dr. laurent brochard's lab the keenan research centre for ...care+digital+assets/... · bench...
TRANSCRIPT
Scientists interested in:• Signal processing• Development of algorithm to automatically
analyze signals• Building gadgets to simulate biological/physical
phenomenon (eg. starling resistor)• Statistical models to analyze complex biological
interactions
• Improve monitoring techniques and support strategies during acute respiratory failure
• Understand patient-ventilator dyssynchrony and develop strategies to improve synchrony
• Understand ventilator induced lung injury and diaphragm dysfunction and develop strategies to decrease damage.
TYPE OF STUDIES METHODOLOGIES
Bench studiesSimulation of patients
breathing spontaneously or passively ventilated
Physiological studies (healthy subject, patients admitted to the general
ward and critically ill patients)
SEE DIAGRAM + data collection from chart
Large, multicenter epidemiological or randomized clinical
studies
Data collection from ventilators and clinical chart
More complex statisticalanalysis
Respiratory mechanics during passive mechanical ventilation
Expiratory flow limitation(EFL)
Respiratory drive / Inspiratory effort(Airway occlusion pressure – P0.1
and pressure-time product – PTPes)
Inspiratory effort / Patient ventilation dyssynchrony
(reverse triggering)
WHO ARE WE LOOKING FOR TO COLLABORATE?
• Respiratory physiology during acute respiratory failure and Mechanical Ventilation
• Acute respiratory distress syndrome (ARDS)• Patient-ventilation interaction during invasive and
non-invasive ventilation• Respiratory muscle function, control of breathing
and sleep during and after mechanical ventilation
RESEARCH AREAS
CLINICAL APPLICATION
Dr. Laurent Brochard's lab - The Keenan Research Centre for Biomedical Research of St. Michael's Hospital
Analysis
Lu Chen , Tài Pham , Martin Dres , Domenico Luca Grieco , Irene Telias , Detajin Junhasavasdikul , Luana Melo , Michael Sklar , Fabiana Madotto , Felipe Damiani , Louisa Matela , Thomas Piraino , Jenny Gu , Gyan Sandhu , Jennifer Hodder , Orla Smith , Laurent Brochard .
1st derivative of flow = 12 L/s2
Flow
Paw
Country of Origin: China, France, Italy, Argentina, Thailand, Brazil, Canada, Chile, Philippines, India