dynamic changes in cognitive activity and global cognition in the memory and aging project members...
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![Page 1: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/1.jpg)
Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and
Aging Project
Members (in alphabetical order): Amber, David, Doug, Emily, Frances,
Joey, Kim, Gerald, Rich
Presenter: Frances
![Page 2: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/2.jpg)
Purpose
• To identify whether cognitive activity is a leading or lagging indicator for global cognition.
• Hypothesis: Cognitive activity will be a leading indicator for global cognition; higher cognitive activity will predict reduced global cognitive decline over time.
![Page 3: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/3.jpg)
∆ ∆∆
∆∆∆
Current cognitive Activity
Cognitive Performance
CA1
CA2
CA3
CA4
CP1
CP2
CP3
CP4
int
int
slope
slope
11
1
time1
time2
time3
time4
time1
time2
time3
time4
Bivariate Dual Change Score Model
![Page 4: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/4.jpg)
Methods
• Sample
– 990 participants who had baseline global cognition score, at least five cognitive activities completed, and no dementia.
![Page 5: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/5.jpg)
Measures• The following were rescaled from 0-100 to be
on the same scale: – Global cognitive score
• Based on 19 tests from the following domains: episodic memory, semantic memory, working memory, perceptual speed, and visuospatial ability
– Cognitive activities• Based on playing games, writing letters, reading books,
magazine, and newspaper• Age: Centered at 75 years old at baseline and standardized
as a continuous variable
![Page 6: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/6.jpg)
Statistical Analysis
• Bivariate Dual Change Score Models
• Mplus v.5.2
• Stata v.10
![Page 7: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/7.jpg)
Results
![Page 8: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/8.jpg)
Description of Global Cognition and Cognitive Activities over 7 Waves
![Page 9: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/9.jpg)
020
4060
80C
ogni
tive
Act
ivity
1 2 3 4 5 6 7Visit
Predicted individual growth curve Mean growth curve
-50
050
100
Glo
bal C
ogni
tion
1 2 3 4 5 6 7Visit
Predicted individual growth curve Mean growth curve
Individual and Mean Trajectories for Cognitive Activity and Global Cognition
![Page 10: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/10.jpg)
Global Cognition Dual Change Score Model
![Page 11: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/11.jpg)
Cognitive Activities Dual Change Score Model
![Page 12: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/12.jpg)
Bivariate Dual Change Score Model for Global Cognition and Cognitive Activities
*All models exclude the proportional change parameter for cognitive activities.
No effect of activity on cognitionNo effect of cognition on activity
![Page 13: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/13.jpg)
∆y
∆∆
∆∆∆x
Current cognitive Activity
Cognitive Performance
CA1
CA2
CA3
CA4
CP1
CP2
CP3
CP4
1
1
time1
time2
time3
time4
time1
time2
time3
time4
Bivariate Dual Change Score (Full Dynamics) Model
57.1*
60.9*
-5.25*
-3.35 n.s
216.5*
246.6*
0.2390.239
0.239
-1.84 n.s -1.84 n.s-1.84 n.s
0 0 0
0.039 n.s 0.039 n.s0.039 n.s
age0.03 n.s
0.03 n.s
-5.9*
14.1
3.7* -0.05 n.s
-0.41
-.07
0.42
#slope and intercept factor inter-correlations are standardized estimates
0.43
0.03
0.35
![Page 14: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/14.jpg)
50
52
54
56
58
60
0 1 2 3 4 5 6 Visit
Global Cognition Cognitive Activity
Change in Mean Global Cognition and Cognitive Activity Over Visit
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Summary
• The decline in cognitive activities & global cognition is correlated over time but the change trajectories do not appear to influence each other.
• Cognitive activities are neither leading nor lagging indicators for cognitive decline over time.
• Relationship is likely due to a third variable that is unmeasured in our model
![Page 16: Dynamic Changes in Cognitive Activity and Global Cognition in the Memory and Aging Project Members (in alphabetical order): Amber, David, Doug, Emily,](https://reader033.vdocuments.mx/reader033/viewer/2022050714/56649d425503460f94a1dbc7/html5/thumbnails/16.jpg)
Next Steps
• We are currently writing up the manuscript for submission to JINS
• We are working on individual cognitive domains as the outcomes of the bivariate dual change score models.