EGFR features in GBM

30 May 2012

Proximal features with highest correlation to GEXP:EGFR +0.80 (n=553) CNVR::chr7:55236000:55237999 +0.78 (n=528) CNVR:7p11.2_GisticROI_r:chr7:54933848:54940054::amp +0.77 (n=528) CNVR:EGFR +0.67 (n=528) CNVR:7p11.2_GisticROI_d:chr7:54933848:54940054::amp

Data sources: GEXP:EGFR -- Agilent mRNA log-ratio expression values from UNC CNVR (copy-number segments)

GisticROI values come from the all_lesions.conf_99.txt file from firehose Gene-based values come from the all_data_by_genes.txt file from firehose Otherwise un-annotated segments are based on a resegmentation of the level-3 SNP chip data

-4 -2 0 2 4 6 8-1

0

1

2

3

4

5 CNVR:chr7:55,236,000 (1kb) vs GEXP:EGFR

-4 -2 0 2 4 6 8-1

0

1

2

3

4

5

6

7CNVR:7p11.2 (Gistic ROI) vs GEXP:EGFR

CNVR:chr7:55,001,000 (1kb) vs CNVR:7p11.2 (Gistic ROI)

-1 0 1 2 3 4 5 6-1

0

1

2

3

4

5

6

-4 -2 0 2 4 6 8-1

1

3

5

7

9

11 CNVR:EGFR vs GEXP:EGFR