dragon score strbian, d, et alpredicting outcome of iv thrombolysis treated ischemic stroke...

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DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427– 432

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Page 1: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

DRAGON Score

Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

Page 2: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

Introducción

EVC isquémico agudo Trombolisis IV Reperfusión

Rha, J, et al. The impact of recanalization on ischemic stroke outcome: a meta-analysis. Stroke 2007;38:967–973.

Page 3: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

Rha, J, et al. The impact of recanalization on ischemic stroke outcome: a meta-analysis. Stroke 2007;38:967–973.

Introducción

50% = Bueno

0 - 2 mRs

Page 4: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

EficaciaAteplase

Edad

NIHSS

Tiempo (OTT)

Introducción

Glucosa CT

Meretoja, A. et al. Off-label thrombolysis is not associated with poor outcome in patients with stroke. Stroke 2010;41:1450 –1458.

ResultadoFinal Bueno

ResultadoFinal Con Cx

•Reoclusión•Recanalización con Perfusión Insuficiente•Recanalización con hemorragia•Recanalización con Territorio previamente dañado

Page 5: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

Justificación

Estimación temprana del pronóstico

Identificación temprana de pacientes con alto riesgio de resultado desfavorable a pesar de TIV

Page 6: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

D – ACM HiperDensaR – mRS (Escala de Rankin Modificada)A – Age (Edad)G – GlucemiaO – On set to treatment (tiempo de inicio a Tratamiento)N – NIHSS (Escala de Stroke de los Institutos Nacionales de Salud)

Page 7: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

D

1.- Signo de arteria Cerebral Media hiperDensa2.- Otros cambios Tempranos TC:

Pérdida de diferenciación Corteza sustancia Blanca Hipodensidad de GBAtenuación Insular

Puntaje: Ambos =2Cualquiera =1 Ninguno =0

Page 8: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

R• Escala de Rankin modificada

• Puntaje previo > 1 = 1

Page 9: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

A – Age

Edad

>80 Años = 265 –79 Años = 1< 65 Años = 0

Page 10: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

G - Glucosa

• Niveles séricos de glucosa al ingreso

• > 144 mg/dL = 1

Page 11: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

O – Onset Time

Tiempo > 90 minutos = 1

Page 12: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

N – NIHSS

> 15 =310–15 =25–9 =10–4 =0

Page 13: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432
Page 14: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

Page 15: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

Proporción de pacientes con resultado favorable

% Puntos DS

96% (0–1)

88% (2)

74% (3)

0% (8–10)

Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

Page 16: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

Page 17: DRAGON Score Strbian, D, et alPredicting outcome of IV thrombolysis treated ischemic stroke patients. The DRAGON score. Neurology 2012;78:427–432

• Auc = .84• [0.5, 6] = Test malo.• [0.6, 0.75] = Test regular.• [0.75, 0.9] = Test bueno.• [0.9, 0.97] = Test muy bueno.• [0.97, 1] = Test excelente.

Zou K, et al. Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive models. Circulation, 6;115(5):654-7.