dr. manfred wentz director, hohenstein institutes (usa) head, oeko-tex certification body (usa) aafa...
TRANSCRIPT
Dr. Manfred WentzDirector, Hohenstein Institutes (USA)
Head, Oeko-Tex Certification Body (USA)
AAFA – Environmental Committee Meeting
November 10, 2008 - Washington, D.C.
Methodology of
Human Risk Assesment
11/10/20081 M. Wentz, Oeko-Tex (USA) - AAFA/RSL
Sustainability of Global Textile MarketTriple Bottom Line (TBL) – Willard (2002)
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL2
Environmental Sustainability
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL3
M. Wentz, Oeko-Tex (USA) - AAFA/RSL4 11/10/20084
Concept of Textile Ecology
M. Wentz, Oeko-Tex (USA) - AAFA/RSL5
Human Health Risk Assessment
Human Ecology Challenges (EPA)
Life stage
Low Dose
Acute
Cumulative
Characterizing uncertainty
(weight of evidence)
Estimating risk from diverse exposure
scenarios:
Applying novel biological data:
Improving human exposure assessment
Toxic genomic
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What is a “Poison” ?“Dose makes the Poison”
“All things are poison, and nothing is without poison. It is the dose only that
makes a thing not a poison.”
Paracelsus (1494-1541)
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Toxics - Basic Definitions
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL7
Risk - Basic Definitions
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11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL9
Exposure and Toxicity
Types of Toxic Effects on Humans
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M. Wentz, Oeko-Tex (USA) - AAFA/RSL11
Risk Assessment and ManagementNational Research Council (1983, 1996)
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Typical Assays for Human Risk Assessment
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Assay Subjects EndpointDose
CriterionExtrapolati
on
Ames BacteriaGenetic Damage
In Vitro Screening
Acute Rodents Death50%
Lethality(LD50)
None
Subacute Rodents MultipleSafe Level
(NOAEL, MTD)
Safety Factor
Cancer -chronic
Rodents CancerAcceptableRisk Level
Mathematical
Epidemiology
-chronicHumans Multiple Variable None
General Risk Assessment Process
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL13
EPA- Design for the Environment (DfE)Voluntary Stakeholder Program
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Chemical and Pesticides Results Measures (CAPRM) 145 Environmental Indicators (EPA/OPPTS-FSU Project)
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL15
Human Health
Ecological Health
Chemical and Pesticides
Food Safety
Product Safety
Transboundary Movement
Product Steward ship
Pollution Prevention
CAPRM /EPA Hierarchy of Indicators
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Complex Process of Regulatory DecisionsSource: EPA
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M. Wentz, Oeko-Tex (USA) - AAFA/RSL18
Factors Affecting Risk Perception“Perception is Reality”
Increased Public Concern Decreased Public Concern
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