EBM Journal reading

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Presented by R3-2012/05/21

ScenarioR ~

Background knowledge

–

– 50 – 80

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1995 1 2004 6.7

300

( )

()

:

( )

Background knowledgeProbiotics

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– 1965 Lilly Stillwell– Probiotics ”for life”WHO

LactobacillusBacillus spp.,

Bifidobacterium spp., Propionibacterium spp.

Ask

Acquire

Appraisal

Apply

Audit

ASK?

Pregnant womenP

ProbioticsI

PlaceboC

Children’s incidence of atopic dermatitis O

Acquire

Database : PubMed

Key word: Probiotics, atopic dermitis, pregnancy

Epidemiology • Volume 23, Number 3, May 2012. Meta-Analysis

Appraisal

Validity

Importance

Practicability

CASP for meta-analysisCritical Appraisal Skills Programmer (CASP)

1. Did the review ask a clearly-focused question? 2. Did the review include the right type of study? 3. Did the reviewers try to identify all studies? 4. Did the reviewers assess the quality of the included studies? 5. If the results of the studies have been combined, was it reasonable to do so? 6. How are the results presented and what is it? 7. How precise are these results? 8. Can the results be applied to the local population? 9. Were all important outcomes considered? 10. Should policy or practice change as a result of the evidence contained in this review?

Validity

AppraisalDid the review ask a clearly-focused question - Yes

AppraisalDid the review include the right type of study- Yes

AppraisalDid the reviewers try to identify all studies - Yes

AppraisalDid the reviewers assess the quality of the included studies - Yes

AppraisalIf the results of the studies have been combined, was it reasonable to do so

Importance

Result

Result

Result

Appraisal -Importance

RR(95%CI)=0.79(0.71~0.88)NNT(95%CI)=5

Practicability

Apply

Can the results be applied to the local population? – Yes

Were all important outcomes considered? – Yes

Should policy or practice change as a result of the evidence contained in this review? – ?

Apply

Practical in Practice?

?

?

?

?

33

Audit

Conclusion

Limitation

mechanism

34

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