neijens, H.J., Kimpen, J.L.L., & Kimman, T.G. (2003). Association of severe respiratory syncytial virus bronchiolitis with Interleukin-4 and Interleukin-4 receptor alpha polymorphisms Journal of Infectious Diseases 187 (1), 2-11. Houten, S.M., Frenkel, J., & Waterham, H.R. (2003). Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation Cellular and Molecular Life Sciences 60, 1118-1134. Hulzebos, E.H.J., Meeteren, N.L.U. van, Bie, R.A. de, Dagnelie, P.C., & Helders, P.J.M. (2003). Prediction of postoperative pulmonary complications on the basis of preoperative risk factors in patients who had undergone coronary artery bypass graft surgery Physical Therapy 83 (1), 8-16. Jager, W. de, Velthuis, H. te, Prakken, A.B.J., Kuis, W., & Rijkers, G.T. (2003). Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clinical and Diagnostic Laboratory Immunology 10 (1), 133-139. Janus, G.J., Engelbert, R.H.H., Beek, E., Gooskens, R.H.J.M., & Pruijs, J.E.H. (2003). Osteogenesis imperfecta in childhood: MR imaging of basilar impression. European Journal of Radiology 47 (1), 19-24.

Kempen-Harteveld, M.L. van, Weel-Sipman, M.H., Emmens, C., Noordijk, E.M., Tweel, I. van der, Révész, T., Struikmans, H., Kal, H.B., Does-van den Berg, A. van der, & Vossen, J.M.J.J. (2003). Eye shielding during total body irradation for bone marrow transplantation in children transplanted for a hematological disorder: risks and benefits. Bone Marrow Transplantation 31, 1151-1156. Kleer, I.M. de, Kamphuis, S.S.M., Rijkers, G.T., Scholtens, L.E., Gordon, G, Jager, W. de, Hafner, R., Zee, R. van der, Eden, W. van, Kuis, W., & Prakken, A.B.J. (2004). The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10 Arthritis and Rheumatism 48 (7), 2001-2010. Klijn, P.H.C., Lagro, S.W.J., Ent, C.K. van der, Net, J.J. van der, Kimpen, J.L.L., & Helders, P.J.M. (2003). Anaerobic exercise in pediatric cystic fibrosis Pediatric pulmonology 36, 223-229. Klijn, P.H.C., Net, J.J. van der, Kimpen, J.L.L., Helders, P.J.M., & Ent, C.K. van der (2003). Longitudinal Determinants of Peak Aerobic Performance in Children With Cystic Fibrosis Chest 124 (6), 2215-2219. Kneyber, M.C.J., & Vught, A.J. van (2003). Respiratory syncytial virus infection and invasive meningococcal disease: is there an association? European Journal of Pediatrics 162 (5), 352-353. Krejci, O., van der Velden, V.H., Bader, P., Kreyenberg, H., Goulden, N., Hancock, J., Schilham, M.W., Lankester, A., Révész, T., Klingebiel, T., & Dongen, JJ van (2003). Level of minimal residual disease prior to haematopoietic stem cell transplantation predicts prognosis in paediatric patients with acute lymphoblastic leukaemia: a report of the Pre-BMT MRD Study Group. Bone Marrow Transplantation 32 (8), 849-851. Lagro, S.W.J., Truyens, N.D.M., Poppel, N. van, Gulmans, V.A.M., Laag, J. van der, & Ent, C.K. van der (2003). Correlation of six different cystic fibrosis chest radiograph scoring systems with clinical parameters Pediatric pulmonology 35, 441-445. Lagro, S.W.J., Bink, M., Vreman, H.J., & Ent, C.K. van der (2003). End-tidal carbon monoxide corrected for lung volume is elevated in patients with cystic fibrosis American Journal of Respiratory and Critical Care Medicine 168, 1227-1231. Markhorst, D.G., Genderingen, H.R. van, Leenhoven, T., & Vught, A.J. van (2003). A system for integrated measurement of ventilator settings, lung volume change and blood gases during high-frequency oscillatory ventilation Journal of Medical Engineering & Technology 27 (3), 128-132. Niers, L.E.M., Rijkers, G.T., Knol, E.F., Meijer, Y., & Hoekstra, M.O. (2003). Probiotics for

47

prevention of atopic disease? Lancet 9 (362), 496. Plotz, F.B., Vreugdenhil, H.A.E., Vught, A.J. van, & Heijnen, C.J. (2003). Mechanical ventilation and multiple organ failure. Lancet 361 (9369), 1654-1654. Prakken, A.B.J., Roord, S., Ronaghy, A., Wauben, M.H.M., Albani, S., & Eden, W. van (2003). Heat shock protein 60 and adjuvant arthritis: a model for T cell regulation in human arthritis Springer seminars in immunopathology 25, 47-63. Puga Yung, G.L., Le, T.D., Roord, S., Prakken, A.B.J., & Albani, S. (2003). Heat shock proteins (HSP) for immunotherapy of rheumatoid arthritis (RA). Inflammation Research 52, 443-451. Rijkers, G.T., Vermeer-de Bondt, P.E., Spanjaard, L., Breukels, M.A., & Sanders, E.A.M. (2003). Return of Haemophilus influenzae type b infections. Lancet 361 (9368), 1563-1564. Rijn, R.S. van, Simonetti, E.R., Hagenbeek, A., Hogenes, M.C., Weger, R.A. de, Canninga-van Dijk, M.R. van, Weijer, K., Spits, H., Storm, G., Bloois, L. van, Rijkers, G.T., Martens, A.C.M., & Ebeling, S.B. (2003). A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/-gammac-/-dubbel-mutant mice Blood 102 (7), 2522-2531. Rossum, AMC van, Gaakeer, M.I., Verweel, G., Hartwig, N.G., Wolfs, T.F.W., Geelen, S.P.M., Lamberts, S.W.J., & Groot, R de (2003). Endocrinologic and immunologic factors associated with recovery of growth in children with human immunodeficiency virus type 1 infection treated with protease inhibitors Pediatric Infectious Disease Journal 22 (1), 70-76. Rossum, M.A.J., Zwinderman, A.H., Boers, M., Dijkmans, B.A.C., Soesbergen, R.M. van, Fiselier, T.J.W., Franssen, M.J.A.M., Cate, R. ten, Suijlekom-Smit, L.W.A., Wulffraat, N.M., Kuis, W., Luijk, W.H.J., Oostveen, J.C.M., & Dijkstra, PF (2003). Radiologic Features in Juvenile Idiopathic Arthritis - A First Step in the Deveopment of a Standarized Assesment Method Arthritis and Rheumatism 48 (2), 507-515. Royen-Kerkhof, A. van, Wulffraat, N.M., Kamphuis, S.S.M., & Brooimans, R.A. (2003). Nonlethal transfusion associated graft-versus-host disease in a severe combined immunodeficient patient. Bone Marrow Transplantation 32 (10), 1027-1030. Ruperto, N., Ravelli, A., Murray, K.J., Lovell, D., Andersson Gäre, B., Feldman, B.M., Garay, S., Kuis, W., Machado, C., Pachman, L., Prieur, A.M., Rider, L.G., Silverman, E., Tsitsami, E., Woo, P., Giannini, E.H., & Martini, A. (2003). Preliminary core sets of measures for disease activity and damage assessment in juvenile systemic lupus erythematosus and juvenile dermatomyositis Rheumatology 42, 1-8.

Saeland, E., Vidarsson, G., Leusen, J.H.W., Garderen, E. van, Nahm, M., Vile, H., Walraven, V., Stemerding, A.M., Verbeek, J.S., Rijkers, G.T., Kuis, W., Sanders, E.A.M., & Winkel, J.G.J. van de (2003). Central Role of Complement in Passive Protection by Human IgG1 ad IgG2 Anti-pneumococcal Antibodies in Mice Journal of Immunology 170 (12), 6158-6164. Saeland, E., Leusen, J.H.W., Vidarsson, G., Kuis, W., Sanders, E.A.M., Jonsdottir, I., & Winkel van de, J.G.J. (). Role of Leukocyte Immunoglobulin G Receptors in Vaccine-Induced Immunity to Streptococcus pneumoniae Journal of Infectious Diseases. Sanders, E.A.M., Veenhoven, R.H., Bogaert, D., Schilder, A.G.M., & Hermans, P.W.M. (2003). Effect of conjugate pneumococcal vaccine on recurrent acute otitis media Lancet 362, 1081-1081. Schoenmakers, M.A.G.C., Gooskens, R.H.J.M., Gulmans, V.A.M., Hanlo, P.W., Vandertop, W.P., Uiterwaal, C.S.P.M., & Helders, P.J.M. (2003). Long-term outcome of neurosurgical untethering on neurosegmental motor and ambulation levels. Developmental Medicine & Child Neurology 45 (8), 551-555. Slieker, M.G., Deckers-Kocken, J.M., Uiterwaal, C.S.P.M., Ent, C.K. van der, & Houwen, R.H.J. (2003). Risk factors for the development of cystic fibrosis related liver disease Hepatology 38, 775-776. Slieker, M.G., & Ent, C.K. van der (2003). The diagnostic and screening capacities of peak expiratory flow measurements in the assessment of airway obstruction and bronchodilator response in children with asthma Monaldi archives for chest disease 59, 155-159. Smit, J.J., Loveren, H. van, Hoekstra, M.O., Nijkamp, F.P., & Bloksma, M.A. (2003). Influence of the macrophage resistance gene Nramp1 (Slc11A1) on the induction of allergic asthma in the mouse FASEB Journal 10, 1096-1096. Smit, J.J., Loveren, H. van, Hoekstra, M.O., Schijf, M.A., Folkerts, G. Prof., & Nijkamp, F.P. (2003). Mycobacterium vaccae administration during allergen sensitization or challenge suppresses asthmatic features Clinical and Experimental Allergy 33, 1083-1089. Smit, J.J., Loveren, H. van, Hoekstra, M.O., Karimi, K., Folkerts, G. Prof., & Nijkamp, F.P. (2003). The Slc11a1 (Nramp1) gene controls efficacy of mycobacterial treatment of allergic asthma Journal of Immunology 171, 754-760. Smit, J.J., Loveren, H. van, Hoekstra, M.O., Kant, P.A.A. van der, Folkerts, G. Prof., & Nijkamp, F.P. (2003). Therapeutic treatment with heat-killed Mycobacterium vaccae (SRL172) in a mild and severe mouse model for allergic asthma European Journal of Pharmacology 470, 193-199. Snepvangers, D.A.C.M., Winter, J.P., Burger, H., Brouwers, H.A.A., Bogaard, J.M., & Ent, C.K. van der (2003). Correction factors for oxygen and flow-rate effects on neonatal Fleish and Lilly pneumotachometers Pediatric Critical Care Medicin 4, 227-232. Straetemans, M., Sanders, E.A.M., Veenhoven, R.H., Schilder, A.G.M., Damoiseaux, R.A.M.J., & Zielhuis, G.A. (). Review of randomized controlled trials on pneumococcal vaccination for prevention

48

of otitis media Pediatric Infectious Disease Journal. Straetemans, M., Sanders, E.A.M., Veenhoven, R.H., Schilder, A.G.M., Damoiseaux, R.A.M.J., & Zielhuis, G.A. (2003). Systematic review of randomised controlled trials on pneumococcal vaccination for prevention of otitis media Pediatric Infectious Disease Journal 22, 515-524. Takken, T., Spermon, N., Helders, P.J.M., Prakken, A.B.J., & Net, J.J. van der (2003). Aerobic Exercise Capacity in Patients with Juvenile Dermatomyositis Journal of Rheumatology 30, 1075-1080. Takken, T., Net, J.J. van der, Kuis, W., & Helders, P.J.M. (2003). Aquatic fitness training for children with Juvenile Idiopathic Arthritis Rheumatology 42 (11), 1408-1414. Takken, T., Net, J.J. van der, Kuis, W., & Helders, P.J.M. (2003). Physical activity and health related physical fitness in children with juvenile idiopathic arthritis Annals of the Rheumatic Diseases 2003 (Sep), 885-889.

Takken, T., Net, J.J. van der, & Helders, P.J.M. (2003). Relationship between functional ability and physical fitness in juvenile idiopathic arthritis patients Scand J Rheumatol 2003 (32), 174-178. Takken, T., Elst, E.F., Spermon, N., Helders, P.J.M., Prakken, A.B.J., & Net, J.J. van der (2003). The physiological and physical determinants of functional ability measures in children with juvenile dermatomyositis. Rheumatology 42 (4), 591-595. Timmers-Raaijmaakers, B.C.M.S., Wolfs, T.F.W., Jansen, N.J.G., Bos, A.P., & Vught, A.J. van (2003). Invasive group A streptococcal infection after tonsillectomy Pediatric Infectious Disease Journal 22 (10), 929-931. Tonnaer, E.L.M.G., Ingels, K.J.A.O., Rijkers, G.T., & Curfs, J.H. (2003). Antigenic as well as nonantigenic stimuli induce similar middle ear responses in the rat. Laryngoscope 113 (2), 322-327. Tonnaer, E.L.M.G., Sanders, E.A.M., & Curfs, J.H. (2003). Bacterial otitis media: a new non-invasive rat model. Vaccine 7 (21(31)), 4539-4544. Veenhoven, R.H., Bogaert, D., Uiterwaal, C.S.P.M., Brouwer, C.N.M., Bruin, J.P. de, Kiezebrink, H., IJzerman, E.P.M., Hermans, P.W.M., Groot, R de, Zegers, B.J.M., Kuis, W., Rijkers, G.T., Schilder, A.G.M., & Sanders, E.A.M. (2003). Effect of conjugate pneumococcal vaccine followed by polysaccharide pneumoccoccal vaccine on recurrent acute otitis media: a randomised study Lancet 361, 2189-2195. Vink, G.R., Arets, H.G.M., Laag, J. van der, & Ent, C.K. van der (2003). Impulse oscillometry: a measure for airway obstruction Pediatric pulmonology 35, 214-219. Vreugdenhil, H.A.E., Haitsma, J.J., Jansen, K.J., Zijlstra, J., Plotz, F.B., Dijk, J.E. van, Lachmann, B., Vught, A.J. van, & Heijnen, C.J. (2003). Ventilator-induced heat shock protein 70 and cytokine mRNA expression in a model of lipopolysaccharide-induced lung inflammation. Intensive Care Medicine 29 (6), 915-922. Walraven, D., Grinten, C.P.M. van der, Bogaard, J.M., Ent, C.K. van der, & Luijendijk, S.C.M. (2003). Modeling of the expiratory flow pattern of spontaneously breathing cats Respiratory Physiology & Neurobiology 134, 23-32. Whiteford, M.L., Woo, P., McDermott, M.F., Hitman, G.A., Aganna, E., Mirakian, R.M., Hammond, L., Hawkins, P.H., Aldea, A., McKee, S.A., Ploos van Amstel, H.K., Mischung, C., Kusuhara, K., Saulsbury, F.T., Lachmann, H.J., Bybee, A., McDermott, E.M., La Regina, M., Arostegui, J.I., Campistol, J.M., Worthington, S., High, K.P., Molloy, M.G., Baker, N., Bidwell, J.L., Castaner, J.L., Janssens-Korpola, P.L., Manna, R., Powell, R.J., Solis, P., Minden, K., Yague, J., & Frenkel, J. (2003). Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes Arthritis and Rheumatism 48 (9), 2632-2644. Woensel, J.B.M. van, Aalderen, W.M.C van, Weerd, W. de, Jansen, N.J.G., Gestel, J.P.J. van, Markhorst, D.G., Vught, A.J. van, Bos, A.P., & Kimpen, J.L.L. (2003). Dexamethasone for treatment of patients mechanically ventilated for lower respiratory tract infection caused by respiratory syncytial virus Thorax 58 (5), 383-387. Woensel, J.B.M. van, Aalderen, W.M.C van, & Kimpen, J.L.L. (2003). Viral lower respiratory tract infection in infants and young children BMJ - British Medical Journal 327, 36-40. Wulffraat, N.M., Brinkman, D., Ferster, A., Opperman, W.J., Cate, R. ten, Wedderburn, L., Foster, H., Abinun, Mario, Prieur, A.M., Horneff, G., Zintl, F., Kleer, I.M. de, & Kuis, W. (2003). Long term follow up after autologous stem cell transplantation for refractory juvenile idiopathic arthritis Bone Marrow Transplantation 32, S61-S64. Wulffraat, N.M., Haas, P. de, Frosch, M., Kleer, I.M. de, Vogl, T., Brinkman, D., Quartier, P., Roth, J., & Kuis, W. (2003). Myeloid related protein 8 and 14 secretion reflects phagocyte activation and correlates with disease activity in juvenile idiopathic arthritis treated with autologous stem cell transplantation. Annals of the Rheumatic Diseases 62, 236-241. Wulffraat, N.M., Rijkers, G.T., Elst, E., Brooimans, R.A., & Kuis, W. (2003). Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation. Rheumatology 42 (2), 375-379. Zandvoort, A., Lodewijk, M.E., Klok, P.A., Breukels, M.A., Rijkers, G.T., & Timens, W. (2003). After chemotherapy, functional humoral response capacity is restored before complete restoration of lymphoid compartments. Clinical and Experimental Immunology 131 (1), 8-16. Trijbels-Smeulders, M.A.J.M., Adriaanse, A.H., Gerards, L.J., & Kimpen, J.L.L. (2003). Strategy to prevent neonatal early onset group B streptococcal (GBS) disease in The Netherlands. Reviews in Medical Microbiology 14, 35-39.

49

Wulffraat, N.M., Armbrust, W., Rademaker, C.M.A., & Kuis, W. (2003). Case discussion: To stem cell transplant or not? Pediatric rheumatology online journal. Wulffraat, N.M., Sakkers, R.J.B., Reisen, M.T. van, & Kuis, W. (2003). Differentiating a septic arthritis secondary to surgical intervention from an aspetic flare of Juvenile Idiopatic Arthritis Pediatric rheumatology online journal. National publications

Arets, H.G.M., & Willemse, C. (2003). De meest gestelde vragen over astma bij baby's en peuters Contrastma, 6-8.

Arets, H.G.M. (2003). Longfunctieonderzoek bij spontaan ademende jonge kinderen Klinische Fysica 4, 19-24. Arets, H.G.M. (2003). Longfunctieonderzoek: technieken en toepassingen bij kinderen met astma Nederlands tijdschrift voor allergie 1, 39-42. Arets, H.G.M. (2003). Luchtwegmechanica bij jonge kinderen. Klinische Fysica 4, 14-18. Aronson, D.C., Schrijver-Levie, N.S., Hoekstra, M.O., & Teeuw, A.H. (2003). Kind met grote hoeveelheid pleuravocht door TB. De anamnese van de patient is essentieel Tegen de tuberculose 2, 39-40. Balemans, W.A.F., Laag, J. van der, & Ent, C.K. van der (2003). Allergische bronchopulmonale aspergillose bij Cystic Fibrosis Nederlands tijdschrift voor allergie 2, 66-72. Bartels, M., Weersink, A.J.L., Wolfs, T.F.W., Bierings, M.B., & Révész, T. (2003). De behandeling van een Epstein-Barr-virus-gerelateerde lymfoproliferatieve ziekte na een allogene stamceltransplantatie: het gebruik van monoklonale anti-CD20-antilichamen Tijdschrift voor kindergeneeskunde 71 (2), 63-66.

Breukels, M.A., Truyens, N.D.M., Brouwers, H.A.A., Ent, C.K. van der, & Arets, H.G.M. (2003). Vier zuigelingen met congenitale cysteuze longafwijkingen: gedifferentieerde diagnostiek en behandeling Nederlands Tijdschrift voor Kindergeneeskunde 147 (30), 1466-1466.

Ermers, M., & Hoekstra, M.O. (2003). Primaire preventie van allergie Nederlands tijdschrift voor allergie 3, 114-118.

Ernst-Kruis, M.R. drs., Rutgers, M.I.L., Révész, T., Wolfs, T.F.W., Fleer, A., & Geelen, S.P.M. (2003). Invasieve infectie met Moraxella catarrhalis bij twee kinderen met lymfatische leukemie en granulocytopenie Nederlands Tijdschrift Geneeskunde 147 (23), 1126-1128.

Flier, M. van der, Dijk, N.B. van, Fluit, A.C., Fleer, A., Wolfs, T.F.W., & Gestel, J.P.J. van (2003). Fatale pneumonie bij een adolescent door thuis opgelopen meticillineresistente Staphylococcus aureus positief voor Panton-Valentine-leukocidine Nederlands Tijdschrift Geneeskunde 147 (22), 1076-1079.

Frenkel, J. (2003). Periodieke koorts en mevalonaatkinasedeficientie Nederlands tijdschrift voor allergie 4, 179-181.

Gerrits, J.A., Wolfs, T.F.W., & Geelen, S.P.M. (2003). Drie peuters met een zwelling in de hals Nederlands Tijdschrift voor Geneeskunde 147 (6), 225-229.

Helders, P.J.M., & Sakkers, R.J.B. (2003). Grensverleggende multidisciplinaire samenwerking Tijdschrift voor kindergeneeskunde 71 (1), 3.

Helders, P.J.M., & Custers, J.W.H. (2003). Kinderfysiotherapie: symptoombestrijding of therapie? Tijdschrift voor kindergeneeskunde 71 (1), 38-41.

Hoepelman, I.M., & Wolfs, T.F.W. (2003). Splenectomie en pneumokokkenvaccinatie Nederlands Tijdschrift Geneeskunde 147 (23), 1143-1143.

Jansen, M.J.C.E., Bax, N.M.A., Révész, T., & Sanders, E.A.M. (2003). Splenectomie bij kinderen; indicaties en chirurgische aspecten. Nederlands Tijdschrift voor Geneeskunde 10, 433-436.

Kimpen, J.L.L., & Kuis, W. (2003). Onderzoek in de kindergeneeskunde: noodzaak voor focus Tijdschrift voor kindergeneeskunde 71, 137-138.

Meeteren, N.L.U. van, & Helders, P.J.M. (2004). Fysiotherapie: toenadering tot de basiswetenschappen Nederlands Tijdschrift voor Fysiotherapie 113 (3), 48-51. Net, J.J. van der, Prakken, A.B.J., Kuis, W., & Helders, P.J.M. (2004). Autoimmuunziekten van het houdings- en bewegingsapparaat: Juveniele Idiopathische Artritis Tijdschrift voor kindergeneeskunde 71 (1), 8-12.

Niers, L.E.M., & Hoekstra, M.O. (2003). Probiotica en allergie: huidige inzichten, vragen en toekomstperspectieven Nederlands tijdschrift voor allergie 4, 155-159.

Steenhuis, T.J., Aalderen, W.M.C van, & Hoekstra, M.O. (2003). Allergie op de kinderleeftijd - een rol voor primaire preventie? Tijdschrift Kindergeneeskunde 71, 217-222.

Armbrust, W., Wulffraat, N.M., & Kuis, W. (2003). Biologicals in de kinderreumatologie; werking en risico's. Tijdschrift voor kindergeneeskunde, 49-49.

Brinkman, D., Kleer, I.M. de, Cate, R. ten, Rossum, M.A.J., Bekkering, P., Fasth, A., Kuis, W., Wulffraat, N.M., & Vossen, J.M.J.J. (2003). Lange termijn follow-up na autologe stamceltransplantatie (ASCT) bij 22 patiënten met juveniele idiopathische artritis. Tijdschrift voor kindergeneeskunde, 48-48. Helders, P.J.M. (2003). The nature of paediatrics Kinderfysiotherapie 2003 (juni), 4-7. Hoepelman, I.M., Rijkers, G.T., & Sanders, E.A.M. (2003). Wat is het beleid voor en na splenectomie ten aanzien van Pneumovax®-injectie? Internisten Vademecum 4.

50

Kleer, I.M. de, Brinkman, D., Cate, R. ten, Kuis, W., & Wulffraat, N.M. (2003). Follow up van 34 kinderen met ernstige Juveniele Idiopathische Arthritis behandeld met een autologe beenmerg transplantatie: de Europese ervaring. Tijdschrift voor kindergeneeskunde, 48-48. Meeteren, N.L.U. van, & Helders, P.J.M. (2003). Fysiotherapie: toenadering tot de basiswetenschappen. Nederlands Tijdschrift voor Fysiotherapie 113 (3), 100-103.

Nusmeier, A., Jongste, J.C. de, Bos, A.P., Lam, J., & Hoekstra, M.O. (2003). Klinisch denken en beslissen in de praktijk. Een pasgeborene met dyspnoe Nederlands Tijdschrift Geneeskunde 147 (13), 1501-1506.

Prakken, A.B.J. (). Alweer ziek? Over kinderziekten, virussen, bacteriën, afweerstoffen, medicijnen en wat je zelf kunt doen. Ouders, pp. 74-81.

Takken, T. (2003). Inspanningstolerantie bij juveniele dermatomyositis NMZ-bulletin 14 (23), 9-9.

Takken, T. (2003). Onderzoek naar het lichamelijke prestatievermogen en functionele mogelijkheden bij patiënten met jeugdreuma Kinderfysiotherapie 2003 (maart), 26-28.

Takken, T. (2003). Onderzoek naar het lichamelijke prestatievermogen en functionele mogelijkheden bij patiënten met jeugdreuma Geneeskunde en sport 1, 20-21.

Takken, T. (2003). ACSM's resources for clinical exercise physiology [Bespreking van het boek ACSM's resources for clinical exercise physiology]. Geneeskunde en sport, 36, 13-13.

Tersmette, J.M., Prins, I., Ent, C.K. van der, & Gracchi, V. Drs. (2003). Spirometrisch onderzoek bij jonge kinderen: het effect van computeranimaties op de reproduceerbaarheid Longkruid 184, 15-19.

Veenhoven, R.H., Bogaert, D., Schilder, A.G.M., Uiterwaal, C.S.P.M., Rijkers, G.T., Hermans, P.W.M., & Sanders, E.A.M. (2003). Klinische ineffectiviteit van gecombineerde vaccinatie met 7-valent pneumokokkenconjugaatvaccin en 2.3-valent pneumokokkenpolysaccharidevaccin bij kinderen met recidiverende acute otitis media; een gerandomiseerd dubbelblind onderzoek Nederlands Tijdschrift voor Geneeskunde 147, 2220-2226.

Verhoeff, M., Rovers, M.M., Sanders, E.A.M., & Schilder, A.G.M. (2003). Een prospectieve, gerandomiseerde, dubbelblinde studie naar de effectiviteit van co-trimoxazol bij kinderen met chronische otitis media. COCO-studie Nederlands Tijdschrift voor KNO-Heelkunde 9, 129-130.

Visser, M. de, Hogeman, P.H.G., Vught, A.J. van, Révész, T., & Wolfs, T.F.W. (2003). Fulminant verlopende pneumokokkensepsis bij een 2-jarig kind met sikkelcelanemie Nederlands Tijdschrift voor Geneeskunde 147 (10), 454-456. Book, book chapters & proceedings

Ent, C.K. van der, Laag, J. van der, & Lammers, J.W.J. (Eds.). (2003). Diagnostiek en behandeling van cystic fibrosis bij kinderen en volwassenen Utrecht: CF Centrum Utrecht.

Hadders-Algra, M., & Helders, P.J.M. (2003). Ontwikkeling van bewegingsvaardigheden In M.J. Meihuizen-de Regt & J.M.H. de Moor (Eds.), Kinderrevalidatie (pp. 48-79). Assen: Koninklijke Van Gorcum.

Heijnen, L., & Helders, P.J.M. (2003). Prevention and treatment of joint problems in children with haemophilia In E.C. Rodriguez-Merchan (Ed.), The haemophilic joints new perspectives (pp. 133-137). Blackwell Publishing.

Kleer, I.M. de, Prakken, A.B.J., Albani, S., & Kuis, W. (2003). The development of immune therapy with HSP60 for juvenile idiopathic arthritis. In W. Prof. Dr. van Eden (Ed.), Heat Shock Proteins and Inflammation Basel, CH: Birkhäuser Publishing Ltd..

Net, J.J. van der, Bekkering, P., & Helders, P.J.M. (2003). Kinderfysiotherapie bij Juveniele Idiopathische Artritis In R Ten Cate, ThJW Fiselier & W Kuis (Eds.), Werkboek Kinderreumatologie (pp. 138-145). Amsterdam: Reumafonds, sterk in beweging.

Ronaghy, A., Huijssoon, E., Rossum, M.A. van, Prakken, A.B.J., Rijkers, G.T., Sanders, E.A.M., Vermeer-de Bondt, P.E., Hoes, A.W., Net, J.J. van der, Kuis, W., Rademaker, C.M.A., Jager, W. de, Klein, M.R., Tol, M.J. van, Engels, C, Amerongen, E. van, & Wulffraat, N.M. (2003). Vaccination does not exacerbate juvenile idiopathic arthritis disease activity in a cohort of dutch patients.. In (Ed.), Clinical and Experimental Rheumatology Vol. 21. Clinical and Experimental Rheumatology (pp. 535). Stresa, Italy.

Sanders, E.A.M., Weemaes, C.M.R., Gerritsen, E.J.A., & Vries, E. de (). Kinderen met recidiverende infecties. In (Ed.), Eerste cursus Inflammatie in de luchtwegen

Takken, T. (2003). [Bespreking van het boek Onderzoek naar het lichamelijke prestatievermogen van en de functionele mogelijkheden bij patiënten met jeugdreuma]. Revalidata, 25, 16-18.

Yung, G.P., Le, T.D., Roord, S.T.A., Prakken, A.B.J., & Albani, S. (2003). Heat shock proteins for immunotherapy of rheumatoid arthritis. In W. Prof. Dr. van Eden (Ed.), Heat Shock Proteins and Inflammation Basel - CH: Birkhäuser Publishing Ltd..

51

National Institute of Public Health and the Environment, Bilthoven Laboratory for Vaccine-Preventable Diseases (LTR)

Research group

Molecular epidemiology, immune- response and prevention of infection

Leader T.G. Kimman

Staff

G. Berbers R. van Binnendijk

H. Boot A.M. Buisman

F. v.d. Klis F.R. Mooi

M. van Oosten L.M. Schouls

P. Vermeer

PhD students Ms. M. Barends

D. Diavatapoulos M.Hijnen

Titles PhD projects Ms. M. Barends: Influence of RSV on the expression of allergy D. Diavatopoulos: Evolution of the Genus Bordetella M. Hijnen: Improvement of the Pertussis vaccine International publications: Barends M, Boelen A, Rond L de, Dormans J, Kwakkel J, Oosten M van, Neijens HJ, Kimman TG. Respiratory syncytial virus enhances respiratory allergy in mice despite the inhibitory effect of virus-induced interferon-γ. J Med Virol 2003;69:156-162. Binnendijk RS van, Hof S van den, Kerkhof H van den, Kohl RHG, Woonink F, Berbers GAM, Conyn-van Spaendonck MAE, Kimman TG. Evalutation of serological and virological tests in the diagnosis of clinical and subclinical measles virus infections during an outbreak of measles in the Netherlands. JID 2003;188:898-903. Boot HJ, Kasteel DTJ, Buisman AM, Kimman TG.Excretion of wild-type and vaccine-derived poliovirus in the feces of poliovirus receptro-transgenic mice. J Virol 2003;11:6541-6545. Buisman AM, Sonsma JAJ, Wijk MGS van, Vermeulen JP, Roholl PJH, Kimman TG. Pathogenesis of poliovirus infection in PVRTg mice: poliovirus replicates in peritoneal macrophages. J Gen Virol 2003;84:2819-2828. Christova I, Pol I van de, Yazar S, Velo E, Schouls LM. Identification of Borrelia burgdorferi sensu lato, Anaplasma and Ehrlichia, and spotted fever group rickettsiae in ticks from Southeastern Europe.Eur J Clin Microbiol Infect Dis 2003;22:535-542. Devereaux L, Polkinghorne A, Meijer A, Timms P. Identification of novel Chlamydial infections in the Koala (Phascolarctos cinereus). System Appl Microbiol 2003;26:245-253. Douglas JT, Qian L, Montoya JC, Musser JM, Embden JDA van, Soolingen D van, Kremer K. Characterization of the Manila family of Mycobacterium tuberculosis. J Clin Microbiol 2003;41:2723-6 Ertl OT, Wenz DC, Bouche FB, Berbers GAM, Muller CP. Immunodominant domains of the measles virus hemagglutinin protein eliciting a neutralizing human B cell response. Archives of Virology 2003;148:2195-2206. Geeraedts F, Wilczak N, Binnendijk R van, Keyser J de. Search for morbillivirus proteins in multiple sclerosis brain tissue. NeuroReport 2003;14:1-6. He Q, Mäkinen J, Berbers G, Mooi FR, Viljanen MK, Arvilommi H, Mertsola J. Bordetella pertussis protein pertactin induces type-specific antibodies: one possible explanation for the emergence of antigenic variants. JID 2003;187:1200-1205. Hellwig SMM, Rodriguez ME, Berbers GAM, Winkel JGJ van de, Mooi FR. Crucial role of antibodies to pertacin in Bordetella pertussis immunity. JID 2003;188:738-742. Hof S van den, Beaumont MTA, Berbers WAM, Melker H de. Antibodies against mumps in the Netherlands as assessed by indirect ELISA and virus neutralization assay. Epidemiol Infect 2003;131:703-709.

52

Hof S van den, Gageldonk-Lafeber AB van, Binnendijk RS van, Gageldonk PGM van, Berbers GAM. Comparison of measles virus-specific antibody titres as measured by enzyme-linked immunosorbent assay and virus neutralisation assay. Vaccine 2003;21:4210-4214. Jefferson T, Price D, Demicheli V, Bianco E. (EUSAFEVAC). Unintended events following immunizationwith MMR: a systematic review. Vaccine 2003;21:3954-3960. Hoebee B, Rietveld E, Bont L, Oosten M van Hodemaekers HM, Nagelkerke NJD, Neijens HJ, Kimpen JLL, Kimman TG. Association of severe respiratory syncytial virus bronchiolitis with Interleukin-4 and Interleukin-4 receptor α polymorphisms. JID 2003;187:2-11. Jacobs JA,Tjhie JHT, Smeets MGJ, Schot CS, Schouls LM. Genotyping by amplified fragment length polymorphism analysis reveals persistence and recurrence of infection with Streptococcus anginosus group organisms. J Clin Microbiol 2003;41:2862-2866. Melker HE de, Hof S van den, Berbers GAM, Conyn-van Spaendonck MAE. Evaluation of the national immunisation programme in the Netherlands: immunity to diphtheria, tetanus, poliomyelitis, measles, mumps, rubella and Haemophilus influenzae type b. Vaccine 2003;21:716-720. Nardone A, Pebody RG, Hof S van den, Levy-Bruhl D, Plesner AM, Rota MC, Tischer A, Andrews N, Berbers G, Crovari P, Edmunds WJ, Gabutti G, Saliou P, Miller E. Sero-epidemiology of mumps in Western Europe. Epidemiol Infect 2003;131:691-701. Schouls LM, Schot CS, Jacobs JA. Horizontal transfer of segments of the 16S rRNA genes between species of the “Streptococcus anginosus group”. J Bactiol 2003; 185:7241-7246. Schouls LM, Reulen S, Duim B, Wagenaar J, Willems RJL, Dingle KE, Colles FM, Embden JDA van. Comparative genotyping of Campylobacter jejuni by amplified fragment length polymorphism, multilocus sequence typing, and short repeat sequencing: strain diversity, host range and recombination. J Clin Microbiol 2002;41:15-26. Stuen S, Bergström K, Petrovec M, Pol I van de, Schouls LM. Differences in clinical manifestations and hematological and serological responses after experimental infection with genetic varinats of anaplasma phagocytophilum in sheep. Clin Diagnostic Lab Immunol 2003;10:692-695. Vandebriel RJ, Hellwig SMM, Vermeulen JP, Hoekman JHG, Dormans JAMA, Roholl PJM, Mooi FR. Association of Bordetella pertussis with host immune cells in the mouse lung. Microbial Pathogenesis 2003;35:19-29. Vlaminckx BJM, Mascini EM, Schellekens J, Schouls LM, Paauw A, Fluit AC, Novak R, Verhoef J, Schmitz FJ. J Clin Microbiol 2003;41:4941-4949. National publications: Boot HJ, Kimman TG. Recombinante poliovaccinstammen: een bedreiging voor de poliovirus eradicatie? Infect Bull 2003;7:247-252. Boot HJ, Melker TG de, Kimman TG. Experimenteel humaan papillomavirus vaccin blijkt zeer effectief. Inf. Bull 2003;14:207-210. Kimman TG. Een nieuw laboratorium voor de Toetsing van het Rijksvaccinatieprogramma: een kennismaking. JGZ 2003;6:118-120.

53

National Institute of Public Health and the Environment, Bilthoven Diagnostic laboratory for infectious diseases and perinatal screening

Research group

Population oriented virology

Leader Ms. M. Koopmans

Staff

Ms. T. Herremans E. Duizer

H. Vennema B. Wilbrink

H. van der Avoort

Post docs Mrs. E. van Strien

PhD students

J. Reimerink PhD projects J. Reimerink: Modulation of allergic responses by enteric infections B. Rockx: Control and prevention of viral diarrhea outbreaks through calicivirus

vaccination International Publications

Widdowson MA, Jaspers WJ, Poel WHvan der, Verschoor F, De Roda Husman AM, Winter HL, Zaaijer HL, Koopmans M. Cluster of cases of acute hepatitis associated with hepatitis e virus infection acquired in the Netherlands. Clin Infect Dis 2003;36(1):29-33.

Vinje J, Vennema H, Maunula L, von Bonsdorff CH, Hoehne M, Schreier E, Richards A, Green J, Brown D, Beard SS, Monroe SS, de Bruin E, Svensson L, Koopmans MP. International collaborative study to compare reverse transcriptase PCR assays for detection and genotyping of noroviruses. J Clin Microbiol 2003 Apr;41(4):1423-33

Van der Poel WH, van der Heide R, Verschoor F, Gelderblom H, Vinje J, Koopmans MP. Epidemiology of Norwalk-like virus infections in cattle in The Netherlands. Vet Microbiol 2003 Apr 29;92(4):297-309

Meijer, M. Du Ry van Beest Holle, R. Fouchier, G. Natrop, B. Wilbrink, A. Bosman, A. Osterhaus, J. van Steenbergen, M. Conyn-van Spaendonck, M. Koopmans. Human infection associated with outbreak of fowl plague (avian influenza) in the Netherlands - update 27 March. Eurosurveillance Weekly 2003;7:March 27th

M. Koopmans, R. Fouchier, B. Wilbrink, A.Meijer, G. Natrop, A.D.M.E. Osterhaus, J.E. van Steenbergen, M. du Ry van Beest Holle, M.A.E. Conyn van Spaendonck, A. Bosman. Update on human infections with highly pathogenic avian influenza virus A/H7N7 during an outbreak in poultry in the Netherlands. Eurosurveillance Weekly 2003;7:may 1st. Koopmans M, Vennema H, Heersma H, van Strien E, van Duynhoven Y, Brown D, Reacher M, Lopman B; European Consortium on Foodborne Viruses. Early identification of common-source foodborne virus outbreaks in Europe. Emerg Infect Dis. 2003 Sep;9(9):1136-42.

J. Despande, H. van der Avoort, J. Martin and W. Dowdle: “Poliovirus type 2 (MEF-1) found in northern India.” Quarterly Update for laboratories of the WHO Polio Network: 2003, IX-3, 1-2.

Chen-Fu Yang, Tary Naquib, Su-Ju Yang, Eman Nasr, Jaume Jorba, Named Ahmed, Ray Campagnoli, Harrie van der Avoort, Hiroyuki Shimizu, Tetsuo Yoneyama, Tatsuo Miyamura, Mark Pallansch and Olen Kew: “Endemic circulation of type 2 vaccine-derived poliovirus in Egypt, 1983 to 1993.” J. Virol. 2003, 2003, 77, 8366-8377. National Publications

H.G.A.M. van der Avoort: ‘Kans op polio door vaccinvirus klein” Reformatorisch Dagblad, opiniepagina: 15 april 2003

Gageldonk-Lafeber A van , Koopmans MPG, Bosman A, Heijnen M-LA. Het vóórkomen van Q-koorts in Nederland. Infectieziektebulletin 2003;14 (5):173 – 177.

54

H. Vennema, G.J. Godeke, E. de Bruin en M. Koopmans. Import van prairiehonden geeft kans op infecties met monkeypox. Infectieziektebulletin 2003, Volume 14 issue 11, 376:377 Koch G, van der Goot J, Bouma A, Elbers ARW, Du Ry van Beest Holle M, Meijer A, Fouchier R, Natrop G, Bosman A, Osterhaus A, van Steenbergen J, Conyn-van Spaendonck M, Koopmans M. Vogelpest in Nederland. Virus ook bij mensen. Infectieziekten bulletin 2003, volume 14, issue 4, 112-116.

55

Netherlands Vaccine Institute Bilthoven

Research group

Vaccine development for bacterial and viral infection

Leader A.J.W. van Alphen

Staff

G. van Amerongen Ms. C.J.P. Boog

J.M. Bos C. Hendriksen P. Hoogerhout

G. Kersten P. van der Ley

Post docs

Ms. G.P.J.M. van den Dobbelsteen Ms. C. A.C.M. van Els

W. Luytjes E.C. Soethout J.P. van Ulsen

G. Vidarsson Ms. M. Widjojoatmodjo

PhD students

A. Javadi M.I. de Jonge

Ms. M. van Pel

Titles PhD projects A. Javadi: Blocking of bacterial porins by peptides and peptidomimetics M.I. de Jonge: Opa-proteins in N. meningitis: structure/function relation and the use as vaccincomponent Ms. M. van Pel: Role of facilitating cells and hematopoietic growth factors in the induction of donor specific tolerance with donor derived stem cells Internationale publicaties Angulo AF ; Jacobs MV ; Damme EHA van ; Akkermans AM ; Kruijff-Kroesen I de ; Brugman J. Colistin sulfate as a suitable substitute of thallium acetate in culture media intended for mycoplasma detection and culture. Biologicals 2003; 31:161-3. Arigita C ; Bevaart L ; Everse LA ; Koning GA ; Hennink WE ; Crommelin DJA ; Winkel JGJ van de; Vugt MJ van ; Kersten GFA ; Jiskoot W. Liposomal meningococcal B vaccination: role of dendritic cell targeting in the development of a protective immune response. Infect Immun 2003; 71:5210-8 Arigita C ; Kersten GFA ; Hazendonk T ; Hennink WE ; Crommelin DJA ; Jiskoot W. Restored functional immunogenicity of purified meningococcal PorA by incorporation into liposomes. Vaccine 2003; 21:950-60. Bleek GM van ; Poelen MC ; Most R van der ; Brugghe HF ; Timmermans HAM ; Boog CJ ; Hoogerhout P ; Otten HG ; Els CACM van. Identification of immunodominant epitopes derived from the respiratory syncytial virus fusion protein that are recognized by human CD4 T cells. J Virol 2003; 77:980-8.

Bos JM ; Rumke H ; Welte R ; Postma MJ. Epidemiological impact and cost-effectiveness of universal infant vaccination with a 7-valent conjugated pneumococcal vaccine in the Netherlands. Clin Therapeutics 2003; 25:2614-30

Cussler K ; Halder M ; Hendriksen C. Future activities: ECVAM and the quality control of biologicals. ATLA 2003; 31:225-6.

Genevrois S ; Steeghs L ; Roholl P ; Letesson JJ ; Ley P van der. The Omp85 protein of Neisseria meningitidis is required for lipid export to the outer membrane. EMBO Journal 2003; 22:1780-9.

56

Gorter AD ; Oostrik J ; Ley P van der ; Hiemstra PS ; Dankert J ; Alphen L van. Involvement of lipopoligosaccharides of Haemophilus influenzae and Neisseria meningitidis in defensin-enhanced bacterial adherence to epithelial cells. Microb Pathog 2003; 34:121-30.

Greeff A de ; Hamilton A ; Sutcliffe IC ; Buys H ; Alphen L van ; Smith HE. Lipoprotein signal peptidase of Streptococcus suis serotype 2. Microbiology 2003; 149:1399-407.

Halder M ; Balls M ; Hendriksen C ; Cussler K. ECVAM's activities on biologicals. ATLA 2003; 31:125-8.

Hendriksen C ; Cussler K ; Halder M. ECVAM's role in the implementation of the three Rs concept in the field of biologicals. ATLA 2003; 31:41-6.

Herberts CA ; Meiring HM ; Gaans-van den Brink JAM ; Heeft E van der ; Poelen MCM ; Boog CJP ; Jong APJM de ; Els CACM van. Dynamics of measles virus protein expression are reflected in the MHC class I epitope display. Mol Immunol 2003; 39:567-75.

Jaye A ; Herberts CA ; Jallow S ; Atabani S ; Klein MR ; Hoogerhout P ; Kidd M ; Els CACM van ; Whittle HC. Vigorous but short-term gamma interferon T-cell responses against a dominant HLA-A*02-restricted measles virus epitope in patients with measles. J Virol 2003; 77:5014-6. Johannes S ; Hartinger J ; Hendriksen CFM ; Morton DB ; Cussler K. Humane endpoints in the efficacy testing of swine erysipelas vaccines. Altex 2003; 20:11-5.

Jonge MI de ; Hamstra HJ ; Alphen L van ; Dankert J ; Ley P van der. Mapping the binding domains on meningococcal Opa proteins for CEACAM1 and CEA receptors. Mol Microbiol 2003; 50:1005-15.

Jonge MI de ; Vidarsson G ; Dijken HH van ; Hoogerhout P ; Alphen L van ; Dankert J ; Ley P van der. Functional activity of antibodies against the recombinant OpaJ protein from Neisseria meningitidis. Infect Immun 2003; 71:2331-40.

Kersten GFA ; Crommelin DJA. Liposomes and ISCOMs. Vaccine 2003; 21:915-20. Ley P van der ; Steeghs L. Lessons from an LPS-deficient Neisseria meningitidis mutant. J

Endotoxin Res 2003; 9:124-8. Lubben IM van der ; Kersten G ; Fretz MM ; Beuvery C ; Verhoef JC ; Junginger HE. Chitosan microparticles for mucosal vaccination against diphtheria: oral and nasal efficacy studies in mice. Vaccine 2003; 21:1400-8.

Luijkx TA ; Dijken H van ; Hamstra HJ ; Kuipers B ; Ley P van der ; Alphen L van ; Dobbelsteen G van den. Relative immunogenicity of PorA subtypes in a multivalent Neisseria meningitidis vaccine is not dependent on presentation form. Infect Immun 2003; 71:6367-71.

Martina BEE ; Bildt MWG van de ; Kuiken T ; Amerongen G van ; Osterhaus ADME. Immunogenicity and efficacy of recombinant subunit vaccines against phocid herpesvirus type 1. Vaccine 2003; 21:2433-40.

Metz B ; Jiskoot W ; Hennink WE ; Crommelin DJ ; Kersten GF. Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines. Vaccine 2003; 22:156-67.

Metz B ; Jiskoot W ; Hennink WE ; Crommelin DJA ; Kersten GFA. Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines. Vaccine 2003; 22:156-67. Oomen CJ ; Hoogerhout P ; Bonvin AMJJ ; Kuipers B ; Brugghe H ; Timmermans H ; Haseley SR ; Alphen L van ; Gros P. Immunogenicity of peptide-vaccine candidates predicted by molecular dynamics simulations. J Mol Biol 2003; 328:1083-9.

Peeters CC ; Lagerman PR ; Weers O de ; Oomen LA ; Hoogerhout ; BeurretM; Poolman JT ; Reddin KM. Preparation of polysaccharide-conjugate vaccines. Methods Mol Med 2003; 87:153-74

Pel M van ; Breugel DWJG van ; Vos W ; Ploemacher RE ; Boog CJP. Towards a myeloablative regimen with clinical potential: I. Treosulfan conditioning and bone marrow transplantation allow induction of donor-specific tolerance for skin grafts across full MHC barriers. Bone Marrow Transplant 2003; 32:15-22.

Pel M van ; Breugel DWJG ; Wijk M van ; Luypen S ; Vingerhoed J ; Roholl PJM ; Boog CJP. Donor-specific tolerance in a murine model: the result of extra-thymic T cell deletion? Transplant Immunol 2003; 11:375-84.

Pel M van ; Hilbrands L ; Smits D ; Breugel DWJG van ; Eck M van ; Boog CJP. Permanent acceptance of both cardiac and skin allografts using a mild conditioning regimen for the induction of stable mixed chimerism in mice. Transplant Immunol 2003; 11:57-63. Ribeiro-do-Couto L ; Poelen M ; Hooibrink B ; Dormans JAMA ; Roholl PJM ; Boog CJP. Ultrastructural characterization of effector-target interactions for human neonatal and adult NK cells reveals reduced intercellular surface contacts of neonatal cells. Human Immunol 2003; 64:490-6.

Rimmelzwaan GF ; Kuiken T ; Amerongen G van ; Bestebroer TM ; Fouchier RAM ; Osterhaus ADME. A primate model to study the pathogenesis of influenza A (H5N1) virus infection. Avian Diseases 2003; 47(Suppl S):931-3.

Saeland E ; Vidarsson G ; Leusen JHW ; Garderen E van ; Nahm MH ; Vile-Weekhout H ; Walraven V; Stemerdink AM ; Verbeek JS ; Rijkers GT ; Kuis W ; Sanders EAM ; Winkel JGJ. Central role of complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice. J Immunol 2003; 170:5168-64.

57

Selm S van ; Cann LM van ; Kolkman MAB ; Zeijst BAM van der ; Putten JPM van. Genetic basis for the structural difference between Streptococcus pneumoniae serotype 15B and 15C capsul polysaccharides. Infect Immun 2003; 71:6192-8. Solzbacher D ; Hanisch FG ; Alphen L van ; Gilsdorf JR ; Schroten H. Mucin in middle ear effusions inhibits attachment of haemophilus influenzae to mucosal epithelial cells. Eur Arch Otorhinolaryngol 2003; 260:141-7.

Sprong T ; Ley P van der ; Steeghs L ; Tax WJ ; Verver-Janssen TJW ; Netea MG ; Meer JWM van der; Deuren M van. Neisseria meningitidis can induce pro-imflammatory cytokine production via pathways independent from CD14 an toll-like receptor 4. Eur Cytokine Netw 2002; 13:411-7. Ulsen P van ; Alphen L van ; Hove J ten ; Fransen F ; Ley P van der ; Tommassen J. A Neisserial autotransporter NaIP modulating the processing of other autotransporters. Mol Microbiol 2003; 50:1017-30. Vermont CL ; Dijken HH van ; Kuipers AJ ; Limpt CJP van ; Keijzers WCM ; Ende A van der ; Groot R de ; Alphen L van ; Dobbelsteen GPJM van den. Cross-reactivity of antibodies against porA after vaccination with a meningococcal B outer membrane vesicle vaccine. Infect Immun 2003; 1650-5. Vermont CL ; Dobbelsteen GP van den ; Groot R de. Recent developments in vaccines to prevent meningococcal serogroup B infections. Curr Opin Mol Ther 2003; 5:33-8. Vermont CL ; Dobbelsteen GP van den. Meningococcal serogroup B infections: a search for a broadly protective vaccine. Expert Rev Vaccines 2003; 2:673-81.

Wedege E ; Kuipers B ; Bolstad K ; Dijken H van ; Froholm LO ; Vermont C; Caugant DA ; Dobbelsteen G van den. Antibody specificities and effect of meningococcal carriage in icelandic teenagers receiving the Norwegian serogroup B outer membrane vesicle vaccine. Infect Immun 2003; 71:3775-81. National publications Vennema H ; Godeke GJ ; Bruin E de ; Koopmans M ; Amerongen G van. Kans op monkeypox door de import van prairiehonden. Infectieziekten Bulletin 2003; 14:376-7. Book, book chapters & proceedings

Peeters CCAM ; Lagerman PR ; Weers O de ; Oomen LA ; Hoogerhout P ; Beurret M ; Poolman JT. Preparation of polysaccharide-conjugate vaccines. In: Robinson A, Hudson MJ, Cranage MP, eds. Vaccine protocols. 2nd ed.Totowa: Humana Press, 2003;153-7.

58

Animal Sciences Group Wageningen UR Division: Infectious disease

Research group Infectious diseases

Leader

J.A. Wagenaar

Participants M.G.M. de Bruin

L. Cornelissen Ms. A. de Greeff

M. Harmsen Ms. W.F. Jacobs – Reitsma

R.J.M. Moormann B.P.H. Peeters Ms. H.E. Smith

N. Stockhofe J.E.R. Thole F-J. v.d. Wal

G. Wellenberg H. Wisselink

PhD students

Ms. E. Gaasbeek

Titles PhD projects B. Boekema: Pathogenesis of Actinobacillus pleuropneumoniae: role of toxins and fimbriae Ms. E. Gaasbeek: Genetic diversity in campylobacter jejuni Theses B. Boekema: Pathogenesis of actinobacillus pleuropneumoniae: role of toxins and fimbrae International publications Al-Garib, S.O., A.L.J. Gielkens, E. Gruys, B.P.H. Peeters and G. Koch. Tissue tropism in the chicken embryo of non-virulent and virulent Newcastle disease strains that express green fluorescent protein. (2003) Avian Pathology 32:591-596. Antonis AF, Schrijver RS, Daus F, Steverink PJ, Stockhofe N, Hensen EJ, Langedijk JP, van der Most RG. J Virol. 2003 Nov;77(22):12067-73. Vaccine-induced immunopathology during bovine respiratory syncytial virus infection: exploring the parameters of pathogenesis. J Virol. 2003 Nov;77(22):12067-73.

Boekema BKHL, Stockhofe-Zurwieden N, Smith HE, Kamp E, van Putten JP, Verheijden JH. Adherence of Actinobacillus pleuropneumoniae to primary cultures of procine lung epithelial cells. Vet. Microbiol. (2003): 93: 133-144 Duim, B., P.C.R. Godschalk, N. van den Braak, K.E. Dingle, J.R. Dijkstra, E. Leyde, J. an der Plas, F.M. Colles, H.Ph. Endtz, J.A. Wagenaar, M.C.J. Maiden, A. Van Belkum. 2003. Molecular evidence for dissemination of unique Campylobacter jejuni clones in Curaçao, Netherlands Antilles. J. Clin. Microbiol. 41:5593-5597.

Greeff A de, Buys H, van Alphen L, Smith HE. Lipoprotein signal peptidase of Streptococcus suis serotype 2. Microbiol.(2003): 149:1399-1407

Heddema ER, Kraan MC, Smith HE, Buys H, Werthheim-van Dillen PME. A 46 year old woman with a lobar infiltrate due to psittacosis detected by polymerase chain reaction (PCR). Scand. J Infect. Dis. (2003) 35:422-424 Heres, L., J.A. Wagenaar, F. van Knapen, and B.A.P. Urlings. 2003. Passage of Salmonella through the crop and gizzard of broiler chickens fed with fermented liquid feed. Avian Pathology 32:173-181. Heres, L., B. Engel, F. van Knapen, M.C.M. de Jong, J.A. Wagenaar, and H.A.P. Urlings. 2003. Fermented liquid feed reduces susceptibility of broilers for Salmonella enteritidis. Poultry Science. 82:603-611.

59

Heres, L., B. Engel, F. van Knapen, J.A. Wagenaar, B.A.P. Urlings. 2003. Effect of fermented feed on the susceptibility for Campylobacter jejuni colonisation in broiler chickens with and without concurrent inoculation of Salmonella enteritidis. Int. J. Food Microbiol. 87:75-86. Heres, L., H.A.P. Urlings, J.A. Wagenaar and M.C.M. de Jong. 2003. Transmission of Salmonella between broiler chickens fed with fermented liquid feed. Epidemiol. Infect. 132:107-116. Kramer, J., A.H. Visscher, J.A. Wagenaar, S.H.M. Jeurissen. 2003. Entry and survival of Salmonella enterica serotype Enteritidis PT4 in chicken macrophage and lymphocyte cell lines. Vet. Micro. 91 (2-3):147-155. Kramer, J., A.H. Visscher, J.A. Wagenaar, J.B.J.W. Cornelissen, and S.H.M. Jeurissen. 2003. Comparison of natural resistance in seven different meat-type chicken lines. British Poultry Science 44:577-585. Leeuw O.S. de, L. Hartog, G. Koch, and B.P. Peeters. Effect of fusion protein cleavage site mutations on virulence of Newcastle disease virus: non-virulent cleavage site mutants revert to virulence after one passage in chicken brain. (2003) J. Gen. Virol. 84:475-484 Rebel, J.M.J., C.H. Leendertse, A. Dekker and R.J.M. Moormann. (2003). Effects of mutations in the VP2/VP4 cleavage site of Swine vesicular disease virus on RNA encapsidation and viral infectivity. Arch. Virol. 148, 1747-1756. Schouls, L.M., S. Reulen, B. Duim, J.A. Wagenaar, R. Willems, K.E. Dingle, F.M. Colles, J.D.A. van Embden. 2003. Comparative genotyping of Campylobacter jejuni by AFLP, MLST and Short Repeat Sequencing: strain diversity, host range, and recombination. J. Clin. Microbiol. 41:15-26. Soethout EC, Rutten VP, Houwers DJ, de Groot HS, Antonis AF, Niewold TA, Muller KE. Alpha4-integrin (CD49d) expression on bovine peripheral blood neutrophils is related to inflammation of the respiratory system. Vet Immunol Immunopathol. 2003 May 30;93(1-2):21-9. Tacken, M.G., P.A. van den Beuken, B.P.H. Peeters, A.A. Thomas, P.J. Rottier and H.J. Boot. Homotypic interactions of the infectious bursal disease virus proteins VP3, pVP2, VP4, and VP5: mapping of the interacting domains. (2003) Virology 312:306-319. Zhao, H. and B.P.H. Peeters. Recombinant Newcastle disease virus as a viral vector: effect of genomic location of foreign gene on gene expression and virus replication. (2003) J. Gen. Virol. 84:781-788. Patents Willemsen PTJ, Westerveen, SF, Bakker, D, van Zijderveld, FG, Thole, JER. 2003. Paramycobacterial diagnostics and vaccines PCT/ NL03/00020

60


Research group Inflammation, iron and tissue damage

(UU UMC 2.1.3)

Leader J.J.M. Marx J. van Strijp

J. Verhoef

Staff B.S. van Asbeck

K. van Kessel H.S.L.M. Nottet

Post docs

J.T. van de Bruggen Ms. N.A. Georgiou

C. de Haas

PhD students Ms. C. da Fonseca Pereira

P.J. Haas Ms. A.E.R. Kartikasari

H. van Leeuwen B. Postma

Ms. S. Rooijakkers

Titles PhD projects Ms. C.F. da Fonseca Pereira: Studies on the efficacy of neuronal receptor antagonists and

anti inflammatory agents on the prevention of neuronal injury in HIV encephalitis

P.J. Haas: Interaction of microbial products with phagocyte cytokine receptors: protein aspects.

Ms. A.E.R. Kartikasari: Interaction of iron, monocytes, micro-organisms and endothelium in development of atherosclerosis.

H. van Leeuwen: Lipoproteins and sepsis B. Postma: Interaction of microbial products with phagocyte chemokine receptors: Receptor aspects. Ms. S. Rooijakkers: Microbial virulence of s. aureus Thesis Leeuwen, H.J. van (25-11-2003). Lipoproteins and sepsis UU Universiteit Utrecht (183 pag.). (Utrecht: Drukkerij Zuidam & Uithof). Prom./coprom.: Verhoef, J., Hoepelman, I.M., Strijp, J.A.G. van, & Kessel, C.P.M. van Pereira, C.F. da Fonseca (25-04-2003). HIV-1 Neuropathogenesis & Antiviral Research UU Universiteit Utrecht (159 pag.). (Wageningen: Ponsen & Looijen B.V.). Prom./coprom.: Verhoef, J., & Nottet, H.S.L.M. International publications A, D. van der, Hel, O.L. van der, Roest, M., Schouw, Y.T. van der, Gils, C.H. van, Marx, J.J.M., Noord, P.A.H. van, & Peeters, P.H.M. (2003). Heterozygosity for the Cys282Tyr mutation in the HFE gene and the risk of colorectal cancer (Netherlands) Cancer causes and control 14, 541-545. Aulock, S. von, Morath, S., Hareng, L., Knapp, S., Kessel, C.P.M. van, Strijp, J.A.G. van, & Hartung, T. (2003). Lipoteichoic acid from staphylococcus aureus is a potent stimulus for neutrophil recruitment Immunobiology 208, 413-422. Kartikasari, A.E.R., Georgiou, N.A. van, Visseren, F.L.J., Kats-Renaud, J.H. van, Asbeck, B.S. van, & Marx, J.J.M. (2003). Iron and atherosclerosis: iron chelators decrease adhesion of monocytes to vascular endothelium Biomarkers and Environment 6 (suppl 1), 34-38. Kessel, C.P.M. van, Veldkamp, K.E., Pesschel, A., Haas, C.J.C. de, Verhoef, J., & Strijp,

61

J.A.G. van (2003). Tips and Tricks from Staphylococcus aureus Advances in experimental medicine and biology 531, 341-350. Kristian, S.A., Durr, M., Strijp, J.A.G. van, Neumeister, B., & Peschel, A. (2003). MprF-mediated lysinylation of phospholipids in Staphylococcus aureus leads to protection against oxygen-independent neutrophil killing Infection and Immunity 71, 546-549. Leeuwen, H.J. van, Heezius, H.C.J.M., Dallinga, G.M., Strijp, J.A.G. van, Verhoef, J., & Kessel, C.P.M. van (2003). Lipoprotein metabolism in patients with severe sepsis Critical Care Medicine 31, 1359-1366. Marx, J.J.M. (2003). Pathophysiology and Treatment of Iron Overload in Thalassemia Patients in Tropical Countries Advances in experimental medicine and biology 531, 57-68. Mete, A., Hendriks, H.G.C.J.M., Klaren, P.H.M., Dorrestein, G.M., Dijk, J.E. van, & Marx, J.J.M. (2003). Iron metabolism in mynah birds (Gracula religiosa) resembles human hereditary haemochromatosis Avian Pathology 32, 625-632. Oostrom, A.J.H.H.M. van, Sijmonsma, T.P., Rabelink, T.J., Asbeck, B.S. van, & Castro Cabezas, M. (2003). Postprandial leukocyte increase in healthy subjects Metabolism 52, 199-202. Pereira, C.F., Bovenkamp, M. van de, Middel, J., Verhoef, J., & Nottet, H.S.L.M. (2003). APHS can act synergically with clinically available HIV-1 reverse transcriptase and protease inhibitors and is active against several drug-resistant HIV-1 strains in vitro Journal of Antimicrobial Chemotherapy 51, 1181-1189.

Pereira, C.F. , Paridaen, J.T., Rutten, K., Huigen, C.D.G., Bovenkamp, M. van de, Middel, J., Beerens, N., Berkhout, B., Schuurman, R., Marnett, L.J., & Verhoef, J. (2003). Aspirin-like molecules that inhibit human immunodeficiency virus 1 replication Antiviral Research 58, 253-263. Sorge, N.M. van, Berg, L.H. van den, Gelijns, K., Strijp, J.A.G. van, Jacobs, B.C., Doorn, P.A. van, Wokke, J.H.J., Winkel, J.G.J. van de, Leusen, J.H.W., & Pol, W.L. van der (2003). Anti-GM1 IgG antibodies induce leukocyte effector functions via Fcgamma receptors Annals of Neurology 53, 570-579. National publications

Giltay, J.C., Marx, J.J.M., & Nieuwenhuis, H.K. (2003). Hoe moet een patiënt geïnformeerd worden als DNA-diagnostiek wordt overwogen (bijvoorbeeld HFE-gen bij verdenking hemochromatose)? Reumatologen Vademecum 5, 2-4.

Marx, J.J.M. (2003). Verdenking op hemochromatose. In: H.A.I.M. van Leusden (Ed.) Diagnostisch Kompas. College voor Zorgverzekeringen, Amstelveen 222-223

62


Research group Microbial virulence and innate immunity

(UU UMC 2.1.6)

Leader H. van Dijk

A. Fleer

Staff Ms. S.P.M. Geelen

T.F.W. Wolfs

PhD students Ms. J.M. Hament

Ms. S. Kuipers

Titles PhD projects Ms. J.M. Hament: Role of virus infections with pneumoccocus adhesion Ms. S. Kuipers: Gonococci and complement Thesis

Hament, J.M. (21-11-2003). The pathogenesis of S. pneumoniae infections. UU Universiteit Utrecht. (Enschede: Febodruk BV). Prom./coprom.: Kimpen, J.L.L., Dijk van, H., Wolfs, T.F.W., Fleer, A., & Sanders, E.A.M. Kuipers, S. (25-09-2003). The Ancient Complement System: Role in Physiology and Defense UU Universiteit Utrecht (103 pag.). (Enschede: Febodruk B.V.). Prom./coprom.: Dijk, H. van, & Verduin, C.M. International publications

Bolm, M., Jansen, W.T.M., Schnabel, R., & Chhatwal, G.S. (2003). Hydrogen peroxide-mediated killing of Caenorhabditis elegans: a common feature of different streptococcal species Infection and Immunity. Dinkla, K., Rohde, M., Jansen, W.T.M., Kapla, E.L., & Chhatwal, G.S. (2003). Rheumatic fever-associated Streptococcus pyogenes isolates aggregate collagen Journal of Clinical Investigation 111 (12), 1905-1912. Dinkla, K., Rohde, M., Jansen, W.T.M., Carapetis, J., Chhatwal, G.S., & Talay, S.R. (2003). Streptococcus pyogenes recruits collagen via surface bound fibronectin: a novel colonization and immune evasion mechanism Molecular Microbiology 47 (3), 861-869. Halkes, C.J.M., Dijk, H. van, Verseyden, C., Jaegere, P.P.T. de, Plokker, H.W.M., Meijssen, S., Erkelens, D.W., & Castro Cabezas, M. (2003). Gender differences in postprandial ketone bodies in normolipidemic subjects and in untreated patients with familial combined hyperlipidemia Arteriosclerosis Thrombosis and Vascular Biology 23 (10), 1875-1880. Hament, J.M., Dijk, H. van, Fleer, A., Aerts, P.C., Schoenmakers, M., Snoo, M. de, Dekker, B.H., Kimpen, J.L.L., & Wolfs, T.F.W. (2003). Pneumococcal immune adherence to human erythrocytes European Journal of Clinical Investigation 33 (2), 169-175. Kuipers, S., Aerts, P.C., Cluysenaer, O.J.J., Bartelink, A.K.M., Ezekowitz, R.A.B., Bax, W.A., Salimans, M., & Dijk, H. van (2003). A Case of Familial Meningococcal Disease Due to Deficiency in Mannose-Binding Lectin (MBL) Advances in experimental medicine and biology 531, 351--355. Kuipers, S., Aerts, P.C., & Dijk, H. van (2003). Differential microorganism-induced mannose-binding lectin activation FEMS Immunology and Medical Microbiology 36 (1-2), 33-39. Verseyden, C., Meijssen, S., Dijk, H. van, Jansen, H., & Castro Cabezas, M. (2003). Effects of atorvastatin on fasting and postprandial complement component 3 response in familial combined hyperlipidemia Journal of Lipid Research 44 (11), 2100-2108. Villadsen, L., Schuurman, J., Beurskens, F.J.M., Dam, T.N., Dagnaes-Hansen, F., Skov, L., Rygaard, J., Voorhorst-Ogink, M.M., Gerritsen, A.F, Dijk, M.A. van, Parren, P.W.H.I., Baadsgaard, O., & Winkel, J.G.J. van de (2003). Resolution of psoriasis upon blockade of interleukin-15 biological activity in a xenograft mouse model. European Journal of Clinical Investigation 112, 1571-1580.

64


Research group Infection and inflammation in the immunocompromised host

(UU UMC 2.1.4)

Leader I.M. Hoepelman

M. Bonten

Staff J.C.C. Borleffs

Ms. M.M.E. Schneider Ms. S.P.M. Geelen Ms. S.E. Geerlings

E. Hak

Post docs F.E.J. Coenjaerts

D. Lafeber

PhD students Ms. P.E. Ellerbroek

Ms. R. Meiland J.J. Oosterheert

A.J. Matute Ms. S. Vervoort

J.P. van Wijk M. van der Flier

H.J. van Leeuwen Ms. L.J.R. van Elden

Titles PhD projects Ms. P.E. Ellerbroek: Leukocyte adhesion to endothelium in Cryptococcus neoformans

infections Ms. R. Meiland: A-symptomatic bacteriuria in women with diabetes mellitus J.J. Oosterheert: Treatment issues in community-acquired pneumonia A.J. Matute: Aspects of infectious diseases in Central America M. van der Flier: VEGF in meningitis and sepsis H.J. van Leeuwen: Lipoproteins and sepsis L.J.R. van Elden: Molecular diagnostics for the detection of respiratory viruses and clinical value J.P. van Wijk: Metabolic consequences of anti-retroviral therapy International publications Bergshoeff, A.S., Fraaij, P.L.A., Rossum, AMC van, Wolfs, T.F.W., Geelen, S.P.M., Groot, R de, & Burger, D.M. (2003). Pharmacokinetics of nelfinavir in children: influencing factors and dose implications Antiviral Therapy 8, 215-222. Bergshoeff, A.S., Wolfs, T.F.W., Geelen, S.P.M., & Burger, D.M. (2003). Ritonavir-enhanced pharmacokinetics of Nelfinavir/M8 during Rifampin use Annals of Pharmacotherapy 37 (4), 521-525.

Borleffs, J.C., Custers, E.J., van Gijn, J., & ten Cate, O.T. (2003). "Clinical reasoning theater": a new approach to clinical reasoning education. Acad Medicine 78, 322-5. Van Elden, L.J., van Loon, A.M., van der Beek, A., Hendriksen, K.A., Hoepelman, A.I., van Kraaij ,M.G., Schipper, P., & Nijhuis, M. (2003). Applicability of a real-time quantitative PCR assay for diagnosis of respiratory syncytial virus infection in immunocompromised adults. Journal of Clinical Microbiology 41, 4378-4381. Flier, M. van der, Geelen, S.P.M., Kimpen, J.L.L., Hoepelman, I.M., & Tuomanen, E. (2003). Reprogramming the host response in bacterial meningitis: how best to improve outcome? Clinical Microbiology Reviews 16 (3), 415-429.

Geelen, S.P.M., Lange, J.M., Borleffs, J.C.C., Wolfs, T.F.W., Weersink, A.J.L., & Schuurman, R. (2003). Failure to detect a non-B HIV-1 subtype by the HIV-1 Amplicor Monitor test, version 1.5: a case of unexpected vertical transmission. AIDS 17 (5), 781-782. Geerlings, S.E., Meiland, R., & Hoepelman, I.M. (2003). Treatment of asymptomatic bacteriuria

65

in diabetic women New England Journal of Medicine 348 (10), 957-958. Hament, J.M., Dijk, H. van, Fleer, A., Aerts, P.C., Schoenmakers, M., Snoo, M. de, Dekker, B.H., Kimpen, J.L.L., & Wolfs, T.F.W. (2003). Pneumococcal immune adherence to human erythrocytes European Journal of Clinical Investigation 33 (2), 169-175. Hak, E., Bonten, M.J., Hoes, A.W. (2003). Pneumococcal vaccination in older adults. New England Journal of Medicine 349, 712-714. Haverkamp, M., Smit, M., Weersink, A.J.L., Boucher, C.A.B., & Hoepelman, I.M. (2003). The effect of lamivudine on the replication of hepatitis B virus in HIV-infected patients depends on the host immune status (CD4 cell count) AIDS 17 (10), 1572-1574. Hoepelman, I.M., Meiland, R., & Geerlings, S.E. (2003). Pathogenesis and management of bacterial urinary tract infections in adult patients with diabetes mellitus International journal of antimicrobial agents 22 (suppl 2), 35-43. Joore, J.C., van Leeuwen, H.J., Meulenbelt, J., Tobe, T.J., Fijen, J.W., & Figen, J.W. (2003). Pro/Con debate of activated protein C in severe sepsis. Critical Care Medicine 31, 2816.

Leavis, H,L., Willems, R.J., Top, J., Spalburg, E., Mascini, E.M., Fluit, A.C., Hoepelman, A., de Neeling, A.J., & Bonten, M.J. (2003). Epidemic and nonepidemic multidrug-resistant Enterococcus faecium. Emerging of Infectious Diseases 9, 1108-1115.

Leeuwen van, H.J., Heezius, E.C., Dallinga, G.M., van Strijp, J.A., Verhoef, J., & van Kessel, K.P. (2003). Lipoprotein metabolism in patients with severe sepsis. Critical Care Medicine 31, 1359-1366. Lefeber, D.J., Benaissa-Trouw, B.J., Vliegenthart, J.F.G., Kamerling, J.P., Jansen, W.T.M., Kraaijeveld, C.A., & Snippe, H. (2003). Influence of adjuvants on the immunogenicity of oligosaccharide-protein conjugate vaccines related to Streptococcus pneumoniae type 3 Infection and Immunity 71 (12), 6915-6920.

Nijssen, S., Bonten, M.J., Franklin, C., Verhoef, J., Hoepelman, A.I., & Weinstein, R.A. (2003). Relative risk of physicians and nurses to transmit pathogens in a medical intensive care unit. Archives of Internal Medicine 63, 2785-2786.

Oosterheert, J.J., Bonten, M.J., Buskens, E., Schneider, M.M., & Hoepelman, I.M. (2003). Algorithm to determine cost savings of targeting antimicrobial therapy based on results of rapid diagnostic testing. Journal of Clinical Microbiology 41, 4708-4713.

Oosterheert, J.J., Bonten, M.J., Hak, E., Schneider, M.M., & Hoepelman, I.M. (2003). How good is the evidence for the recommended empirical antimicrobial treatment of patients hospitalized because of community-acquired pneumonia? A systematic review. Journal of Antimicrobial Chemotherapy 52, 555-563.

Oosterheert, J.J., Bonten, M.J., Hak, E., Schneider, M.M., & Hoepelman, A.I. (2003). Severe community-acquired pneumonia: what's in a name? Current Opinion of Infectious Diseases 16, 153-159. Rossum, A.M.C. van, Gaakeer, M.I., Verweel, G., Hartwig, N.G., Wolfs, T.F.W., Geelen, S.P.M., Lamberts, S.W.J., & Groot, R de (2003). Endocrinologic and immunologic factors associated with recovery of growth in children with human immunodeficiency virus type 1 infection treated with protease inhibitors Pediatric Infectious Disease Journal 22 (1), 70-76. Vandebriel, R.J., Hellwig, S.M.M., Vermeulen, J.P., Hoekman, J.H.G., Dormans, J.A.M.A., Roholl, P.J.M., & Mooi, F.R. (2003). Association of Bordetella pertussis with host immune cells in the mouse lung Microbial pathogenesis 35, 19-29.

Walenkamp, A.M.E., Ellerbroek, P., Scharringa, J., Rijkers, E., Hoepelman, I.M., & Coenjaerts, F.E.J. (2003). Interference of Cryptococcus neoformans with Human Neutrophil Migration Advances in experimental medicine and biology 531, 315-339. Wensing, A.M.J., & Boucher, C.A.B. (2003). Worldwide transmission of drug-resistant HIV AIDS Rev. 5 (3), 140-155. Wijk van, J.P., Halkes, C.J., De Jaegere, P.P., Plokker, H.W., Erkelens, D.W., & Cabezas, M.C. (2003). Normalization of daytime triglyceridemia by simvastatin in fasting normotriglyceridemic patients with premature coronary sclerosis. Atherosclerosis 171, 109-116. Wijk van, J.P., van Oostrom, A.J., & Castro Cabezas, M. (2003). Normal ranges of non-fasting triglycerides in healthy Dutch males and females. Clinical Chim Acta 337, 49-57. Wijk van, J.P., de Koning, E.J., Martens, E.P., & Rabelink, T.J. (2003). Thiazolidinediones and blood lipids in type 2 diabetes. Arteriosclerosis Thrombosis Vascular Biology 23, 1744-1749. Wijk van, J.P., Halkes, C.J., Erkelens, D.W., & Castro Cabezas, M. (2003). Fasting and daylong triglycerides in obesity with and without type 2 diabetes. Metabolism 52, 1043-1049. National publications

Dijk van, G.W., Leeuwen van, H.J., Gijn van, J., & Hoepelman, I.M. (2003). Geen milt meer: inidicatie voor pneumokokkenvaccinatie. Nederlands Tijdschrift voor Geneeskunde 147, 425-428.

Fanoy, E.B., & Boucher, C.A.B. (2003). Dieren op markten in China vormen mogelijk de bron van aan SARS gerelateerd virus Nederlands Tijdschrift voor Geneeskunde 147 (45), 2251.

Flier, M. van der, Dijk, N.B. van, Fluit, A.C., Fleer, A., Wolfs, T.F.W., & Gestel, J.P.J. van (2003). Fatale pneumonie bij een adolescent door thuis opgelopen meticillineresistente Staphylococcus aureus positief voor Panton-Valentine-leukocidine Nederlands Tijdschrift Geneeskunde 147 (22), 1076-1079.

66

Hoepelman, I.M., & Wolfs, T.F. (2003). Splenectomy and pneumococcal vaccination. Nederlands Tijdschrift voor Geneeskunde 147, 1143.

Montfrans, C. van, Sanders, C.J.G., & Borleffs, J.C.C. (2003). Haarafwijkingen geassocieerd met HIV-infectie Nederlands tijdschrift voor dermatologie & venereologie 13, 46-47.

Oosterheert, J.J., Bonten, M.J.M., Schneider, M.M.E., & Hoepelman, I.M. (2003). Buiten het ziekenhuis opgelopen pneumonie; geen reden om huidige antibioticumrichtlijnen te herzien. Nederlands Tijdschrift voor Geneeskunde 147, 381-386.

Visser, M. de, Hogeman, P.H.G., Vught, A.J. van, Révész, T., & Wolfs, T.F.W. (2003). Fulminant verlopende pneumokokkensepsis bij een 2-jarig kind met sikkelcelanemie Nederlands Tijdschrift voor Geneeskunde 147 (10), 454-456. Book, book chapters & proceedings

Greeff, S.C. de, Schellekens, J.F.P., Mooi, F.R., & Melker, H.E. de (2003). Pertussis in The Netherlands, 2001-2003 Bilthoven: RIVM.

Hoepelman, I.M. (2003). Chapter 237: Opportunistic fungi. Infection Diseases, editors J. Cohen and W.G. Powderly, 2341-2362.

67

University Medical Center Utrecht Department of Ophthalmology

Research group Inflammation of the inner eye

(UU UMC 2.1.1)

Leader A. Rothova

Staff

J. de Boer N.ten Dam

W. de Loos(✟ 2004) G. v.d. Lelij

PhD students

PhD projects B. van Kooij: title unknown K. Probst: title unknown

Thesis Vidovic Valentincic, N. (16-06-2003). The effects of tinted optical filters on visual acuity and contrast sensitivity in patients with inflammatory cystoid macular edema University of Ljubljana (57 pag.). . Prom./coprom.: Hawlina, M., & Rothova, A. International publ;ications Boer, J.H. de, Wulffraat, N.M., & Rothova, A. (2003). Visual loss in uveitis of childhood British Journal of Ophthalmology 87, 879-884. Kerkhoff, F.T., Zee, A. van der, Bergmans, M., & Rothova, A. (2003). Polymerase chain reaction detection of Neisseria meningitidis in the intraocular fluid of a patient with endogenous endophthalmitis but without associated meningitis. Ophthalmology 110 (11), 2134-2136. Kerkhoff, F.T., Lamberts, Q.J., Biesen, P.R. van den, & Rothova, A. (2003). Rhegmatogenous retinal detachment and uveitis Ophthalmology 110, 427-431. Kooij, B. van, Dijk, M.C. van, Boer, J. de, Sigurdsson, V., & Rothova, A. (2003). Is granuloma annulare related to intermediate uveitis with retinal vasculitis? British Journal of Ophthalmology 87 (6), 763-766. Rothova, A. (2003). Medical treatment of cystoid macular edema. Ocular immunology and inflammation 10 (4), 239-246. Rothova, A. (2003). Ocular manifestations of toxoplasmosis Current Opinion in Ophthalmology 14 (6), 384-388. Zwart, S., Rovers, M.M., Melker, R.A. de, & Hoes, A.W. (2003). Penicillin for acute sore throat in children: randomised, double blind trial. BMJ - British Medical Journal 327, 1324-1324.

68

National Institute for Public Health and the Environment Bilthoven

Research group Effects of exogenous factors on the immune system

Leader

H. van Loveren

Staff W.H. de Jong P.J.M. Roholl

P.A. Steerenberg R.J. Vandebriel

PhD students

Ms. A. Sleijffers

Titles PhD projects A. Sleijffers The influence of UV radiation on hepatitis B vaccination F. Termorshuizen Observational studies on UVB K. Baken Immunotoxicogenomics J. de Jonge Food allergy International publications Buisman AM, Sonsma JAJ, Wijk M van, Roholl PJM and Kimman TG. Pathogenesis of poliovirus infection in PVRtg mice: poliovirus replicates in peritoneal macrophages, J Gen Virology, 84, 2819-2828, 2003 Genevrois S, Steeghs L, Roholl PJM, Letesson J-J and van der Ley P. The Pmo85 protein of Neisseria meningitidis is required for lipid transport to the outer membrane protein. The Embo Journaal 22(8), 1780-1789, 2003 Putman E, Van Der Laan JW, Van Loveren H. Assessing immunotoxicity: guidelines. Fund. & Clin. Pharmacol., 2003, 17, 1-12. Putman E, Van Der Laan JW, Van Loveren H. Assessing immunotoxicity: guidelines. Fund. Clin. Pharmacol., 2003, 615-626, 2003. Ribeiro-do-Couto LM, Poelen M, Hooibrink B, Dormans J, Roholl PJM and Boog CJP. Ultrastructural characterization of effector-target interactions for human neonatal and adult NK cells reveals reduced intercellular surface contacts of neonatal cells. Human Immunology 64, 490-496, 2003 Sleijffers A, Yucesoy B, Kashon M, Garssen J, De Gruijl FR, Boland J, Van Hattum J, Luster MI, Van Loveren H. Cytokine polymorphisms play a role in susceptibility to ulltraviolet B-induced modulation of immune responses after Hepatitis B vaccination. J. Immunol., 2003, 170, 3423-3428 Sleijffers A, Herreilers M, Van Loveren H, Garssen J. Ultraviolet B radiation induces upregulation of calcitonin gene-related peptide levels in human Finn chamber skin samples. J. Photochem. Photobiol B: Biol. 2003, 69, 149-152. Sleijffers A, Kammeyer A, de Gruijl FR, Boland GJ, Van Hattum J, Van Vloten WA, Van Loveren H, Teunissen MBM, Garssen J. Epidermal cis-urocanic acid lrevels correlate with lower specific cellular immune responses after hepatitis B vaccination of ultraviolet B-exposed humans. Photochem. Photobiol. 2003,77, 271-275. Smit JJ, Van Loveren H, Hoekstra MO, Nijkamp FP, Bloksma N. Influence of the macrophage bacterial resistance gene Nramp1 (Slc11a1) on the induction of allergic asthma in the mouse. FASEB 2003, 17, 958-960. Smit JJ, Van Loveren H, Hoekstra MO, Karimi K, Folkerts G, Nijkamp FP. The Slc11a1 (Nramp1) gene controls efficacy of mycrobacterial treatment of allergic asthma. J. Immunol., 2003, 171, 754-760. Smit JJ, Van Loveren H, Hoekstra MO, Van Der Kant PAA, Folkerts G, Nijkamp FP. Therapeutic treatment with heat-killed Mycobacterium vaccae (SRL172) in a mild and severe mouse model for allergic asthma. Eur. J. Pharmacol., 2003, 470, 193-199. Smit JJ, Van Loveren H, Hoekstra MO, Schijf MA, Folkerts G, Nijkamp FP. Mycobacterium vaccae administration during allergen sensitization or challenge suppresses asthmatic features. Clin. Exp. Allergy 2003, 33, 1-7. Steerenberg PA, Janssen NAH, de Meer G, Fischer PH, Nierkens S, Van Loveren H, Opperhuizen A, Brunekreef B, Van Amsterdam JCG. Relationship between exhaled NO, respiratory

69

symptoms, lung function, bronchial hyperresponsiveness, and blood eosinophilia in school children. Thorax, 2002, 58, 242-245. Steerenberg PA, Bischoff EWMA, De Klerk A, Verlaan APJ, Jongbloets LMN, Van Loveren H, Opperhuizen A, Zomer G, Heisterkamp SH, Hady M, Spieksma FTM, Fischer PH, Dormans JAMA, Van Amsterdam JGC. Acute effect of air pollution on respiratory complaints, exhaled NO and biomarkers in nasal lavages of allergic children during the pollen season. Int Archs Allergy Immunol., 2003, 131, 127-137. Steerenberg PA, Withagen CET, Dormans JAMA, Van Dalen WJ, Van Loveren H, Cassee FR. Adjuvant activity of various diesel exhaust and ambient particles in two allergic models. J. Toxicol. Environm. Health, Part A, 2003, 66, 1421-1439. Steerenberg PA, Van Dalen WJ, Withagen CET. Optimization of route of administration for coexposure to ovalbumin and particle matter to induce adjuvant activity in respiratory allergy in the mouse. Inhalation Toxicol. 2003, 15, 1309-1325. Ten Tusscher GW, Steerenberg PA, Van Loveren H, Vos JG, Vo Dem Borne AEGK, Van Der Slikke JW, Olie K, Pluim HJ, Koppe JG. Persistent hematologic disturbances in 8-year old children associated with perinatal dioxin exposure. Env. Health Perspect. 111, 1519-1523, 2003. Termorshuizen F, Hogewoning AA, Bouwes-Bavinck JN, Goettsch WG, De Fijter JW, Van Loveren H. Skin infections in renal recipients and the relation with solar ultraviolet radiation. Clin. Transplant. 2003, 17, 1-6. Termorshuizen F, Hogewoning AA, Bouwes-Bavinck JN, Goettsch WG, De Fijter JW, Van Loveren H. Skin infections in renal transplant patients and the relation with ultraviolet radiation. Clinical Transpl. 2003, 17, 522-527 Van Amsterdam JGC, Bisschoff EWMA, De Klerk A, Verlaan APJ, Jongbloets LMN, Van Loveren H, Opperhuizen A, Zomer G, Hady M, Sieksma FTM, Dormans JAMA, Steerenberg PA. Exhaled NO level and number of eosinophils in nasal lavage as markers of pollen-induced upper and lower airway inflammation in children sensitive to grass pollen. Int Archs Occup Environm health, 2003, 76, 309-312 Van Amsterdam JGC, Zanen P, Somer S, Van Loveren H, Opperhuizen A, Steerenberg PA, Flow dependency and off-line measurement of exhaled NO in children. Pediatr. Allergy Immunol., 2003, 14, 266-271. Van Amsterdam JGC, Janssen NAH, De Meer G, Fischer PH, Nierkens S, Vna Loveren H, Opperhuyizen A, Steerenberg PA, Brunekreef B. The relatiuoinship between exhaled nitric oxide and allergic sensitization in a random sample of school children. Clin. Exp. Allergy 2003, 33, 187-191. Vandebriel RJ, De Jong WH, Hendriks JJA, Van Loveren H. Impact of exposure duration by low molecular wieght compounds on interferon-γ and interleukin-4 mRNA expression and production in the draining lymph nodes of mice. Toxicology 188, 1-13, 2003. Vandebriel, R.J., S.M.M. Hellwig, J.P. Vermeulen, J.H.G. Hoekman, J.A.M.A. Dormans, P.J.M. Roholl & F.R. Mooi. Association of Bordetella pertussis with host immune cells in the mouse lung. Microb. Pathog. 35, 19-29 (2003). Van Och, F.M.M., R.J. Vandebriel, W.H. De Jong & H. Van Loveren. Effect of prolonged exposure to low antigen concentration for sensitization. Toxicology 184, 23-30 (2003).

Van Loveren H; Vos JG.; Putman E; Piersma. A. Immunotoxicological consequences of perinatal chemical exposures: a plea for inclusion of immune parameters in reproduction studies. Toxicology (2003); 185:185-191. Van Pel M, van Breugel DWJG, van Wijk M, Luypen S, Vingerhoed J, Roholl PJM and Boog CJP. Donor-specific tolerance in a murine model: result of extra-thymic T cell deletion? Transplantation Immunology 11, 375-384, .2003 Book, book chapters & proceedings Smit JJ, Van Loveren H, Hoekstra MO, Folkerts G, Nijkamp FP. Prophylactic treatment with heat-killed M. vaccae (SRL172) in a mouse model for allergic asthma. Chapter 56. Vos JG, Van Loveren H (co-authors of consortium). Global assessment of the state of the art of the science of endocrine disruptors. Eds. T Damstra, S Barlow, A Bergman, R Kavlock, G Van Der Kraak. WHO/IPCS, Geneva, 2002

70

University Medical Center Utrecht Department of Immunology

Research group Regulation of immune cell function

(UU UMC 2.2.5)

Leader Ms. L. Meyaard

Staff

Ms. M.A. Oosterwegel

Post doc Ms. W. Bril R.M. Hoek

PhD students

Ms. M. van Berkel P. Koenen

R.J. Lebbink Ms. E. Rijkers

Ms. A. Verbrugge

Titles PhD projects Ms. M. van Berkel: The role of inducible CD28 homologue ICOS in T cell responses P. Koenen: Nef impars CTLA-4 function R.J. Lebbink: The role of LAIR 1 engagement by Epcam in tolerence and Tumorimmunity Ms. E. Rijkers: Molecular mechanisms of inhibition through OX2 receptor Ms. A. Verbrugge: The mechanism of LAIR-1 mediated inhibition of immune Functions International publications Meyaard, L., Vuurst de Vries, A.R. van der, Ruiter, T. de, Lanier, L.L., Phillips, J.H., & Clevers, H.C. (2003). Retraction Journal of Experimental Medicine 198 (7), 1129-1129. Verbrugge, A., Ruiter, T. de, Clevers, H.C., & Meyaard, L. (2003). Differential contribution of the immunoreceptor tyrosine-based inhibitor motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment. International Immunology 15 (11), 1349-1358.

71

University Medical Center Utrecht Department of Immunology

Research group Fc receptors and Immunotherapy

(UU UMC 2.2.1)

Leader J.G.J. van de Winkel

Ms. J. Leusen

Post docs Ms. M. van Egmond

Ms. S. Genevrois J. van Roon

Ms. L. Steeghs G. Vidarsson

PhD students Ms. J. Bakema

J. Beekman Ms. L. Bevaart

Ms. A. Ioan-Facsinay Ms. A. van Royen Ms. N. van Sorge

Ms. A. Stemerding Ms. S. Wijngaarden

Titles PhD projects Ms. J. Bakema: Molecular cell biology of FcγR I J. Beekman: The cell biology of the high affinity IgG receptor FcγRI (CD 64) Ms. L. Bevaart: Fc Receptor directed immunotherapy of cancer Ms. A. Ioan-Facsinay: In vivo molecular dissection of IgG Fc receptor function Ms. M. Otten: Fc receptor directed therapy of liver carcinoma Ms. A. van Royen: Fc-receptor mediated immunomodulation Ms. N. van Sorge: Role of FcR and antibodies in polyneuropathies Ms. A. Stemerding: Role of FcR on phagocytes Ms. S. Wijngaarden: Expression and function of Fc Receptors in Reumatoid Arthritis Thesis Ioan-Facsinay, A. (28-02-2003). The biological function of the activating IgG Fc receptors, FcγRI and FcγRIII UU Universiteit Utrecht.. Prom./coprom.: Winkel, J.G.J. van de, Ommen, GJ van, & Verbeek, J.S. International publications Arigita, C., Bevaart, L., Everse, L.A., Koning, G.A., Hennink, W.E., Crommelin, D.J.A., Winkel, J.G.J. van de, Vugt, M.J. van, Kersten, G.F.A., & Jiskoot, W. (2003-). Liposomal meningococcal B vaccination: Role of dendritic cell targeting in the development of a protective immune response Infection and Immunity 71 (9), 5210-5218. Armour, K.L., Winkel, J.G.J. van de, Williamson, L.M., & Clark, M.R. (2003). Differential binding to human FcγRIIa and FcγRIIb receptors by human IgG wildtype and mutant antibodies. Molecular Immunology 40, 585-593. Breij, E.C.W., Pol, W.L. van der, Winsen, L van, Jansen, M.D., Dijkstra, C.D., Winkel, J.G.J. van de, & Uitdehaag, B.M.J. (2003). No association of FcgRIIa, FcgRIIIa and FcgRIIIb polymorphisms with MS. Journal of Neuroimmunology 140, 210-215. Genevrois, S.A.M., Steeghs, L.J.J.M., Roholl, P., Letesson, J.J., & Ley, P. van der (2004). The Omp85 protein of Neisseria meningitidis is required for lipid export the outer membrane. EMBO Journal 22 (8), 1780-1789. Glennie, M.J., & Winkel, J.G.J. van de (2003). Renaissance of cancer therapeutic antibodies. Drug discovery today 8, 503-510. Hellwig, S., Rodriguez, M., Berbers, G., Winkel, J.G.J. van de, & Mooi, F.R. (2003). Crucial role of antibodies to pertactin in Bordetella pertussis immunity. Journal of Infectious Diseases 188 (5), 738-

72

742. Kumpel, B.M., Haas, M. de, Koene, H.R., Winkel, J.G.J. van de, & Goodrick, M.J. (2003). Clearance of red cells by monoclononal IgG3 anti-D in vivo is affected by the VF polymorphism of FcgRIIIa (CD 16). Clinical and Experimental Immunology 132, 81-86. Ley, P. van der, & Steeghs, L.J.J.M. (2003). Lessons from an LPS-deficient Neisseria meningitidis mutant. Journal of Endotoxin Research 9 (2), 124-128. Loos, B.G., Leppers, F.G.J., Winkel, J.G.J. van de, & Velden, U van der (2003). Fcg receptor polymorphisms in relation to periodontitis. Journal of Clinical Periodontology 30, 595-602. Monteiro, R.C., & Winkel, J.G.J. van de (2003). IgA Fc receptors Annual review of immunology 21, 177-204. Ojik, H.H., Bevaart, L., Dahle, C.E., Bakker, J.M., Jansen, J.H.M., Vugt, M.J. van, Winkel, J.G.J. van de, & Weiner, G.J. (2003). CpG-A and B oligodeoxynucleotides enhance the efficacy of antibody therapy by activating different effector cell populations. Cancer Research 63 (17), 5595-5600. Parren, P.W.H.I., Leusen, J.H.W., & Winkel, J.G.J. van de (2003). Antibody-catalyzed water oxidation: state-of-the-art immunity or ancient history? Trends in Immunology 24, 467-471. Pleass, R.J., Ogun, S.A., McGuinness, D.H., Winkel, J.G.J. van de, Holder, A.A., & Woof, J.M. (2003). Novel anti-malarial antibodies highlight the importance of the antibody Fc region in mediating protection. Blood 102, 4424-4430. Pol, W.L. van der, Jansen, M.D., Kuks, J.B.M., Baets, M.H. de, Leppers-van de Straat, F.G.J., Wokke, J.H.J., Winkel, J.G.J. van de, & Berg, L.H. van den (2003). Association of the Fc¿ receptor IIA-R/R131 genotype with myasthenia gravis in Dutch patients. Journal of Neuroimmunology 144, 143-147. Pol, W.L. van der, Jansen, M.D., Sluiter, W.J., Sluis, B. van de, Dijstelbloem, H., Leppers-van de Straat, F.G.J., Kobayashi, T., Westendorp, R.G.J., Huizinga, T.W., & Winkel, J.G.J. van de (2003). Evidence for non-random distribution of Fcγ receptor genotype combinations. Immunogenetics 55 (4), 240-246. Repp, R., Ojik, H.H., Valerius, T., Groenewegen, G., Wieland, G., Oetzel, C., Stockmeyer, B., Becker, W.-D., Eisenhut, M., Steininger, H., Deo, Y.M., Blijham, G.H., Kalden, J.R., Winkel, J.G.J. van de, & Gramatzki, M. (2003). Phase I clinical trial of the bispecific antibody MDX-H210 (anti_FcgrammaRI x anti-HER-2/neu in combination with Filgrastim (G-CSF) for treatment of advanced breast cancer. British Journal of Cancer 15 (89), 2234-43. Roon, J.A.G. van, Wijngaarden, S., Lafeber, F.P.J.G., Damen, C, Winkel, J.G.J. van de, & Bijlsma, J.W.J. (2003). Interleukin 10 treatment of patients with rheumatoid arthritis enhances Fc gamma receptor expression on monocytes and responsiveness to immunocomplex stimulation Journal of Rheumatology 30, 648-651. Roon, J.A.G. van, Vuuren, A.J. van, Wijngaarden, S., Jacobs, K.M.G., Bijlsma, J.W.J., Lafeber, F.P.J.G., Thepen, T., & Winkel, J.G.J. van de (2003). Selective eliminimation of synovial inflammatory macrophages in rheumatoid arthritis by an FcgRI-directed immunotoxin. Arthritis and Rheumatism 48 (5), 1229-1238. Saeland, E., Vidarsson, G., Leusen, J.H.W., Garderen, E. van, Nahm, M., Vile, H., Walraven, V., Stemerding, A.M., Verbeek, J.S., Rijkers, G.T., Kuis, W., Sanders, E.A.M., & Winkel, J.G.J. van de (2003). Central Role of Complement in Passive Protection by Human IgG1 ad IgG2 Anti-pneumococcal Antibodies in Mice Journal of Immunology 170 (12), 6158-6164. Saeland, E., Leusen, J.H.W., Vidarsson, G., Kuis, W., Sanders, E.A.M., Jonsdottir, I., & Winkel, J.G.J. van de (2003). Role of Fcy receptors in vaccine induced immunity to Streptococcus pneumoniae. Journal of Infectious Diseases 187 (11), 1686-1693. Sorge, N.M. van, Berg, L.H. van den, Geleijns, K, Strijp, J.A. van, Jacobs, B.C., Doorn, P.A. van, Wokke, J.H.J., Winkel, J.G.J. van de, Leusen, J.H.W., & Pol, W.L. van der (2003). Anti-GM1 antibodies induce leukocyte effector functions via Fcγ receptors. Annals of Neurology 53, 570-579. Sorge, N.M. van, Pol, W.L. van der, & Winkel, J.G.J. van de (2003). FcgR polymorphisms: implications for function, disease susceptibility and immunotherapy. Tissue Antigens 61, 189-202. Spriel, A.B. van, Ojik, H.H., Bakker, J.M., Jansen, J.H.M., & Winkel, J.G.J. van de (2003). Mac-1 (CD11b/CD18) is crucial for effective Fc receptor-mediated immunity to melanoma Blood 101, 253-258. Stassen, M, Meng, F, Melgert, E, Machiels, B.M., Im, S.H., Fuchs, S., Gerritsen, A.F, Dijk, M.A. van, Winkel, J.G.J. van de, & Baets, M.H. de (2003). Experimental autoimmune myasthenia gravis in mice expressing human immunoglobulin loci Journal of Neuroimmunology 135 (1-2), 56-61. Tur, M.K., Huhn, M., Thepen, T., Stöcker, M, Krohn, R., Vogel, S., Jost, E., Osieka, R., & Winkel, J.G.J. van de (2003). Recombinant CD64-specific single chain immunotoxin exhibits specific cytotoxicity against acute myeloid leukemia cells. Cancer Research 63, 8414-8419. Villadsen, L., Schuurman, J., Beurskens, F.J.M., Dam, T.N., Dagnaes-Hansen, F., Skov, L., Rygaard, J., Voorhorst-Ogink, M.M., Gerritsen, A.F, Dijk, M.A. van, Parren, P.W.H.I., Baadsgaard, O., & Winkel, J.G.J. van de (2003). Resolution of psoriasis upon blockade of interleukin-15 biological activity in a xenograft mouse model. Journal of Clinical Investigation 112, 1571-1580. Wijngaarden, S., Roon, J.A.G. van, Bijlsma, J.W.J., Winkel, J.G.J. van de, & Lafeber, F.P.J.G. (2003). Fc gamma receptor expression levels on monocytes are elevated in rheumatoid arthritis patients with high erythrocyte sedimentation rate who do not use anti-rheumatic drugs. Rheumatology 42, 681-688.

74

University Medical Center Utrecht Department of Allergology and Dermatology

Research group Cutaneous and food allergy

(UU UMC 2.3.2)

Leader Ms. C.A.F.M. Bruijnzeel-Koomen

E. Knol

Staff Ms. M. de Bruin - Weller

A. Knulst V. Sigurdsson

A. Willemse

Post docs E. van Hoffen

E. Nijhuis R. Kiekens

PhD students

Ms. W. Kölgen Ms. A. Sleijffers

Ms. M. Tiemessen B. Ruiter

Ms. A. Flinterman Ms. S. Bolhaar

D.J. Hijnen Ms. I. Beeren

Ms. M. Oldhoff

Titles PhD projects M. Tiemessen: A new generation of tolerance-inducing components for food-allergic patients W. Kölgen: Pathogenesis of chronic polymorphic photodermatoses J. Sinke: Immunopathogenesis of atopic dermatitis in dogs Y. Schlotter Atopic dermatitis in dogs: regulation of the inflammatory response A. Sleijffers: The influence of UV radiation on Hepatitis B vaccination B. Ruiter: T-cell epitopes in cow’s milk allergy A. Flinterman: Thresholds for food allergy in children S. Bolhaar: Clinical and immunological aspects of apple allergy K. Peeters: Clinical and immunological aspects of nut allergy D.J. Hijnen: Micro-array analysis in atopic dermatitis I. Beeren: The role of IgE mediated antigen presentation in allergic diseases I. Schornagel: Pathomechanisms of UV-allergy M. Oldhoff: Cutaneous inflammation in atopic dermatitis E. Veenhof: Food allergy in dogs Thesis Kolgen, W. (01-04-2003). Unraveling the pathogenesis of polymorphous light eruption UU Universiteit Utrecht. (Utrecht: Labor Grafimedia BV Utrecht). Prom./coprom.: Vloten, W.A. van, Bruijnzeel-Koomen, C.A.F.M., Gruijl, F.R. de, & Knol, E.F. Sleijffers, A. (18-02-2003). Ultraviolet B-induced immunomodulation of hepatitis B vaccination responses UU Universiteit Utrecht. (Wageningen: Ponsen en Looijen, Wagingen). Prom./coprom.: Vloten, W.A. van, Loveren, H. van, Garssen, J., Gruijl, F.R. de, & Boland, G.J. International publications Kolgen, W., Steeg, H. van, Horst, G.T.J. van der, Hoeijmakers, J.H., Vloten, W.A. van, Gruijl, F.R. de, & Garssen, J. (2003). Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppresion. Journal of Investigative Dermatology 121 (4), 751-756.

75

Koppelman, S.J., Knol, E.F., Vlooswijk, R., Wensing, M., Knulst, A.C., Hefle, S.L., Gruppen, H, & Piersma, S. (2003). Peanut allergen Ara h3: Isolation from peanuts and biochemical characterization. Allergy 58 (11), 1144-1151. Lie, W.J., Homburg, C.H., Kuijpers, T.W., Knol, E.F., Mul, F.P., Roos, D., & Tool, A.T. (2003). Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. Clinical and Experimental Allergy 33 (8), 1125-1134. Niers, L.E.M., Rijkers, G.T., Knol, E.F., Meijer, Y., & Hoekstra, M.O. (2003). Probiotics for prevention of atopic disease? Lancet 9 (362), 496. Oosting, A.J., Bruin-Weller, M.S. de, & Bruijnzeel-Koomen, C.A.F.M. (2003). In response to Dr. Gutgesell's 5 points Journal of Allergy and Clinical Immunology 111 (1), 203-204. Rijssenbeek-Nouwens, L., Oosting, A.J., Bruijnzeel-Koomen, C.A.F.M., & Bruin-Weller, M.S. de (2003). Anti-allergic mattress covers in asthma: to do or not to do? Clinical and Experimental Allergy 33, 1613-1617. Schade, R.P., Tiemessen, M.M., Knol, E.F., Bruijnzeel-Koomen, C.A.F.M., & Hoffen, E. van (2003). The cow's milk protein-specific T cell response in infancy and childhood. Clinical and Experimental Allergy 33 (6), 725-730. Terreehorst, I, Hak, E., Oosting, A.J., Tempels-Pavlica, Z, Monchy, J.G.R. de, Bruijnzeel-Koomen, C.A.F.M., Aalberse, R.C., & Gerth van Wijk, R (2003). Evaluation of impermeable covers for bedding in patients with allergic rhinitis. New England Journal of Medicine 17 (349), 237-246. Tiemessen, M.M., Kunzmann, S., Schmidt-Weber, C.B., Garssen, J., Bruijnzeel-Koomen, C.A.F.M., Knol, E.F., & Hoffen, E. van (2003). Transforming growth factor-beta inhibits human antigen-specific CD4+ T cell proliferation without modulating the cytokine response. International Immunology 15 (12), 1495-1504. Wensing, M., Knulst, A.C., Piersma, S., O'Kane, F., Knol, E.F., & Koppelman, S.J. (2003). Patients with anaphylaxis to peanut can have peanut allergy caused by cross-reactive IgE to vicilin (Ara h1) . Journal of Allergy and Clinical Immunology 111 (2), 420-424. National publications

Balemans, W.A.F., Laag, J. van der, & Ent, C.K. van der (2003). Allergische bronchopulmonale aspergillose bij Cystic Fibrosis Nederlands tijdschrift voor allergie 2, 66-72.

Bolhaar, S.T.H.P., Ree, R. van, & Knulst, A.C. (2003). Appelallergie: verschillende klachtenpatronen binnen Europa. Nederlands Tijdschrift voor Geneeskunde 147 (33), 1620-1620. Bolhaar, S.T.H.P., Zuidmeer, L., Ree, R. van, & Knulst, A.C. (2004). Anafylaxie na het eten van exotisch fruit bij een tweetal berkenpollen allergische patienten. Nederlands tijdschrift voor dermatologie & venereologie 13, 17-18. Bolhaar, S.T.H.P., Ree, R. van, & Knulst, A.C. (2003). Appelallergie: verschillende klachtenpatronen binnen Europa. Nederlands tijdschrift voor dermatologie & venereologie 13, 19-20. Diederen, P.V.M.M., Kortenhof, N.M.M. van, Dam, P.S. van, Bruijnzeel-Koomen, C.A.F.M., & Bruin-Weller, M.S. de (2004). Inductie van secundaire bijnierinsufficientie/hypocortisolisme door langdurig gebruik van dermatocorticosteroiden. Nederlands tijdschrift voor dermatologie & venereologie 13, 14-15. Flinterman, A.E., Meijer, Y., Knulst, A.C., Bruijnzeel-Koomen, C.A.F.M., & Pasmans, S.G.M.A. (2003). Diagnostiek van koemelkallergie bij jonge kinderen. Nederlands tijdschrift voor dermatologie & venereologie 13, 25-26. Ginkel, C.J.W. van, & Stadhouders-Keet, S.A.E. (2003). Beroepsallergie voor kunstnagels. Nederlands tijdschrift voor dermatologie & venereologie 13, 16-17. Hijnen, D.J., Knol, E.F., Oldhoff, J.M., Bruijnzeel-Koomen, C.A.F.M., & Bruin-Weller, M.S. de (2003). Ziekte monitoring bij patienten met constitutioneel eczeem: serum TARC-waarden als objectieve parameter voor ziekteactiviteit? Nederlands tijdschrift voor dermatologie & venereologie 13, 8-10.

Hijnen, D.J., Knol, E.F., Oldhoff, J.M., Bruijnzeel-Koomen, C.A.F.M., & Bruin-Weller, M.S. de (2003). Ziekte-monitoring bij patienten met constitutioneel eczeem: de serumconcentratie thymus and activation regulated chemokine (TARC) als objectieve parameter voor ziekteactiviteit. Nederlands Tijdschrift voor Geneeskunde 147 (33), 1619-1619. Hoffen, E. van, Tiemessen, M.M., Schade, R.P., Bruijnzeel-Koomen, C.A.F.M., & Knol, E.F. (2003). Voedselallergie en tolerantie-inductie. Nederlands tijdschrift voor dermatologie & venereologie 13, 27-28. Knol, E.F. (2003). De immunopathogenese van constitutioneel eczeem: een overzicht. Nederlands tijdschrift voor dermatologie & venereologie 13, 6-7.

Mascini, E.M., Sanders, C.J.G., & Peeters, K.A.B.M. (2003). Toename van resistentie tegen fusidinezuur van Staphylococcus aureus-isolaten bij opgenomen patienten met constitutioneel eczeem - reactie op commentaar Nederlands Tijdschrift voor Geneeskunde. Studenteneditie 147 (3), 135. Oldhoff, J.M., Hijnen, D.J., Graaf, E.A. van de, Bruijnzeel-Koomen, C.A.F.M., & Bruin-Weller, M.S. de (2004). Moeilijk behandelbaar constitutioneel eczeem en astma: ervaringen met oraal tacrolimus. Nederlands tijdschrift voor dermatologie & venereologie 13, 11-12. Oosting, A.J., Bruijnzeel-Koomen, C.A.F.M., & Bruin-Weller, M.S. de (2003). De rol van atopie bij constitutioneel eczeem: is eliminatie van allergeen zinvol? Nederlands tijdschrift voor dermatologie &

76

venereologie 13, 12-13. Oosting, A.J., Bruijnzeel-Koomen, C.A.F.M., & Bruin-Weller, M.S. de (2003). Effect van

matrashoezen bij patienten met constitutioneel eczeem. Nederlands Tijdschrift voor Geneeskunde 147 (33), 1617-1617.

Steenhuis, T.J., Aalderen, W.M.C van, & Hoekstra, M.O. (2003). Allergie op de kinderleeftijd - een rol voor primaire preventie? Tijdschrift Kindergeneeskunde 71, 217-222. Timmer-de Mik, L., Toonstra, J., & Ginkel, C.J.W. van (2003). Anafylactische reactie op de plasma-expander Gelofusine. Nederlands tijdschrift voor dermatologie & venereologie 13, 255-256. Wensing, M., Penninks, A.H., Bruijnzeel-Koomen, C.A.F.M., & Knulst, A.C. (2003). Drempelwaarden voor klinische reacties bij voor pinda- en hazelnootallergische patienten. Nederlands tijdschrift voor dermatologie & venereologie 13, 23-24.

Wensing, M., Bruijnzeel-Koomen, C.A.F.M., Penninks, A.H., & Knulst, A.C. (2003). Drempelwaarden voor klinische reacties bij patienten die allergisch zijn voor pinda en hazelnoot. Nederlands Tijdschrift voor Geneeskunde 147 (33), 1616-1616.

77

University Medical Center Utrecht Department of Hematology – Jordan Laboratory

Research group Immuno gene therapy

(UU UMC 2.3.7)

Leader A. Hagenbeek

Staff

Ms. S.B. Ebeling A.C.M. Martens

T. Mutis H. Otten

Ms. I. Slaper - Cortenbach

Post docs Ms. C. Olivo

H. Rozemuller

PhD students R. Ivanov

T. van Meerten Ms. R. van Rijn

Ms. M. Stijns

Titles PhD projects R. Ivanov: Identification of minor histocompatibility antigens in CML T.van Meerten: CD20 antigen in suicide gene therapy for leukaemia Ms. R. van Rijn: Graft-versus-host/graft-versus-leukemia Ms. M. Stijns: Genetic modification of normal hemopoietic progenitor cells to produce growth factor toxin fusion protein secreting cells for the treatment of ressidual leukemia in the bone marrow International publications Agthoven, M. van, P. Sonneveld, A. Hagenbeek, C. Uyl-de Groot - A review of recruitment criteria, patient characteristics and results of CHOP chemotherapy in prospective randomized phase III clinical trails for aggressive non-Hodgkin’s lymphoma - The Hematology Journal 4 (2003) pp. 399-409

Aleman, B. M. P., Raemaekers, J.M.M., Tirelli, U., Bortolus, R., Veer, M.B. van 't, Lybeert, M.L.M., Keuning, J.J., Carde, P., Girinsky, T., Maazen, R.W.M., Tomsic, R., Vovk, M., Hoof, A. van, demeestere, G, Lugtenburg, P.J., Thomas, J., Schroyens, W., Boeck, K. de, Baars, J.W., Kluin-Nelemans, J.C., Carrie, C., Aoudjhane, M., Bron, D., Eghbali, H., Smit, W.G.J.M., Meerwaldt, J.H., Hagenbeek, A., Pinna, A., & Henry-Amar, M. (2003). Involved-field radiotherapy for advanced hodgkin's lymphoma New England Journal of Medicine 348, 2396-2406. Bleek, G.M. van, M.C. Poelen, R. van der Most, H.F. Brugghe, H.A.M. Timmermans, C.J. Boog, P. Hoogerbrugge, H.G. Otten, C.A.C.M. van Els – Identification of immunodominant epitopes derived from the respiratory syncytial virus fusion protein that are recognized by human CD4 T-cells. Journal of Virology 77 (2003) pp. 980-988 Bonini, c., Grez, m., Traversari, c., Ciceri, f., Marktel, s., Ferrari, g., Dinauer, m., Sadat, m., Aiuti, a., Deola, s., Radrizzani, m., Hagenbeek, A., Apperley, J., Ebeling, S.B., Martens, A.C.M., Kolb, H.J., Weber, M, Lotti, F., Grande, A., weissinger, e., bueren, j.a., lamana, m., falkenburg, j.h.f., heemskerk, m.h.m., austin, t., kornblau, s., marini, f., benati, c., magnani, z., cazzaniga, s., toma, s., gallo-stampino, c., introna, m., Slavin, S., Greenberg, P.D., bregni, m., mavilio, f., & bordignon, c. (2003). Safety of retroviral gene marking with a truncated NGF receptor Nature Medicine 9 (4), 367-369. Cornelissen, J.J., Holt, B. van der, Petersen, E.J., Vindelov, L., Russel, C.A., Hoglund, M., Maertens, J., Schouten, H.C., Braakman, E., Steijaert, M.M., Zijlmans, M.J., Slaper-Cortenbach, I.C.M., Boogaerts, M.A., Lowenberg, B., & Verdonck, L.F. (2003). A randomized multicenter comparison of CD34(+)-selected progenitor cells from blood vs from bone marrow in recipients of HLA-identical allogeneic transplants for hematological malignancies. Experimental Hematology 31 (10), 855-864. Ebeling, S.B., Borst, H.P.E., Simonetti, E.R., Hol, S., Garin, M.I., Slaper-Cortenbach, I.C.M., &

78

Hagenbeek, A. (2003). Development and application of quantitative real time PCR and RT-PCR assays that discriminate between the full-length and truncated herpes simplex virus thymidine kinase gene Journal of virological methods 109, 177-186. Ebeling, S.B., Ivanov, R., Hol, S., Aarts, T.I., & Hagenbeek, A. (2003). HLA-DRB1*16-restricted recognition of myeloid cells, including CD34+ CML progenitor cells British Journal of Haematology 121, 721-729. Ebeling, S.B., Simonetti, E.R., Borst, H.P.E., Blok, A., Schelen, A.M., Braakman, E., & Ederveen, J. (2003). Human primary T lymphocytes have a low capacity to amplify MLV-based amphotropic RCR and the virons produced are largely non-infectious Gene therapy 10, 1800-1806. Ferrand, C., perruche, s., robinet, e., Martens, A.C.M., Tiberghien, P., & saas, p. (2003). How should chimerism be decoded? Transplantation 75 (9), 50S-54S. Kolen, s., Weijtens, M., Hagenbeek, A., Spronsen, A.M. van, Smulders, S., Weger, R.A. de, Witte, T. de, Dolstra, H., Wiel van Kemenade, E. van de, & Martens, A.C.M. (2003). Monitoring of developing graft-versus-host disease mediated by herpes simplex virus thymidine kinase gene-transduced T Cells Human gene therapy 14, 341-351. Mutis, T. de (2003). Targeting alloreactive donor T-cells to hematopoietic system-restricted minor histocompatibility antigens to disect graft-versus-leukemia effects from graft-versus-host disease after allogeneic stem cell transplantation The International Journal of Hematology 78, 208-213. Otten, H.G., G.C. de Gast, W.C. Vooijs, A.P. van der Gouw, M. de Boer, M.A. Ossevoort, M. Jonker – Preclinical evaluation of anti-CD86 immunotoxin in rhesus monkeys: analysis of systemic toxicity, pharmacokinetics, and effect on primary T-cell responses – Cancer Immunology Immunotherapy 52 (2003) pp. 569-575 Rookmaker, M.B., Smits, A.M., Tolboom, H., Wout, K. van't, Martens, A.C.M., Goldschmeding, R., Joles, J.A., Zonneveld, A.J. van, Grone, H.J., Rabelink, A.J., & Verhaar, M.C. (2003). Bone-marrow-derived cells contribute to glomerular endothelial repair in experimental glomerulonephritis American Journal of Pathology 163, 553-562. Ebeling, S.B., Simonetti, E.R., Garin, M.I., Gaiser, J.F., Ferrand, C., Apperley, J.F., Chalmers, D., & Hagenbeek, A. (2003). Herpes Simplex Virus Thymidine kinase-transduced human T-lymphocytes In W. Hiddemann, T. Buchner, J. Ritter, M. Unterhalt & T. Haferlach (Eds.), Acute Leukemias IX (pp. 491-496). Berlin: Springer Verlag. Rijn, R.S. van, E.R. Simonetti, A. Hagenbeek, M.C.H. Hogenes, R.A. de Weger, M.R. Cannniga-van Dijk, K. Weijer, H. Spits, G. Storm, L. van Bloois, G. Rijkers, A.C.M. Martens, S.B. Ebeling – A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG -/- γc-/- double-mutant mice. Blood 102 (2003) pp. 2522-2531 Book, book chapters & proceedings Agthoven, M. van, A. Hagenbeek, C.A. Uyl-de Groot - An observational study on resource use and costs in low-grade follicular non-Hodgkin’s lymphoma - Publication from the Institute for Medical Technology Assessment, Erasmus Medical Center Rotterdam, The Netherlands (2003) pp. 1-90

79

University Medical Center Utrecht Departments of Hematology and Immunology

Research group Multiple myeloma (UU UMC 2.3.6)

Leader

A.C. Bloem H.M. Lokhorst

Staff

E.J.E.G. Bast Ms. G. Boersma - Vreugedenhil

L.F. Verdonk

PhD students N. van der Donk

Ms. P. Holloway P.Y.Y. Ng

Ms. E. van Stralen

Titles PhD projects N. van der Donk: Treatment of multiple myeloma by down regulation of the apoptosis inhibiting protein bcl2-2 by antisense digonucleotides Ms. M. Eurelings: Analysis of risk-factors for development of hematological malignancies in patients with MGUS associated with polyneuropathy Ms. P.Holloway: Adaptive T-cell therapy in multiple myeloma Ms. A. van Marion: Inhibition of angiogenesis in multiple myeloma P.Y.Y. Ng: Retro viral gene marking to study the source of relapse and long term haematopuisis after peripheral blood stem cell transplantation in multiple myeloma Ms. E. van Stralen: The occurance and molecular consequences of the t (14;20) (q32, q11) translocation in multiple myeloma Thesis Donk, N.W.C.J. van de (07-10-2003). New treatment strategies for multiple myeloma by targeting Bcl-2 and the mevalonate pathway UU Universiteit Utrecht.. Prom./coprom.: Clevers, H.C., Hagenbeek, A., Bloem, A.C., & Lokhorst, H.M. Ng, P.Y.Y. (21-01-2003). Human hematopoietic stem cells: Ex vivo expension, gene transfer and molecular characterization UU Universiteit Utrecht.. Prom./coprom.: Logtenberg, T., Hagenbeek, A., Bloem, A.C., Lokhorst, H.M., & Staal, F.J.T. International publications

Barjesteh van Waalwijk van Doorn-Khosrovani S, Erpelinck C, van Putten WL, Valk PJ, van der Poel-van de Luytgaarde S, Hack R, Slater R, Smit EM, Beverloo HB, Verhoef G, Verdonck LF, Ossenkoppele GJ, Sonneveld P, de Greef GE, Lowenberg B, Delwel R. Related Articles, Links High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients. Blood. 2003 Feb 1;101(3):837-45. Epub 2002 Oct 03. Boersma-Vreugdenhil, G.R., Peeters, T, Bast, E.J.E.G., & Lokhorst, H.M. (2003). Translocation of the IgH locus is nearly ubiquitous in multiple myeloma as detected by immuno-FISH. Blood 101 (4), 1653.

Canninga-van Dijk MR, Sanders CJ, Verdonck LF, Fijnheer R, van den Tweel JG. Related Articles, Links Differential diagnosis of skin lesions after allogeneic haematopoietic stem cell transplantation. Histopathology. 2003 Apr;42(4):313-30.

Cornelissen JJ, van der Holt B, Petersen EJ, Vindelov L, Russel CA, Hoglund M, Maertens J, Schouten HC, Braakman E, Steijaert MM, Zijlmans MJ, Slaper-Cortenbach I, Boogaerts MA, Lowenberg B, Verdonck LF. Related Articles, Links A randomized multicenter comparison of CD34(+)-selected progenitor cells from blood vs from bone marrow in recipients of HLA-identical allogeneic transplants for hematological malignancies. Exp Hematol. 2003 Oct;31(10):855-64.

Corradini P, Cavo M, Lokhorst H, Martinelli G, Terragna C, Majolino I, Valagussa P, Boccadoro M, Samson D, Bacigalupo A, Russell N, Montefusco V, Voena C, Gahrton G; Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT). Related Articles, Links Molecular remission after myeloablative allogeneic stem cell transplantation predicts a better

80

relapse-free survival in patients with multiple myeloma. Blood. 2003 Sep 1;102(5):1927-9. Epub 2003 May 08. Derksen, P.W., Gorter, D.J. de, Meijer, H.P., Bende, R.J., Dijk, M.E.A. van, Lokhorst, H.M., Bloem, A.C., Spaargaren, M., & Pals, S.T. (2003). The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma. Leukemia 17 (4), 764-774. Donk, N.W.C.J. van de, Kamphuis, M.M., Dijk, M.E.A. van, Borst, H.P.E., Bloem, A.C., & Lokhorst, H.M. (2003). Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of Bcl-2 protein. Leukemia 17 (1), 211-219. Donk, N.W.C.J. van de, Kamphuis, M.M., Kessel, B. van, Lokhorst, H.M., & Bloem, A.C. (2003). Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels. Blood 102 (9), 3354-3362. Donk, N.W.C.J. van de, Schotte, D., Kamphuis, M.M., Marion, A.M.W. van, Kessel, B. van, Bloem, A.C., & Lokhorst, H.M. (2003). Protein geranylgeranylation is critical for the regulation of survival and proliferation of lymphoma tumor cells. Clinical Cancer Research 9 (15), 5735-5748. Doorduijn, J.K., Holt, B. van der, Imhoff, G.W. van, Hem, K.G. van der, Kramer, M.H.H., Oers, M.H.J. van, Ossenkoppele, G.J., Schaafsma, M.R., Verdonck, L.F., Verhoef, G.E.G., Steijaert, M.M.C., Buijt, I., Uyl-de Groot, C.A., Agthoven, M. van, Mulder, A.H., & Sonneveld, P. (2003). CHOP compared with CHOP plus granulocyte colony-stimulating factor in elderly patients with aggressive non-Hodgkin's lymphoma Journal of Clinical Oncology 21, 3041-3050.

Ebeling SB, Ivanov R, Hol S, Aarts TI, Hagenbeek A, Verdonck LF, Petersen EJ. Related Articles, Links HLA-DRB1*16-restricted recognition of myeloid cells, including CD34+ CML progenitor cells. Br J Haematol. 2003 Jun;121(5):721-9.

Fijnheer R, Sanders CJ, Canninga MR, de Weger RA, Verdonck LF. Related Articles, Links Complete remission of a radiochemotherapy-resistant cutaneous T-cell lymphoma with allogeneic non-myeloablative stem cell transplantation. Bone Marrow Transplant. 2003 Aug;32(3):345-7. Goldschmidt, H., Sonneveld, P., Cremer, T.W., Holt, B. van der, Westveer, I., Breitkreutz, I., Benner, A., Glasmacher, A., Schmidt-Wolf, I.G., Martin, H., Hoelzer, D., Ho, A.D., & Lokhorst, H.M. (2003). Joint HOVON-50/GMMG-HD3 randomized trial on the effect of thalidomide as part of a high-dose therapy regimen and as maintenance treatment for newly diagnosed myeloma patients Annals of Hematology 82, 654-659. Holloway, P.A., Kaldenhoven, N., Kok-Schoemaker, H., Kessel, B. van, Blokland, W.T. van, Bloem, A.C., & Lokhorst, H.M. (2003). Antigens shared by malignant plasma cells and normal B cells may be involved in graft versus myeloma. Clinical and Experimental Immunology 131 (2), 340-346.

van Kooij B, Thijsen SF, Meijer E, Niesters HG, van Esser JW, Cornelissen JJ, Verdonck LF, van Loon AM. Related Articles, Links Sequence analysis of EBV DNA isolated from mouth washings and PBMCs of healthy individuals and blood of EBV-LPD patients. J Clin Virol. 2003 Sep;28(1):85-92. Laterveer, L., Verdonck, L.F., Peeters, T, Borst, H.P.E., Bloem, A.C., & Lokhorst, H.M. (2003). Graft versus myeloma may overcome the unfavorable effect of deletion of chromosome 13 in multiple myeloma. Blood 101 (3), 1201-1202.

Lokhorst HM, Segeren CM, Verdonck LF, van der Holt B, Raymakers R, van Oers MH, Barge RM, Schouten HC, Westveer PH, Steijaert MM, Cornelissen JJ, Sonneveld P; Dutch-Belgian Hemato-Oncology Cooperative Group. Related Articles, Links Partially T-cell-depleted allogeneic stem-cell transplantation for first-line treatment of multiple myeloma: a prospective evaluation of patients treated in the phase III study HOVON 24 MM. J Clin Oncol. 2003 May 1;21(9):1728-33. Lowenberg, B., Putten, W. van, Theobald, M., Gmur, J., Verdonck, L.F., Sonneveld, P., Fey, M., Schouten, H.C., Greef, G. de, Ferrant, A., Kovacsovics, T., Gratwohl, A., Daenen, S., Huijgens, P.C., & Boogaerts, M.A. (2003). Effect of priming with granulocyte colony-stimulating factor on the outcome of chemotherapy for acute myeloid leukemia (Dutch-Belgian Hemato-Oncology Cooperative Group;Swiss Group for Clinical Cancer Research New England Journal of Medicine 349, 743-752.

Lowenberg B, van Putten W, Theobald M, Gmur J, Verdonck L, Sonneveld P, Fey M, Schouten H, de Greef G, Ferrant A, Kovacsovics T, Gratwohl A, Daenen S, Huijgens P, Boogaerts M; Dutch-Belgian Hemato-Oncology Cooperative Group; Swiss Group for Clinical Cancer Research. Related Articles, Links Effect of priming with granulocyte colony-stimulating factor on the outcome of chemotherapy for acute myeloid leukemia. N Engl J Med. 2003 Aug 21;349(8):743-52.

Mandigers CM, Verdonck LF, Meijerink JP, Dekker AW, Schattenberg AV, Raemaekers JM. Related Articles, Links Graft-versus-lymphoma effect of donor lymphocyte infusion in indolent lymphomas relapsed after allogeneic stem cell transplantation. Bone Marrow Transplant. 2003 Dec;32(12):1159-63.

Meijer E, Cornelissen JJ, Lowenberg B, Verdonck LF. Related Articles, Links Antithymocyteglobulin as prophylaxis of graft failure and graft-versus-host disease in recipients of partially T-cell-depleted grafts from matched unrelated donors: a dose-finding study. Exp Hematol. 2003 Nov;31(11):1026-30.

Meijer E, Dekker AW, Verdonck LF. Related Articles, Links Influence of antithymocyte globulin dose on outcome in cytomegalovirus-seropositive recipients of partially T cell-depleted stem cell grafts from matched-unrelated donors. Br J Haematol. 2003 May;121(3):473-6.

81

Meijer E, Boland GJ, Verdonck LF. Related Articles, Links Prevention of cytomegalovirus disease in recipients of allogeneic stem cell transplants. Clin Microbiol Rev. 2003 Oct;16(4):647-57. Meijer, E., Bloem, A.C., Dekker, A.W., & Verdonck, L.F. (2003). Effect of antithymocyte globulin on quantitative immune recovery and graft-versus-host disease after partially T-cell-depleted bone marrow transplantation: a comparison between recipients of matched related and matched unrelated donor grafts. Transplantation 75 (11), 1910-1913.

Minnema MC, Fijnheer R, De Groot PG, Lokhorst HM. Related Articles, Links Extremely high levels of von Willebrand factor antigen and of procoagulant factor VIII found in multiple myeloma patients are associated with activity status but not with thalidomide treatment.J Thromb Haemost. 2003 Mar;1(3):445-9. Ng, P.Y.Y., Kessel, B. van, Lokhorst, H.M., Baert, M.R., Burg, C.M. van den, Bloem, A.C., & Staal, F.J.T. (2003). Gene-expression profiling of CD34+ cells from various hematopoietic stem-cell sources reveals functional differences in stem-cell activity. Journal of Leukocyte Biology 75 (2), 314-323. Staa, T.P. van, Boulton, F., Cooper, C., Hagenbeek, A., Inskip, H., & Leufkens, H.G.M. (2003). Neutropenia and Agranulocytosis in England and Wales: Incidence and Risk factors AMERICAN JOURNAL OF HEMATOLOGY 72, 248-254.

Segeren CM, Sonneveld P, van der Holt B, Vellenga E, Croockewit AJ, Verhoef GE, Cornelissen JJ, Schaafsma MR, van Oers MH, Wijermans PW, Fibbe WE, Wittebol S, Schouten HC, van Marwijk Kooy M, Biesma DH, Baars JW, Slater R, Steijaert MM, Buijt I, Lokhorst HM; Dutch-Belgian Hemato-Oncology Cooperative Study Group. Related Articles, Links Overall and event-free survival are not improved by the use of myeloablative therapy following intensified chemotherapy in previously untreated patients with multiple myeloma: a prospective randomized phase 3 study. Blood. 2003 Mar 15;101(6):2144-51. Epub 2002 Nov 27. Waalwijk van Doorn-Khosrovani, S.B. van, Erpelinck, C., Putten, W.L.J. van, Valk, P.J.M., van der Poel-van de Luytgaarde, S., Hack, R., Slater, R., Smith, E.M.E., Beverloo, H.B., Verhoef, G.E.G., Verdonck, L.F., Ossenkoppele, G.J., Sonneveld, P., Greef, G.E. de, Lowenberg, B., & Delwel, R. (2003). High EV11 expression predicts poor survival in acute myeloid leukaemia: a study of 319 de novo AML patients Blood 101, 837-845. National publications

Bartels, M., Weersink, A.J.L., Wolfs, T.F.W., Bierings, M.B., & Révész, T. (2003). De behandeling van een Epstein-Barr-virus-gerelateerde lymfoproliferatieve ziekte na een allogene stamceltransplantatie: het gebruik van monoklonale anti-CD20-antilichamen Tijdschrift voor kindergeneeskunde 71 (2), 63-66.

Petersen EJ, Lokhorst HL, Verdonck LF. Related Articles, Links [Allogeneic stem cell transplantation following non-myeloablative conditioning: favorable results in 21 high risk patients with hematological malignancies treated in the Utrecht University Medical Center, the Netherlands] Ned Tijdschr Geneeskd. 2003 Nov 22;147(47):2328-32.

Book, book chapters & proceedings Agthoven, M. van, Hagenbeek, A., & Uyl-de Groot, C.A. (2003). An observational study on

resource use and costs in low-grade follicular non-Hodgkin's lymphoma-Publication from hte Insitute for Medical Technology Assesment Rotterdam: Eramus Medical Center Rotterdam.

82

University Medical Center Utrecht Departments of Pathology, Cardiology and Immunology

Research group Immunology of transplantation

(UU UMC 2.3.5)

Leader R. de Weger

M. Tilanus N. de Jonge

F. Gmelig Meyling

Staff P. van Diest

H.F.J. Dullens J.H. Kirkels C. Klöpping

L.H.P.M. Rademakers E. Rozemuller P.J. Slootweg

J. van den Tweel R. Goldschmeding

M.E.I. Schipper

PhD students A. Gijsbers-Bruggink

G. Koene J. Reinders

Ms. J. Schellekens

Titles PhD projects A. Gijsbers-Bruggink: Remodeling in transplanted and LVAD supported heart G. Koene: HLA expression in HNSCC Ms. J. Reinders: HLA diversity in head and neck squamous cell carcinoma, bone marrow

transplantation and populations Ms. J. Schellekens: Role of NK cells in BMT and GVHD Thesis Kraaij, M.G.J. van (07-10-2003). New developments in the diagnosis and the prevention of infections in stem cell transplant recipients UU Universiteit Utrecht (176 pag.). (Enschede: PrintPartners Ipskamp B.V.). Prom./coprom.: Hagenbeek, A., Dekker, A.W., & Loon, A.M. van Meijer, E. (02-09-2003). T cell immunodeficiency and severe herpes virus infections after allogeneic stem cell transplantation UU Universiteit Utrecht.. Prom./coprom.: Hagenbeek, A., & Verdonck, L.F. International publications

Al-Hussein, K.A., Rama, N.R., Ahmad, M., Rozemuller, E.H., & Tilanus, M.G.J. (2003). HLA-DPB1*0401 is associated with dominant protection against type 1 diabetes in teh general Saudi population and in subjects with a high-risk DR/DQ haplotype European journal of immunogenetics 30, 115-119. Bekkenk, M.W., Vermeer, M.H., Jansen, P.M., Marion, A.M.W. van, Canninga-van Dijk, M.R. van, Kluin, P.M., Geerts, M.L., Meijer, C.J.L.M., & Willemze, R. (2003). Peripheral T-cell lymphomas unspecified presenting in the skin: analysis of prognostic factors in a group of 82 patients Blood 102 (6), 2213-2219. Bijlsma, F.J., Bruggink, A.H., Gmelig Meyling, F.H.J., & Weger, R.A. de (2003). Cytokine Gene Polymorphism in Heart Transplantation: A Review Current Genomics 4 (3), 205-215. Bleek, G.M. van, Poelen, M.C.M., Most, R.G. van der, Brugghe, H.F., Timmermans, H.A.M., Boog, C.J.P., Hoogerhout, P., Otten, H.G., & Es, C.A.C.M. van (2003). Identification of immunodominant epitopes derived from the respiratory syncytical virus fusion protein that are recognized by human CD4

83

T cells Journal of Virology 77, 980-988. Brandsma, D., Jansen, G.H., Spliet, W.G.M., Nielen, K.M.B. van, & Taphoorn, M.J.B. (2003). The diagnostic difficulties of menigeal and intacerebral plasma cell granulomas; presentation of three cases Journal of Neurology 250 (11), 1302-1306. Brigstock, D.R., Goldschmeding, R., Katsube, K.I., Lam, S.C., Lau, L.F., Lyons, K., Naus, C., Perbal, B., Riser, B, Takigawa, M., & Yeger, H. (2003). Proposal for a unified CCN nomenclature Molecular Pathology : MP. 56 (2), 127-128. Canninga-van Dijk, M.R. van, Sanders, C.J.G., Verdonck, L.F., Fijnheer, R., & Tweel, J.G. van den (2003). Differential diagnosis of skin lesions after allogeneic haematopoietic stem cell transplantation. Histopathology 42 (4), 313-330. Cornelissen, J.J., Holt, B. van der, Petersen, E.J., Vindelov, L., Russel, C.A., Hoglund, M., Maertens, J., Schouten, H.C., Braakman, E., Steijaert, M.M., Zijlmans, M.J., Slaper-Cortenbach, I.C.M., Boogaerts, M.A., Lowenberg, B., & Verdonck, L.F. (2003). A randomized multicenter comparison of CD34(+)-selected progenitor cells from blood vs from bone marrow in recipients of HLA-identical allogeneic transplants for hematological malignancies. Experimental Hematology 31 (10), 855-864. Corradini, P., Cavo, M., Lokhorst, H.M., Martinelli, G., Terragna, C., Majolino, I., Valagussa, P., Boccadora, M., Samson, D., Bacigalupo, A., Russell, N., Montefusco, V., Voena, C., & Gahrton, G. (2003). Molecular remission after myeloablative allogeneic stem cell transplantation predicts a better relapse-free survival in multiple myeloma Blood 102, 1927-1929. Fijnheer, R., Sanders, C.J.G., Canninga-van Dijk, M.R. van, Weger, R.A. de, & Verdonck, L.F. (2003). Complete remission of a radiochemotherapy-resistant cutaneous T-cell lymphoma with allogeneic non-myeloablative stam cell transplantation. Bone Marrow Transplantation 32 (3), 345-347. Goulden, N., Bader, P., van der Velden, V.H., Moppett, J., Schilham, M.W., Masden, H.O., Krejci, O., Kreyenberg, H., Lankester, A., Révész, T., Klingebiel, T., & Dongen, JJ van (2003). Minimal residual disease prior to stem cell transplant for childhood acute lymphoblastic leukaemia. British Journal of Haematology 122 (1), 27-29. Jonge, N. de, Wichen, D.F. van, Kuik, J.A. van, Kirkels, J.H., Lahpor, J.R., Gmelig Meyling, F.H.J., Tweel, J.G. van den, & Weger, R.A. de (2003). Cardiomyocyte death in patients with end-stage heart failure before and after support with a left ventricular assist device: low incidence of apoptosis despite ubiquitous mediators. Journal of Heart and Lung Transplantation 22 (9), 1028-1036. Kempen-Harteveld, M.L. van, Weel-Sipman, M.H., Emmens, C., Noordijk, E.M., Tweel, I. van der, Révész, T., Struikmans, H., Kal, H.B., Does-van den Berg, A. van der, & Vossen, J.M.J.J. (). Eye shielding during total body irradiation for bone marrow transplantation in children transplanted for a hematological disorder: risks and benefits Bone Marrow Transplantation. Koene, G.J.P.A., Arts-Hilkes, Y.H.A., Ven, K. van de, Rozemuller, E.H., Slootweg, P.J., Weger, R.A. de, & Tilanus, M.G.J. (2003). Loss of heterozygosity of the B2M gene detected with microsatellites does not reflect B2M gene copy number in head and neck squamous cell carcinoma Human Immunology 64 (10 Supp), 151-151. Kolen, S., Weijtens, M., Hagenbeek, A., Spronsen, A.M. van, Smulders, S., Weger, R.A. de, Witte, T. de, Dolstra, H., Wiel van Kemenade, E. van de, & Martens, A.C.M. (2003). Monitoring of developing graft-versus-host disease mediated by herpes simplex virus thymidine kinase gene-transduced T Cells Human gene therapy 14, 341-351. Kooij, B. van, Thijsen, S.F.T., Meijer, E., Niesters, H.G.M., Esser, J.W.J van, Cornelissen, J.J., Verdonck, L.F., & Loon, A.M. van (2003). Sequence analysis of EBV DNA isolated from mouth washings and PBMCs of healthy individuals and blood of EBV-LPD patients Journal of clinical virology 28, 85-92. Krejci, O., van der Velden, V.H., Bader, P., Kreyenberg, H., Goulden, N., Hancock, J., Schilham, M.W., Lankester, A., Révész, T., Klingebiel, T., & Dongen, JJ van (2003). Level of minimal residual disease prior to haematopoietic stem cell transplantation predicts prognosis in paediatric patients with acute lymphoblastic leukaemia: a report of the Pre-BMT MRD Study Group. Bone Marrow Transplantation 32 (8), 849-851. Laterveer, L., Verdonck, L.F., Peeters, T, Borst, H.P.E., Bloem, A.C., & Lokhorst, H.M. (2003). Graft versus myeloma may overcome the unfavorable effect of deletion of chromosome 13 in multiple myeloma. Blood 101 (3), 1201-1202. Lokhorst, H.M., Segeren, C.M., Verdonck, L.F., Holt, B. van der, Raymaker, R., Oers, M.H.J. van, Barge, R.M.Y., Schouten, H.C., Westerveer, P.H.M., Steijaert, M.M.C., Cornelissen, J.J., & Sonneveld, P. (2003). Partially T-cell-depleted allogeneic stem cell transplantation for first-line treatment of multiple myeloma: a prospective evaluation of patients treated in tje phase III study HOVON 24 MM Journal of Clinical Oncology 21, 1728-1733. Mandigers, C.M, Verdonck, L.F., Meijerink, J.P., Dekker, A.W., Schattenberg, A.V., & Raemaekers, J.M.M. (2003). Graft-versus-lymphoma effect of donor lymphocyte infusion in indolent lymphomas relapsed after allogeneic stem cell transplantation Bone Marrow Transplantation 32, 1159-1163. Meijer, E., Cornelissen, J.J., Lowenberg, B., & Verdonck, L.F. (2003). Antithymocyteglobulin as prophylaxis of graft failure and graft-versus-host disease in recipients of partially T-cell depltede grafts from matched unrelated donors: a dose-finding study Experimental Hematology 11, 1026-1030. Meijer, E., Bloem, A.C., Dekker, A.W., & Verdonck, L.F. (2003). Effect of antithymocyte globulin on quantitative immune recovery and graft-versus-host disease after partially T-cell-depleted bone

84

marrow transplantation: a comparison between recipients of matched related and matched unrelated donor grafts. Transplantation 75 (11), 1910-1913. Meijer, E., Dekker, A.W., & Verdonck, L.F. (2003). Influence of antithymocyte globulin dose on outcome in cytomegalovirus-seropositive recipients of partially T-cell depleted stem cell grafts from matched-unrelated donors British Journal of Haematology 121, 474-476. Meijer, E., Boland, G.J., & Verdonck, L.F. (2003). Prevention of cytomegalovirus disease in recipients of allogeneic stem cell transplants Clinical Microbiology Reviews 16 (4), 647-657. Otten, H.G., Gast, G.C. de, Vooijs, W.C., Gouw, A.P. van der, Boer, M. de, Ossevoort, M.A., & Jonker, M. (2003). Preclinical evaluation of anti-CD86 immunotoxin in rhesus monkeys: analysis of systemic toxicity, pharmacokinetics, and effect on primary T-cell responses Cancer Immunology Immunotherapy 52, 569-575. Poulin, N.M., Frost, A., Carraro, A., Mommers, E.C., Guillaud, M., Diest, P.J. van, Grizzle, W., & Beenken, S. (2003). Risk biomarker assessment for breast cancer progression: Replication precision of nuclear morphometry Analytical Cellular Pathology 25, 129-138. Reinders, J., Rozemuller, E.H., Ongkosuwito, J.V., Jager, M.J. de, Tilanus, M.G.J., & Suttorp-Schulten, M.S.A. van (2003). MICA association with presumed ocular histoplasmosis syndrome (POSH) Molecular Vision 9, 420-424. Rijn, R.S. van, Simonetti, E.R., Hagenbeek, A., Hogenes, M.C., Weger, R.A. de, Canninga-van Dijk, M.R. van, Weijer, K., Spits, H., Storm, G., Bloois, L. van, Rijkers, G.T., Martens, A.C.M., & Ebeling, S.B. (2003). A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/-gammac-/-dubbel-mutant mice Blood 102 (7), 2522-2531. Rookmaker, M.B., Smits, A.M., Tolboom, H., Wout, K. van't, Martens, A.C.M., Goldschmeding, R., Joles, J.A., Zonneveld, A.J. van, Grone, H.J., Rabelink, A.J., & Verhaar, M.C. (2003). Bone-marrow-derived cells contribute to glomerular endothelial repair in experimental glomerulonephritis American Journal of Pathology 163, 553-562. Roos, A, Bouwman, L.H., Munoz, J, Zuiverloon, T., Faber-Knol, M.C, Fallaux-van den Houten, F.C., Klar-Mohamad, N., Hack, C.E., Tilanus, M.G.J., & Daha, M.R. (2002). Functional characterization of the lectin pathway of complement in human serum Molecular Immunology 1218, 1-14. Segeren, C.M., Sonneveld, P., Holt, B. van der, Croockewit, A.J., Verhoef, G.E.G., Cornelissen, J.J., Schaafsma, M.R., Oers, M.H.J. van, Wijermans, P.W., Fibbe, W.E., Wittebol, S., Schouten, H.C., Marwijk Kooy, M. van, Biesma, D.H., Baars, J.W., Slater, R., Steijaert, M.C.M., Buijt, I., & Lokhorst, H.M. (2003). Overall and event-free survival are not important by the use of myeloablative therapy following multiple myeloma: a prospective randomised phase 3 study Blood 101, 2144-2151. Tweel, J.G. van den, & Taylor, C.R. (2003). Globalisation of pathology training and examinations. The time to begin is now. Human pathology 9, 861-862. Weger, R.A. de, & Tweel, J.G. van den (2003). The molecular detection of recurrent disease after bone marrow transplantation. Update in Pathology, 221-222. National publications

Bartels, M., Weersink, A.J.L., Wolfs, T.F.W., Bierings, M.B., & Révész, T. (2003). De behandeling van een Epstein-Barr-virus-gerelateerde lymfoproliferatieve ziekte na een allogene stamceltransplantatie: het gebruik van monoklonale anti-CD20-antilichamen Tijdschrift voor kindergeneeskunde 71 (2), 63-66.

Petersen, E.J., Lokhorst, H.M., & Verdonck, L.F. (2003). Allogene stamceltransplantatie na niet-myeloablatieve conditionering: gunstige ervaringen bij 21 hoogrisicopatienten met een hematologische maligniteit behandeld in het Universitair Medisch Centrum Utrecht Nederlands Tijdschrift voor Geneeskunde 127, 2328-2332. Book, book chapters & proceedings Tweel, J.G. van den (2003). Bloed en beenmerg In Ph.J Hoedemaker & et al (Eds.), Pathologie (pp. 515-544). Elsevier. Begthel, H.L., Broekhuizen, R., Dullens, H.F.J., Scheidel-Jacobse, C.C., Verdaasdonk, M.A.M., Weger, R.A. de, & Weiden, R. van der (). Handleiding cursus Moderne Histochemie 10e editie, deel I: Theorie Begthel, H.L., Broekhuizen, R., Dullens, H.F.J., Scheidel-Jacobse, C.C., Verdaasdonk, M.A.M., Weger, R.A. de, & Weiden, R. van der (). Handleiding cursus Moderne Histochemie 10e editie, deel II: Praktijk

85

Faculty of Pharmacy, Utrecht University Department of Pharmacology and Pathophysiology

Research group

Immunopharmacology (UU PHARM 1)

Leader

F.P. Nijkamp

Staff F. Engels

G. Folkerts P.A.J. Henricks

Ms. A.H. van Houwelingen Ms. A.D. Kraneveld

A.J.M. van Oosterhout F.A.M. Redegeld

Post docs

P.C. de Groot M.W. van der Heijden

K. Karimi Ms. J.P.M. van der Kleij

Ms. S. McKay J.L.M. Vissers E. v.d. Worm

PhD students

Ms. A. Rijnierse J.J. Smit

Ms. D.L. Valstar

Titles PhD projects Ms. A. Rijnierse: The role of substance P and TNFα in the development of colonic delate type

hypersensitivity; a murine model for inflammatory bowl disease. J.J. Smit: Asthma, a disease due to lack of bacterial infections in childhood. Ms. D.L. Valstar: Role of pulmonary macrophages in the development of airway

hyperreactivity in animal models for occupational asthma. Thesis Smit, J.J. (02-05-2003). Mycobacteria and the Nramp1 gene in asthma. Universiteit Utrecht (124 pag.). Prom./coprom.: Nijkamp, F.P., Loveren, H. van, & Folkerts, G. International publications Abraham, B., Anto, J.M., Barreiro, E., Bel, E.H.D., Bonsignore, G., Bousquet, J., Castellsague, J., Chanez, P., Cibella, F., Cuttitta, G., Dahlen, B., Dahlen, S-E., Drews, N., Djukanovic, R., Fabbri, L.M., Folkerts, G., Gaga, M., Gratziou, C., Holgate, S.T., Howarth, P.H., Johnston, S.L., Kanniess, F., Kips, J.C., Kerstjens, H.A.M., Kumlin, M., Magnussen, H., Nijkamp, F.P., Papageorgio, N., Papi, A., Postma, D.S., Pauwels, R.A., Rabe, K.F., Richter, K., Roldaan, A.C., Romagnoli, M., Roquet, A., Sanjuas, C., Siafakas, N.M., Timens, W., Tzanakis, N., Vachier, I., Vignola, A.M., Watson, L., & Yourgioti, G. (2003). The ENFUMOSA cross-sectional European multicentre study of the cinical phenotype of chronic severe asthma. European Respiratory Journal 22, 470-477. Arts, J.H.E., Bloksma, M.A., Leusink-Muis, A., & Kuper, C.F. (2003). Respiratory allergy and pulmonary irritation to trimellitic anhydride in Brown Norway rats. Toxicology and Applied Pharmacology 187, 38-49. Broeke, R. ten, Brandhorst, M.C., Leusink-Muis, A., Villain, M., Clerck, F. de, Blalock, J.E., Nijkamp, F.P., & Folkerts, G. (2003). Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma. European Journal of Pharmacology 476, 151-157. Deurloo, D.T., Berkel, E.A.T. van, Lobato-van Esch, E.C.A.M., Hofhuis, F.M.A., Nijkamp, F.P., Oosterwegel, M.A., & Oosterhout, A.J.M. van (2003). CD28/CTLA4 double deficient mice demonstrate crucial role for B7 co-stimulation in the induction of allergic lower airways disease. Clinical and

86

Experimental Allergy 33, 1297-1304. Houtman, R., Kool, M., Romijn, E.P., Redegeld, F.A.M., Nijkamp, F.P., Heck, A.J.R., & Humphery-Smith, I. (2003). Lung proteome alterations in a mouse model for nonallergic asthma. Proteomics 3, 2008-2018.

Houtman, R., Smit, J.J., & Wijk, F. van (2003). 2nd EAACI Davos meeting on basic immunology in allergy and clinical immunology. Pulmonair 10, 14-15. Kips, J.C., Anderson, G.P., Fredberg, J.J., Herz, U., Inman, M.D., Jordana, M., Kemeny, D.M., Lotvall, J., Pauwels, R.A., Plopper, C.G., Schmidt, D., Sterk, P.J., Oosterhout, A.J.M. van, Vargaftig, B.B., & Chung, K.F. (2003). Murine models of asthma. European Respiratory Journal 22, 374-382. Kleij, H.P. van der, Ma, D., Redegeld, F.A.M., Kraneveld, A.D., Nijkamp, F.P., & Bienenstock, J. (2003). Functional expression of neurokinin 1 receptors on mast cells induced by IL-4 and stem cell factor. Journal of Immunology 171, 2074-2079. Kleij, H.P. van der, Kraneveld, A.D., Redegeld, F.A.M., Gerard, N.P., Morteau, O., & Nijkamp, F.P. (2004). The tachykinin NK1 receptor is crucial for the development of non-atopic airway inflammation and hyperresponsiveness. European Journal of Pharmacology 476, 249-255. Kloek, J., Ark, I. van, Clerck, F. de, Bloksma, M.A., Nijkamp, F.P., & Folkerts, G. (2003). Modulation of airway hyperresponsiveness by thiols in a murine in vivo model of allergic asthma. Inflammation Research 52, 126-131. Little, F.F., Bie, J.J. de, Oosterhout, A.J.M. van, Kornfeld, H., Center, D.M., & Cruikshank, W.W. (2003). Immunomodulatory effect of interleukin-16 on allergic airway inflammation. Chest 123, 431S-432S. Redegeld, F.A.M., & Nijkamp, F.P. (2003). Immunoglobulin free light chains and mast cells: pivotal role in T-cell-mediated immune reactions? Trends in Immunology 24 (4), 181-185. Ricciardolo, F.L.M., Timmers, M.C., Sont, J.K., Folkerts, G., & Sterk, P.J. (2003). Effect of bradykinin on allergen induced increase in exhaled nitric oxide in asthma. Thorax 58, 840-845. Smit, J.J., Loveren, H. van, Hoekstra, M.O., Nijkamp, F.P., & Bloksma, M.A. (2003). Influence of the macrophage bacterial resistance gene Nramp1 (Slc11al) on the induction of allergic asthma in the mouse. FASEB Journal 17, 958-960. Smit, J.J., Loveren, H. van, Hoekstra, M.O., Schijf, M.A., Folkerts, G., & Nijkamp, F.P. (2003). Mycobacterium vaccae administration during allergen sensitization or challenge suppresses asthmatic features. Clinical and Experimental Allergy 33, 1083-1089. Smit, J.J., Loveren, H. van, Hoekstra, M.O., Karimi, K., Folkerts, G., & Nijkamp, F.P. (2003). The Slc11a1 (Nramp1) gene controls efficacy of mycobacterial treatment of allergic asthma. Journal of Immunology 171, 754-760. Smit, J.J., Loveren, H. van, Hoekstra, M.O., Kant, P.A.A. van der, Folkerts, G., & Nijkamp, F.P. (2003). Therapeutic treatment with heat-killed Mycobacterium vaccae (SRL172) in a mild and severe mouse model for allergic asthma. European Journal of Pharmacology 470, 193-199.

Vissers, J.L.M. (2003). Keystone Symposia in Taos, New Mexico. Pulmonair 10, 27-28. Book, book chapters & proceedings Kleij, H.P. van der, Blennerhassett, M., & Bienenstock, J. (2003). Nerve-mast cell interactions - Partnership in health and disease. In J. Bienenstock, M. Blennerhassett & E. Goetzl (Eds.), Autonomic Neuroimmunology (Autonomic Neuroscience Series, 15, pp. 139-170).

Muijsers, R.B.R., Nijkamp, F.P., & Folkerts, G. (2003). Nitric oxide and other inflammatory mediators. In S.L. Johnston & N.G. Papadopoulos (Eds.), Respiratory infections in allergy and asthma (pp. 229-250). New York: Marcel Dekker Inc.. Smit, J.J., Loveren, H. van, Hoekstra, M.O., Folkerts, G., & Nijkamp, F.P. (2003). Prophylactic treatment with heat-killed M. vaccae (SRL172) in a mouse model for allergic asthma. In G. Marone (Ed.), Clinical Immunology and Allergy in Medicine (pp. 385-396). Napels, Italy: JGC Editions. Patent Oosterhout, A.J.M. van, Lobato-van Esch, E.C.A.M., & Vissers, J.L.M. (28-03-2003). Methods and means to suppress symptoms of an allergic disease. no EPO No. 03075908.8. Oosterhout, A.J.M. van, Lobato-van Esch, E.C.A.M., Vissers, J.L.M., Weller, F.R., & Kapsenberg, M.L. (28-03-2003). Methods of inducing immunotolerance and compositions for use therein. no EPO No. 03075909.6.

87

Faculty of Pharmacy, Utrecht University Department of Pharmaco-epidemiology & Pharmacotherapy

Research group

Pharmaco-epidemology of pulmonary diseases (UU PHARM 6 )

Leader

Ms. M. Bracke H.G.M. Leufkens

Staff

T.P. van Staa

Post docs --

PhD students

Ms. T.T. Menckeberg W. ten Hove

F. de Vries Ms. M.P.G. Zuidgeest

Titles PhD projects Ms. T.T. Menckeberg: Compliance in Asthma Therapy W. ten Hove: Pharmacogenetics of allergic asthma F. de Vries: Disease Severity in Asthma/COPD Ms. M.P.G. Zuidgeest: Effectiveness and safety of asthmamedication in young children International publications

Ardouin, L, Bracke, M, Mathiot, A, Pagakis, S.N, Norton, T, Hogg, N, & Tybulewicz, V.L. (2003). Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse. European Journal of Immunology 33(3), 790-797.

Gerrits, C.M., Herings, R.M., Leufkens, H.G., & Lammers, J.W. (2003). N-acetylcysteine reduces the risk of re-hospitalisation among patients with chronic obstructive pulmonary disease. Eur Respir J. 21(5), 795-798.

Gerrits, C.M., Herings, R.M., Leufkens, H.G., & Lammers, J.W. (2003). N-acetylcysteine is unlikely to reduce hospitalisation for chronic obstructive pulmonary disease. Eur Respir J. 22(5), 865-866; author reply

Smith, A., Bracke, M, Leitinger, B., Porter, J.C., & Hogg, N. (2003). LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment. Journal of Cell Science 116, 3123-3133. van Staa, T.P., Cooper, C, Brusse, L.S., Leufkens, H, Javaid, M.K., & Arden, N.K. (2003). Inflammatory bowel disease and the risk of fracture. Gastroenterology. 125(6), 1591-1597. Van Staa, T.P., Leufkens, H.G., & Cooper, C. (2003). Inhaled corticosteroids and hip fracture: disease or drugs? Am J Respir Crit Care Med. 168(1), 128. Van Staa, T.P., Cooper, C, Leufkens, H.G., Lammers, J.W., & Suissa, S. (2003). The use of inhaled corticosteroids in the United Kingdom and the Netherlands. Respir Med. 97(5),578-585. Van Staa, T.P., Cooper, C., Leufkens, H.G., & Bishop, N. (2003). Children and the risk of fractures caused by oral corticosteroids. J Bone Miner Res. 18(5), 913-918. Van Staa, T.P., Boulton, F, Cooper, C, Hagenbeek, A, Inskip, H, & Leufkens, H.G. (2003). Neutropenia and agranulocytosis in England and Wales: incidence and risk factors. Am J Hematol 72(4), 248-254. University Medical Center Utrecht

88

Department of Pulmonary Diseases

Research group Chronic inflammatory pulmonary diseases

(UU UMC 2.3.1)

Leaders P.J. Coffer

L. Koenderman J-W.J. Lammers

Staff

E.A. van de Graaf P. Zanen

Post docs

Ms. K. Birkenkamp E. Fortunati

H. Honing Ms. A. Pietersen

Ms. L. Ulfman

PhD students Ms. M. Buitenhuis

C.R. Geest Ms. A.H. van Gorp

H.D. Luijk E. Nijhuis

J.D. Oudijk Ms. M. Rosas Rosas

Titles PhD projects Ms. M. Buitenhuis: Characterization of transcription factors involved in the differentiation of

eosinophilic granulocytes C.R. Geest: Characterization of signalling defects in granulocytes and myeloid precursor

cells from myelodysplasia patients: its relation to apoptosis Ms. H.A. van Gorp: Molecular mechanisms regulating hematopoetic stem cell fate H.D. Luijk: Monitoring of the effect of anti-inflammatory therapy on the disease severity

of allergic asthma E. Nijhuis: Development and characterization of disease monitors for COPD J.D. Oudijk: Molecular markers of the inflammation applied as prognostic tools in COPD Ms. M. Rosas Rosas: Characterization and antagonism of cytokine priming of human

granulocytes Thesis Buitenhuis, M. (16-12-2003). Regulation of lineage choices during granulopoiesis. UU Universiteit Utrecht (173 pag.). . Prom./coprom.: Koenderman, L., Lammers, J.W.J., & Coffer, P.J Gerrits, C.M.J.M. (02-09-2003). Pharmacoepidemiological Determinants of Exacerbations of Chronic Obstructive Lung Diseases. Universiteit Utrecht (141 pag.). . Prom./coprom.: Leufkens, H.G.M., Lammers, J.W.J., & Herings, R.M.C. Hage, R. (25-03-2003). Pulmonary neuroendocrine carcinomas. UU Universiteit Utrecht (110 pag.). . Prom./coprom.: Brutel de la Rivière, A., Lammers, J.W.J., & Bosch, J.M.M. van den Nijhuis, E.H.J. (06-05-2003). Systemic neutrophil activation in COPD. UU Universiteit Utrecht (175 pag.). . Prom./coprom.: Koenderman, L., Lammers, J.W.J., & Coffer, P.J Grutters, J.C. (17-10-2003). Genetic polymorphisms and phenotypes in sarcoidosis. UU Universiteit Utrecht (175 pag.). . Prom./coprom.: Lammers, J.W.J., Bois, R.M. du, Welsh, K.I., & Bosch, J.M.M. van den Tjoe Nij, E.I.M. (20-11-2003). Respiratory health in construction workers exposed to silica containing dust. UU Universiteit Utrecht (161 pag.). . Prom./coprom.: Heederik, D.D.J., & Lammers, J.W.J.

89

International publications Abdallah, A., Sato, H., Grutters, J.C., Veeraraghavan, S., Lympany, P.A., Ruven, H.J.T., Bosch, J.M.M. van den, Wells, A.U., Bois, R.M. du, & Welsh, K.I. (2003). Inhibitor kappa B-alpha (IkappaB-alpha) promoter polymorphisms in UK and Dutch sarcoidosis. Genes and immunity 4 (6), 450-454. Amsterdam, J.G.C. van, Zanen, P., Somer, S., Loveren, H. van, Opperhuizen, A., & Steerenberg, P.A. (2003). Flow dependency and off-line measurement of exhaled NO in children. Pediatric allergy and immunology 14 (4), 266-271. Birkenkamp, K.U., & Coffer, P.J (2003). FOXO transcription factors as regulators of immune homeostasis: molecules to die for? Journal of Immunology 171 (4), 1623-9. Birkenkamp, K.U., & Coffer, P.J (2003). Regulation of cell survival and proliferation by the FOXO (Forkhead box class O) subfamily of Forkhead transcription factors. Biochemical Society Transactions 31 (Pt 1), 292-297. Buitenhuis, M., Baltus, B., Lammers, J.W.J., Coffer, P.J, & Koenderman, L. (2003). Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells. Blood 101 (1), 134-42. Coffer, P.J (2003). OutFOXing the grim reaper: novel mechanisms regulating longevity by forkhead transcription factors. Science's STKE [E] 2003 (201), PE 39. Coffer, P.J (2003). Transcriptional regulation of lymphocyte quiescence: as cunning as a FOX. Trends in immunology 24 (9), 470-1. Da Costa Martins, P., Berk, N. van den, Ulfman, L.H., Koenderman, L., Hordijk, P., & Zwaginga, J.J. (2003). Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation. Arteriosclerosis, thrombosis and vascular biology nov (13). Elden, L.J.K. van, Loon, A.M. van, Beek, A. van der, Hendriksen, K.A., Hoepelman, I.M., Kraaij, M.G.J. van, Schipper, P., & Nijhuis, M. (2003). Applicability of a real-time quantitative PCR assay for diagnosis of respiratory syncytial virus infection in immunocompromised adults. Journal of Clinical Microbiology 41 (9), 4378-4381. Gerrits, C.M.J.M., Herings, R.M.C., Leufkens, H.G.M., & Lammers, J.W.J. (2003). N-Acetylcysteine reduces the risk of re-hospitalisation among patients with chronic obstructive pulmonary disease. European Respiratory Journal 21, 795-798. Gilley, J., Coffer, P.J, & Ham, J (2003). FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. Journal of Cell Biology 162 (4), 613-622. Hak, E., Hoes, A.W., Grobbee, D.E., Lammers, J.W.J., Essen, G.A. van, Loon, A.M. van, & Verheij, Th.J.M. (2003). Conventional influenza vaccination is not associated with complications in working-age patients with asthma or chronic obstructive pulmonary disease. American Journal of Epidemiology 157 (8), 692-700. Lenting, P.J., & Sixma, J.J. (2003). DDAVP and interleukin-11: a boosting combination. Blood 102, 415a-416. Leufkens, H.G.M., Staa, T.P. van, Cooper, C., Lammers, J.W.J., & Suissa, S. (2003). The use of inhaled corticosteroids in the United Kingdom and the Netherlands. Respiratory Medicine 97, 578-585. Maas, K.W., Lee, I. van der, Bolt, K., Zanen, P., Lammers, J.W.J., & Schramel, F.M. (2003). Lung function changes and pulmonary complications in patients with stage III non-small cell lung cancer treated with gemcitabine/cisplatin as part of combined modality treatment. Lung cancer 41 (3), 345-51. Oudijk, E.J., Lammers, J.W.J., & Koenderman, L. (2003). Systemic inflammation in chronic obstructive pulmonary disease. European Respiratory Journal 46, 5s-13s. Pitz, C.C., Brutel de la Rivière, A., Swieten, H.A. van, Westermann, C.J.J., Lammers, J.W.J., & Bosch, J.M.M. van den (2003). Results of surgical treatment of T4 non-small cell lung cancer. European Journal of Cardio-Thoracic Surgery 24 (6), 1013-8. Romijn, R.A.P., Westein, E., Bouma, B., Schiphorst, M.E., Sixma, J.J., Lenting, P.J., & Huizinga, E.G. (2003). Mapping the collagen-binding site in the von Willebrand Factor-A3 domain. Journal of Biological Chemistry 278 (17), 15035-15039. Sluijs, K.F. van der, Elden, L.J.K. van, Nijhuis, M., Schuurman, R., Florquin, S., Jansen, H.M., Lutter, R., & Poll, T. van der (2003). Toll-like receptor 4 is not involved in host defense against respiratory tract infection with Sendai virus. Immunology Letters 89 (2-3), 201-6. Stevens, H., Bakker, P.F.A., Schlosser, N.J., Rijk, P.P. van, & Klerk, J.M.H. de (2003). Use of a dual-head coincidence camera and 18F-FDG for detection and nodal staging of non-small cell lung cancer: accuracy as determined by 2 independent observers. Journal of Nuclear Medicine 44 (3), 336-340. Sunters, A., Fernandez de Mattos, S., Stahl, M., Brosens, J.J., Zoumpoulidou, G., Saunders, C.A., Coffer, P.J, Medema, R.H., Coombes, R.C., & Lam, E.W.-F. (2003). FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. Journal of Biological Chemistry 278 (50), 49795-805. Ulfman, L.H., Joosten, D.P., Aalst, C.W. van, Lammers, J.W.J., Graaf, E.A. van de, Koenderman, L., & Zwaginga, J.J. (2003). Platelets promote eosinophil adhesion of patients with asthma to endothelium under flow conditions. American Journal of Respiratory Cell and Molecular

90

Biology 28 (4), 512-519. Woltman, A.M., Kooij, S.W. van der, Coffer, P.J, Offringa, R., Daha, M.R., & Cooten, C. van (2003). Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression. Blood 15, 1439-1445. National publications

Bauwens, A.A.M., & Jonkers, R. (2003). Is vaccinatie met pneumokokkkenvaccin bij patiënten met COPD zinvol? Longartsen Vademecum 6 (15).

Lammers, J.W.J. (2003). De behandeling van COPD: een stand van zaken. Patient Care mei. Lammers, L.A., & Lammers, J.W.J. (2003). bronchusverwijders bij COPD. Therapie afstemmen

op de individuele patiënt. Pharmaceutisch Weekblad 138 (31), 1087-93. Schweizer, R.C., & Lammers, J.W.J. (2003). Mag een prednisonstootkuur bij astma worden

verlengd? Is dan bij plotseling stoppen een effect te verwachten? Vademecum permanente nascholing huisartsen 21 (42a).

Stadhouders-Keet, S.A.E., Kort, W.J.A. de, Lammers, J.W.J., & Sigurdsson, V. (2003). Dermatomyositis met longfibrose en pleuritis carcinomatosa. Nederlands Tijdschrift voor Geneeskunde 147 (33), 1619-1620.

91

University Medical Center Utrecht Rheumatology & Clinical Immunology

Research group Inflammatory joint diseases

(UU UMC 2.3.3)

Leaders J.W.J. Bijlsma

F.P.J.G. Lafeber

Staff Ms. A.A.M. Blaauw R.H.W.M. Derksen

J.W.G. Jacobs A.A. Kruize

Post docs

Ms. A.C.A. Marijnissen J.A.G. van Roon Ms. L.S. Taams

PhD students

Ms. J. van Amelsfort M. Hooiveld

H. de Jong S. Mastbergen

R.H.W.M. de Nijs Ms. S. Wijngaarden

Titles PhD projects Ms. J. van Amelsfort: Regulation of inflammation and joint damage in RA by a suppressive T-cell

population A. Hartkamp: Moeheid en welbevinden bij patienten met SLE en SS M. Hooiveld: The suspectibility of cartilage to blood-induced damage Z.N. Jahangier: Radiosynoviorthese bij persisterende arthritis H. de Jong: Self peptide responses in reumatoid arthritis S. Mastbergen: The chondroprotective effect of selective COX-inhibitors on human articular cartilage explants R.H.W.M. de Nijs: Preventie van steroid osteoporose bij reumatische aandoeningen Ms. S. Verstappen: De economische aspecten van reumatoide artritis Ms. S. Wijngaarden: Helicobacter eradication in patients with RA J.M. van Woerkom: Regulation of inflammation in SS Thesis Hooiveld, M.J.J. (28-01-2003). Blood-induced cartilage damage: from mechanisms to arthropathy Universiteit Utrecht (150 pag.). Prom./coprom.: Bijlsma, J.W.J., Lafeber, F.P.J.G., & Roosendaal, G. Verstappen, S.S.M. (10-10-2003). Descriptive and predictive: clinical and economic outcomes in the Utrecht Rheumatoid Arthritis Cohort UU Universiteit Utrecht (187 pag.). . Prom./coprom.: Bijlsma, J.W.J., & Jacobs, J.W.G. Evers, A.W.M. (17-04-2003). Predictors of disease outcome in Rheumatoid Artritis KUN Katholieke Universiteit Nijmegen (237 pag.). (Wageningen: Ponsen & Looijen BV). Prom./coprom.: Kraaimaat, F.W., & Bijlsma, J.W.J. International publications Bijlsma, J.W.J. (2003). Etanercept was effective and safe for ankylosing spondylitis ACP journal club 138 (1), 19-19. Bijlsma, J.W.J., Boers, M., Saag, K.G., & Furst, D.E. (2004). Glucocorticoids in the treatment of early and late RA Annals of the Rheumatic Diseases 62 (11), 1033-1037. Bijsterveld, O.P. van, Kruize, A.A., & Bleys, R.L.A.W. (2003). Central nervous system mechanisms in Sjogren's syndrome, a theory British Journal of Ophthalmology 87 (2), 128-130. Brey, R., Chapman, J., Levine, S., Ruiz-Irastorza, G., Derksen, R.H.W.M., Khamashta, M.A., &

92

Shoenfeld, Y. (2003). Stroke and the antiphospholipid syndrome: consensus meeting Taormina 2002 Lupus 12, 508-513. Derksen, R.H.W.M., Groot, P.G. de, & Kappelle, L.J. (2003). Low dose aspirin after ischemic stroke associated with antiphospholipid syndrome Neurology 61, 111-114. Erkan, D., Asherson, R.A., Espinosa, G., Cervera, R., Font, J., Piette, J.C., Lockshin, M.D., Derksen, R.H.W.M., & Catastr. antiphos. syndrome, project group (2003). Long term outcome of catastrophic antiphospholipid syndrome survivors Annals of the Rheumatic Diseases 62, 530-533. Everdingen, A.A. van, Siewertsz van Reesema, D.R., Jacobs, J.W.G., & Bijlsma, J.W.J. (2003). Low-dose glucocorticoids in early rheumatoid arthritis: discordant effect bone mineral density and fractures? Clinical and Experimental Rheumatology 21 (2), 155-160. Evers, A.W.M., Kraaimaat, F.W., Geenen, R., Jacobs, J.W.G., & Bijlsma, J.W.J. (2003). Pain, coping and social support as predictors of long-term functional disability and pain in early rheumatoid arthritis Behavior Research and Therapy 41, 1295-1310. Evers, A.W.M., Kraaimaat, F.W., Geenen, R., Jacobs, J.W.G., & Bijlsma, J.W.J. (2003). Stress-vulnerability factors as long-term predictors of disease activity in early rheumatoid arthritis Journal of Psychosomatic Research 55, 293-302. Grootscholten, C., Ligtenberg, G., Derksen, R.H.W.M., Schreurs, K.M.G., Hagen, E.C., Huizinga, T.W., Hoogen, F.H.J., van den Bijl, M., Houwelingen, J.C., Snoek, F.J. en Berden, J.H. (2003). Health-related quality of life in patients with systemic lupus erythemathosus: development and validation of a lupus specific symptom checklist. Qual Life Res. 2003 Sep;12(6):635-44. Heerde, W.L. van, Reutelingsperger, C.P.M., Maassen, C., Lux, P., Derksen, R.H.W.M., & Groot, P.G. de (2003). The presence of antiphospohlipid antibodies is not related to increased levels of annexin A5 in plasma The Journal of Thrombosis and Haemostasis 1, 532-536. Hooiveld, M.J.J., Roosendaal, G., Vianen, M.E., Berg, H.M. van den, Bijlsma, J.W.J., & Lafeber, F.P.J.G. (2003). Blood-induced joint damage: longterm effects in vitro and in vivo Journal of Rheumatology 30 (2), 339-344. Hooiveld, M.J.J., Roosendaal, G., Berg, H.M. van den, Bijlsma, J.W.J., & Lafeber, F.P.J.G. (2003). Haemoglobin-derived iron-dependent hydroxyl radical formation in blood induced joint damage: an in vitro study Rheumatology 42 (6), 784-790. Hooiveld, M.J.J., Roosendaal, G., Vianen, M.E., Berg, H.M. van den, Bijlsma, J.W.J., & Lafeber, F.P.J.G. (2003). Immature articular cartilage is more susceptible to blood-induced damage than mature articular cartilage Arthritis and Rheumatism 48 (2), 396-403. Hooiveld, M.J.J., Roosendaal, G., Wenting-van Wijk, M.J.G., Berg, H.M. van den, Bijlsma, J.W.J., & Lafeber, F.P.J.G. (2003). Short-term exposure of cartilage to blood results in chondrocyte apoptosis American Journal of Pathology 162 (3), 943-951. Huisman, A.M., Everdingen, A.A. van, Wenting-van Wijk, M.J.G., Lafeber, F.P.J.G., Siewertsz van Reesema, D.R., Jacobs, J.W.G., & Bijlsma, J.W.J. (2003). Glucocorticoid receptor up-regulation in early-diagnosed rheumatoid arthritis. Clinical and Experimental Rheumatology 21 (2), 217-220. Huisman, A.M., Meulen, M.F.G. van der, Raaymakers, T.W.M., Canninga-van Dijk, M.R. van, Bijlsma, J.W.J., & Coremans, A. (2003). Subacute painful quadriplegia and purpura Annals of Internal Medicine 139 (12), W86. Jacobs, J.W.G., & Bijlsma, J.W.J. (2003). Interpretation of trial methodology not always easy: comment on the editorial by Landewé Arthritis and Rheumatism 48, 2693-2694. Jordan, KM, Arden, N., Doherty, M., Bannwarth, B, Bijlsma, J.W.J., Dieppe, P, Gunther, K, Hauselmann, H., Herrero-Beaumont, G., Kaklamanis, P., Lohmander, S., Leeb, B., Lequesne, M., Mazieres, B., Martin-Mola, E., Pavelka, K., Pendleton, A., Punzi, L., Serni, U., Swoboda, B., Verbruggen, G., Zimmerman-Gorska, I., & Dougados, M. (2003). EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a task force of the standing committee for international clinical studies including therapeutic trials (ESCISIT) Annals of the Rheumatic Diseases 62 (12), 1145-1155. Kuiper-Geertsma, D.G., & Derksen, R.H.W.M. (2003). Newer drugs for the treatment of lupus nephritis Drugs 63 (2), 167-180. Lafeber, F.P.J.G., & Roosendaal, G. (2003). Blood-induced joint damage in hemophilia Seminars in thrombosis and hemostasis 29 (1), 37-42. Lutters, B.C.H., Derksen, R.H.W.M., Tekelenburg, W.L.H., Lenting, P.J., Arnout, J., & Groot, P.G. de (2003). Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2' Journal of Biological Chemistry 278, 33831-33838. Marijnissen, A.C.A, Roermund, P.M. van, Melkebeek, J. van, & Lafeber, F.P.J.G. (2003). Clinical benefit of joint distraction in the treatment of ankle osteoarthritis Foot and Ankle Clinics 8, 335-346. Marijnissen, A.C.A, & Lafeber, F.P.J.G. (2003). Re: E.B. Hunziker. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis and Cartilage 2002; 10:432-63 Osteoarthritis and cartilage 22, 300-301. Meroni, P.L., Moia, M., Derksen, R.H.W.M., Tincani, A., McIntyre, J.A., Arnout, J., Koike, T, Piette, J.C., Khamashta, M.A., & Shoenfeld, Y. (2003). Venous thromboembolism in the antiphospholipid syndrome: management guidelines for secondary prophylaxis Lupus 12, 504-507.

93

Roon, J.A.G. van, Glaudemans, C.A.F.M., Bijlsma, J.W.J., & Lafeber, F.P.J.G. (2003). Differentiation of naive CD4+ T cells towards T helper 2 cells is not impaired in rheumatoid arthritis patients. Arthritis research & therapy 5 (5), 269-276. Roon, J.A.G. van, Wijngaarden, S., Lafeber, F.P.J.G., Damen, C.A., Winkel, J.G.J. van de, & Bijlsma, J.W.J. (2003). Interleukin 10 treatment of patients with rheumatoid arthritis enhances Fc gamma receptor expression on monocytes and responsiveness to immunocomplex stimulation Journal of Rheumatology 30 (4), 648-651. Roon, J.A.G. van, Glaudemans, C.A.F.M., Bijlsma, J.W.J., & Lafeber, F.P.J.G. (2003). Interleukin 7 stimulates tumour necrosis factor alpha and Th1 cytokin production in joints of patients with rheumatoid arthritis Annals of the Rheumatic Diseases 62 (2), 113-119.

Roon, J.A.G. van, Vuuren, A.J. van, Wijngaarden, S., Jacobs, K.M.G., Bijlsma, J.W.J., Lafeber, F.P.J.G., Thepen, T., & Winkel, J.G.J. van de (2003). Selective elimination of synovial inflammatory macrophages in rheumatoid arthritis by an Fc gamma receptor I-directed immunotoxin Arthritis and Rheumatism 48 (5), 1229-1238. Simmelink, M.J.A., Derksen, R.H.W.M., Arnouts, J., & Groot, P.G. de (2003). A simple method to discriminate between beta2-glycoprotein I- and prothrombin-dependent lupus anticoagulants The Journal of Thrombosis and Haemostasis 1, 740-747. Simmelink, M.J.A., Groot, P.G. de, & Derksen, R.H.W.M. (2003). A study on associations between antiprothrombin antibodies, antiplasminogen antibodies and thrombosis The Journal of Thrombosis and Haemostasis 1, 735-739. Steege, J.C.A. ter, Vianen, M.E., Bilsen, J.H.M. van, Bijlsma, J.W.J., Lafeber, F.P.J.G., & Wauben, M.H.M. (2003). Identification of self-epitopes recognized by T cells in rheumatoid arthritis demonstrates matrix metalloproteinases as a novel T cell target Journal of Rheumatology 30 (6), 1147-1156. Verstappen, S.S.M. (2003). Effectiveness and costs of multidisciplinary care in patients with rheumatoid arthritis by GJ Tijhuis international journal of integrated care augustus. Verstappen, S.S.M., Jacobs, J.W.G., Bijlsma, J.W.J., Heurkens, A.H.M., Booma-Frankfort, C. van, Borg, E.J. ter, Hofman, D.M., & Veen, M.J. van der (2003). Five-year followup of rheumatic arthritis patients after early treatment with disease-modifying antirheumatic drugs versus treatment according to the pyramid approach in the first year Arthritis and Rheumatism 48 (7), 1797-1807. Verstappen, S.S.M., Jacobs, J.W.G., & Bijlsma, J.W.J. (2003). The Utrecht experience with different treatment strategies in early rheumatoid arthritis Clinical and Experimental Rheumatology 21 (5(s31)), S165-S168. Vugt, R.M. van, Kater, L., Dijkstra, PF, Schardijn, G.H., Kastelein, J.J., & Bijlsma, J.W.J. (2003). The outcome of angiography in patients with Raynaud's phenomenon: an unexpected role for atherosclerosis and hypercholesterolemia. Clinical and Experimental Rheumatology 21 (4), 445-450. Wijngaarden, S., Roon, J.A.G. van, Bijlsma, J.W.J., Winkel, J.G.J. van de, & Lafeber, F.P.J.G. (2003). Fc gamma receptor expression levels on monocytes are elevated in rheumatoid arthritis patients with high erythrocyte sedimentation rate who do not use anti-rheumatic Rheumatology 42 (5), 681-688. National publications Braack, P.M. ter, & Blaauw, A.A.M. (2003). De ontwikkeling van een keuzecoassistentschap Reumatologie en Klinische Immunologie Nederlands tijdschrift voor reumatologie 3, 9-13.

Geenen, R., & Jacobs, J.W.G. (2003). Fibromyalgie, chronisch vermoeiheidssyndroom en andere somatische klachtensyndromen. De reactie van 'splitters' op 'lumpers' Gedrag & Gezondheid 31, 113-121. Gorter, K.J., Jacobs, J.W.G., Romeijnders, A.C.M., Folmer, H., & Assendelft, W.J.J. (2003). Benzbromaron van de markt. Welke behandeling van jicht is nu de eerste keuze? Online juni 2003. Jacobs, J.W.G. (2003). Medische Misvattingen. Bij acute artritis is het bepalen van de BSE zinvol Medisch Contact 58, 721. Jacobs, J.W.G., & Kruize, A.A. (2003). Nieuwe mogelijkheden in de medicamenteuze behandeling van reumatoide artritis Patient Care. Het tijdschrift voor de huisarts 30, 33-42. Nijs, R.N.J.T.L. de, Lems, W.F., Laan, R.F.J.M., Struijs, A., Staa, T.P. van, Geusens, P., & Bijlsma, J.W.J. (2003). Preventie en behandeling van glucocorticosteroid geinduceerde osteoporose Nederlands Tijdschrift voor Calcium- en Botstofwisseling 1, 87-92. Ton, E., & Jacobs, J.W.G. (2003). Zijn er nieuwe indicaties voor TNF-antagonisten binnen de reumatologie? Reumatologen Vademecum 4. Wesseling, J., & Bijlsma, J.W.J. (2003). "Cohort Heup En Cohort Knie (CHECK), een 10-jarig follow-up onderzoek van beginnende heup- en knieartrose" Nederlands tijdschrift voor reumatologie 3, 3-9. Book, book chapters & proceedings

Roosendaal, G., & Lafeber, F.P.J.G. (). Pathogenesis of hemophilic synovitis and arthropathy In E.C. Rodriguez-Merchan (Ed.), Haemophilic joints, new perspectives (pp. 12-17). Blackwell Publishing.

94

Everdingen, A.A. van, Jacobs, J.W.G., & Siewertsz van Reesema, D.R. (2003). Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, disease-modifying properties, and side effects. A randomized, double-blind placebo-controlled clinical trial. In RS Panush (Ed.), The year book of rheumatology, arthritis, and musculoskeletal disease. (pp. 53-55). Philadelphia: Mosby:.

95

University Medical Center Utrecht Department of Immunology and Pediatrics

Research group Psychoneuroimmunology

(UU UMC 2.4)

Leader Ms. C.J. Heijnen

Staff

F. van Bel F. Groenendaal

Ms. A. Kavelaars

Post docs Ms. M.S. Lombardi

PhD students N. Eijkelkamp

Ms. W. Kleibeuker Ms. C. Nijboere

M. Teunis Ms. H. Vreugedenhil

Ms. A. Vroon

Titles PhD projects N. Eijkelkamp: Role of regulation of GRK in irritable bowel syndrome R. Karemaker: Effects of neonatal treatment with corticosteroids on childrens health at a

later age Ms. W. Kleibeuker: GRK and arrestin in inflammatory pain Ms. C. Nijboer: Hypoxic[Ischemic cerebral injury in a model of the preterm neonate and the

role of cytokines and nitric oxide synthase Ms. E. Sajti: Individual differences in neuroendocrine and immune activity in arthritis M. Teunis: Influence of the hemoendorine system on the development of autoimmune disease Ms. E. v. d. Tweel: Immunologic consequences of hypoxic/ischemic stress in the neonatal brain Ms. H. Vreugedenhil: Biotrauma: pro- and anti imflammation in disbalance? Ms. A. Vroon: GRK in the immune system Ms. M. ter Wolbeek: Biological and psyhological correlations of tiredness in adolescents Thesis

Teunis, M.A.T. (06-05-2003). Dopamine & Disease, a role for the dopaminergic system in immune responses and tumor progression. UU Universiteit Utrecht (160 pag.). (Enschede: Febodruk BV). Prom./coprom.: Heijnen, C.J., Cools, A.R., & Kavelaars, A.M.A.A. Vreugdenhil, H.A.E. (28-11-2003). Mechanical ventilation and immune function. UU Universiteit Utrecht.. Prom./coprom.: Vught, A.J. van, Heijnen, C.J., Lachmann, B., & Jansen, N.J.G. Vroon, A. (04-09-2003). GRK2 and GRK6 - Regulators of inflammation and autoimmunity. UU Universiteit Utrecht (149 pag.). (Enschede: Febodruk BV). Prom./coprom.: Heijnen, C.J., & Kavelaars, A.M.A.A. International publications

F. Cowan, M. Rutherford, F. Groenendaal, P. Eken, E. Mercuri, G. M. Bydder, L. C. Meiners, L. M. S. Dubowitz, and L. S. de Vries. Origin and timing of brain lesions in term infants with neonatal encephalopathy. Lancet 361:736-742, 2003.

96

F. Groenendaal, C. Lindemans, C. S. P. M. Uiterwaal, and L. S. de Vries. Early arterial lactate and prediction of outcome in preterm neonates admitted to a neonatal intensive care unit. Biol Neonate 83:171-176, 2003. Heide-Jalving, M., P. J. Kamphuis, M. J. van der Laan, J. M. Bakker, V. M. Wiegant, C. J. Heijnen, S. Veen, and F. Van Bel. Short- and long-term effects of neonatal glucocorticoid therapy: is hydrocortisone an alternative to dexamethasone? Acta Paediatr. 92:827-835, 2003. Kamphuis, P.J.G.H., Gardoni, F., Kamal, A., Croiset, G.J., Bakker, J.M., Cattabeni, F., Gispen, W.H., Bel, F. van, Di Luca, M., & Wiegant, V.M. (2003). Long-lasting effects of neonatal dexamethasone treatment on spatial learning and hippocampal synaptic plasticity: involvement of the NMDA receptor complex. FASEB Journal 17 (8), 911-913. Kavelaars, A.M.A.A., Vroon, A., Raatgever, R.P., Fong, A.M., Premont, R.T., Patel, D.D., Lefkowitz, R.J., & Heijnen, C.J. (2003). Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. Journal of Immunology 171 (11), 6128-6134. Pawlak, C.R., Witte, T., Heiken, H., Hundt, M., Schubert, J., Wiese, B., Bischoff-Renken, A., Gerben, K., Licht, B., Goebel, M.U., Heijnen, C.J., Schmidt, R.E., & Schedlowski, M. (2003). Flares in patients with systemic lupus erythematosus are associated with daily psychological stress. Psychotherapy and psychosomatics 73 (3), 159-165.

C. Peeters-Scholte, K. Braun, J. Koster, N. Kops, K. Blomgren, G. Buonocore, S. van Buul-Offers, H. Hagberg, K Nicolay, F. Van Bel, and F. Groenendaal. Effects of allopurinol and deferoxamine on reperfusion injury of the brain in newborn piglets after neonatal hypoxia-ischemia. Pediatr Res 54:516-522, 2003.

C. Peeters-Scholte, E. van den Tweel, F. Groenendaal, and F. Van Bel. Redox state of near infrared spectroscopy-measured cytochrome aa(3) correlates with delayed cerebral energy failure following perinatal hypoxia-ischaemia in the newborn pig. Exp Brain Res, 2003.

C. Peeters, D. Hoelen, F. Groenendaal, F. Van Bel, and D Bär. Deferoxamine, allopurinol and oxypurinol are not neuroprotective after oxygen/glucose deprivation in an organotypic hippocampal model, lacking functional endothelial cells. Brain Res 963:72-80, 2003. Peters, M.L., Godaert, G.L.R., Ballieux, R.E., & Heijnen, C.J. (2003). Moderation of physiological stress responses by personality traits and daily hassles: Less flexibility of immune system responses. Biological Psychology 65 (1), 21-48. Plotz, F.B., Vreugdenhil, H.A.E., Vught, A.J. van, & Heijnen, C.J. (2003). Mechanical ventilation and multiple organ failure. Lancet 361 (9369), 1654-1654. Smeets, M.B., Fontijn, J., Kavelaars, A.M.A.A., Pasterkamp, G., & Kleijn, D.P.V. de (2003). The acute phase protein haptoglobin is locally expressed in arthritic and oncological tissues. International Journal of Experimental Pathology 84, 69-74. Vreugdenhil, H.A.E., Haitsma, J.J., Jansen, K.J., Zijlstra, J., Plotz, F.B., Dijk, J.E. van, Lachmann, B., Vught, A.J. van, & Heijnen, C.J. (2003). Ventilator-induced heat shock protein 70 and cytokine mRNA expression in a model of lipopolysaccharide-induced lung inflammation. Intensive Care Medicine 29 (6), 915-922. Vroon, A., Lombardi, M.S., Kavelaars, A.M.A.A., & Heijnen, C.J. (2003). Changes in the G-protein-coupled receptor desensitization machinery during relapsing-progressive experimental allergic encephalomyelitis. Journal of Neuroimmunology 137 (1-2), 79-86.

Wijnberger, L. D., T. G. Krediet, G. H. Visser, F. Van Bel, and J. Egberts.. Early neonatal antioxidant capacity after preexisting impaired placental function. Early Hum.Dev. 71:111-116. 2003.

National publications C. Peeters-Scholte, F. Groenendaal, and F. Van Bel. Neuroprotectieve

behandelingsstrategieën na perinatale hypoxie-ischemie. Tijdschr Kindergeneeskd 71:138-143, 2003.

97


Research group

Regulation of antigen specific defense mechanisms, fundamental aspects with application in human and veterinary medicine

(UU VET 07.05)

Leader W. van Eden

Staff

G. Arkesteijn C.M.B. Broeren (✟ 2004)

E.J. Hensen E.J. Ruitenberg V.P.M.G. Rutten

E.J. Tijhaar M.H.M. Wauben

R. van der Zee

Post docs A.P. Koets

R. van der Most L. Vervelde

PhD students Ms. S.E. Berlo Ms. P.J. Boot

E. Claassen T. Guichelaar

Ms. E. ‘t Hoen T. Luijkx

Titles PhD projects Ms. S.E. Berlo: Origin of hsp-reactivity and regulation in arthritis Ms. P.J. Boot: Modifying chronic inflammatory conditions using advanced drug delivery systems E. Claassen: Intracellular bacteria as carriers for nucleic acid vaccines T. Guichelaar: Co stimulation in a transgenic exp. Arthritis model- Ms. E. ‘t Hoen: Anergic T cells as active regulators of the immune response T. Luijkx: Meningococcus B vaccine Thesis Haan, E.C. de (06-10-2003). Peptide modification in T cell immunology Universiteit Utrecht (126 pag.). . Prom./coprom.: Liskamp, R.M.J., Moret, E.E., & Wauben, M.H.M. Hoen, E.N.M. 't (01-12-2003). Tuning of T cell responses by regulatory T cells Universtiteit Utrecht, Faculty of Veterinary Medic (128 pag.). (Enschede: PrintPartners Ipskamp). Prom./coprom.: Eden, W. van, & Wauben, M.H.M. Kornalijnslijper, J.E. (09-10-2003). Health and welfare of high producing dairy cows Universiteit Utrecht, faculteit diergeneeskunde (195 pag.). (Enschede: Febodruk b.v.). Prom./coprom.: Noordhuizen-Stassen, E.N., Rutten, V.P.M.G., & Beerda, B. Pel, M. van (03-06-2003). Induction and maintenance of mixed chimerism and donor-specific tolerance in a murine model UU Universiteit Utrecht.. Prom./coprom.: Kuis, W., Boog, C.J.P., Eden, W. van, Hagenbeek, A., Ploemacher, R.E., Kimpen, J.L.L., & Claas, F. Boot, E.P.J. (24-04-2003). Targeting activated T helper cells for therapeutic intervention in inflammatory disease Universiteit Utrecht.. Prom./coprom.: Eden, W. van, Storm, G., Wauben, M.H.M., & Everse, L.A. International publications

Amedei, A., Bergman, M.P., Appelmelk, B.J., Azzurri, A., Benagiano, M., Tamburini, C., Zee, R. van der, Telford, J.L., Vandenbroucke-Grauls, C.M.J.E., D'Elios, M.M., & Del Prete, G. (2003). Molecular mimicry between Helicobacter pylori antigens and H+, K+ -- adenosine triphosphatase in

98

human gastric autoimmunity Journal of Experimental Medicine 198 (8), 1147-1156. Antonis, A.F.G., Schrijver, R.S., Daus, F., Steverink, P., Stockhofe, N., Hensen, E.J., Langedijk, J.P., & Most, R.G. van der (2003). Vaccine-induced immunopathology during bovine respiratory syncytial virus infection: exploring the parameters of pathogenesis Journal of Virology 77 (22), 12067-12073. Bergman, M.P., Amedei, A., D'Elios, M.M., Azzurri, A., Benagiano, M., Tamburini, C., Zee, R. van der, Vandenbroucke-Grauls, C.M.J.E., Appelmelk, B.J., & Del Prete, G. (2003). Characterization of H+, K+ -ATPase T cell epitopes in human autoimmune gastritis European Journal of Immunology 33 (2), 539-245. Bleek, G.M. van, Poelen, M.C.M., Most, R.G. van der, Brugghe, H.F., Timmermans, J.A.M., Boog, C.J.P., Hoogerhout, P., Otten, H.G., & Els, C.A.C.M. van (2003). Identification of immunodominant epitopes derived from the respiratory syncytial virus fusion protein that are recognized by human CD4 T cells Journal of Virology 77 (2), 980-988. Bosch, B.J., Zee, R. van der, Haan, C.A.M. de, & Rottier, P.J.M. (2003). The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex Journal of Virology 77, 8801-8811. Eden, W. van, & Waksman, B.H. (2003). Immune regulation in adjuvant-induced arthritis Arthritis and Rheumatism 48 (7), 1788-1796. Eden, W. van, Koets, A.P., Kooten, P. van, Prakken, A.B.J., & Zee, R. van der (2003). Immunopotentiating heat shock proteins: negotiators between innate danger and control of autoimmunity Vaccine 14, 897-901. Gerlofs-Nijland, M.E., Assmann, K.J., Son, J.P. van, Dijkman, H.B., Loeke, N.A te, Zee, R. van der, Wetzels, J.F., & Groenen, P.J. (2003). Epitope mapping of monoclonal antibodies directed to aminopeptidase A and their relevance for albuminuria in mice Nephron 94 (1), e25-34. Ghoreschi, K., Thomas, P., Breit, T., Dugas, M., Mailhammer, R., Eden, W. van, Zee, R. van der, Biedermann, T., Prinz, J.F., Mack, M.J., Mrowietz, U., Christophers, E., Schlondorff, D., Plewig, G., Sander, C.J., & Rocken, M. (2003). Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease Nature Medicine 9 (1), 40-46. Habich, C., Kempe, K., Zee, R. van der, Burkart, V., & Kolb, H. (2003). Different heat shock protein 60 species share pro-inflammatory activity but not binding sites on macrophages FEBS letters 533 (1-3), 105-109. Hanyecz, A., Bárdos, T., Berlo, S.E., Buzás, E, Nesterovitch, A.B., Mikecz, K, & Glant, T. (2003). Induction of arthritis in SCID mice by T cells specific for the "Shared Epitope" sequence in the G3 domain of human cartilage proteoglycan Arthritis and Rheumatism 48 (10), 2959-2973. Huising, M.O., Guichelaar, T., Hoek, C., Verburg-van Kemenade, B.M., Flik, G., Savelkoul, H.F.J., & Rombout, J.H. (2003). Increased efficacy of immersion vaccination in fish with hyperosmotic pretreatment Vaccine 21 (27-30), 4178-4193. Kanobana, K.U., Koets, A.P., Kooyman, F.N.J., Bakker, N., Ploeger, H.W., & Vervelde, L. (2003). B cells and antibody response in calves primary-infected or re-infected with Cooperia oncophora: influence of priming dose and host responder types International Journal for Parasitology 33 (13), 1487-1502. Kanobana, K.U., Koets, A.P., Bakker, N., Ploeger, H.W., & Vervelde, L. (2003). T-cell mediated immune responses in calves primary-infected or re-infected with Cooperia oncophora: similar effector cells but different timing International Journal for Parasitology 33 (13), 1503-1514. Kleer, I.M. de, Kamphuis, S.S.M., Rijkers, G.T., Scholtens, L.E., Gordon, G, Jager, W. de, Hafner, R., Zee, R. van der, Eden, W. van, Kuis, W., & Prakken, A.B.J. (2004). The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10 Arthritis and Rheumatism 48 (7), 2001-2010. Knoflach, M., Kiechl, S., Kind, M., Said, M., Sief, R., Gisinger, M., Zee, R. van der, Gaston, H., Jarosch, E., Willeit, J., & Wick, G. (2003). Cardiovascular risk factors and atherosclerosis in young males: ARMY study (Atherosclerosis Risk-Factors in Male Youngsters) Circulation 108 (9), 1064-1069. Kornalijnslijper, J.E., Werven, T. van, Daemen, A.J.J.M., Broek, J. van den, Niewold, T.A., Rutten, V.P.M.G., & Noordhuizen-Stassen, E.N. (2003). In vitro growth of mastitis-inducing Escherichia coli in milk and milk fractions of dairy cows Veterinary microbiology 2-91 (2-3), 125-134. Kornalijnslijper, J.E., Beerda, B., Daemen, A.J.J.M., Werf, J. van der, Werven, T. van, Niewold, T.A., Rutten, V.P.M.G., & Noordhuizen-Stassen, E.N. (2003). The effect of milk production level on host resistance of dairy cows, as assessed by the of experimental Escherichia coli mastitis Veterinary research 34, 721-736. Metselaar, J.M., Bruin, P., Boer, L.W., Vringer, T. de, Snel, C.J., Oussoren, C., Wauben, M.H.M., Crommelin, D.J., Storm, G., & Hennink, W.E. (2003). A novel family of L-amino acid-based biodegradable polymer-lipid conjugates for the development of long-circulating liposomes with effective drug-targeting capacity Bioconjugate Chemistry 14 (6), 1156-1164. Metselaar, J.M., Wauben, M.H.M., Wagenaar-Hilbers, J.P.A., Boerman, O.C., & Storm, G. (2003). Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulation liposomes Arthritis and Rheumatism 48 (7), 2059-66. Most, R.G. van der, Murali-Krishna, K., Lanier, J.G., Wherry, E.J., Puglielli, M.T., Blattman,

99

J.N., Sette, A., & Ahmed, A. (2003). Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation Virology 315 (1), 93-102. Murali-Krishna, K., Ahmed, R., & Most, R.G. van der (2003). Prolonged presence of effector-memory CD8 T cells in the central nervous system after dengue virus encephalitis International Immunology 15 (1), 119-125. Murali-Krishna, K., Ahmed, R., Most, R.G. van der, Wherry, E.J., & Blattman, J.N. (2003). Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment Journal of Virology 77, 4911-4927. Perschinka, H., Mayr, M., Millonig, G., Mayerl, C., Zee, R. van der, Morrison, S.G., Morrison, R.P., Xu, Q., & Wick, G. (2003). Cross-Rective B-Cell Epitopes of Microbial and Human Heat Shock Protein 60/65 in Artherosclerosis Arteriosclerosis Thrombosis and Vascular Biology 23. Prakken, A.B.J., Roord, S., Ronaghy, A., Wauben, M.H.M., Albani, S., & Eden, W. van (2003). Heat shock protein 60 and adjuvant arthritis: a model for T cell regulation in human arthritis Springer seminars in immunopathology 25, 47-63. Schmidt, J., Metselaar, J.M., Wauben, M.H.M., Toyka, K.V., Storm, G., & Gold, R. (2003). Drug targeting by long-circulation liposomal glucocorticosteriods increases therapeutic efficacy in a model of multiple sclerosis Brain 126 (8), 1895-904. Scibelli, A., d'Angelo, D., Pelagalli, A., Tafuri, S., Avallone, L., Della Morte, R., & Staiano, N. (2003). Expression levels of the focal adhesion-associated proteins paxillin and p130cas in canine and feline mammary tumors Veterinary research 34, 193-202. Scibelli, A., Tafuri, S., Ferrante, M.C., Alimenti, E., Naso, B., Lucisano, A., Staiano, N., & Della Morte, R. (2003). Ochratoxin A affects COS cell adhesion and signaling Toxicology and Applied Pharmacology 192 (3), 222-230. Soethout, E.C., Rutten, V.P.M.G., Houwers, D.J., Groot, H.S. de, Antonis, A.F.G, Niewold, D.J.H., & Müller, K.E. (2003). Alpha(4)-Integrin (CD49d) expression on bovine peripheral blood neutrophils is related to inflammation of the respiratory system Veterinary Immunology and Immunopathology 93 (1-2), 21-29. Steege, J.C.A. ter, Vianen, M.E., Bilsen, J.H.M. van, Bijlsma, J.W.J., Lafeber, F.P.J.G., & Wauben, M.H.M. (2003). Identification of self-epitopes recognized by T cells in rheumatoid arthritis demonstrates matrix metalloproteinases as a novel T cell target Journal of Rheumatology 30 (6), 1147-1156. Wilmink, J.M., Veenman, J.N., Boom, R. van den, Rutten, V.P.M.G., Niewold, T.A., Broekhuisen-Davies, J.M., Lees, P., Armstrong, S., Weeren, P.R. van, & Barneveld, A. (2003). Differences in polymorphonucleocyte function and local inflammatory response between horses and ponies Equine veterinary journal 35 (6), 561-569. Book, book chapters & proceedings

Koets, A.P. (2003). Mycobacterial heat shock proteins and the bovine immune system In W. van Eden (Ed.), Heat Shock Proteins and Inflammation (PIR, pp. 233-244). Basel: Birkhäuser Verlag. Zee, R. van der, Paul, L., & Eden, W. van (2003). Heat Shock proteins and suppression of inflammation In W. van Eden (Ed.), Heat Shock Proteins and Inflammation (PIR, pp. 15-31). Basel: Birkhäuser Verlag. Rutten, V.P.M.G., Sinke, J.D., Schlotter, Y.M., & Willemse, T. (2003). Cytokines in Canine Atopic dermatitis: tools for Cytokine detection, Cytokine expression, Immunopathogenesis. In (Ed.), Proceedings of the Annual Congress of the ESVD-ECVD (pp. 84-86). Tenerife. Rutten, V.P.M.G., Pinelli, E., Solano-Callego, L., Fernández Bellon, H.M., & Ruitenberg, E.J. (2003). Immune responsiveness in Canine Leishmaniasis. In (Ed.), Proceedings of the Annual Congress of the ESVD-ECVD (pp. 105-107). Tenerife. Scibelli, A., Tafuri, S., Alimenti, E., Belisario, M.A., Della Morte, R., & Staiano, N. (2003). Biochemical analysis of the molecular mechanism of action of natural integrin inhibitors. In (Ed.), Veterinary Research Communications Vol. 27. Veterinary Research Communications (pp. 627-630). Netherlands: Kluwer Academic Publishers. Wauben, M.H.M., Hoen, E.N.M. 't, & Taams, L.S. (2003). Modulation of T cell repsonses after cross-talk between antigen presenting cells and T cells: a give-and-take relationship. In (Ed.), Novartis Found Symp Vol. 252. Novartis Foundation Symposium (pp. 211-220).. Eden, W. van (Ed.). (2003). Heat Shock Proteins and Inflammation Basel: Birkhäuser Verlag. Patents Koets, A.P., Eden, W. van, & Rutten, V.P.M.G. (27-08-2003). Diagnosis and treatment of slow progressive infections no 03077682.7.

100

Faculty of Pharmacy, Utrecht University Department of Medicinal Chemistry

Research group Drug design for immune intervention

(UU PHARM 3.1)

Leader Professor R.M.J. Liskamp

Senior Staff

Dr. R.J. Pieters Dr.ir. D.T.S. Rijkers

Dr. J. Kemmink Dr.ir. J.A.W. Kruijtzer

Junior staff and post-docs

Mw.dr. C.C.M. Appeldoorn Dr. L. Ballell Pages

Mw.dr. M.C. Chamorro Perez Dr. J.A.F. Joosten

Dr. P. van der Veken Dr. I. Vrasidas

PhD students

Ing. H.B. Albada C.J. Arnusch

Mw.drs. R. Autar Drs. H.M. Branderhorst Mw.drs. H.T. ten Brink

Drs. F.J. Dekker Drs.ing. R. Elgersma

Drs. N. Ghalit Drs. R. de Jong

Drs. N.S.M. Merkx Drs. ing. D.J. van Zoelen

Thesis Vrasidas, I. (23-05-2003). Synthesis of carbohydrate functionalized dendrimers and their interactions with lectins. UU Universiteit Utrecht (184 pag.). . Prom./coprom.: Liskamp, R.M.J., & Pieters, R.J.

Haan, E.C. de (06-10-2003). Peptide modification in T cell immunology. Universiteit Utrecht (126 pag.). Prom./coprom.: Liskamp, R.M.J., Moret, E.E., & Wauben, M.H.M. International publications Ameijde, J. van., Liskamp, R.M.J. (2003). Synthesis of novel trivalent amino acid glycoconjugates based on the cyclotriveratrylene (CTV’) scaffold. Organic & Biomolecular Chemistry 1, 2661-2669. Arnusch, C.J., & Pieters, R.J. (2003). Solid phase synthesis of Vancomycine mimics. European Journal of Organic Chemistry, 3131-3138. Autar, R., Khan, A.S., Schad, M., Hacker, J., Liskamp, R.M.J., & Pieters, R.J. (2003). Adhesion inhibition of F1C-fimbriated Escherichia coli and Pseudomonas aeruginosa PAK and PAO by multivalent carbohydrate ligands. ChemBioChem 4, 1317-1325. Catalina Caballero, M.I., Dekker, F.J., Liskamp, R.M.J., Versluis, C., Maier, C.S., & Heck, A.J.R. (2003). Structural analysis of high affinity divalent phosphopeptide hybrids of spleen tyrosine kinase. International Journal of Mass Spectrometry and Ion Processes 228, 879-890. Chamorro Pérez, M.C., & Liskamp, R.M.J. (2003). Approaches to the solid phase of a cyclotriveratrylene scaffold-based tripodal library as potential artificial receptors. Journal of Combinatorial Chemistry 5, 794-801. Dekker, F.J., Mol, N.J. de, Fischer, M.J.E., & Liskamp, R.M.J. (2003). Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the Syk SH2 domains with equally high affinity as the natural ligand. Bioorganic & Medicinal Chemistry Letters 13, 1241-1244. Dekker, F.J., Mol, N.J. de, Fischer, M.J.E., Kemmink, J., & Liskamp, R.M.J. (2003). Cyclic phosphopeptides for interference with Grb2 SH2 domain signal transduction prepared by ring-closing

101

metathesis and phosphorylation. Organic & Biomolecular Chemistry 1, 3297-3303. Dekker, F.J., Mol, N.J. de, Bultinck, P.R.E., Kemmink, J., Hilbers, H.W., & Liskamp, R.M.J. (2003). Role of solution conformation and flexibility of short peptide ligands that bind to the p56lck SH2 domain. Bioorganic & Medicinal Chemistry 11, 941-949.

Haan, E.C. de, Wauben, M.H.M., Wagenaar-Hilbers, J.P.A., Grosfeld-Stulemeyer, M.C., Rijkers, D.T.S., Moret, E.E., & Liskamp, R.M.J. (2003). Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation - implications for immunological studies. Molecular Immunology 40, 943-948. Kol, M.A., Laak, A.N.C. van, Rijkers, D.T.S., Killian, J.A., Kroon, A.I.P.M. de, & Kruijff, B. de (2003). Phospholipid flop induced by transmembrane peptides in model membranes is modulated by lipid composition. Biochemistry 42, 231-237. Kopitz, J., André, S., Reitzenstein, C. Von, Versluis, C., Kaltner, H., Pieters, R.J., Wasano, K., Kuwabara, I., Liu, F-T., Cantz, M., Heck, A.J.R., & Gabius, H-J. (2003). Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells. Oncogene 22, 6277-6288. Merkx, N.S.M., Rijkers, D.T.S., Kemmink, J., & Liskamp, R.M.J. (2003). Chemoselective coupling of peptide fragments using the Staudinger ligation. Tetrahedron Letters 44, 4515-4518. Mol, N.J. de., Fischer, M.J.E. (2003). Applications in surface plasmon resonance (SPR) in ligand-receptor binding studies: affinity, kinetics and thermodynamics. Recent Res. Devel. Anal. Biochem. 3, 1-19. Nijenhuis, W.A.J., Kruijtzer, J.A.W., Wanders, N., Vrinten, D.H., Garner, K.M., Schaaper, W.M.M., Meloen, R.H., Gispen, W.H., Liskamp, R.M.J., & Adan, R.A.H. (2003). Discovery and in vivo evaluation of new melanocortin-4 receptor-selective peptides. Peptides 24 (2), 271-280. Planque, M.R.R. de, Rijkers, D.T.S., Liskamp, R.M.J., & Separovic, F. (2004). The alphaM1 transmembrane segment of the nicotinic acetylcholine receptor interacts strongly with model membranes. Magnetic Resonance in Chemistry 42. Vrasidas, I., Andre, S., Valentini, P., Bock, C., Lensch, M., Kaltner, H., Liskamp, R.M.J., Gabius, H-J., & Pieters, R.J. (2003). Rigidified multivalent lactose molecules and their interactions with mammalian galectins: a route to selective inhibitors. Organic & Biomolecular Chemistry 1, 803-810. Patents Kessel, C.P.M. van, Gosselaar-de Haas, C.J.C., Kruijtzer, J.A.W., & Strijp, J.A.G. van (23-01-2003). Combination of CHIPS (Chemotaxis Inhibiting Protein from Staphylococcus Aureus)-based compounds. no WO 03/006048 A1.

102

Faculty of Pharmacy, Utrecht University Department of Biopharmacy

Research group

Liposomes for immune intervention (UU PHARM 4)

Leader

D.J.A. Crommelin W.E. Hennink

G. Storm

Staff W. Jiskoot

Post docs

-

PhD students Ms. C. Arigita

Ms. E. Boot

Titles PhD projects Ms. C. Arigita: Conformation and immunogenicity of Pos A in different presentation foms. Ms. E. Boot: Modifying chronic inflammatory conditions using advanced drug delivery systems S. Hermeling: The effect of formulating pharmaceutical proteins on their structure and

immunogenicity B. Metz: Development and validation of in vitro biochemical and immunochemical methods for

the in-process and final controls of toxoid vaccines Thesis Arigita, C. (18-09-2003). Towards an improved Neisseria menigitidis B vaccine: vesicular PorA formulations. UU Universiteit Utrecht (206 pag.). . Prom./coprom.: Crommelin, D.J.A., Hennink, W.E., Jiskoot, W., & Kersten, G.F.A. Boot, P.J. (24-04-2003). Targeting activated T helper cells for therapeutic intervention in inflammatory disease. UU Universiteit Utrecht (120 pag.). . Prom./coprom.: Eden, W. van, Storm, G., Wauben, M.H.M., & Everse, L.A. Metselaar, J.M. (14-02-2003). Liposomal targeting of glucocorticoids. A novel treatment approach for inflammatory disorders. UU Universiteit Utrecht (187 pag.). . Prom./coprom.: Storm, G., Crommelin, D.J.A., & Wauben, M.H.M. Neradovic, D. (16-09-2003). Thermoresponsive polymeric nanoparticles with controlled instability based on hydrolytically sentitive N-isopropylacrylamide copolymers. UU Universiteit Utrecht (168 pag.). . Prom./coprom.: Hennink, W.E., & Nostrum, C.F. van Wit, T.R. Drs. (20-02-2003). Weibel-Palade bodies an exciting way out! UU Universiteit Utrecht (175 pag.). . Prom./coprom.: Mertens, K., & Mourik, J.A. van Yilmaz, G. (12-02-2003). Thermoplastic Starch Matrices for Encapsulation and Controlled Release of Volatile Compounds. UU Universiteit Utrecht (159 pag.). . Prom./coprom.: Hennink, W.E., Dijk, C. van, & Feil, H. Bovenschen, N. (16-06-2003). The interaction between coagulation factor VIII and its clearance receptors. UU Universiteit Utrecht.. Prom./coprom.: Mertens, K., Meijer, A.B., & Lenting, P.J. International publications Arigita, C., Bevaart, L., Everse, L.A., Koning, G.A., Hennink, W.E., Crommelin, D.J.A., Winkel, J.G.J. van de, Vugt, M.J. van, Kersten, G.F.A., & Jiskoot, W. (2004). Liposomal meningococcal B vaccination: Role of dendritic cell targeting in the development of a protective immune response. Infection and Immunity 71 (9), 5210-5218. Arigita, C., Kersten, G.F.A., Hazendonk, T., Hennink, W.E., Crommelin, D.J.A., & Jiskoot, W. (2003). Restored functional immunogenicity of purified meningococcal PorA by incorporation into liposomes. Vaccine 21, 950-960. Bouma, M., Nuijen, B., Harms, R., Rice, J.R., Nowotnik, D.P., Stewart, D.R., Jansen, B.A.J., Zutphen, S. van, Reedijk, J., Steenbergen, M.J. van, Talsma, H., Bult, A., & Beijnen, J.H. (2003). Pharmaceutical development of a parenteral lyophilized formulation of the investigational polymer-

103

conjugated platinum anticancer agent AP5280. Drug Development and Industrial Pharmacy 29, 981-995. Crommelin, D.J.A., & Storm, G. (2003). Liposomes: From the bench to the bed. Journal of Liposome Research 13, 33-36. Crommelin, D.J.A., Storm, G., Jiskoot, W., Stenekes, R.J.H., Mastrobattista, E., & Hennink, W.E. (2004). Nanotechnological approaches for the delivery of macromolecules. Journal of Controlled Release 87, 81-88. Crommelin, D.J.A., Storm, G., Verrijk, R., Leede, L. de, Jiskoot, W., & Hennink, W.E. (2003). Shifting paradigms: biopharmaceuticals versus low molecular weight drugs. International Journal of Pharmaceutics 266, 3-16. Everts, M., Koning, G.A., Kok, R.J., Asgeirsdottir, S.A., Vestweber, D., Meijer, D.K.F., Storm, G., & Molema, G. (2003). In vitro cellular handling and in vivo targeting of E-selectin-directed immunoconjugates and immunoliposomes used for drug delivery to inflamed endothelium. Pharmaceutical Research 20, 64-72. Fonseca, M.J., Jagtenberg, J.C., Haisma, H.J., & Storm, G. (2003). Liposome-mediated targeting of enzymes to cancer cells for site-specific activation of prodrugs: Comparison with the corresponding antibody-enzyme conjugate. Pharmaceutical Research 20, 423-428. Hermeling, S., Schellekens, H., Crommelin, D.J.A., & Jiskoot, W. (2003). Micelle-Associated Protein in Epoetin Formulations: A Risk Factor for Immunogenicity ? Pharmaceutical Research 20, 1903-1908. Janssen, A.P.C.A., Schiffelers, R.M., Hagen, T.L.M. ten, Koning, G.A., Schraa, A.J., Kok, R.J., Storm, G., & Molema, G. (2003). Peptide-targeted PEG-liposomes in anti-angiogenic therapy. International Journal of Pharmaceutics 254, 55-58. Kersten, G.F.A., & Crommelin, D.J.A. (2003). Liposomes and ISCOMs. Vaccine 21, 915-920. Koten, J.W., Luyn, M.J. van, Cadee, J.A., Bouwer, L., Hennink, W.E., Bijleveld, C., & Otter, W. den (2003). IL-2 loaded dextran microspheres with attractive histocompatibility properties for local IL-2 cancer therapy. Cytokine 24, 57-66. Koten, J.W., Luyn, M.J. van, Cadée, J.A., Brouwer, L., Hennink, W.E., Bijleveld, C., & Otter, W. den (2003). IL-2 loaded dextran microspheres with attractive histocompatibility properties for local IL-2 cancer therapy. Cytokine 24, 57-66. Leemhuis, M., Steenis, J.H van, Uxem, M.J. van, Nostrum, C.F. van, & Hennink, W.E. (2003). A versatile route to functionalized dilactones as monomers for the synthesis of poly(alpha-hydroxy) acids. European Journal of Organic Chemistry 17, 3344-3349. Luten, J., Steenis, J.H van, Someren, R. van, Kemmink, J., Schuurmans-Nieuwenbroek, N.M.E., Koning, G.A., Crommelin, D.J.A., Nostrum, C.F. van, & Hennink, W.E. (2003). Water-soluble biodegradable cationic polyphosphazenes for gene delivery. Journal of Controlled Release 89, 483-497. Metselaar, J.M., Bruin, P., Boer, L.W.T. de, Vringer, T. de, Snel, C.J., Oussoren, C., Wauben, M.H.M., Crommelin, D.J.A., Storm, G., & Hennink, W.E. (2003). A novel family of L-amino acid-based biodegradable polymer-lipid conjugates for the development of long-circulating liposomes with effective drug-targeting capacity. Bioconjugate Chemistry 14, 1156-1164. Metselaar, J.M., Bruin, P., Boer, L.W., Vringer, T. de, Snel, C.J., Oussoren, C., Wauben, M.H.M., Crommelin, D.J., Storm, G., & Hennink, W.E. (2003). A novel family of L-amino acid-based biodegradable polymer-lipid conjugates for the development of long-circulating liposomes with effective drug-targeting capacity. Bioconjugate Chemistry 14 (6), 1156-1164. Metselaar, J.M., Wauben, M.H.M., Wagenaar-Hilbers, J.P.A., Boerman, O.C., & Storm, G. (2003). Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes. Arthritis and Rheumatism 48, 2059-2066. Metz, B., Jiskoot, W., Hennink, W.E., Crommelin, D.J.A., & Kersten, G.F.A. (2003). Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines. Vaccine 22 (I12), 156-167. Neradovic, D., Steenbergen, M.J. van, Vansteelant, L., Meijer, Y.J., Nostrum, C.F. van, & Hennink, W.E. (2003). Degradation mechanism and kinetics of thermosensitive polyacrylamides containing lactic acid side chains. Macromolecules 36, 7491-7498. Nostrum, C.F. van, Jong, S.J. de, Kettenes-van den Bosch, J.J., & Hennink, W.E. (2003). Hydrogels by stereocomplex formation and their use as drug delivery matrices. A.C.S. symposium series 846, 129-141. Rijn, R.S. van, Simonetti, E.R., Hagenbeek, A., Hogenes, M.C., Weger, R.A. de, Canninga-van Dijk, M.R. van, Weijer, K., Spits, H., Storm, G., Bloois, L. van, Rijkers, G.T., Martens, A.C.M., & Ebeling, S.B. (2003). A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2(-/-) gamma c(-/-) double-mutant mice. Blood 102, 2522-2531. Rijn, R.S. van, Simonetti, E.R., Hagenbeek, A., Hogenes, M.C., Weger, R.A. de, Canninga-van Dijk, M.R. van, Weijer, K., Spits, H., Storm, G., Bloois, L. van, Rijkers, G.T., Martens, A.C.M., & Ebeling, S.B. (2003). A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/-gammac-/-dubbel-mutant mice. Blood 102 (7), 2522-2531.

104

Schellekens, H., & Crommelin, D.J.A. (2003). Equivocal role of micelles in Eprex adverse events. Nature biotechnology 21, 1265-1265. Schiffelers, R.M., Koning, G.A., Hagen, T.L.M. ten, Fens, M.H.A.M., Schraa, A.J., Janssen, A.P.C.A., Kok, R.J., Molema, G., & Storm, G. (2003). Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin. Journal of Controlled Release 91, 115-122. Schmidt, J., Metselaar, J.M., Wauben, M.H.M., Toyka, K.V., Storm, G., & Gold, R. (2003). Drug targeting by long-circulating liposomal glucocorticosteroids increases therapeutic efficacy in a model of multiple sclerosis. Brain 126, 1895-1904 Steenis, J.H van, Maarseveen, N.M. van, Verbaan, F.J., Verrijk, R., Crommelin, D.J.A., Storm, G., & Hennink, W.E. (2003). Preparation and characterization of folate-targeted pEG-coated pDMAEMA-based polyplexes. Journal of Controlled Release 87, 167-176. Stubbe, B., Horkay, F., Amsden, B., Hennink, W.E., Smedt, S.C. de, & Demeester, J. (2003). Tailoring the swelling pressure of degrading dextran hydroxyethyl methacrylate hydrogels. Biomacromolecules 4, 691-695. Verbaan, F.J., Dam, I. van, Takakura, Y., Hashida, M., Hennink, W.E., & Storm, G. (2003). Intravenous fate of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes. European Journal of Pharmaceutical Sciences 20, 419-427.

105

Faculty of Veterinary Medicine, Utrecht University Institute for Risk Assessment Sciences

Research group

Immunotoxicology (UU VET 04.05)

Leader

R.H.H. Pieters

PhD students Ms. M. Bol-Schoenmakers

C. de Haar S. Nierkens

Ms. F. van Wijk Titles PhD projects Ms. M. Bol-Schoenmakers: Immunomodulation at mucosal sites C. de Haar: Adjuvant effects of airborne particulate matter on the development of respiratory

allergy S. Nierkens: Mechanisms of drug induced autoimmunity Ms. F. van Wijk: Mechanisms of oral sensitization to food proteins International publications

Albers, R., Bol-Schoenmakers, M., Bleumink, A.R.J., Willems, A.A., & Pieters, R.H.H. (2003). Effects of supplementation with vitamins A, C, and E, selenium, and zinc on immune function in a murine sensitization model. Nutrition 19, 940-946. Ezendam, J., Vissers, I., Bleumink, R., Vos, J.G., & Pieters, R.H.H. (2003). Immunomodulatory effects of tetrachlorobenzoquinone, a reactive metabolite of hexachlorobenzene. Chemical Research in Toxicology 16, 688-694.

Nieuwenhuizen, W.F., Pieters, R.H.H., Knippels, L.M., Jansen, M.C.J.F., & Koppelman, S.J. (2003). Is candida albicans a trigger in the onset of coeliac disease. Lancet 361, 2152-2154.

Pieters, R.H.H., Ezendam, J., & Nierkens, S. (2003). Chemical-specific properties co-determine the type of adverse immune response. Autoimmunity Reviews 2, 25-29

Ezendam, J., Hassing I., Bleumink, R., Vos, J.G., & Pieters, R. (2004) Hexachlorobenzene-induced Immunopathology in Brown Norway rats is partly mediated by T cells. Toxicol. Sci. 78, 88-96, 2004

Nierkens, S., Nieuwenhuijsen, L., Thomas, M., & Pieters, R. (2004) Evaluation of the use of reporter antigen in an auricular lymph node assay to assess the immunosensitizing potential of drugs. Toxicol. Sci. 79, 90-97.

Ezendam, J., Staedtler, F., Pennings, J., Vandebriel, R.J., Pieters, R., Harleman, J.H., & Vos J.G. (2004) Toxicogenomics of subchronic hexachlorobenzene exposure in Brown Norway rats. Env. Health Persp. 112, 782-791.

106

Institute for Animal Science & Health ID - Lelystad Division of Animal Sciences

Division

Immunology and immunopathology of large farm animals

Participants W.J.A. Boersma

Ms. A. Bouma Ms. M.G. de Bruin

Ms. J. de Groot Ms. S.H.M. Jeurissen

A. Kijlstra R.J. Moormann

T.A. Niewold Ms. A. Rebel

P.J.G.M. Steverink

PhD students E.E. Agbo

Ms. P. Jochemsen Ms. M.E. Koenen

Ms. J. Kramer Ms. T.G.M. Lauterslager

Ms. M.G.J. Tacken

Titles PhD projects E.E.C. Agbo: DNA based resources in sensitive & species/specific identification of trypanosomes and as a tool for molecular epidemiology of trypanosomosis Ms. P. Jochemsen: In ovo vaccination: the mode of action of immune complexed live infectious bursal disease virus (IBDV) vaccine Ms. M. Koenen: Pre-en probiotica in landbouwhuisdieren en pluimvee. Ook varkens en kippen aan de gezonde bacterie? Ms. J. Kramer: The development of genetic markers for macrophage functions and their role in resistance to salmonella in fection in chicken Ms. T. Lautenslager: Edible vaccins in plants Ms. I.van der Linden Cellular immune response of the pig against PRRSV Ms. M.G.J. Tacken: Benutten van specifieke eiwit-eiwit interacties voor het verbeteren en

ontwikkelen van agrarische producten B. Zekarias Strain differences in disease susceptibility and immune reactivity in chickens No report received before September 2004.

eijkman graduate school for immunology & infectious diseases report 2003.pdf · 1 annual report...

Documents