ebola hemorrhagic fever presented by: jamie mcgee
Post on 22-Dec-2015
258 views
TRANSCRIPT
![Page 1: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/1.jpg)
Ebola Hemorrhagic FeverPresented by: Jamie McGee
![Page 2: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/2.jpg)
The Hot Zone by Richard Preston
•“The red spots on the skin grow and spread and merge to become huge, spontaneous bruises, and the skin goes soft and pulpy, and can tear off if it is touched with any kind of pressure. Your mouth bleeds...
![Page 3: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/3.jpg)
Ebola virus
•RNA virus in filovirus family
•5 subtypes
![Page 4: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/4.jpg)
Ebola virus
•RNA virus in filovirus family
•5 subtypes•Level 4 agent
![Page 5: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/5.jpg)
Ebola virus•Exact origins and “natural
reservoir” are unknown
![Page 6: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/6.jpg)
Ebola virus•Exact origins and “natural
reservoir” are unknown•Animal-borne (primates in
Africa/Philippines; recently found in pigs)
![Page 7: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/7.jpg)
Ebola virus•Exact origins and “natural
reservoir” are unknown•Animal-borne (primates in
Africa/Philippines; recently found in pigs)
•Humans infected through contact with infected animal
![Page 8: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/8.jpg)
Ebola was discovered in 1976
![Page 9: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/9.jpg)
Subsequent epidemics have beensmall but very deadly
![Page 10: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/10.jpg)
![Page 11: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/11.jpg)
The symptoms of Ebola are nasty!
•Fever, headache, joint/muscle ache, diarrhea, vomiting, rash, internal/external bleeding
![Page 12: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/12.jpg)
Ebola is highly virulent and works quickly!
![Page 13: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/13.jpg)
Ebola is only spread by direct contactwith blood/secretions or a contaminated object
![Page 14: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/14.jpg)
Viral life cycle
![Page 15: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/15.jpg)
What does Ebola do to the body?•Blood clots form
![Page 16: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/16.jpg)
What does Ebola do to the body?•Blood clots form•Hemorrhages (bleeding)
develop
![Page 17: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/17.jpg)
What does Ebola do to the body?•Blood clots form•Hemorrhages (bleeding)
develop•Virus kills a large
amount of tissue
![Page 18: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/18.jpg)
What does Ebola do to the body?•Blood clots form•Hemorrhages (bleeding)
develop•Virus kills a large
amount of tissue•“Crashing out”
(mechanism for spreading)
![Page 19: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/19.jpg)
But the virus isn’t necessarily “efficient”
•Kills host too rapidly…little time or opportunity to transmit itself to other hosts successfully
![Page 20: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/20.jpg)
Ebola and the immune system interact in an interesting and mysterious way
•Unsure why some recover and others do not
![Page 21: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/21.jpg)
There is currently no effective treatment…
but see hope in “antisense PMOs”!
![Page 22: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/22.jpg)
Many ideas for possible vaccines…
![Page 23: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/23.jpg)
Many ideas for possible vaccines…
…but few have turned out to be effective
![Page 24: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/24.jpg)
…but is it worth it?
•Challenge—no clinical trials on humans
•Poor animal models•Virus burns itself out anyway
•$$$
![Page 25: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/25.jpg)
So…why do we care?•Viral mutations…evolution…airborne?
•Implications for developing world
•Bioterrorism▫We are unprepared!
![Page 26: Ebola Hemorrhagic Fever Presented by: Jamie McGee](https://reader033.vdocuments.mx/reader033/viewer/2022061512/56649d775503460f94a5865c/html5/thumbnails/26.jpg)
Sourceshttp://www.who.int/csr/don/archive/disease/
ebola_haemorrhagic_fever/en/index.htmlhttp://www.brown.edu/Courses/Bio_160/Projects2004/
ebola/epi.htmlhttp://www.nature.com/nrd/journal/v5/n2/full/
nrd1969.htmlhttp://www.cdc.gov/ncidod/dvrd/spb/mnpages/
dispages/ebola/ebolatable.htmhttp://www.bepast.org/dataman.pl?c=lib&dir=docs/
photos/Ebolahttp://www.cdc.gov/ncidod/dvrd/spb/mnpages/
dispages/Fact_Sheets/Ebola_Fact_Booklet.pdfhttp://www.microbiologytext.com/index.php?
module=Book&func=displayarticle&art_id=493http://www.bio.davidson.edu/Courses/Immunology/
Students/Spring2003/Austin/Immune-2.html