dr peterdonnellybiobusinessei letterkenny

Ideagen Workshop

Dr Peter DonnellyChief Executive OfficerBioBusiness Ltd.

Chief Technology OfficerBluescope Medical Technologies Ltd.

Copyright © 2010 BioBusiness Ltd.

Life and Health Technologies Sector in Ireland

Ideagen Workshop

Background

BluescopeMedical

Technologies

IQ Medical Systems

BluescopeMedical

TechnologiesAxellis

Development of Medical Device and Technology Platform



IQ Solutions BioBusiness

Support to the Life and Health Technology Sector

Ideagen Workshop

Bluescope Medical Technologies

� First patent filed in 2002

� Bluescope established as QUB spin-out in 2004.

� Partner (CEO) and I bought out other parties in

2006.

� Opened office in Lisburn May 2006

� Funded by Invest NI April 2007



� Funded by Invest NI April 2007

� Acquired by Axellis in November 2007

� HQ London, 3 offices in the US, 1 office SW

England, 1 office in NI.

� Axellis Product Platforms:

• Compensators and Immobilisers for Radiotherapy

Treatment.

• Cardio-respiratory Platform for Vital Sign Monitoring

Ideagen Workshop

Clinical Need – Critical Care

� Non-invasive and unobtrusive

� Continuously monitor lung sounds

to assess respiratory condition.

� Identify trends in disease, and

treatment states.

� Provide an ‘easy-view’ user

interface to provide real time

Acute Trauma Patient



interface to provide real time

feedback on lung condition.

� Provide access to key respiratory

sites.

� Diagnostically consistent.

Ideagen Workshop

Nightingale® Monitor



Provides continuous visual

anatomical representation of

lung condition, respiratory rate

and trended information

Ideagen Workshop

Clinical Need – General Ward

� Respiratory condition and rate is

an important vital sign & an

indicator of deterioration.

� Increasing prevalence of

respiratory conditions in aging

patients.

� Provide a glanceable user interface

Deteriorating Patient



� Provide a glanceable user interface

for real-time feedback of lung

condition for nursing support.

� Hospital Scoring Systems to

identify at-risk patients.

� Wireless capability

Ideagen Workshop

Clinical Need – Home-Based

� Reduction in hospital admissions,

hospital bed days and A&E visits.

� Healthcare cost savings.

� Improved quality of life for aging

and chronically ill patients.

� Improved disease management

and life trending analysis.

Chronically Ill Aging Patient



and life trending analysis.

� Carer alert facility.

� Integration into telemedicine and

telecare systems.

� Wireless capability

Ideagen Workshop

Problems with current solutions

� Entirely subjective.

� Quantification difficult.

� Cross infection.

� Lack of access.

� Poorly recorded.

� No continuous trend assessment.



� No continuous trend assessment.

� Difficulty operating in noisy environments.

� No continuous, unobtrusive, robust method

of assessing respiratory condition currently

exists.

Ideagen Workshop

Key Lessons Learned

� Academic prototypes are not ready for market.

� Clinicians do not make good business people.

� Business conditions and models are constantly

changing.

� Investment timelines are much much longer than



� Investment timelines are much much longer than

you anticipate.

� 1 Golden Rule –

He who has the gold makes the rule.

Ideagen Workshop

BioBusiness

� Established May 2004 as Northern Ireland organisation

� All-Island organisation in 2010 with All-Island membership

� Sector representation covers:

• Medical Devices, Diagnostics, Pharmaceuticals, Biotechnology, Agri-Foods and

Support Companies

� Funding Support

• Invest NI, InterTradeIreland & Enterprise Ireland



• Invest NI, InterTradeIreland & Enterprise Ireland

• Dept Employment & Learning (NI)

• European (FP7, NPP, Interreg, Eurostars)

� Capability

• Trained facilitators

• Experienced project managers

• Clinical advisor on staff

Ideagen Workshop

Strategic Goals

� Provide a strong advocacy role for the industry.

� Contribute to the competitiveness and size of Life

and Health Technology Sector in Ireland.

� Facilitate and broker opportunities in innovation

and collaboration.



and collaboration.

� Play an industrial role in the skills development of

the Sector.

� Champion Ireland and UK Connected Health and

Personalised Medicine activities.

Ideagen Workshop

Programmes & Initiatives

� Current Programmes• ABC Collaborations

• Medical Devices in Connected Health

• ABC Ireland

• Healthy Living

• Medilink UK

ABCIreland



• Health Tech & Medicines KTN

• Skills Academy

� Connected Health Initiatives

• All-Island Connected Health Review

• Connected Health Clinical Trials

• UK Connected Health @ IBIZ

• All-Island Connected Health Mission to Boston

Ideagen Workshop

ABC Innovation Model

HSC Innovations

HSC R&D Office

RCS in Ireland

RCP in Ireland

GP Consortia

Universities /

Colleges and

Institutes of

Technology

Academia Clinical

Priority Areas



Priority areas have strong

All-Island capability

Connected Health and

Personalised Medicine

Healthy Living

BioBusiness &

MembersABC Interface

Business

Ideagen Workshop

ABC Innovation Model

Identify Clinical

Need

Provide Clinical

Efficacy

Early Adopters

Applied research

for medium term

innovation.

Blue skies

research for long

term innovation

Academia Clinical

Priority Areas



Priority areas have strong

All-Island capability

Connected Health and

Personalised Medicine

Healthy Living

Commercial

Regulatory

Approved

ProductsABC Interface

Business

Ideagen Workshop

Innovation

� Key to any Innovation Strategy is the correct insights and

knowledge of the:

• Market,

• Customer base,

• Technologies,

• Regulatory environment and



• Regulatory environment and

• Internal capability.

� Collaboration is often the easiest way to gain knowledge,

find solutions and source capability.

� Successful ABC collaborations are very important to

successful commercial opportunities and initiatives.

Ideagen Workshop

Capability Building

Regulatory Environment

Clinical Trials

• Statistical Requirements

• Trial Protocols

• Ethics Approval

Sales and Marketing



Innovation

• Insights

• Collaboration

• Intellectual Property

Investment

Environment

• FDA, MDD, GxP,

• Ethics Approval

Ideagen Workshop

Academic & Clinical Engagement

� Altnagalvin Hospital

� Beacon Hospital

� Beaumont Hospital

� Belfast Hospital Trust

� Cork University Hospital

� Craigavon Area Hospital

� HSC Innovation and R&D Division



� Nenagh Hospital

� RCSI & RCPI

� St James’ Hospital

� St Vincent’s Hospital

� Tallaght Hospital

� Ulster Hospital

� General Practitioners (GPs)

Ideagen Workshop

BioBusiness Projects

� Doctor Office Laboratory

� Cardiac Care in the Community

� Connected Health Monitoring Centre

� Addressing Rural Isolation using Telecare

� Clinical Trial Network

� Remote Vital Sign Monitoring



� Remote Vital Sign Monitoring

� mHealth Applications for Mental Illness

� Stroke Screening

� Thrombolysis Automated Work Practice

� Respiratory Database Development

� Tissue Sample Database

Ideagen Workshop

McElwaine Smart Case Study

� McElwaine Smart offers tele-health and

tele-care solutions.

� International partnership established

with Bosch GmbH.

� Academic research collaborations

established with UU, QUB, DkIT and

Limerick University.



Limerick University.

� Commercial links established with

McElwaine SMART, Friendly Call Service.

� Invested £3.5 million in new staff,

products, infrastructure and marketing.

� Leverage of funding ratio 1:35

Ideagen Workshop

Intelesens Case Study

� Intelesens company providing remote vital

sign monitoring devices.

� First home-based clinical trial.

� Clinical trial protocols developed and ethics

approval achieved.

� Commercial links established between

device company and communication



device company and communication

platform company –Valentia Technologies.

� Invested £800,000 with public grant

support.

� Leverage of funding ratio 1:30

dr peterdonnellybiobusinessei letterkenny

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