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Efector functions of CD4 + and CD8 + T-cells

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Page 1: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Efector functions of CD4+ and CD8+ T-cells

Page 2: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Naivna CD4+TNaive CD4+T

Th1

Th2

Th17

Defense- intracellular pathogens, stimulation of IgG production

Defense- helmints

Defense- extracellular bacteria, fungi

Organ-specific autoimmune diseases

Allergy

Autoimmunity and chronic inflammation

Page 3: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Naivna CD4+TNaive CD4+T

Th1

Th2

Th17

IL-4

IL-12

IL-23

T-bet

GATA-3

RORt

IL-4IL-5IL-13

Macrofage activation

B-cells

EosinophilactivationB-cells…

Neutrophil activation...

IL-17IL-22

IFN-γ

Page 4: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

TH1respons

e

Page 5: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Efector functions of TH1 cells• Macrophage activation at the site of infection

Page 6: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Efector functions of TH1 cells• Macrophage activation at the site of infection

Page 7: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Efector functions of TH1 cells• Macrophage activation at the site of infection

Page 8: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Efector functions of TH1 cells• Macrophage activation at the site of infection

Page 9: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Efector functions of TH1 cells• Macrophage activation at the site of infection

Page 10: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Efector functions of TH1 cells• Macrophage activation at the site of infection

Page 11: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Efector functions of TH1 cells• B-cell activation

Page 12: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Naivna CD4+TNaive CD4+T

Th1

Th2

Th17

Defense- intracellular pathogens, stimulation of IgG production

Defense- helmints

Defense- extracellular bacteria, fungi

Organ-specific autoimmune diseases

Allergy

Autoimmunity and chronic inflammation

Page 13: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

TH2response

Page 14: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production
Page 15: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production
Page 16: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production
Page 17: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Naivna CD4+TNaive CD4+T

Th1

Th2

Th17

Defense- intracellular pathogens, stimulation of IgG production

Defense- helmints

Defense- extracellular bacteria, fungi

Organ-specific autoimmune diseases

Allergy

Autoimmunity and chronic inflammation

Page 18: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production
Page 19: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

TH17response

Page 20: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Naivna CD4+TNaive CD4+T

Th1

Th2

Th17

Defense- intracellular pathogens, stimulation of IgG production

Defense- helmints

Defense- extracellular bacteria, fungi

Organ-specific autoimmune diseases

Allergy

Autoimmunity and chronic inflammation

Page 21: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

CTL effector function

Page 22: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Mechanisms ofCD8+ T-cellcytotoxicity

Page 23: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Mechanisms ofCD8+ T-cellcytotoxicity

Page 24: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Mechanisms ofCD8+ T-cellcytotoxicity

Page 25: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Mechanisms ofCD8+ T-cellcytotoxicity

Page 26: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

CD8+ CTLTarget cell

Mechanisms ofCD8+ T-cellcytotoxicity

Page 27: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

CD8+ CTL

perforinTarget cell

Mechanisms ofCD8+ T-cellcytotoxicity

Page 28: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

granzimi

apoptosis

CD8+ CTL

perforinTarget cell

Mechanisms ofCD8+ T-cellcytotoxicity

Page 29: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

FasL

CD8+ CTLTarget cell

Mechanisms ofCD8+ T-cellcytotoxicity

Page 30: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Ciljna ćelija

FasL Fas apoptosis

CD8+ CTL

Mechanisms ofCD8+ T-cellcytotoxicity

Page 31: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Pathogens avoid cellular immunity

Inhibition of fusion of phagosome with lysosome

Page 32: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Inhibition of presentation

of viral antigens

0

Page 33: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

Inhibition of immune response by virokines and viroreceptors

Page 34: Efector functions of CD4 + and CD8 + T-cells. Naivna CD4 + T Naive CD4 + T Th1 Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production

killing virus-infected and tumor cellsj.CTL killing mechanisms are10.

perforin, granzymes, Fas-FasL interaction

i.CTL effector function is9.

intracellular pathogensh.IL-178.

IFN-γ production and macrophage activation g.

IL-4 and IL-13 induce also7.

mobilises and activates neutrophilsf.TH2 subpopulation induces6.

alternative macrophage activatione.TH2 cells are important for defense against

5.

TH1, TH2 i TH17d.TH2 effector function is4.

helminatsc.TH1 cells are important for defense against

3.

Inflammatory reaction rich in eosinophilsb.TH1 effector function is2.

production of IL-4, IL-5, IL-13a.Subpopulations of efektor CD4+ T-cells are

1.

1._____ 2._____ 3._____ 4._____ 5._____ 6._____ 7._____ 8._____ 9._____ 10.____d. g. h. a. c. b. e. f. j. i.


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