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大阪大学大学院薬学研究科研究業績集(2005)

青字論文は薬学研究科内分野間共同研究

高分子化学 (Biophysical Chemistry) X-ray crystallography study on ribosome recycling: the mechanism of binding and action of RRF on the 50S ribosomal subunit Wilson DN, Schluenzen F, Harms JM, Yoshida T, Ohkubo T, Albrecht R, Buerger J, Kobayashi Y, Fucini P EMBO J., 24, 251-260 (2005) Different effects of 4-hydroxyproline and 4-fluoroproline on the stability of collagen triple helix Nishi Y, Uchiyama S, Doi M, Nishiuchi Y, Nakazawa T, Ohkubo T, Kobayashi Y Biochemistry, 44, 6034-6042 (2005) Solution NMR structure investigation for releasing mechanism of neocarzinostatin chromophore from the holoprotein Takashima H, Yoshida T, Ishino T, Hasuda K, Ohkubo T, Kobayashi Y J. Biol. Chem., 280, 11340-11346 (2005) Structural and functional study of an anemonia elastase inhibitor, a “nonclassical” Kazal-type inhibitor from Anemonia sulcata Hemmi H, Kumazaki T, Yoshizawa-Kumagaye K, Nishiuchi Y, Yoshida T, Ohkubo T, Kobayashi Y Biochemistry, 44, 9626-9636 (2005) Sulfoquinovosylmonoacylglycerol inhibitory mode analysis of rat DNA polymerase β Kasai N, Mizushina Y, Murata H, Yamazaki T, Ohkubo T, Sakaguchi K, Sugawara F FEBS J., 272, 4349-4361 (2005) Crystallization and preliminary X-ray crystallographic analysis of a conserved domain in plants and prokaryotes from Pyrococcus horikoshii OT3 Lin L, Nakano H, Uchiyama S, Fujimoto S, Matsunaga S, Nakamura S, Kobayashi Y, Ohkubo T, Fukui K Acta Cryst., F61, 414-416 (2005) Collagen-like triple helix formation of synthetic(Pro-Pro-Gly)10 analogues: (4(S)- hydroxyprolyl-4(R)-hydroxyprolyl-Gly)10, (4(R)-hydroxyprolyl-4(R)-hydroxyprolyl- -Gly)10 and (4(S)-fluoroprolyl-4(R)-fluoroprolyl-Gly)10 Doi M, Nishi Y, Uchiyama S, Nishiuchi Y, Nishio H, Nakazawa T, Ohkubo T, Kobayashi Y

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J. Pept. Sci., 11, 609-616 (2005) Cloning, expression, crystallization and preliminary X-ray characterization of cytochrome c552 from a moderate thermophilic bacterium, Hydrogenophilus thermoluteolus Ichiki S, Nakamura S, Ohkubo T, Kobayashi Y, Hasegawa J, Uchiyama S, Nishihara H, Mizuta K, Sambongi Y Acta Cryst., F61, 395-398 (2005) 機能素子化学 (Medicinal and Organic Chemistry) Bromoallenes as allyl dication equivalents in the absence of palladium(0): synthesis of bicyclic sulfamides by tandem cyclization of bromoallenes Hamaguchi H, Kosaka S, Ohno H, Tanaka T Angew. Chem. Int. Ed., 44, 1513-1517 (2005); Angew. Chem., 117, 1537-1541 (2005) Diastereoselective Ni(0)-catalyzed carbocyclization to chiral vinylic sulfoxide Maezaki N, Sawamoto H, Ishihara H, Tanaka T Chem. Commun., 3992-3994 (2005) Palladium(0)-catalyzed tandem cyclization of allenenes: direct construction of tricyclic heterocycles through aromatic C-H activation Ohno H, Miyamura K, Mizutani T, Kadoh Y, Takeoka Y, Hamaguchi H, Tanaka T Chem. Eur. J., 11, 3728-3741 (2005) Total synthesis of murisolins and evaluation of tumor-growth inhibitory activity Maezaki N, Tominaga H, Kojima N, Yanai M, Urabe D, Ueki R, Tanaka T, Yamori T Chem. Eur. J., 11, 6237-6245 (2005) Palladium-catalyzed tandem cyclization of bromoenynes through aromatic C-H bond functionalization Ohno H, Yamamoto M, Iuchi M, Tanaka T Angew. Chem. Int. Ed., 44, 5103-5106 (2005); Angew. Chem., 117, 5233-5236 (2005) Thermal intramolecular [2+2] cycloaddition of allenenes and allenynes: diastereoselective access to bicyclic nitrogen heterocycles Ohno H, Mizutani T, Kadoh Y, Miyamura K, Tanaka T Angew. Chem. Int. Ed., 44, 5113-5115 (2005); Angew. Chem., 117, 5243-5245 (2005) Chemo- and stereoselectivity in titanium-mediated regioselective ring-opening reaction of epoxides at the more substituted carbon

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Tanaka T, Hiramatsu K, Kobayashi Y, Ohno H Tetrahedron, 61, 6726-6742 (2005) Vinylaziridines in organic synthesis (Review) Ohno H Aziridines and Epoxides in Organic Synthesis, ed. by A. K. Yudin, Wiley-VCH, 37-71 (2005) Development of useful reactions based on the novel reactivities of allenic compounds and their application to tandem cyclizations (Review) Ohno H Yakugaku Zasshi, 125, 899-925 (2005) Development of useful reactions involving tandem cyclizations based on the novel reactivities of allenic compounds (Review) Ohno H Chem. Pharm. Bull., 53, 1211-1226 (2005) 生体機能分子化学（Bio-Functional Molecular Chemistry） Stimulation of hepatocyte survival and suppression of CCl4-induced liver injury by the adenovirally introduced C/EBPβ gene Isoda K, Koide H, Kojima M, Arita E, Ikkaku M, Higashiyama S, Tashiro F, Yamato E, Miyazaki J, Kawase M, Yagi K Biochem. Biophys. Res. Commun., 329, 182-187 (2005) Suppression of cell death in primary rat hepatocytes by α1-acid glycoprotein Kagaya N, Kamiyoshi A, Tagawa Y, Akamatsu S, Isoda K, Kawase M, Yagi K J. Biosci. Bioeng., 99, 81-83 (2005) Tea catechin, epigallocatechin-3-gallate, inhibits rubratoxin B-induced apoptosis of hepatocytes through MAPK p38 pathway Kagaya N, Kamiyoshi A, Tagawa Y, Nagashima H, Kawase M, Yagi K Mycotoxins, 55, 17-22 (2005) Interaction of rubratoxin B with serum albumin Kagaya N, Kamiyoshi A, Tagawa Y, Nagashima H, Kawase M, Yagi K Mycotoxins, 55, 23-26 (2005) Effect of zinc on hepatoprotectivity of α1-acid glycoprotein Kawase M, Kagaya N, Kamiyoshi A, Tagawa Y, Yagi K Biomed. Res. Trace Elements, 16, 299-301 (2005)

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Note in statistical treatment of medical and pharmaceutical data Kawase M, Konishi H, Yagi K, Nishikiori R, Takagi T J. Biosci. Bioeng., 100, 116-118 (2005) Unusual accumulation of demethylspheroidene in anaerobic-phototrophic growth of crtA-deleted mutants of Rhodovulum sulfidophilum Maeda I, Yamashiro H, Yoshioka D, Onodera M, Ueda S, Miyasaka H, Umeda F, Kawase M, Takaichi S, Yagi K Curr. Microbiol., 51, 193-197 (2005) Availability of bone marrow stromal cells in three-dimensional coculture with hepatocytes and transplantation into liver-damaged mice Takeda M, Yamamoto M, Isoda K, Higashiyama S, Hirose M, Ohgushi H, Kawase M, Yagi K J. Biosci. Bioeng., 100, 77-81 (2005) 標本再抽出法を用いた新規多重比較法の開発

高木達也, 岡本晃典, 錦織理華, 川下理日人, 山下典之, 安永照雄, 川瀬雅也 大阪大学サイバーメディアセンターニュース, 1, 3-11 (2005) 分子生物学 (Biochemistry and Molecular Biology) Stable expression and visualization of Mat-8 (FXYD-3) tagged with a fluorescent protein in Chinese Hamster Ovary (CHO)-K1 cells Arimochi J, Kobayashi A, Maeda M Biotechnol. Lett., 27,1017-1024 (2005) Characterization of cAMP-dependent proteolysis of GATA-6 Ishida A, Iijima R, Kobayashi A, Maeda M Biochem. Biophys. Res. Commun., 332, 976-981 (2005) Isolation of CHO-K1 clones defective in cAMP-dependent proteolysis, as determined by the stability of exogenously expressed GATA-6 Maeda M, Ishida A, Ni L, Kobayashi A Biochem. Biophys. Res. Commun., 329, 140-146 (2005) Further extension of mammalian GATA-6 (Review) Maeda M, Ohashi K, Ohashi-Kobayashi A Dev. Growth Differ., 47, 591-600 (2005)

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分子合成化学 (Synthetic Organic Chemistry) Efficient synthesis of thioesters and amides from aldehydes by using an intermolecular radical reaction in water Nambu H, Hata K, Matsugi M, Kita Y Chem. Eur. J., 11, 719-727 (2005) SnCl4-promoted rearrangement of 2,3-epoxy alcohol derivatives: stereochemical control of the reaction Kita Y, Matsuda S, Inoguchi R, Ganesh JK, Fujioka H Tetrahedron Lett., 46, 89-91 (2005) A double iodoetherification of σ-symmetric diene acetals for installing four stereogenic centers in a single operation: short asymmetric total synthesis of rubrenolide Fujioka H, Ohba Y, Hirose H, Murai K, Kita Y Angew. Chem. Int. Ed., 44, 734-737 (2005)

Novel and direct oxidative cyanation reactions of heteroaromatic compounds mediated by a hypervalent iodine(III) reagent Dohi T, Morimoto K, Kiyono Y, Tohma H, Kita Y Org. Lett., 7, 537-540 (2005) The novel and efficient direct synthesis of N,O-acetal compounds using a hypervalent iodine(III) reagent: an improved synthetic method for a key intermediate of discorhabdins Harayama Y, Yoshida M, Kamimura D, Kita Y Chem. Commun., 1764-1766 (2005) A unique site-selective reaction of ketones with new recyclable hypervalent iodine(III) reagents based on a tetraphenylmethane structure Dohi T, Maruyama A, Yoshimura M, Morimoto K, Thoma H, Shiro M, Kita Y Chem. Commun., 2205-2207 (2005) A mild and efficient one-pot synthesis of 2-dihydroimidazoles from aldehydes Fujioka H, Murai K, Ohba Y, Hiramatsu A, Kita Y Tetrahedron Lett., 46, 2197-2199 (2005)

Lipase-catalyzed domino kinetic resolution of α-hydroxynitrones/intramolecular

1,3-dipolar cycloaddition: a concise asymmetric total synthesis of (－ )-rosmarinecine

Akai S, Tanimoto K, Kanao Y, Omura S, Kita Y Chem. Commun., 2369-2371 (2005)

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A new synthesis of dienone lactones using a combination of hypervalent iodine(III) reagent and heteropoly acid Hata K, Hamamoto H, Shiozaki Y, Kita Y Chem. Commun., 2465-2467 (2005) The synthesis of head-to-tail (H-T) dimers of 3-substituted thiophenes by the hypervalent iodine(III)-induced oxidative biaryl coupling reaction Dohi T, Morimoto K, Kiyono Y, Maruyama A, Tohma H, Kita Y Chem. Commun., 2930-2932 (2005) Asymmetric synthesis by the intramolecular haloetherification reaction of ene acetal: discrimination of prochiral dienes in cyclohexane systems Fujioka H, Kotoku N, Sawama Y, Kitagawa H, Ohba Y, Wang TL, Nagatomi Y, Kita Y Chem. Pharm. Bull., 53, 952-957 (2005) Mild and efficient removal of hydroxyethyl unit from 2-hydroxyethyl ether derivatives leading to alcohols Fujioka H, Ohba Y, Hirose H, Murai K, Kita Y Org. Lett., 7, 3303-3306 (2005) Domino reaction of 2,3-epoxy-1-alcohols and PIFA in the presence of H2O and the concise synthesis of (+)-tanikolide Kita Y, Matsuda S, Fujii E, Horai M, Hata K, Fujioka H Angew. Chem. Int. Ed., 44, 5857-5860 (2005) Versatile hypervalent-iodine(III)-catalyzed oxidations with m-chloroperbenzoic acid as a cooxidant Dohi T, Maruyama A, Yoshimura M, Morimoto K, Tohma H, Kita Y Angew. Chem. Int. Ed., 44, 6193-6196 (2005) Asymmetric total synthesis of fredericamycin A : an intramolecular cycloaddition pathway Akai S, Tsujino T, Fukuda N, Iio K, Takeda Y, Kawaguchi K, Naka T, Higuchi K, Akiyama E, Fujioka H, Kita Y Chem. Eur. J., 11, 6286-6297 (2005) Hypervalent iodine(III) reagent-promoted rearrangement and subsequent oxidative ring cleavage of cyclic 2,3-epoxy-1-alcohol derivatives Kita Y, Matsuda S, Fujii E, Kitagaki S, Inoguchi R, Hata K, Fujioka H Heterocycles, 66, 309-317 (2005) Pyrroloiminoquinone alkaloids: discorhabdins and makaluvamines (Review)

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Harayama Y, Kita Y Cur. Org. Chem. 9. 1567-1588 (2005) Development of highly stereoselective reactions using lone pairs of oxygen atoms (Review) Fujioka H Yakugaku Zasshi, 125, 699-715 (2005)

ディスコハブディン類の合成：超原子価ヨウ素化合物の反応

北泰行, 原山悠, 当麻博文

現代化学・増刊, 43, 166-180 (2005)

ターゲット分子の合成と生体分子・医薬品の化学

北泰行, 赤井周司

化学系薬学Ⅱ（日本薬学会編,東京化学同人）, 4-19 (2005)

超原子価ヨウ素化合物を用いる有機合成

土肥寿文, 北泰行

ファインケミカルズシリーズ ヨウ素化合物の機能と応用（シーエムシー出版）, 105-115 (2005) 分子反応解析学 (Analytical Chemistry) Notable deuterium effect on the electron transfer rate of myoglobin Mie Y, Yamada C, Uno T, Neya S, Mizutani F, Nishiyama K, Taniguchi I Chem. Commun., 250-252 (2005) Stabilization of guanine quadruplex DNA by the binding of porphyrins with cationic side arms Yamashita T, Uno T, Ishikawa Y Bioorg. Med. Chem., 13, 2423-2430 (2005) Direct electrochemistry of engineered cytochrome b562 molecules with a ligand binding pocket Mie Y, Mizutani F, Uno T, Yamada C, Nishiyama K, Taniguchi I J. Inorg. Biochem., 99, 1245-1249 (2005) The strucrural properties of multiple myoglobin mutants as revealed by X-ray crystallography Kiyota K, Tomisugi Y, Ishikawa Y, Ikemizu S. Uno T 薬学雑誌, 125, Suppl.1, 77 (2005)

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A design of fluorescent probes for superoxide based on a nonredox mechanism Maeda H, Yamamoto K, Nomura Y, Kohno I, Hafsi L, Ueda N, Yoshida S, Fukuda M, Fukuyasu Y, Yamauchi Y, Itoh N J. Am. Chem. Soc., 127, 68-69 (2005) High performance liquid chromatography equipped with a cathodic detector and column-switching device as a high-throughput method for a phosphatase assay with p-nitrophenyl phosphate Yamauchi Y, Ido M, Maeda H J. Chromatogr. A, 1066, 127-132 (2005) 2,4-Dinitrobenzenesulfonyl fluoresceins as fluorescent alternatives to Ellman's reagent in thiol-quantification enzyme assays Maeda H, Matsuno H, Ushida M, Katayama K, Saeki K, Itoh N Angew. Chem. Int. Ed., 44, 2922-2925 (2005) Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin Sawai H, Makino M, Mizutani Y, Ohta T, Sugimoto H, Uno T, Kawada N, Yoshizato K, Kitagawa T, Shiro Y Biochemistry, 44, 13257-13265 (2005) Important role of the 3-mercaptopropionamide moiety in glutathione: promoting effect on decomposition of the adduct of glutathione with the oxoammonium ion of TEMPO Maeda H, Wu HY, Yamauchi Y, Ohmori H J. Org. Chem., 70, 8338-8343 (2005)

レーザーラマン分光光度計

宇野公之, 西村善文

機器分析の事典 (日本分析化学会編, 朝倉書店), 130-132 (2005)

顕微ラマン分光光度計

宇野公之, 西村善文

機器分析の事典 (日本分析化学会編, 朝倉書店), 133-134 (2005)

薬用資源解析学（三栄源エフ・エフ・アイ）寄附講座 (Medicinal Plant Resource Exploration)

Metabolic behavior of enzymatically modified isoquercitrin by α-amylase and gastric juices Tamura S, Tsuji K, Moriwaki M, Murakami N

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Jpn. J. Food Chem., 12, 152-156 (2005) Enhancement of anthocyanin content in red radishes (Raphanus sativus L.) by γ-ray irradiation Tsuji K, Tamura S, Ohno T, Koda T, Murakami N Jpn. J. Food Chem., 12, 162-165 (2005) Kola acuminata proanthocyanidins: a class of anti-trypanosomal compounds effective against Trypanosoma brucei Kubata BK, Nagamune K, Murakami N, Merkel P, Kabututu Z, Martin SK, Kalulu TM, Mustakuk H, Yoshida M, Ohnishi-Kameyama M, Kinoshita T, Duszenko M, Urade Y Int. J. Parasitol., 35, 91-103 (2005)

細胞生物学 (Cell Biology)

Direct interaction of multidrug efflux transporter AcrB and outer membrane channel TolC detected via site-directed disulfide cross-linking Tamura N, Murakami S, Oyama Y, Ishiguro M, Yamaguchi A Biochem., 44, 11115-11121 (2005) ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms Kubo Y, Sekiya S, Ohigashi M, Takenaka C, Tamura K, Nada S, Nishi T, Yamamoto A, Yamaguchi A Mol. Cell. Biol ., 25, 4138-4149 (2005) Genome-Wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system Nishino K, Honda T, Yamaguchi A J. Bacteriol., 187, 1763-1772 (2005) Indole induces the expression of multidrug exporter genes in Escherichia coli Hirakawa H, Inazumi Y, Masaki T, Hirata T, Yamaguchi A Mol. Microbiol., 55, 1113-1126 (2005)

多剤耐性化を引き起こす薬剤排出タンパク質 (Review) 村上聡（分担執筆） タンパク質のかたちから生命の謎を解く 生物マシーナリー構造生物学の最前線, 178-190 (2005)

異物排出タンパク質、ABC トランスポーター (Review)

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山口明人（分担執筆）

タンパク質科学 構造・物性・機能, 505-517 (2005) 生物有機化学 (Bioorganic Chemistry)

Adjustment of theγdihedral angle of an oligonucleotide P3' N5' phosphoramidate enhances its binding affinity towards complementary strands Obika S, Sekiguchi M, Somjing R, Imanishi T Angew. Chem. Int. Ed., 44, 1944-1947 (2005); Angew. Chem., 117, 1980-1983 (2005) Synthesis and triplex-forming ability of 2',4'-BNAs bearing imidazoles as a nucleobase Hari Y, Obika S, Inohara H, Ikejiri M, Une D, Imanishi T Chem. Pharm. Bull., 53, 843-846 (2005) Promotion of stable triplex formation by partial incorporation of 2',5'-phosphodiester linkages into triplex-forming oligonucleotides Obika S, Hiroto A, Nakagawa O, Imanishi T Chem. Commun., 2793-2795 (2005) Combination of poly(L-lysine)-graft-dextran copolymer and 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) modification synergistically stabilizes pyrimidine motif triplex at neutral pH Torigoe H, Katayama T, Obika S, Maruyama A, Imanishi T Nucleosides, Nucleotides, Nucleic Acids, 24, 635-638 (2005)

Presence of 2',5'-linkages in a homopyrimidine DNA oligonucleotide promotes stable triplex formation under physiological conditions Obika S, Hiroto A, Nakagawa O , Imanishi T Nucleosides, Nucleotides, Nucleic Acids, 24, 1055-1058 (2005) Synthesis and properties of a novel bridged nucleic acid analogue, 5'-amino-3',5'-BNA Sekiguchi M, Obika S, Somjing R , Imanishi T Nucleosides, Nucleotides, Nucleic Acids, 24, 1097-1100 (2005) Synthesis and properties of 2',4'-BNANC, a second generation BNA Rahman SMA, Seki S, Utsuki K, Obika S, Miyashita K, Imanishi T Nucleic Acids Symp. Ser., 49, 5-6 (2005) Promotion of acid-mediated cleavage of oligonucleotide P3'→N5’phosphoramidates by triplex formation: a novel approach to sequence-specific DNA detection Tomizu M, Nakagawa O, Obika S, Imanishi T

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Nucleic Acids Symp. Ser., 49, 157-158 (2005) Synthesis and triplex-forming properties of 2',4'-BNA derivatives bearing pyridines as an unnatural nucleobase Matsugu S, Inohara H, Obika S, Imanishi T Nucleic Acids Symp. Ser., 49, 159-160 (2005) Effects of the 2',4'-BNA modification on the sequence specificity of molecular beacons Fujii S, Obika S, Imanishi T Nucleic Acids Symp. Ser., 49, 211-212 (2005) Antigene-block strategy: effective regulation of gene expression by 2',4'-BNA-modified TFOs with an additional stem-loop structure Tsuda N, Matsumoto A, Ito A, Uneda T, Tanabe A, Obika S, Imanishi T Nucleic Acids Symp. Ser., 49, 335-336 (2005) Syntheses of natural products having an epoxyquinone structure (Review) Miyashita K, Imanishi T Chem. Rev., 105, 4515-4536（2005） Sugar-modified nucleic acid analogues as potential materials for genomic technologies (Review) Imanishi T, Obika S Frontiers in Organic Chemistry, Atta-ur-Rahman Ed., Bentham Science Publishers, 209-228 (2005) Effect of modifications on the intracellular activity of a DNA enzyme (Review) Warashina M, Nawrot B, Obika S, Woniak LA, Kuwabara T, Imanishi T, Stec WJ, Taira K Synthetic Nucleic Acids as Inhibitors of Gene Expression, Khachigian L M Ed., CRC Press, 95-113 (2005) 新規 RNA 型人工核酸 (Review) 今西武, 小比賀聡

臨床化学, 34, 224-232 (2005)

高機能化 siRNA による遺伝子発現抑制－BNA による siRNA の機能化－ (Review) 津田直人, 小比賀聡, 今西武

バイオテクノロジージャーナル, 5, 738-742 （2005）

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細胞生理学 (Immunology)

The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effects Shimozato O, Ugai S, Chiyo M, Takenobu H, Nagakawa H, Wada A, Kawamura K, Yamamoto H, Tagawa M Immunology, 117, 22-28 (2005) High expression of a new marker PCA-1 in human prostate carcinoma Konishi N, Nakamura M, Ishida E, Shimada K, Mitsui E, Yoshikawa R, Yamamoto H, Tsujikawa K Clin. Cancer Res., 11, 5090-5097 (2005)

MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 or estradiol-17 (β-D-glucuronate) Noguchi T, Ren XQ, Aoki S, Igarashi Y, Che XF, Nakajima Y, Takahashi H, Mitsuo R, Tsujikawa K, Sumizawa T, Haraguchi M, Kobayashi M, Goto S, Kanehisa M, Aikou T, Akiyama S, Furukawa T Biochem. Pharmacol., 70, 1056-1065 (2005) 毒性学 (Toxicology) Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions Nakanishi T, Nishikawa J, Hiromori Y, Yokoyama H, Koyanagi M, Takasuga S, Ishizaki J, Watanabe M, Isa S, Utoguchi N, Itoh N, Kohno Y, Nishihara T, Tanaka K Mol. Endocrinol., 19, 2502-2516 (2005) Reduced bactericidal activity and nitric oxide production in metallothionein-deficient macrophages in response to lipopolysaccharide stimulation Itoh N, Shibayama H, Kanekiyo M, Namphung D, Nakanishi T, Matsuyama A, Odani T, Tanaka K Toxicology, 216, 188-196 (2005) Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor (PPAR) γ/retinoid X receptor (RXR) pathway Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J Mol. Pharmacol., 67, 766-774 (2005) STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart

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Oshima Y, Fujio Y, Nakanishi T, Itoh N, Yamamoto Y, Negoro S, Tanaka K, Kishimoto T, Kawase I, Azuma J Cardiovasc. Res., 65, 428-435 (2005) A design of fluorescent probes for superoxide based on a nonredox mechanism Maeda H, Yamamoto K, Nomura Y, Kohno I, Hafsi L, Ueda N, Yoshida S, Fukuda M, Fukuyasu Y, Yamauchi Y, Itoh N J. Am. Chem. Soc., 127, 68-69 (2005) 2,4-Dinitrobenzenesulfonyl fluoresceins as fluorescent alternatives to Ellman's reagent in thiol-quantification enzyme assays Maeda H, Matsuno H, Ushida M, Katayama K, Saeki K, Itoh N Angew. Chem. Int. Ed., 44, 2922-2925 (2005) Some organotin compounds enhance histone acetyltransferase activity Osada S, Nishikawa J, Nakanishi T, Tanaka K, Nishihara T Toxicol. Lett., 155, 329-335 (2005) Comparison of transgene expression mediated by several fiber-modified adenovirus vectors in trophoblast cells Koizumi N, Kondoh M, Mizuguchi H, Nakanishi T, Masuyama A, Ida F, Fujii M, Hayakawa T, Nakashima E, Tanaka K, Watanabe Y Placenta, 26, 729-734 (2005) Characterization and carcinogenic risk assessment of polycyclic aromatic hydrocarbons in the respirable fraction of airborne particles in the bangkok metropolitan area Norramit P, Cheevaporn V, Itoh N, Tanaka K J. Health Science, 51,.437-446 (2005) 神経薬理学 (Molecular Neuropharmacology) Sulpiride in combination with fluvoxamine increases in vivo dopamine release selectively in rat prefrontal cortex Ago Y, Nakamura S, Baba A, Matsuda T Neuropsychopharmacology, 30, 43-51 (2005) SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger, attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia Nagano T, Osakada M, Ago Y, Koyama Y, Baba A, Maeda S, Takemura M, Matsuda T Br. J. Pharmacol., 144, 669-679 (2005)

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Differential expression of mRNAs for PACAP and its receptors during neural differentiation of embryonic stem cells Hirose M, Hashimoto H, Shintani N, Nakanishi M, Arakawa N, Iga J, Niwa H, Miyazaki J, Baba A Regul. Pept., 126, 109-113 (2005) Neuroprotective action of endogenous PACAP in cultured rat cortical neurons Shintani N, Suetake S, Hashimoto H, Koga K, Kasai A, Kawaguchi C, Morita Y, Hirose M, Sakai Y, Tomimoto S, Matsuda T, Baba A Regul. Pept., 126, 123-128 (2005) Monoaminergic neuronal development is not affected in PACAP-gene-deficient mice Ogawa T, Nakamachi T, Ohtaki H, Hashimoto H, Shintani N, Baba A, Watanabe J, Kikuyama S, Shioda S Regul. Pept., 126, 103-108 (2005) Endothelin increases expression of exon III- and exon IV-containing brain-derived neurotrophic factor transcripts in cultured astrocytes and rat brain Koyama Y, Tsujikawa K, Matsuda T, Baba A J. Neurosci., Res. 80, 809-816 (2005) Antidepressant-like effect of coadministration of sulpiride and fluvoxamine in mice Ago Y, Harasawa T, Itoh S, Nakamura S, Baba A, Matsuda T Eur. J. Pharmacol., 520, 86-90 (2005) Mechanism for serotonin1A receptor activation-induced reversal of methamphetamine- induced behavioral sensitization in mice: a study using microdialysis Ago Y, Nakamura S, Baba A, Matsuda T Yakugaku Zasshi 125 (Suppl. 2), 31-33 (2005) Effect of the selective serotonin1A receptor agonist osemozotan on cocaine-induced behavioral sensitization in mice Nakamura S, Ago Y, Baba A, Matsuda T Yakugaku Zasshi, 125 (Suppl. 2), 104-105 (2005) Endothelins stimulate the expression of neurotrophin-3 in rat brain and rat cultured astrocytes Koyama Y, Baba A, Matsuda T Neuroscience, 136, 425-433 (2005) Effect of zotepine on dopamine, serotonin and noradrenaline release in rat prefrontal cortex

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Nakamura S, Ago Y, Itoh S, Koyama Y, Baba A, Matsuda T Eur. J. Pharmacol., 528, 95-98 (2005) Functional proteins involved in regulation of intracellular Ca2+ for drug development: pharmacology of SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger (Review) Matsuda T, Koyama Y, Baba A J. Pharmacol. Sci., 97, 339-343 (2005) PACAP ノックアウトマウス-新しい精神機能障害モデル (Review) 新谷紀人, 田中一裕, 橋本均, 馬場明道

脳 21, 8, 16-20 (2005) 抗てんかん薬 松田敏夫, 馬場明道 カッツング薬理学, 原著 9 巻（丸善）, 419-442 (2005) 全身麻酔薬 松田敏夫, 馬場明道 カッツング薬理学、原著 9版（丸善）, 443-459 (2005) 薬剤学 (Biopharmaceutics) Immunological properties and vaccine efficacy of murine dendritic cells simultaneously expressing melanoma-associated antigen and interleukin-12 Okada N, Iiyama S, Okada Y, Mizuguchi H, Hayakawa T, Nakagawa S, Mayumi T, Fujita T, Yamamoto A Cancer Gene Ther., 12, 72-83 (2005) Augmentation of the migratory ability of DC-based vaccine into regional lymph nodes by efficient CCR7 gene transduction Okada N, Mori N, Koretomo R, Okada Y, Nakayama T, Yoshie O, Mizuguchi H, Hayakawa T, Nakagawa S, Mayumi T, Fujita T, Yamamoto A Gene Ther., 12, 129-139 (2005) Fusogenic liposome can be used as an effective vaccine carrier for peptide vaccination to induce cytotoxic T lymphocyte (CTL) response Sugita T, Yoshikawa T, Gao JQ, Shimokawa M, Oda A, Niwa T, Akashi M, Tsutsumi Y, Mayumi T, Nakagawa S Biol. Pharm. Bull., 28, 192-193 (2005) Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector

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into cells Maeda M, Kida S, Hojo K, Eto Y, Gao JQ, Kurachi S, Sekiguchi F, Mizuguchi H, Hayakawa T, Mayumi T, Nakagawa S, Kawasaki K Bioorganic & Medicinal Chemistry Letters, 15 , 621-624 (2005) Preparation and characterization of liposomes encapsulating chitosan nanoparticles Huang YZ, Gao JQ, Liang WQ, Nakagawa S Biol. Pharm. Bull., 28, 387-390 (2005) A single intratumoral injection of a fiber-mutant adenoviral vector encoding interleukin 12 induces remarkable anti-tumor and anti-metastatic activity in mice with Meth-A fibrosarcoma Gao JQ, Sugita T, Kanagawa N, Iida K, Eto Y, Motomura Y, Mizuguchi H, Tsutsumi Y, Hayakawa T, Mayumi T, Nakagawa S Biochemical and Biophysical Research Communications, 328, 1043-1050 (2005) RNA interference of PPARγ using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells Hosono T, Mizuguchi H, Katayama K, Koizumi N, Kawabata K, Yamaguchi T, Nakagawa S, Watanabe Y, Mayumi T, Hayakawa T Gene, 348, 157-165 (2005) PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability Eto Y, Gao JQ, Sekiguchi F, Kurachi S, Katayama K, Maeda M, Kawasaki K, Mizuguchi H, Hayakawa T, Tsutsumi Y, Mayumi T, Nakagawa S J. Gene Med., 7, 604-612 (2005) Anti-tumor responses induced by chemokine CCL19 transfected into an ovarian carcinoma model via fiber-mutant adenovirus vector Gao JQ, Sugita T, Kanagawa N, Iida K, Okada N, Mizuguchi H, Nakayama T, Hayakawa T, Yoshie O, Tsutsumi Y, Mayumi T, Nakagawa S Biol. Pharm. Bull., 28, 1066-1070 (2005) Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma Okada Y, Okada N, Mizuguchi H, Hayakawa T, Nakagawa S, Mayumi T Cancer Gene Therapy, 12, 608-616 (2005) Fusogenic liposome delivers encapsulated nanoparticles for cytosolic controlled gene release Kunisawa J, Masuda T, Katayama K, Yoshikawa T, Tsutsumi Y, Akashi M, Mayumi T,

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Nakagawa S J. Control. Release, 105 , 344-353 (2005) Optimization of protein therapies by polymer-conjugation as an effective DDS (Review) Shibata H, Nakagawa S, Tsutsumi Y Molecules, 10 , 162-180 (2005) Nuclear receptors as targets for drug development: the role of nuclear receptors during neural stem cell proliferation and differentiation (Review) Katayama K, Wada K, Nakajima A, Kamisaki Y, Mayumi T J. Pharmacol. Sci., 97 , 171-176 (2005) Analysis of immune cell-recruitment and tumor suppressive effect in murine B16BL6 melanama injected with chemokine-expressing adenoviral vector (Review) Niwa M, Okada N, Sasaki A, Hatanaka Y, Tani Y, Mizuguchi H, Nakagawa S, Fujita T, Yamamoto A Drug METABOLISMREVIEWS, 37, 725-726 (2005) Cell delivery systemに基づく次世代がん免疫療法 (Review) 杉田敏樹, 高建青, 中川晋作 Drug Delivery System, 20, 42-48 (2005) 細胞内DDSによるナノ治療システムの開発 (Review) 吉川友章，中川晋作 日本香粧品学会誌, 29 , 235-239 (2005) 細胞性製剤と細胞送達システム (Cell Delivery System) ( Review) 中川晋作，真弓忠範 PHARM TECH JAPAN, 21, 164-167 (2005) 天然物化学 (Natural Product Chemistry) MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 or estradiol-17 (β-D-glucuronate) Noguchi T, Ren XQ, Aoki S, Igarashi Y, Che XF, Nakajima Y, Takahashi H, Mitsuo R, Tsujikawa K, Sumizawa T, Haraguchi M, Kobayashi M, Goto S, Kanehisa M, Aikou T, Akiyama S, Furukawa T Biochemical Pharmacology , 70, 1056-1065 (2005)

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Shimalactone A, a novel polyketide, from marine-derived fungus Emericella variecolor GF10 Wei H, Itoh T, Kinoshita M, Kotoku N, Aoki S, Kobayashi M Tetrahedron, 61, 8054-8058 (2005) Efficient total synthesis of bastadin 6, an anti-angiogenic brominated tyrosine-derived metabolite from marine sponge Kotoku N, Tsujita H, Hiramatsu A, Mori C, Koizumi N, Kobayashi M Tetrahedron, 61, 7211-7218 (2005) Absolute stereo-structure of kendarimide A, a novel MDR modulator, from a marine sponge Kotoku N, Cao L, Aoki S, Kobayashi M Heterocycles, 65, 563-578 (2005) GSH inhibits trypsinization of the C-terminal half of human MRP1 Ren XQ, Furukawa T, Nakajima Y, Takahashi H, Aoki S, Sumizawa T, Haraguchi M, Kobayashi M, Chijiiwa K, Akiyama S J. Biol. Chem., 280, 6231-6237 (2005) 複合薬物動態学（Medicinal Pharmacology）

Sulpiride in combination with fluvoxamine increases in vivo dopamine release selectively in rat prefrontal cortex Ago Y, Nakamura S, Baba A, Matsuda T Neuropsychopharmacology, 30, 43-51 (2005) Neuroprotective action of endogenous PACAP in cultured rat cortical neurons Shintani N, Suetake S, Hashimoto H, Koga K, Kasai A, Kawaguchi C, Morita Y, Hirose M, Sakai Y, Tomimoto S, Matsuda T, Baba A Regul. Pept., 126, 123-128 (2005) SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger, attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia Nagano T, Osakada M, Ago Y, Koyama Y, Baba A, Maeda S, Takemura M, Matsuda T Br. J. Pharmacol., 144, 669-679 (2005) Antidepressant-like effect of coadministration of sulpiride and fluvoxamine in mice Ago Y, Harasawa T, Itoh S, Nakamura S, Baba A, Matsuda T Eur. J. Pharmacol., 520, 86-90 (2005)

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Endothelins stimulate the expression of neurotrophin-3 in rat brain and rat cultured astrocytes Koyama Y, Baba A, Matsuda T Neuroscience, 136, 425-433 (2005) Mechanism for serotonin1A receptor activation-induced reversal of methamphetamine- induced behavioral sensitization in mice: a study using microdialysis Ago Y, Nakamura S, Baba A, Matsuda T Yakugaku Zasshi, 125 (Suppl. 2), 31-33 (2005) Effect of the selective serotonin1A receptor agonist osemozotan on cocaine-induced behavioral sensitization in mice Nakamura S, Ago Y, Baba A, Matsuda T Yakugaku Zasshi, 125 (Suppl. 2), 104-105 (2005) Effect of zotepine on dopamine, serotonin and noradrenaline release in rat prefrontal cortex Nakamura S, Ago Y, Itoh S, Koyama Y, Baba A, Matsuda T Eur. J. Pharmacol., 528, 95-98 (2005) Endothelin increases expression of exon III- and exon IV-containing brain-derived neurotrophic factor transcripts in cultured astrocytes and rat brain Koyama Y, Tsujikawa K, Matsuda T, Baba A J. Neurosci. Res., 80, 809-816 (2005) Functional proteins involved in regulation of intracellular Ca2+ for drug development: pharmacology of SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger (Review) Matsuda T, Koyama Y, Baba A J. Pharmacol. Sci., 97, 339-343 (2005) グリア細胞の遅発性アポトーシス (Review) 田熊一敞, 山田清文, 松田敏夫 Clinical Neuroscience , 23, 181-183 (2005) 抗てんかん薬

松田敏夫, 馬場明道 カッツング薬理学, 原著 9 版, (丸善株式会社）, 419-442 (2005) 全身麻酔薬

松田敏夫, 馬場明道 カッツング薬理学, 原著 9 版, (丸善株式会社）, 443-459 (2005)

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薬の副作用

松田敏夫 スタンダード薬学シリーズ 6, 薬と疾病Ⅰ, 薬の効くプロセス,（日本薬学会編, 東京化

学同人）, 47-50 (2005) 臨床薬効解析学 (Clinical Evaluation of Medicines and Therapeutics) Novel structure of the CYP2D6 gene that confuses genotyping for the CYP2D6*5 allele Fukuda T, Maune H, Ikenaga Y, Naohara M, Fukuda K, Azuma J Drug Metab. Pharmacokinet. 20, 345-350 (2005) No positive association between adrenergic receptor variants of α2cDel322-325, β1Ser49, β1Arg389 and the risk for heart failure in the Japanese population Nonen S, Okamoto H, Akino M, Matsui Y, Fujio Y, Yoshiyama M, Takemoto Y, Yoshikawa J, Azuma J, Kitabatake A British J. Clin. Pharmacol., 60, 414-417 (2005) Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages Sumita C, Yamane M, Matsuda T, Maeda M, Nariai T, Fujio Y, Azuma J FEBS letters, 579, 4038-4042 (2005) The frequency of candidate alleles for CYP2D6 genotyping in the Japanese population with an additional respect to the -1584C to G substitution Ikenaga Y, Fukuda T, Fukuda K, Nishida Y, Naohara M, Maune H, Azuma J Drug Metab. Pharmacokinet., 20, 113-116 (2005) Influence of itraconazole Co-administration and CYP2D6 genotype on the pharmacokinetics of the new antipsychotic ARIPIPRAZOLE Kubo M, Koue T, Inaba A, Takeda H, Maune H, Fukuda T, Azuma J Drug Metab. Pharmacokinet., 20, 55-64 (2005) STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart Oshima Y, Fujio Y, Nakanishi T, Itoh N, Yamamoto Y, Negoro S, Tanaka K, Kishimoto T, Kawase I, Azuma J Cardiovasc. Res., 65, 428-435 (2005) N-cadherin-mediated cell adhesion determines the plasticity for cell alignment in response to mechanical stretch in cultured cardiomyocytes Matsuda T, Takahashi K, Nariai T, Ito T, Takatani T, Fujio Y, Azuma J

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Biochem. Biophys. Res. Commun. 326, 228-232 (2005) Marked hyperglycemia after androgen-deprivation therapy for prostate cancer and usefulness of pioglitazone for its treatment Inaba M, Otani Y, Nishimura K, Takaha N, Okuyama A, Koga M, Azuma J, Kawase I, Kasayama S Metabolism, 54, 55-59 (2005)

Controlled clinical comparison of paroxetine and fluvoxamine considering the serotonin transporter promoter polymorphism Kato M, Ikenaga Y, Wakeno M, Okugawa G, Nobuhara K, Fukuda T, Fukuda K, Azuma J, Kinoshita T Int. Clin. Psychopharmacol., 20, 151-156 (2005) 循環器疾患用薬のファーマコジェノミクスと薬剤感受性

南畝晋平, 藤尾慈, 東純一

最新医学, 60, 1891-1897 (2005)

遺伝子多型情報に基づく投与指針作成に向けて－CYP2C9－

田邊智子, 福田剛史, 大野雅子, 景山茂, 東純一

臨床薬理, 36, 255-260 (2005)

DE-091 錠（メトレートⓇ錠 2mg）の生物学的同等性試験

檜垣實男, 東純一

新薬と臨牀, 54, 215-223 (2005)

リマプロスト アルファデクス（プロレナールⓇ）の単回経口投与による臨床薬物動

態試験

三上洋, 薮野孝, 竹本勇一, 日下典子, 伊藤忠雄, 東純一

臨床医薬, 21, 361-366 (2005)

SSRI 血中濃度の個体差に影響を及ぼす因子の解析

福田剛史, 池永有香, 加藤正樹, 分野正貴, 福田和大, 山下恵実, 奥川学, 延原健二, 木下利彦, 東純一

TDM 研究, 22, 175-176 (2005)

薬物代謝酵素の遺伝子型情報を加味した生理学的薬物動態解析

大本まさのり, 大野雅子, 福田剛史, 渡邊悠貴, 赤澤堅造, 東純一

TDM 研究, 22, 173-174 (2005) N-アセチルトランスフェラーゼ 2遺伝子多型に基づいた結核治療の試み

窪田竜二, 大野雅子, 安永実沙, 横田総一郎, 前倉亮二, 東純一

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TDM 研究, 22, 336-340 (2005) Progress in research on function and mechanism of cardiac vascular system of taurine (Review) Hua HM, Ito T, Qiu ZG, Azuma J Zhongguo Zhongyao Zazhi, 30, 653-658 (2005)

チトクロム P450 の遺伝子多型と個別化医療 (Review) 福田剛史, 東純一

Molecular Medicine, 42, 903-911 (2005) FDA ファーマコゲノミクスガイダンス－医薬品開発に対するインパクト－

Ronald A. Salerno (Wyeth Research), 訳:東純一, 加藤恭一

臨床評価, 32, 311-322 (2005)

医薬情報解析学 (Pharmaceutical Information Science) Note in statistical treatment of medical and pharmaceutical data Kawase M, Konishi H, Yagi K, Nishikiori R, Takagi T J. Biosci. Bioeng., 100, 116-118 (2005) 標本再抽出法を用いた新規多重比較法の開発

高木達也, 岡本晃典, 錦織理華, 川下理日人, 山下典之, 安永照雄, 川瀬雅也 大阪大学サイバーメディアセンターニュース, 1, 3-11 (2005)

多重比較入門 (Review) 高木達也, 岡本晃典

CICSJ Bull., 23, 2-8 (2005)

統計学は役に立つのか？(Review) 高木達也

CICSJ Bull., 23, 61-64 (2005) 一ユーザーから見た情報の安全と安心～巻頭言に変えて (Review) 高木達也

CICSJ Bull., 23, 75-78 (2005)

分子生理病態学 (Molecular Pathophysiology) Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into

23

cardiac myocytes Kawamura T, Ono K, Morimoto T, Wada H, Hirai M, Hidaka K, Morisaki T, Heike T, Nakahata T, Kita T, Hasegawa K J. Biol. Chem., 280, 19682-19688 (2005) Proteasomal degradation of Kir6.2 channel protein and its inhibition by a Na+ channel blocker aprindine Tanaka H, Miake J, Notsu T, Sonyama K, Sasaki N, Iitsuka K, Kato M, Taniguchi S, Igawa O, Yoshida A, Shigemasa C, Hoshikawa Y, Kurata Y, Kuniyasu A, Nakayama H, Inagaki N, Nanba E, Shiota G, Morisaki T, Ninomiya H, Kitakaze M, Hisatome I Biochem. Biophys. Res. Commun., 331, 1001-1006 (2005) Partial correction of abnormal cardiac development in caspase-8-deficient mice by cardiomyocyte expression of p35 Yajima N, Yamada S, Morisaki T, Toyokuni S, Yonehara S, Sakamaki K Transgenic Res., 14, 593-604 (2005) Recombinant HBsAg inhibits LPS-induced COX-2 expression and IL-18 production by interfering with the NFκB pathway in a human monocytic cell line, THP-1 Cheng J, Imanishi H, Morisaki H, Liu W, Nakamura H, Morisaki T, Hada T J. Hepatol., 43, 465-471 (2005) Stable and uniform gene suppression by site-specific integration of siRNA expression cassette in murine embryonic stem cells Zheng GD, Hidaka K, Morisaki T Stem Cells, 23, 1028-1034 (2005) Subtype switching of T-type Ca2+ channels from Cav3.2 to Cav3.1 during differentiation of embryonic stem cells to cardiac cell lineage Mizuta E, Miake J, Yano S, Furuichi H, Manabe K, Sasaki N, Igawa O, Hoshikawa Y, Shigemasa C, Nanba E, Ninomiya H, Hidaka K, Morisaki T, Tajima F, Hisatome I Circ. J., 69, 1284-1289 (2005) Evidence for proteasomal degradation of Kv1.5 channel protein Kato M, Ogura K, Miake J, Sasaki N, Taniguchi S, Igawa O, Yoshida A, Hoshikawa Y, Murata M, Nanba E, Kurata Y, Kawata Y, Ninomiya H, Morisaki T, Kitakaze M, Hisatome I Biochem. Biophys. Res. Commun., 337, 343-348 (2005) Impairment of cardiomyogenesis in embryonic stem cells lacking scaffold protein JSAP1 Sato T, Hidaka K, Iwanaga A, Ito M, Asano M, Nakabeppu Y, Morisaki T, Yoshioka K Biochem. Biophys. Res. Commun., 338, 1152-1157 (2005)

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Different effect of statins on platelet oxidized-LDL receptor (CD36 and LOX-1) expression in hypercholesterolemic subjects Bruni F, Pasqui AL, Pastorelli M, Bova G, Cercignani M, Palazzuoli A, Sawamura T, Auteri A, Puccetti L Clin. Appl. Thromb. Hemost., 11, 417-428 (2005) Adhesion molecule expression in fibroblasts: alteration in fibroblast biology after transfection with LOX-1 plasmids Chen K, Chen J, Liu Y, Xie J, Li D, Sawamura T, Hermonat PL, Mehta JL Hypertension., 46, 622-627 (2005) Essential role of cytoplasmic sequences for cell-surface sorting of the lectin-like oxidized LDL receptor-1 (LOX-1) Chen M, Sawamura T J. Mol. Cell. Cardiol., 39, 553-561 (2005) Enhanced plasma levels of oxidized low-density lipoprotein increase circulating nuclear factor-κ B activation in patients with unstable angina Cominacini L, Anselmi M, Garbin U, Pasini AF, Stranieri C, Fusaro M, Nava C, Agostoni P, Keta D, Zardini P, Sawamura T, Cascio VL J. Am. Coll. Cardiol., 46, 799-806 (2005) Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation Pasini AF, Garbin U, Nava MC, Stranieri C, Davoli A, Sawamura T, Cascio VL, Cominacini L J. Hypertens., 23, 589-596 (2005) Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice Inoue K, Arai Y, Kurihara H, Kita T, Sawamura T Circ. Res., 97, 176-184 (2005) Angiotensin II increases the expression of lectin-like oxidized low-density lipoprotein receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway Limor R, Kaplan M, Sawamura T, Sharon O, Keidar S, Weisinger G, Knoll E, Naidich M, Stern N Am. J. Hypertens., 18, 299-307 (2005) Atorvastatin reduces platelet-oxidized-LDL receptor expression in hypercholesterolaemic patients Puccetti L, Sawamura T, Pasqui AL, Pastorelli M, Auteri A, Bruni F Eur. J. Clin. Invest., 35, 47-51 (2005)

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Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells Theriault JR, Mambula SS, Sawamura T, Stevenson MA, Calderwood SK FEBS Lett., 579, 1951-1960 (2005) LOX-1 unlocked (Review) Sawamura T Structure., 13, 834-835 (2005) 再生医療と社会 (Review) 森崎隆幸 治療学, 39, 759 (2005) βウレイドプロピオナーゼ欠損症の遺伝子解析 (Review) 森崎隆幸 高尿酸血症と痛風, 13, 96 (2005) AMPデアミナーゼと循環器疾患 (Review) 森崎隆幸 高尿酸血症と痛風, 13, 122-126 (2005) 糖尿病の遺伝カウンセリング (Review) 森崎裕子, 吉政康直, 森崎隆幸, 千代豪昭 ホルモンと臨床, 53, 166-173 (2005) LOX-1 NAVIGATOR・酸化ストレスナビゲーター (Review) 沢村達也

メディカルレビュー社, 102-103 (2005) 臨床薬物学 (Clinical Pharmaceuticals) Examination of purification methods and development of intravitreal injection of triamcinolone acetonide Oishi M, Maeda S, Nakamura A, Kurokawa N, Ohguro N, Tano Y Jpn. J. Ophthalmol., 49, 384-387 (2005) カルバマゼピン／フェニトイン併用例においてカルバマゼピン活性代謝物の血中濃度

モニタリングが副作用のコントロールに有効であった一例

松本章士, 上島悦子, 大島和美, 荒川行生, 吉田哲彦, 阿部和夫, 佐古田三郎, 黒川信夫

日本ＴＤＭ研究, 22, 147-148 (2005)

26

続・薬学的管理の実践的記録 (13)－エッセンシャルシートとフォローアップシート－

脳卒中科領域－Ⅰ〈検査・診断〉(Review) 大島和美, 上島悦子, 黒川信夫 医薬ジャーナル, 41, 151-162 (2005) 続・薬学的管理の実践的記録（14）－エッセンシャルシートとフォローアップシート

－脳卒中科領域－Ⅱ〈治療〉(Review) 大島和美, 上島悦子, 黒川信夫 医薬ジャーナル, 41, 831-840 (2005)

続・薬学的管理の実践的記録（15）－エッセンシャルシートとフォローアップシート

－脳卒中科領域－Ⅲ〈リハビリ・予防〉(Review) 大島和美, 上島悦子, 黒川信夫 医薬ジャーナル, 41, 1041-1049 (2005) 続・薬学的管理の実践的記録（16）－エッセンシャルシートとフォローアップシート

－腎臓内科領域－Ⅰ〈検査〉(Review) 上島悦子, 黒川信夫 医薬ジャーナル, 41, 1259-1271 (2005) 続・薬学的管理の実践的記録（17）－エッセンシャルシートとフォローアップシート

－腎臓内科領域－Ⅱ〈治療１〉(Review) 上島悦子, 黒川信夫 医薬ジャーナル, 41, 1453-1464 (2005) 続・薬学的管理の実践的記録（18）－エッセンシャルシートとフォローアップシート

－腎臓内科領域－Ⅲ〈治療２〉(Review) 上島悦子, 黒川信夫 医薬ジャーナル, 41, 1667-1678 (2005) 続・薬学的管理の実践的記録（19）－エッセンシャルシートとフォローアップシート

－腎臓内科領域－Ⅳ〈治療３〉(Review) 上島悦子, 黒川信夫 医薬ジャーナル, 41, 1873-1886 (2005) 続・薬学的管理の実践的記録（20）－エッセンシャルシートとフォローアップシート

－乳腺・内分泌外科領域－Ⅰ〈乳癌１〉(Review) 山本智也, 岡本禎晃, 上島悦子, 黒川信夫 医薬ジャーナル, 41, 2108-2117 (2005) 続・薬学的管理の実践的記録（21）－エッセンシャルシートとフォローアップシート

－乳腺・内分泌外科領域－Ⅱ〈乳癌２〉(Review)

27

山本智也, 岡本禎晃, 上島悦子, 黒川信夫 医薬ジャーナル, 41, 2309-2320 (2005) 続・薬学的管理の実践的記録（22）－エッセンシャルシートとフォローアップシート

－乳腺・内分泌外科領域－Ⅲ〈乳癌３〉(Review) 山本智也, 岡本禎晃, 上島悦子, 黒川信夫 医薬ジャーナル, 41, 2518-2529（2005） 続・薬学的管理の実践的記録（23）－エッセンシャルシートとフォローアップシート

－婦人科領域－Ⅰ〈周術期編〉(Review) 岡本禎晃, 橋本陵, 上島悦子, 黒川信夫 医薬ジャーナル, 41, 2742-2751 (2005) 続・薬学的管理の実践的記録（24）－エッセンシャルシートとフォローアップシート

－婦人科領域－Ⅱ〈良性疾患編〉(Review) 岡本禎晃, 橋本陵, 上島悦子, 黒川信夫 医薬ジャーナル, 41, 2964-2974 (2005) 細胞構造学 (Cellular Physiology) Studies of Schizosaccharomyces pombe TFIIE indicate conformational and functional changes in RNA polymerase II at transcription initiation Hayashi K, Watanabe T, Tanaka A, Furumoto T, Sato-Tsuchiya C, Kimura M, Yokoi M, Ishihama A, Hanaoka F, Ohkuma Y Genes Cells, 10, 207-224 (2005) UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex Sugasawa K, Okuda Y, Saijo M, Nishi R, Matsuda N, Chu G, Mori T, Iwai S, Tanaka K, Tanaka K, Hanaoka F Cell, 121, 387-400 (2005) Different mutation signatures in DNA polymerase η- and MSH6-deficient mice suggest separate roles in antibody diversification Martomo SA, Yang WW, Wersto RP, Ohkumo T, Kondo Y, Yokoi M, Masutani C, Hanaoka F, Gearhart PJ Proc. Natl. Acad. Sci. USA, 102, 8656-8661 (2005) Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein Nishi R, Okuda Y, Watanabe E, Mori T, Iwai S, Masutani C, Sugasawa K, Hanaoka F

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Mol. Cell. Biol., 25, 5664-5674 (2005) Structural insights into the asymmetric effects of zinc-ligand cysteine mutations in the novel zinc ribbon domain of human TFIIEα for transcription Okuda M, Tanaka A, Hanaoka F, Ohkuma Y, Nishimura Y J. Biochem., 138, 443-449 (2005)

遺伝子機能解析学 (Experimental Genome Research) Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation Hara-Chikuma M, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S, Uchida S, Verkman AS J. Biol. Chem., 280, 15493-15496 (2005) The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs Inoue N, Ikawa M, Isotani A, Okabe M Nature, 434, 234-238 (2005) Genomic imprinting of XX spermatogonia and XX oocytes recovered from XX←→XY chimeric testes Isotani A, Nakanishi T, Kobayashi S, Lee J, Chuma S, Nakatsuji N, Ishino F, Okabe M Proc. Natl. Acad. Sci. U S A, 102, 4039-4044 (2005) Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization Kondoh G, Tojo H, Nakatani Y, Komazawa N, Murata C, Yamagata K, Maeda Y, Kinoshita T, Okabe M, Taguchi R, Takeda J Nat. Med., 11, 160-166 (2005) Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice Kumanogoh A, Shikina T, Suzuki K, Uematsu S, Yukawa K, Kashiwamura S, Tsutsui H, Yamamoto M, Takamatsu H, Ko-Mitamura EP, Takegahara N, Marukawa S, Ishida I, Morishita H, Prasad DVR, Tamura M, Mizui M, Toyofuku T, Akira S, Takeda K, Okabe M, Kikutani H Immunity, 22, 305-316 (2005) Wild-type measles virus infection in human CD46/CD150-transgenic mice: CD11c-positive dendritic cells establish systemic viral infection Shingai M, Inoue N, Okuno T, Okabe M, Akazawa T, Miyamoto Y, Ayata M, Honda K, Kurita-Taniguchi M, Matsumoto M, Ogura H, Taniguchi T, Seya T J. Immunol., 175, 3252-3261 (2005)

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HANP1/H1T2, a novel histone H1-like protein involved in nuclear formation and sperm fertility Tanaka H, Iguchi N, Isotani A, Kitamura K, Toyama Y, Matsuoka Y, Onishi M, Masai K, Maekawa M, Toshimori K, Okabe M, Nishimune Y Mol. Cell. Biol., 25, 7107-7119 (2005) Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2 Uchida S, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S Mol. Cell. Biol., 25, 7357-7363 (2005) Dysregulation of TGF-β1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice Wang X, Inoue S, Gu J, Miyoshi E, Noda K, Li W, Mizuno-Horikawa Y, Nakano M, Asahi M, Takahashi M, Uozumi N, Ihara S, Lee SH, Ikeda Y, Yamaguchi Y, Aze Y, Tomiyama Y, Fujii J, Suzuki K, Kondo A, Shapiro SD, Lopez-Otin C, Kuwaki T, Okabe M, Honke K, Taniguchi N Proc. Natl. Acad. Sci. USA, 102, 15791-15796 (2005) Multi-gene Gateway clone design for expression of multiple heterologous genes in living cells: conditional gene expression at near physiological levels Yahata K, Kishine H, Sone T, Sasaki Y, Hotta J, Chesnut JD, Okabe M, Imamoto F J. Biotechnol., 118, 123-134 (2005) 遺伝子操作動物を通して見る受精のメカニズム (Review) 岡部勝 関西実験動物研究会会報, 26, 74-77 (2005) 生殖と細胞接着 (Review) 伊川正人, 井上直和, 岡部勝 Molecular Medicine, 42, 1358-1367 (2005) RNAiによる哺乳動物個体レベルでのノックダウン (Review) 蓮輪英毅, 岡部勝 RNA工学の最前線, 67-76 (2005) 受精はどこまでわかったか？ (Review) 井上直和, 山口亮, 伊川正人 蛋白質 核酸 酵素, 50, 1405-1412 (2005) トランスジェニックマウスを利用した機能解析 (Review) 伊川正人, 上新結子, 岡部勝 図・写真で観るタンパク構造・機能解析実験実践ガイド, 164-172 (2005)

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受精の膜融合における必須分子Izumoの発見 (Review) 井上直和, 岡部勝 ブレインテクノニュース, 110, 21-24 (2005)

受精の膜融合必須分子Izumoの発見 (Review) 井上直和, 岡部勝 細胞工学, 24, 490-491 (2005) レンチウイルスベクターを用いた遺伝子操作動物作製法 (Review) 伊川正人 脳 21, 8, 86-90 (2005) 目で見る受精過程 -受精の初期過程- (Review) 山口亮, 岡部勝 HORMONE FRONTIER IN GYNECOLOGY, 12, 2-5 (2005) 遺伝情報解析学 (Environmental Science and Microbiology) Visualization and enumeration of bacteria carrying a specific gene sequence by in situ rolling circle amplification Maruyama F, Kenzaka T, Yamaguchi N, Tani K, Nasu M Appl. Environ. Miclobiol., 71, 7933-7940 (2005) Recognition of individual genes in diverse microorganisms by cycling primed in situ amplification Kenzaka T, Tamaki S, Yamaguchi N, Tani K, Nasu M Appl. Environ. Miclobiol., 71, 7236-7244 (2005) rRNA sequence-based scanning electron microscopic detection of bacteria Kenzaka T, Ishidoshiro A, Yamaguchi N, Tani K, Nasu M Appl. Environ. Miclobiol., 71, 5523-5531 (2005) Development of phylogenetic oligonucleotide probes for screening foodborne bacteria Ikeda M, Yamaguchi N, Tani K, Nasu M J. Health Sci., 51, 469-476 (2005) Enumeration of respiring Pseudomonas spp. in milk within 6 hours by fluorescence in situ hybridization following formazan reduction Kitaguchi A, Yamaguchi N, Nasu M Appl. Environ. Miclobiol., 71, 2748-2752 (2005)

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Multicolour digital image analysis system for identification of bacteria and concurrent assessment of their respiratory activity Ogawa M, Tani K, Ochiai A, Yamaguhi N, Nasu M J. Appl. Microbiol., 98, 1101-1106 (2005) Rapid and simple quantification of bacterial cells by using a microfluidic device Sakamoto C, Yamaguchi N, Nasu M Appl. Environ. Microbiol., 71, 1117-1121 (2005) Rapid monitoring of microbial contamination on herbal medicines by fluorescent staining method Nakajima K, Nonaka K, Yamamoto K, Yamaguchi N, Tani K, Nasu M Lett. Appl. Microbiol., 40, 128-132 (2005) 蛍光活性染色法による注射用水製造工程の衛生微生物学的評価

荒賀昌幸, 山口進康, 那須正夫 防菌防黴, 33, 7-12 (2005) 自然生態系における細胞外 DNA の動態と遺伝子伝播 (Review) 丸山史人, 谷佳津治, 那須正夫 環境バイオテクノロジー学会誌, 4, 131-137 (2005) 蛋白情報解析学 (Protein Molecular Engineering) Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T Nuclear Receptor, 3:3, 1-17 (2005) Microarray-based gene expression profiling of retransplanted rat cardiac allografts that develop cardiac allograft vasculopathy Kitagawa-Sakakida S, Fukushima N, Sawa Y, Horiguchi K, Doi T, Shirakura R, Matsuda H The Journal of Heart and Lung Transplantation, 24, 2068-2074 (2005) 巨核球・血小板系列特異的遺伝子発現制御に関与する転写因子群の解析 (Review) 土井健史, 岡田欣晃 生産と技術, 57, 38-41 (2005)

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巨核球・血小板系列の遺伝子発現に関与する転写因子 (Review) 土井健史 薬学雑誌, 125, 685-697 (2005)

微生物動態学 (Environmental Biochemistry) Some organotin compounds enhance histone acetyltransferase activity Osada S, Nishikawa J, Nakanishi T, Tanaka K, Nishihara T Toxicol. Lett., 155, 329-335 (2005) Cloning and characterization of a cDNA encoding the histone acetyltransferase monocytic leukemia zinc finger protein (MOZ) in the rat Ohta K, Osada S, Nishikawa J, Nishihara T J. Health Sci., 51, 253-256 (2005)

Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor (PPAR) γ/retinoid X receptor (RXR) pathway Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J Mol. Pharmacol., 67, 766-774 (2005)

Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions Nakanishi T, Nishikawa J, Hiromori Y, Yokoyama H, Koyanagi M, Takasuga S, Ishizaki J, Watanabe M, Isa S, Utoguchi N, Itoh N, Kohno Y, Nishihara T, Tanaka K Mol. Endocrinol., 19, 2502-2516 (2005)

Chromatin assembly factor Asf1p-dependent occupancy of the SAS histone acetyltransferase complex at the silent mating-type locus HMLα Osada S, Kurita M, Nishikawa J, Nishihara T Nucleic Acid Res., 33, 2742-2750 (2005)

Biodegradation of bisphenol A and disappearance of its estrogenic activity by the green alga Chlorella fusca var. vacuolata Hirooka T, Nagase H, Uchida K, Hiroshige Y, Ehara Y, Nishikawa J, Nishihara T, Miyamaoto K, Hirata K Environ. Toxicol. Chem., 24, 1896-1901 (2005)

微生物制御学 (Environmental Biotechnology) Production of alternatives to fuel oil from organic waste by the alkane-producing

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bacterium, Vibrio furnissii M1 Park MO, Heguri K, Hirata K, Miyamoto K J. Appl. Microbiol., 98, 324-331 (2005) Comparative analysis of the two-step reaction catalyzed by prokaryotic and eukaryotic phytochelatin synthase by an ion-pair liquid chromatography assay Tsuji N, Nishikori S, Iwabe O, Matsumoto S, Shiraki K, Miyasaka H, Takagi M, Miyamoto K, Hirata K Planta, 222, 181-191 (2005) Biodegradation of bisphenol A and disappearance of its estrogenic activity by the green alga Chlorella fusca var. vacuolata Hirooka T, Nagase H, Uchida K, Hiroshige Y, Ehara Y, Nishikawa J, Nishihara T, Miyamoto K, Hirata K Environ. Toxicol. Chem., 24, 1896-1901 (2005) Improvement of selective removal of heavy metals in cyanobacteria by NaOH treatment Nagase H, Inthorn D, Oda A, Nishimura J, Kajiwara Y, Park MO, Hirata K, Miyamoto K J. Biosci. Bioeng., 99, 372-377 (2005) Biosynthetic regulation of phytochelatins, heavy metal-binding peptides (Review) Hirata K, Tsuji N, Miyamoto K J. Biosci. Bioeng., 100, 593-599 (2005) 地衣と藻類を用いた環境影響評価

永瀬裕康, 安藤智紀, 廣岡孝志, 江口郁, 山本好和, 宮本和久, 平田收正

Lichenology, 4, 122 (2005) 淡水性微細藻類を用いた排ガス中の NOx 処理システム

永瀬裕康, 廣岡孝志, 江原良枝, 山下梨沙子, 谷本聡子, 平田收正, 宮本和久

J. Environ. Biotechnol., 5, 37-41 (2005)

環境病因病態学 (Clinical and Experimental Pathophysiology) Evaluation of coronary artery calcification by multi-detector row computed tomography for the detection of coronary artery stenosis in Japanese patients Kitamura A, Kobayashi T, Ueda K, Okada T, Awata N, Sato S, Shimamoto T J. Epidemiol., 15, 187-193 (2005) 骨・軟部腫瘍の遺伝子治療 -肉腫破壊ウイルスによる新しい細胞標的治療- (Review) 高橋克仁, 山村倫子 NEW MOOK 整形外科, 18, 235-245 (2005)

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Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia Hamanaka Y, Mukai M, Shimamura M, Kitagawa T, Nishida T, Isohashi F, Ito T, Nishizawa Y, Tatsuta M, Matsuda H, Inoue M Biochem. Biophys. Res. Commun., 330, 318-326 (2005) Efficacy of a selective antagonist of 5-HT2A receptor, sarpogrelate hydrochloride, compared with prostaglandin I2 derivative, beraprost sodium, on painful diabetic neuropathy in patients with type 2 diabetic mellitus in prospective randomized well-controlled comparative study Nishizawa Y, Nishizawa Y, Yoshioka F, Nosaka S, Amakata Y, Fushiki S Chronic Pain, 24, 149-158 (2005) 新規２種のドライパウダー式吸入ステロイド薬の臨床評価 前向き無作為多施設比較

臨床評価試験：ブデソニドタービュヘイラーvs フルチカゾンディスクヘラー 西澤芳男, 西澤恭子, 吉岡二三, 後藤グレイシイ広恵, 野坂修一, 雨森保憲, 天方義邦, 谷垣由美子, 永野富美代, 川田陽子, 安田理絵, 山田まゆみ, 平田弥生, 伏木信次 Allergology & Immunology, 12, 538-548 (2005) 多施設無作為 Dry Powder 製剤型 Inhaled Corticosteroid の気道結核発症率比較検討試

験 西澤芳男, 西澤恭子, 後藤グレイシイ広恵, 谷垣由美子, 吉岡二三, 野坂修一, 雨森保

憲, 天方義邦, 永野富美代, 川田陽子, 安田理絵, 山田まゆみ, 平田－大山－弥生, HIT研究会, 伏木信次 日本耳鼻咽喉科感染症研究会会誌, 23, 86-91 (2005) 風邪症候群患者に対する麻黄附子細辛湯と西洋感冒薬の咳嗽改善効果無作為比較検

討

西澤芳男, 永野富美代, 山田まゆみ, 安田理絵, 川田陽子, 平田弥生, 伏木信次,

野坂修一, 西澤恭子, 後藤グレイシイ広恵, 谷垣由美子, 吉岡二三, 雨森保憲,

天方義邦

漢方と免疫・アレルギ－, 18, 56-67 (2005) 病原微生物学 (Bacteral Infections) EspB from enterohaemorrhagic Escherichia coli is a natively partially folded protein Hamada D, Kato T, Ikegami T, Suzuki KN, Hayashi M, Murooka Y, Honda T, Yanagihara I FEBS J., 272, 756-768 (2005) A pH-dependent conformational change in EspA, a component of the Escherichia coli O157 : H7 type Ⅲ secretion system

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Kato T, Hamada D, Fukui T, Hayashi M, Honda T, Murooka Y, Yanagihara I FEBS J., 272, 2773-2783 (2005) Thermostable direct hemolysin of Vibrio parahaemolyticus is a bacterial reversible amyloid toxin Fukui T, Shiraki K, Hamada D, Hara K, Miyata T, Fujiwara S, Mayanagi K, Yanagihara K, Iida T, Fukusaki E, Imanaka T, Honda T, Yanagihara I Biochemistry, 44, 9825-9832 (2005) Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus Bhattacharjee RN, Park KS, Okada K, Kumagai Y, Uematsu S, Takeuchi O, Akira S, Iida T, Honda T Biochem. Biophys. Res. Commun., 335, 328-334 (2005) Genome-wide analyses of Escherichia coli gene expression responsive to BaeSR two-component regulatory system Nisino K, Honda T, Yamaguchi A J. Bacteriol., 187, 1763-1772 (2005) vpaH, a gene encoding a novel histone-like nucleoid structure-like protein that was possibly horizontally acquired, regulates the biogenesis of lateral flagella in trh-positive Vibrio parahaemolyticus TH3996 Park KS, Arita M, Iida T, Honda T Infect. Immun., 73, 5754-5761 (2005) Inhibitory effects of active compounds from Punica granatum pericarp on verocytotoxin production by enterohemorrhagic Escherichia coli O157 : H7 Voravuthikunchai SP, Sririrak T, Limsuwan S, Supawita T, Iida T, Honda T Journal of health science, 51, 590-596 (2005) Importance of Providencia species as a major cause of travellers’ diarrhoea Yoh M, Matsuyama J, Ohnishi M, Takagi K, Miyagi H, Mori K, Park KS, Ono T, Honda T J. Medic. Microbiol., 54, 1077-1082 (2005) Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest Bhattacharjee RN, Park KS, Uematsu S, Okada K, Hoshino K, Takeda K, Takeuchi O, Akira S, Iida T, Honda T FEBS Lett., 579, 6604-6610(2005)

Vibrios commonly possess two chromosomes

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Okada K, Iida T, Kita –Tsukamoto K, Honda T J. Bacteriol., 187, 752-757 (2005) 感染症の続発症と併発症 (Review) 本田武司 最新医学, 60, 171-172 (2005) 感染症の続発症－細菌感染症の場合－(Review) 本田武司 最新医学, 60, 173-178 (2005) 腸管感染症の現況とその治療 (Review) 松山純子, 橋本洋之, 本田武司 日本薬剤師会雑誌, 57, 89-94 (2005) 食中毒菌の特徴とその対策 (Review) 橋本洋之, 本田武司 こころのオアシス, 3, 16-18 (2005) 腸炎ビブリオ－細菌の話題－(Review) 本田武司 感染症と化学療法, 7, 2-4 (2005) MRSA 感染症 (Review) 橋本洋之, 本田武司 MEDICAMENT NEWS, 1837, 1-2 (2005) 院内感染事件の調査を経験して (Review) 本田武司 DAIKOKU MEDICAL NEWS, 34, 1 (2005) 腸管出血性大腸菌ウレアーゼの関係 (Review) 中野政之, 飯田哲也, 本田武司 感染症流行予測調査結果報告書, 40, 41-43 (2005) 新しい食中毒菌としてのプロビデンシア・アルカリファシエンス (Review) 本田武司 食品衛生学雑誌, 46, 234-236 (2005) 広範囲血液・尿化学検査免疫学的検査―その数値をどう読むか― Ⅷ．免疫学的検査

E. 非ウイルス性感染症関連検査（抗原および抗体を含む）菌体外蛋白毒素 (Review) 本田武司

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日本臨牀, 63, 202-205 (2005) 感染と免疫 感染とワクチン (Review) 松田重輝, 本田武司 日本医師会雑誌, 134, 78-81 (2005) 特集・海外旅行と感染症 2. コレラ (Review) 谷口暢, 本田武司 化学療法の領域, 21, 1409-1414 (2005) バイオセーフティのあり方 微生物の管理 (Review) 余明順, 本田武司 臨床と微生物, 32, 561-566 (2005) 以上 270 件