DRUG ADDICTION:RNA

AND CELL CYCLE, TWO

POINT TO ATTACK IT

Ana Maria Rincon Gonzalez

Medicine student

3rd semester

FOLDING

FOLDING

INTRODUCCIONMany ways have been

described to attack the drug

addiction trouble, but recentstudies have shown specifically

that intervening into gene

expression and cell cycle

On one hand reducing a setof microRNAs - may reducesthe urge for a cocaine fix inmice. Another point suggestthe stimulation ofhipocampal nervous cells, toprevent addiction before itstarts.

ScienceDaily (Feb. 27, 2010)

Tuning Cocaine Addiction ScienceDaily (July 20, 2010)

MicroRNAs

influence gene

expression whose

are implicated in

disorders such as

drug addiction.

Tuning Cocaine Addiction ScienceDaily (July 20, 2010)

Ago2, a neuronal protein essential

for the production and

function of certain

microRNAs

Tuning Cocaine Addiction ScienceDaily (July 20, 2010)

Ago2-deficient (neurons lack Ago2) shows a

regulation of the expression of

genes known to be involved in drug addiction

and lead patient into a less drug

taking

THIS FIND GIVE VERY GOOD INFORMATION AS FOR THE

ADDICTION TROUBLE, IT LETS TO GO INTO THE TOPIC. I THINK IT

WOULD BE INTERESTING IF IT WAS DETERMINATED WHICH OF

THESE MICRO RNAS CONTROL COCAINE ADDICTION AND HOW

COULD THE SCIENCE TO INTERVENE IN TO THE TREATMENT OF

THESE PATIENTS.

STUDENT OPINION

ScienceDaily (Feb. 27, 2010)

Increasing Neurogenesis Might Prevent Drug

Addiction and Relapse ScienceDaily (Feb. 27, 2010)

If the

neurogenesis in

the hippocampus

is stimulated

positively might

be a potential

way to combat

drug addiction

and relapse.

Increasing Neurogenesis Might Prevent Drug Addiction and

Relapse ScienceDaily (Feb. 27, 2010)

Only with recent

technological

advances have

scientists been

able to test their

theories in animals by manipulating

the birth of new

nerve cells in the

hippocampus of the adult brain.

Increasing Neurogenesis Might Prevent Drug Addiction and Relapse ScienceDaily (Feb. 27, 2010)

The made experiment used advanced radiation delivery techniques to prevent hippocampal neurogenesis, rats were allowed to self-administer cocaine by pressing a lever. Rats with radiated brains took more cocaine and seemed to find it more rewarding than rats that did not receive radiation.

STUDENT OPINION

I think these kind of investigations shouldcontinue up to being proved in human beings, ,similar and especificsfindings woluld help in the visión of a

diferent treatment in patiences with any type of drup addiction, not just cocaine.

MEDICAL UTILITY

MEDICAL UTILITY

Drug addiction is a clear problem nowadays and implícate in the

medical area not just the diagnosis but also de treatment.

MEDICAL UTILITY

MEDICAL UTILITY

To know the bases of the life helps to understand the complexity that there re-joins the human being and all that of the way or himself that manages to affect it

BIBLIOGRAFIA

Rockefeller University Press (2010, July 20). Tuning cocaine addiction. ScienceDaily. Retrieved July 25, 2010, from http://www.sciencedaily.com­ /releases/2010/07/100719124400.htm

UT Southwestern Medical Center (2010, February 27). Increasing neurogenesismight prevent drug addiction and relapse. ScienceDaily. Retrieved July 26, 2010, from http://www.sciencedaily.com­ /releases/2010/02/100226121317.htm