early life experiences - rccn · kate tillingl, steve horvath3'4 sonja kunze5, annette peters...
TRANSCRIPT
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Early Life Experiences
Dr. Frances A. ChampagneDepartment of Psychology
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Poverty
Environmental Influences During Infancy & Childhood
Social & Physical Environment
Childhood Abuse & Neglect
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Epigenetic Control of Gene Activity
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10 20 30 40 50
epigenetic age
chro
no
logi
cal a
ge
Epigenetic age during pregnancy
epigenetic age acceleration
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Epi-AA in adolescent males
Epi-AA at birth in ceasarean
Epi-AA at birth with maternal smoking
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Walsh et al. (2019) PNAS
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Preterm Birth and Maternal Stress
Walsh et al. (2019) PNAS
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Elevated 2nd Trimester PSS Score “masculinizes” aromatase profile in females
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Fetal Exposure to Testosterone
Firestein et al. in preparation
ASD RISK
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Impact of prenatal exposures on the maternal brain
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Conceptual model depicting hypothesized mediational
pathways and moderators linking childhood maltreatment to
risk for MCI and AD
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Thanks
Canadian Institutes
of Health ResearchNIH Director's
New Innovator
Award
Centers for Children's Environmental
Health & Disease Prevention Research
Columbia University
Rahia Mashoodh
Cate Jensen
Emily Jordan
Marija Kundakovic
Kathryn Gudsnuk
Becca Franks
Morgan Firestein
Columbia Center for
Children’s Environmental
Health
Rachel Miller
Frederica P. Perera
Columbia University
Catherine Monk
Ben Tycko