efector functions of cd4 + and cd8 + t-cells
DESCRIPTION
Efector functions of CD4 + and CD8 + T-cells. Th1. Naivna CD4 + T. Naiv e CD4 + T. Th17. Th2. Defense- intracellular pathogens, stimulation of IgG production. Or gan-specific autoim m une diseases. Defense- helmints. Allergy. Defense- e x tracel l ular bacteria, fungi. - PowerPoint PPT PresentationTRANSCRIPT
Efector functions of CD4+ and CD8+ T-cells
Naivna CD4+TNaive CD4+T
Th1
Th2
Th17
Defense- intracellular pathogens, stimulation of IgG production
Defense- helmints
Defense- extracellular bacteria, fungi
Organ-specific autoimmune diseases
Allergy
Autoimmunity and chronic inflammation
Naivna CD4+TNaive CD4+T
Th1
Th2
Th17
IL-4
IL-12
IL-23
T-bet
GATA-3
RORt
IL-4IL-5IL-13
Macrofage activation
B-cells
EosinophilactivationB-cells…
Neutrophil activation...
IL-17IL-22
IFN-γ
TH1respons
e
Efector functions of TH1 cells• Macrophage activation at the site of infection
Efector functions of TH1 cells• Macrophage activation at the site of infection
Efector functions of TH1 cells• Macrophage activation at the site of infection
Efector functions of TH1 cells• Macrophage activation at the site of infection
Efector functions of TH1 cells• Macrophage activation at the site of infection
Efector functions of TH1 cells• Macrophage activation at the site of infection
Efector functions of TH1 cells• B-cell activation
Naivna CD4+TNaive CD4+T
Th1
Th2
Th17
Defense- intracellular pathogens, stimulation of IgG production
Defense- helmints
Defense- extracellular bacteria, fungi
Organ-specific autoimmune diseases
Allergy
Autoimmunity and chronic inflammation
TH2response
Naivna CD4+TNaive CD4+T
Th1
Th2
Th17
Defense- intracellular pathogens, stimulation of IgG production
Defense- helmints
Defense- extracellular bacteria, fungi
Organ-specific autoimmune diseases
Allergy
Autoimmunity and chronic inflammation
TH17response
Naivna CD4+TNaive CD4+T
Th1
Th2
Th17
Defense- intracellular pathogens, stimulation of IgG production
Defense- helmints
Defense- extracellular bacteria, fungi
Organ-specific autoimmune diseases
Allergy
Autoimmunity and chronic inflammation
CTL effector function
Mechanisms ofCD8+ T-cellcytotoxicity
Mechanisms ofCD8+ T-cellcytotoxicity
Mechanisms ofCD8+ T-cellcytotoxicity
Mechanisms ofCD8+ T-cellcytotoxicity
CD8+ CTLTarget cell
Mechanisms ofCD8+ T-cellcytotoxicity
CD8+ CTL
perforinTarget cell
Mechanisms ofCD8+ T-cellcytotoxicity
granzimi
apoptosis
CD8+ CTL
perforinTarget cell
Mechanisms ofCD8+ T-cellcytotoxicity
FasL
CD8+ CTLTarget cell
Mechanisms ofCD8+ T-cellcytotoxicity
Ciljna ćelija
FasL Fas apoptosis
CD8+ CTL
Mechanisms ofCD8+ T-cellcytotoxicity
Pathogens avoid cellular immunity
Inhibition of fusion of phagosome with lysosome
Inhibition of presentation
of viral antigens
0
Inhibition of immune response by virokines and viroreceptors
killing virus-infected and tumor cellsj.CTL killing mechanisms are10.
perforin, granzymes, Fas-FasL interaction
i.CTL effector function is9.
intracellular pathogensh.IL-178.
IFN-γ production and macrophage activation g.
IL-4 and IL-13 induce also7.
mobilises and activates neutrophilsf.TH2 subpopulation induces6.
alternative macrophage activatione.TH2 cells are important for defense against
5.
TH1, TH2 i TH17d.TH2 effector function is4.
helminatsc.TH1 cells are important for defense against
3.
Inflammatory reaction rich in eosinophilsb.TH1 effector function is2.
production of IL-4, IL-5, IL-13a.Subpopulations of efektor CD4+ T-cells are
1.
1._____ 2._____ 3._____ 4._____ 5._____ 6._____ 7._____ 8._____ 9._____ 10.____d. g. h. a. c. b. e. f. j. i.