Effects of IMTH-232 when applied orally @25mg/days for a period of 30 days to a ol!nteer female scientist of 2" years#$oc!mented after "0 days after the period of administration#

Mental function$iffic!lty remem%ering or coming !p with theright word$iffic!lty concentrating$iffic!lty learning new materialThe nere cells in the %rain release different amo!nts of some chemical messengers &which send imp!lses from cell to cell'( and the n!m%er of receptors on nere cells may decrease# Th!s( the %rain does not send or process imp!lse as well or as)!ic*ly#Physical activity+nsteadiness or loss of %alance,tr!ct!res in the inner ear that helpwith %alance stiffen and deteriorate slightly#The part of the %rain that controls %alance &cere%ell!m' may degenerate#$i--iness or light-headedness when standingThe heart does not p!mp eno!gh %lood to the head %eca!se the heart is lessa%le to respond to changes in position#The nero!s system signals the heart to increase %lood flow less effectiely#The %lood essels do not constrict eno!gh to maintain normal %lood press!re when a person stands#.oss of m!scle strengthThe n!m%er and si-e of m!scle fi%res decrease#The %ody prod!ces less growth hormoneand &in men' less testosterone( whichhelp maintain m!scles#$iffic!lty moing.ess fle/i%ility.ess 0oint fl!id is prod!ced#The cartilage %etween %ones in 0oints%ecomes stiffer and may erode#Tendons and ligaments %ecome stiffer and wea*er#M!scle tiss!e is lost( replaced %y fatty or fi%ro!s tiss!e( decreasing strength and ma*ing m!scles stiffer#$iffic!lty e/ercising stren!o!slyThe heart cannot *eep !p with the demand for more %lood d!ring e/ercise# It cannot speed !p as )!ic*ly or p!mp as fast as it !sed to( partly %eca!se the heart and %lood essels %ecome stiffer and lesselastic# 1lso( the heart does not respond as )!ic*ly or as well to chemical messengers that normally stim!late it to speed !p#The l!ngs cannot *eep !p with the demand for o/ygen d!ring e/ercise# .ess air is ta*en in with each %reath( and the l!ngs do not a%sor% as m!ch o/ygen#The senses2eed for reading glassesThe lens of the eye stiffens( ma*ing foc!sing on close o%0ects more diffic!lt#$iffic!lty seeing in dim lightThe retina of the eye %ecomes less sensitie to light#The lens of the eye %ecomes less transparent#$iffic!lty ad0!sting to changes in light leelsThe p!pils react more slowly to changes in light#$ar*ened areas in the lens of the eyeincrease glare#$ry eyes The n!m%er of cells that prod!ce fl!ids to l!%ricate the eyes decreases#The tear glands prod!ce fewer tears#$iffic!lty !nderstanding words1ge-related hearing loss &pres%yc!sis' deelops( which often affects mainly high fre)!encies &which incl!de consonants3the so!nds that help people identify words'#.oss of taste Taste %!ds %ecome less sensitie#4eople detect odo!rs less well %eca!se the lining of the nose %ecomes thinner and drier and the nere endings in the nose deteriorate#$ry mo!th .ess salia is prod!ced#Eating problems$iffic!ltyThe mo!th is dry#swallowing The m!scles inoled in swallowing wea*en( and coordination is impaired#4eople may not chew food eno!gh %eca!se teeth are missing or dent!resdo not fit well# Then( ch!n*s of foodare too large to swallow#The %ones at the top of the spine change( tipping the head forward and th!s compressing the throat#$isinterest in eatingTaste decreases( ma*ing food less appeti-ing#,mell decreases( ma*ing food less appeti-ing#The mo!th is dry( leading to loss of taste#5hewing may %e diffic!lt %eca!se teeth are missing( 0aw m!scles are wea*( or dent!res do not fit well#,wallowing is diffic!lt#Skin and hair6rin*lesMore tears in the s*inThe fat layer !nder the s*in( which acts as a c!shion( thins#The %ody prod!ces less collagen and elastin( which ma*e the s*in to!gh and elastic#$ry s*in 7lands in the s*in prod!ce less oil#8r!ises and %ro*en%lood essels8lood essels in the s*in %ecome morefragile#,low healing of wo!ndsThe n!m%er of %lood essels in the s*in decreases#5ells responsi%le for healing wo!nds act more slowly and decrease in n!m%er$iffic!lty ad0!sting to changes in temperat!reThe fat layer !nder the s*in( which helps consere %ody heat( thins#The n!m%er of sweat glands decrease( and the sweat glands prod!ce less sweat# ,weat helps cool the %ody#The n!m%er of %lood essels decreases( and %lood flow in the deeplayers of the s*in decreases# 1s a res!lt( the %ody cannot remoe heat from %ody as well#$ecreased sensation and sensitiity to painThe n!m%er of nere endings in the s*in decreases#7rey or white hair The hair follicles prod!ce less pigment &melanin'#Thinning or loss of hairHairs( which m!st %e replaced periodically( grow more slowly( and some hair follicles stop prod!cing new hair#Sexual function$ryness of the agina.ess oestrogen is prod!ced#