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Dramatic Increase in Cortical Thickness Induced byFemoral Marrow Ablation Followed by a 3-MonthTreatment With PTH in Rats

In [1], Fig. 1C was inadvertently omitted. Figure 1 is reprinted here in its entirety. The Publisher regrets the error.

Fig. 1. Femoral marrow ablation followed by treatment with PTH for 3 months (84 days) increases cortical bone thickness: results of radiograhic, pQCT,

mCT, and histologic analysis. (Full caption appears on p. 2090.)

Journal of Bone and Mineral Research, Vol. 25, No. 9, September 2010, pp 2089–2090

DOI: 10.1002/jbmr.188

� 2010 American Society for Bone and Mineral Research

2089

Fig. 1. Femoral marrow ablation followed by treatment with PTH for 3 months (84 days) increases cortical bone thickness: results of radiographic, pQCT,

mCT, and histologic analysis. (A) High-resolution radiograms of the left operated and right unoperated femurs from control, sham-operated, and bone

marrow–ablated (bmx) rats that were treated 5 days a weekwith PBS or PTH for a duration of 21 or 84 days. Two groups of rats were treatedwith PTH for 21

days and then with PBS or alendronate for 63 days. Note that the representative marrow-ablated femur from rats that were treated with PTH for 84 days is

more intensely radiopaque than any other femur and is also more intensely radiopaque than its contralateral femur, which is itself more radiopaque than

the control femur. X-ray images are representatives of the overall data. (B) mCT analysis of femoral shafts from control and marrow-ablated femurs from

rats treated with PBS or PTH for 21 or 84 days. Note the dramatic increase in cortical thickness of the ablated femur from rats treated with PTH for 84 days.

(C) Histologic analysis following calcein labeling. The intramedullary bone formed in response to marrow ablation followed by 21 days of treatment with

PTH is undergoing calcification, as demonstrated by the regular fluorescent signal from calcein that has been incorporated into mineralizing bone. Note

that after 84 days of treatment with PTH, most of the calcein label highlights the endosteal and periosteal bone surfaces.

Reference

1. Zhang Q, Carlson J, Ke HZ, Li J, Kim M, Murphy K, Mehta N, Gilligan J, Vignery A. Dramatic increase in cortical thickness induced by femoral marrow

ablation followed by a 3-month treatment with PTH in rats J Bone Miner Res. 2010;25:1350–1359. DOI: 10.1002/jbmr.25.

2090 Journal of Bone and Mineral Research ERRATUM