dr. klassen's cv

Henry J. Klassen, M.D., Ph.D. Gavin Herbert Eye Institute

University of California, Irvine Dept. of Ophthalmology & Stem Cell Research Center

Sue & Bill Gross Hall, Room 2035 845 Health Sciences Road

Irvine, CA 92697-1705 Tel: (949) 824 7750 Fax: (949) 824 9626

email: [email protected]

Curriculum Vitae: June 30, 2014

Current Position:

Associate Professor and Director, Stem Cell & Retinal Regeneration Program, Gavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, 2011-present

Prior Positions

Assistant Professor and Director, Stem Cell & Retinal Regeneration Program, Department of Ophthalmology, University of California, Irvine, 2006-2011

Visiting Professor, Peking University Third Hospital, Beijing, 2007-2009

Senior Clinician-Scientist, Singapore Eye Research Institute, 2006

Visiting Associate Researcher, Stem Cell and Regeneration Program, the Burnham Institute, 2004-2009

Faculty, Human Embryonic Stem Cell Culture Training Course, Children’s Hospital of Orange County/Burnham Institute/National Institutes of Health, 2004-2009

Visiting Associate Researcher, Department of Ophthalmology, University of California, Irvine, 2003-2006

Director, Stem Cell Research, Children’s Hospital of Orange County, 1998-2006

Education and Training

B.A., Neurobiology, University of California, Berkeley, 1979

M.S., Psychology, University of California, Santa Cruz, 1983

Ph.D., Neurobiology, Anatomy and Cell Science, University of Pittsburgh, 1989

M.D., University of Pittsburgh, 1991

Internship, Cambridge Hospital, Cambridge, MA, 1991-1992

Residency in Ophthalmology, Yale University, 1992-1995

Visiting Ophthalmologist, Princess Margaret Hospital, Nassau, Bahamas, 1994

Fellowship, Medical Retina and Retinal Research, Moorfields Eye Hospital and Institute of Ophthalmology, London, United Kingdom, 1995-1997

Clinical and Research Fellowships

First Year Graduate Student Fellowship, University of California, 1980-1981

Mellon Foundation Fellowship, 1986-1991

mailto:[email protected]

2

Student Research Program Fellowship, University of Pittsburgh, 1986

Charles E. Culpeper Foundation Fellowship, 1987-1988

Clinical Fellow in Medicine, Harvard Medical School, 1991-1992

Foundation Fighting Blindness, Career Development Award, 1995

NATO Student Fellowship, June 1997

Awards

B.A. degree with Distinction in General Scholarship, 1979

Pittsburgh Neuroscience Society Annual Award for Excellence in Basic Science Research, 1987

Citation for Excellence in Research, University of Pittsburgh School of Medicine, 1989

Outstanding Presentation of the 1989 Eastern Student Research Forum

Certificate of Recognition for Excellence in Medical Student Research, AMA, 1989

Yale Alumni in Ophthalmology Resident Research Prize, 1994

Career Development Award, Foundation Fighting Blindness, 1997

Stewardship Stars Award, University of California, Irvine, 2011

Dean's Junior Physician/Scientist Award, Research Associates, UCI School of Medicine, 2011

Professional Societies

American Association for the Advancement of Science

Association for Research in Vision and Ophthalmology

International Society for Cellular Therapy

International Society for Eye Research

International Society for Stem Cell Research

Sigma Xi

Society for Clinical and Translational Science

Companies

jCyte, Inc., Founder, 2012

Consultancies:

Research Corporation Technologies, Tucson, 2002-2003

Schepens Eye Research Institute, Boston, 2004-2011

Human Embryonic Stem Cell Culture Training Course, 2004-2009

ReNeuron, Ltd., Guildford, Surrey, UK, 2006-2011

Foundation Fighting Blindness, Stem Cell Consortium, 2006-present

AVOS Life Sciences, ad hoc, 2009

French National Research Agency (ANR), ad hoc, 2009

Stem Cells, Inc., Palo Alto, ad hoc, 2009

GlaxoSmithKline, ad hoc, 2011

3

Allergan ARENA Meeting, Gavin Herbert Eye Institute, Irvine, 2014

Allergan LATAM Meeting, Gavin Herbert Eye Institute, Irvine, 2014

Conference Organizational Committees

Pink Tank I: Stem Cell Transplantation in the Pig, Boston, 2002

XVI International Congress of Eye Research, Retinal Stem Cell Symposium Co-Chair, Sydney, Australia, 2004

Pink Tank II: Stem Cell Transplantation in the Pig, Arild, Sweden, 2006

Asia ARVO, Stem Cell Biology Symposium Co-Chair, 2007

Pacific Ocular Regenerate Biology Conference XII, Retina Stem Cell Session Chair, 2007

Pink Tank III: Modeling AMD Repair in the Pig Retina, Lead Organizer, Univ. of Calif. Irvine Medical Center, 2007

XVIII International Congress of Eye Research, Retinal Stem Cell Symposium Co-Chair, Beijing, China, 2008

Pink Tank IV: Modeling AMD Repair in the Pig Retina, Co-Organizer, Rockport, MA, 2008

ARVO Annual Meeting, Moderator, Poster Session 353, Stem Cells: Translational Research, Ft. Lauderdale, 2010

XIX Biennial Meeting of the International Society for Eye Research, Session Chair, Drug Delivery for Treatment of Retinal Degeneration, Montreal, 2010

Invited Presentations at Professional Meetings

American Medical Association, 1st Annual Symposium for Scientific Advancement and Excellence in Medical Student Research, Chicago, 1989

6th Annual Vision Research Conference, ARVO Annual Meeting, Ft. Lauderdale, 2002

XV International Congress of Eye Research, Geneva, Switzerland, 2002

XVI International Congress of Eye Research, Sydney, Australia, 2004

Vision Down Under, ICER Satellite Meeting, Fraser Island, Australia, 2004

All-Myanmar Ophthalmology Symposium, Rangoon, Burma, 2005

Nanotechnology Applied to Ophthalmology, ARVO Special Topic Session, Ft. Lauderdale, 2005

Asia ARVO, Stem Cell Biology Symposium, Singapore, 2007

International Molecular Medicine Tri-Conference, Stem Cell Congress, San Francisco, 2008

XXXI World Ophthalmology Congress; Immunol., Mol. Biol. And Genetics; Hong Kong, 2008

XXXI World Ophthalmology Congress; New Technology: Bioeng./Nanotech.; Hong Kong, 2008

XVII International Congress of Eye Research, Beijing, China, 2008

XXXII SIMASP-UNIFESP, Sao Paulo, Brazil, 2009

ARVO Annual Meeting, Special Interest Group, Stem Cell Therapy: Challenges in Translation to the Clinic, Ft. Lauderdale, 2009

24th Congress of the Asia-Pacific Academy of Ophthalmology, Nusa Dua, Indonesia, 2009

XXXII World Ophthalmology Congress, Berlin, 2010

XIX Biennial Meeting of the International Society for Eye Research, Montreal, 2010

4th Annual Retinal Innovations Symposium, Guest Speaker, Newport Beach, 2011

4

1. ARVO Annual Meeting, Special Interest Group, Cellular Therapy for the Dysfunctional RPE and Retina: Delivery Methods including Cell Suspension and Cellular Sheets; Therapeutic Goal: Functional Replacement versus Neuroprotection, Ft. Lauderdale, 2011

Visual Restoration: Regenerative Medicine in Ophthalmology, University of Pittsburgh, Pittsburgh, 2011

5th Annual Gavin Herbert Eye Institute Colloquium, Newport Beach, 2011

Hereditary Retinal Diseases-from Research to Treatment, Department of Ophthalmology, Oslo University Hospital and Norwegian Retinitis Pigmentosa Association, Oslo, 2011

1st Beckman Initiative for Macular Research, Startups & Industry Pre-Meeting, Irvine, 2012

5th Annual Foundation Fighting Blindness/Gavin Herbert Eye Institute-UCI Ocular Innovation Symposium, Newport Beach, 2012

Cell Therapy in the Retina: Opportunities and Challenges to Clinical Translation, Schepens Eye Research Institute and Harvard Stem Cell Institute, Boston, 2012 (declined due to conflict)

Essen Bioscience, 1st Annual IncuCyte User Group Meeting, South San Francisco, 2012

6th Annual Gavin Herbert Eye Institute Colloquium, Newport Beach, 2012

2nd Beckman Initiative for Macular Research, Startups & Industry Pre-Meeting, Irvine, 2013

10th Annual International Symposium in Ocular Pharmacology and Therapeutics (ISOPT) Clinical, Retinal Degeneration Session Co-Chair, Paris, 2013

American Society of Cataract and Refractive Surgery, Innovators at the ASCRS Symposium, San Francisco, 2013

1st Orange County Ophthalmology Technology Summit (OCOTS), Keynote Presentation, Newport Beach, 2013

Annual Beckman Scholars and Young Investigator Symposium, Distinguished Panel Speaker, Irvine, 2013

Orange County Summit on Regenerative Medicine, Stem Cell Delivery and Bioengineering, Irvine, 2013

7th Annual Gavin Herbert Eye Institute Colloquium, Irvine, 2013

3rd Annual Regenerative Medicine Partnering Forum, Stem Cell Meeting on the Mesa, Company Presentations, La Jolla, 2013

3rd Beckman Initiative for Macular Research, Industry Meeting, Irvine, 2014

SPIE Photonics West, BiOS, Optogenetics and Control of Cells, 2014 (cancelled due to illness)

6th Annual Foundation Fighting Blindness-Gavin Herbert Eye Institute Ophthalmic Innovation Symposium, University of California, Irvine, 2014

World Ophthalmology Congress, Emerging Therapies Symposium, 2014

2. ARVO Annual Meeting, Saturday Course, Cell Therapy in Ocular Disease- Emerging Research and Therapy, presenter and panel speaker, Orlando, 2014

3. Gavin Herbert Eye Institute and The Discovery Center for Eye Research “Bench to Bedside” Symposium, 2014

11th Annual International Symposium in Ocular Pharmacology and Therapeutics (ISOPT) Clinical, Retinal Degeneration Session Co-Chair, Reykjavik, 2014

Invited Presentations: Educational/Governmental Institutions

University of Pittsburgh, Center for Neuroscience, 1987

University of Pittsburgh, School of Medicine, 1989

5

University of Wisconsin, Department of Ophthalmology, 1996

University of California, Los Angeles, Department of Pathology, 2000

Johns Hopkins University, Wilmer Eye Institute, Baltimore, 2000

University of California, Irvine, Tissue Engineering Group, 2001

University of Southern California, Design Fundamentals, 2001

University of California, Irvine, Visual Culture, 2002

University of Miami, Bascom Palmer Eye Institute, 2002

Children's Hospital of Los Angeles, Department of Ophthalmology, 2002

Pink Tank: Stem Cell Transplantation in the Pig, Boston, 2002

University of California, San Diego, Department of Bioengineering, 2002

Neural Stem Cell Think Tank, University of California, Irvine, 2003

Institute of Ophthalmology, London, England, 2003

University of California, Irvine, Center for Molec. and Mitochondrial Med. and Genetics, 2003

Harbor-UCLA Medical Center, Research & Education Inst., Los Angeles, 2003

University of Missouri, Columbia, Division of Biological Sciences, 2004

University of Missouri, Columbia, Department of Ophthalmology, 2004

Burnham Institute, Human Embryonic Stem Cell Course, 2004

Children's Hospital of Orange County, Grand Rounds, 2004

University of Louisville, Kentucky, Department of Ophthalmology, 2004

The Glaucoma Foundation, Think Tank, New York City, 2004

Harbor-UCLA Medical Center, Research & Education Inst., Los Angeles, 2004

Peking University Eye Center, Beijing, China, 2004

Singapore Eye Research Institute, Singapore General Hospital, Singapore, 2005

Children's Hospital of Orange County, Human Embryonic Stem Cell Course, 2005

University of California, Irvine, Department of Ophthalmology, 2005

Iowa State University, Ames, Iowa, 2005

Discovery Eye Foundation, Los Angeles, 2005

Singapore National Eye Centre, Singapore, 2006

Retinitis Pigmentosa Society Singapore, 2006

Pink Tank II: Stem Cell Transplantation in the Pig, Arild, Sweden, 2006

Peking University Eye Center, Beijing, China, 2006


Foundation Fighting Blindness, Stem Cells for Inherited Retinal Diseases, Washington DC, 2006

University of California, Irvine, Department of Ophthalmology, Grand Rounds, 2007

Stem Cell Research Center, Stem Cells: Patient, Physician, Scientist, U.C. Irvine, 2007


Peking University, Third Hospital, Beijing, China, 2007

City of Hope, Beckman Research Institute, Division of Neurosciences, 2007

6

Pink Tank III: Modeling AMD Repair in the Pig Retina, Univ. of Calif. Irvine Med. Center, 2007


Southern California College of Optometry, Fullerton, CA, 2008


He College of Ophthalmology and Visual Sciences, Shenyang, China, 2008

School of Medicine, Gyeongsang National University, Jinju, South Korea, 2008

Graduate Program, Gyeongsang National University, Jinju, South Korea, 2008

Pink Tank IV: Modeling AMD Repair in the Pig Retina, Rockport, MA, 2008

California State University Fullerton, Stem Cell Biology, Fullerton, CA, 2008


Stem Cell Research Center, Journal Club, U.C. Irvine, 2009

Nippon Medical School, Department of Ophthalmology, 2009

Los Angeles Vision Symposium, Skirball Cultural Center, Los Angeles, 2009

California State University Fullerton, Stem Cell Biology, Fullerton, CA, 2009


The National Academy of Sciences, Distinctive Voices @ The Beckman Center, Irvine, 2010


University of California, Riverside, Department of Cell Biology and Neuroscience, 2010

Complutense University of Madrid, Ramon Castroviejo Institute of Ophthalmological Investigation, 2010

Orange County Vision Symposium, U.C. Irvine, 2010

University of California, Irvine, Stem Cell Research Center, Stem Cell Techniques Course, 2010

University of California, Irvine, Stem Cell Research Center, Graham Group Reception, 2011

Foundation Fighting Blindness, Speaker Series, Braille Institute, Anaheim, 2011

University of California, Irvine, Department of Ophthalmology, Grand Rounds, 2012

University of California, Irvine, School of Medicine, Dean’s Quarterly, 2012

Foundation Fighting Blindness, Speaker Series, Los Angeles, 2012

University of California, Irvine, Stem Cell Research Center, Friday Seminar Series, 2012

University of Michigan, Kellogg Eye Center, 2012

University of California, Irvine, Stem Cell Research Center, Stem Cell Awareness Day, 2012

Southern California College of Optometry, Fullerton, CA, 2012

City of Hope, Stem Cell Group Seminar, 2013

University of California, Irvine, Department of Ophthalmology, Scientific Meeting, 2013

California Institute of Regenerative Medicine, Public Event Participant, San Francisco, 2013

Foundation Fighting Blindness, Southern California Vision Seminar, Long Beach, 2013

University of California, Santa Barbara, Graduate Student Seminar Series, 2013

Foundation Fighting Blindness and Western University of Health Sciences, Vision & Health Seminar, Pomona 2013

World Presidents Organization, Gavin Herbert Eye Institute, Irvine, 2013

7

University of California, Irvine, Medical Cohort, Program in Nursing and Public Health, 2013

University of California, Irvine, Chinese Administration of Quality Supervision, Inspection, and Quarantine (AQSIQ) Delegation, 2013

Southern California College of Optometry, Marshall B. Ketchum Univ., Fullerton, CA, 2014

University of California, Irvine, Korean participants in Leaders in Industry-University Cooperation and Global Pioneers Program (LINC-GPP) from Gyeongsang National University (GNU), Jinju, South Korea, 2014

PLA Hospital, Department of Ophthalmology, Beijing, 2014

Osher Life Long Learning, Educational Class, Irvine, 2014

Laguna Beach Seniors, Health Series, Laguna Beach, 2014

Invited Participation at International Meetings

Beckman Initiative for Macular Research, Irvine, CA, 2009

4th Asia Bio-Business Partnering, Shenyang, China, 2009


CIRM-Germany Stem Cell Workshop, San Francisco, 2010 (deferred)



4. CIRM-UK House of Lords, Panel on Models for Translation, San Francisco, 2012


3rd Stem Cell Meeting: Working Towards a Cell-Based Therapy IND, National Eye Institute (NEI) and National Institutes for Health Center for Regenerative Medicine (NIH CRM), Bethesda, 2013

Monaciano Symposium, Siena, 2013


Research Funding

Previous Grants

Edmond & Marianne Blaauw Grant for Research in Ophthalmology, Sigma Xi, 1988

Chairman's Grant for Research, Yale Eye Center, 1992

Postdoctoral Research Fellowship (NRSA), National Eye Institute, 1995-1997

CHOC Foundation and Padrinos, Stem Cell Research, 1999-2001, PI

CHOC Padrinos, Immunogenicity of retino-tropic stem cells, 2001-2002, PI

CHOC Foundation, Characterization and uses of CNS stem cells, 2002-2005, PI

CHOC Foundation, Characterization and transplantation of human CNS stem cells from donated post-natal tissue, 2002-2005, Co-PI

Stem Cell Research Foundation, Isolation of stem cells from the human neural retina, 2002-2003, renewed for 2003-2004, PI

NIH/NINDS, Characterization of transgenic neural stem cells, R21 NS44060-01, 2002-2004, PI

8

NIH/NINDS, Administrative supplement 3 R21 NS44060-01S1 for study of human embryonic stem cells, one time award, PI

NIH/NINDS, Human embryonic stem cell culture training course, T15 HL074286-01, Co-PI

Hoag Foundation, Development of a therapy for degeneration of the central retina, 2004-2005, PI

NIST Advanced Technology Program, Novel technologies for adult stem cell therapeutics, Proposal Number 2004-00-6034, 2005-2007, Collaborator

Biomedical Research Council (A*Star BMRC Grant, Singapore), Isolation of multipotent progenitor cells from the retina of the GFP-transgenic pig and transplantation to the pig retina in conjunction with biodegradable polymer scaffolds, 2006, PI

Foundation Fighting Blindness, Multipotent progenitor cells: isolation and transplantation to the retina, 2006-2007, PI

California Institute for Regenerative Medicine. Stem cells for neuroprotection of photoreceptors in retinitis pigmentosa, CIRM Disease Team Planning Award DT1-00690, 2008-2009, PI, $37, 367.

Andrei Olenicoff Memorial Foundation, unrestricted funds for research on RP, 2008-2010, PI

Lincy Foundation/Discovery Eye Foundation. Functional reconstruction of the outer retina, 2007-2011, Group Leader and Co-PI

Allergan. Development of a novel retinal stem cell-based therapy for retinitis pigmentosa. 2010, Co-PI.

Beckman Initiative for Macular Research, GDNF-microspheres for treatment of atrophic AMD, 2010, PI

Josephine Herbert Gleis Foundation, unrestricted funds for research on AMD, 2011, PI, $5,000

California Institute for Regenerative Medicine. CIRM Early Translational II Research Award Application TR2-01794: Human retinal progenitor cells as candidate therapy for retinitis pigmentosa, PI, total award amount (3 Years): $3,855,277. Scientific Review Final Score 93. Start date May 1, 2011. End date September 30, 2012 (transition to DT2)

Present Grants

Polly and Michael Smith Foundation, unrestricted funds for research on AMD, 2010-2014, PI

Discovery Eye Foundation, unrestricted funds for work on retinal diseases, 2011-present

California Institute for Regenerative Medicine. CIRM Disease Team Therapy Development Award, DR2A-05739: Retinal progenitor cells for treatment of retinitis pigmentosa, PI, total award amount (4 Years): $17,306,668. Approved September 5, 2012. Start date January 1, 2013.

Research Partnership

National Institutes of Health (NIH)/National Center for Advancing Translational Science (NCATS). Therapeutics for Rare and Neglected Diseases (TRND) Program: Use of retinal progenitor cells for the treatment of retinitis pigmentosa, PI, approved April 30, 2013.

NIH Study Sections

National Heart, Lung, and Blood Institute, ad hoc reviewer, 2002

Neurogenesis and Cell Fate, ad hoc reviewer, 2005

hESC Challenge Grants, Subject Matter Expert, Special Expert Stage 1 reviewer, 2009

9

Other External Grant Reviews

LA BioMed at Harbor-UCLA Medical Center, 2006

King/Drew Medical Center, 2007

Fight for Sight, UK, 2007

The M. J. Murdock Charitable Trust, 2008

Medical Research Council, UK, 2008

Agence Nationale de la Recherche, Programme Blanc, France, 2009

Scott & White Healthcare, Research Grants Program, 2009



CIMIT, Center for Integration of Medicine & Innovative Technology, Boston, 2010

Agence Nationale de la Recherche, Laboratories for Excellence, France, 2011 (invited, no need)

CIMIT, Center for Integration of Medicine & Innovative Technology, Boston, 2011

Guide Dogs for the Blind Association, Hillfields, Reading, Berkshire, UK, 2011



Foundation Fighting Blindness (FFB), Early Translational Research Program (TRAP), 2013

The Government of the Hong Kong SAR, Health and Medical Research Fund (HMRF), 2013


Czech Science Foundation, 2013

The Government of the Hong Kong SAR, Health and Medical Research Fund (HMRF), 2014


NYSTEM Consortia Review, 2014

Editorial Service

Investigative Ophthalmology and Visual Science: ad hoc reviewer, since 1999

Experimental Eye Research: ad hoc reviewer, since 2001

Ophthalmic Research: ad hoc reviewer, since 2002

Human Gene Therapy: ad hoc reviewer, since 2003

Stem Cells: ad hoc reviewer, since 2003

Leonardo: expert opinion, 2003

Experimental Neurology: ad hoc reviewer, since 2004

Nature Biotechnology: ad hoc reviewer, since 2005

Developmental Brain Research: ad hoc reviewer, since 2005

Journal of Neuroscience: expert opinion, 2005

Cancer Cell International: ad hoc reviewer, since 2005

Acta Ophthalmologica Scandinavica: ad hoc reviewer, since 2006

Cell Death and Differentiation: ad hoc reviewer, since 2006

10

Journal of Neural Engineering: ad hoc reviewer, since 2006

European Journal of Neuroscience: ad hoc reviewer, since 2006

Journal of Neuroscience Methods: ad hoc reviewer, since 2007

Cell Research: ad hoc reviewer, since 2007

Stem Cells: ad hoc reviewer, since 2007

Neuroscience: ad hoc reviewer, since 2007

Molecular and Cellular Neuroscience: ad hoc reviewer, since 2008

Journal of Biomedical Materials Research: Part A: ad hoc reviewer, since 2008

Ophthalmic Research: ad hoc reviewer, since 2008

Current Stem Cell Research & Therapy: ad hoc reviewer, since 2008

Nature Protocols: ad hoc reviewer, since 2008

Clinical and Experimental Ophthalmology: ad hoc reviewer, since 2009

Stem Cells and Development: ad hoc reviewer, since 2009

Tissue Engineering: ad hoc reviewer, since 2009

Journal of Neuroscience Research: ad hoc reviewer, since 2009

Regenerative Medicine: ad hoc reviewer, since 2009

Cell Proliferation: ad hoc reviewer, since 2009

Journal of Ocular Biology Diseases and Informatics: ad hoc reviewer, since 2009

Expert Opinion On Biological Therapy: ad hoc reviewer, since 2010

PLoS ONE: ad hoc reviewer, since 2010

Stem Cell Reviews and Reports, ad hoc reviewer, since 2010

Journal of Neuroscience: ad hoc reviewer, since 2010

Gene Therapy and Regulation: ad hoc reviewer, since 2010

Journal of Tissue Engineering and Regenerative Medicine: ad hoc reviewer, since 2011

ACS Nano: ad hoc reviewer, since 2011

Stem Cells International: ad hoc reviewer, since 2011

Neurotherapeutics: ad hoc reviewer, since 2011

Science Translational Medicine: ad hoc reviewer, since 2011

Translational Vision Science & Technology: ad hoc reviewer, since 2012

Neuroscience Letters: ad hoc reviewer, since 2012

Asia-Pacific Journal of Ophthalmology: ad hoc reviewer, since 2012

Journal of Visualized Experiments (JoVE): ad hoc reviewer, since 2013

5. Lead Guest Editor, Special Issue: Stem Cells in Large Animal Models of Retinal and Neurological Disease, Stem Cells International, 2012

External Faculty Examiner or Evaluator

Christina Flaxel, MD, promotion to Clinical Associate Professor, Doheny Eye Institute, 2002

Anita Wojciechowski, doctoral dissertation, Lund University, 2004

11

Yau Wen Yee, Thesis: Bachelor of Medical Science, University of Melbourne, 2004

Mark Kirk, PhD, promotion to Professor, University of Missouri, 2004

Hui Shao, MD, promotion to Associate Professor, University of Louisville, 2005

Leonard Hetherington, doctoral dissertation, University of Sheffield, 2005

Sophia Liao, MS, predoctoral CIRM scholarship, University of California, Irvine, 2007

Sara Dawen Qi, Thesis: Bachelor of Medical Science, University of Melbourne, 2010

Samarendra Mohanty, promotion to Associate Professor, University of Texas at Arlington, 2013

Stephen Redenti, promotion to Associate Professor, Lehman College, City University of New York, 2013

University Service, U.C. Irvine

Faculty interviewer, student applicants to School of Medicine, 2010-present

Executive Committee, Department of Ophthalmology, 2010-present

Ad Hoc Space Committee, Stem Cell Research Center, 2013

Core & Shared Resources Committee, Stem Cell Research Center, 2013-present

Reviewer, 2014 ICTS Pilot Grants, Institute for Clinical and Translational Science, 2013

Search Committee for Beckman Postdoctoral Fellowships, Gavin Herbert Eye Institute, 2014

Intellectual Property

Klassen, H., Whiteley, S., Young, M. Low dose IL-1-induced photoreceptor rescue without retinal dysplasia. International Patent Application PCT/US00/12565. Abandoned.

Young, M., Gage, F., Ray, J.,Whiteley, S., Klassen, H. Integration of transplanted neural progenitor cells into neural tissue of immature and mature recipients. International Patent Application PCT/US00/03534. Abandoned.

Klassen, H., Schwartz, M., Young, M. Isolation of neural stem cells using gangliosides and other surface markers. U.S. Patent No. 7,419,825.

Young, M., Klassen, H., Shatos, M., Mizumoto, K. Isolation and transplantation of retinal stem cells. U.S. Patent No. 7,514, 259. European patent No. 01 907 195.0 (1 261 357).

Young, M. and Klassen, H. Composite graft for treatment of retinal diseases. U.S. Patent Application No. 60/343,402. Abandoned.

Desai, T., Tao, S., Young, M., Klassen, H. Topographically engineered structures and methods for using the same in regenerative medicine applications. International Application Number: PCT/US2008/056436.

Tao, S, Klassen, H., Young, M. Ocular scaffolds and methods for subretinal repair of Bruch’s membrane. International Application Number: PCT/US2009/0306772. Abandoned.

Klassen, H., Yang, J. Composition and methods for treating retinal diseases. International Application Number: PCT/US2012/038342.

Klassen, H., Schwartz, M., Young, M. Isolation of neural stem cells using gangliosides and other surface markers. U.S. Patent No. 8,241,897 (Continuation of 7,419,825).

12

Refereed Journal Articles

1. Bridgeman, B. and Klassen, H. (1983) On the origin of stroboscopic induced motion. Percep. Psychophys. 34:149-154.

Klassen, H. and Lund, R. (1987) Retinal transplants can drive a pupillary reflex in host rat brains. Proc. Natl. Acad. Sci. USA 84: 6958-6960.

Klassen, H. and Lund, R. (1988) Anatomical and behavioral correlates of a xenograft-mediated pupillary reflex. Exp. Neurol. 102:102-108.

Klassen, H. and Lund, R. (1990) Retinal graft-mediated pupillary responses in rats: restoration of a reflex function in the mature mammalian brain. J. Neurosci. 10:578-587.

Klassen, H. and Lund, R. (1990) Parameters of retinal graft-mediated responses are related to underlying target innervation. Brain Res. 533:181-191.

Huncharek, M., Klassen, H. and Klassen, M. (1994) Splenic artery aneurysm and upper gastrointestinal bleeding in a nulliparous woman--a case history. Angiology 45:733-735.

Filatov, V., Tom, D., Alexandrakis, G., Skolik, S., Klassen, H. and Liggett, P. (1995) Branch retinal artery occlusion associated with directional coronary atherectomy after percutaneous transluminal coronary angioplasty. Am. J. Ophthalmol. 120:391-393.

Klassen, H., Klassen, M. and Huncharek, M. (1995) Group B streptococcal meningitis presenting as stroke in a nondebilitated man. Yale J. of Biol. and Med. 68:1-6.

Sauvé, Y., Klassen, H., Whiteley, S., and Lund, R. (1998) Visual field loss in RCS rats and the effect of RPE cell transplantation. Exp. Neurol. 152(2):243-250.

Schnell, L., Fearn, S., Klassen, H., Schwab, M., Perry, V.H. (1999) Acute inflammatory responses to mechanical lesions in the CNS: differences between brain and spinal cord. Eur. J. Neurosci. 11:3648-3658.

Sauvé, Y., Klassen, H., Whiteley, S., and Lund, R. (1999) Age-dependent visual field loss in RCS rats and the relative benefits of subretinal over intravitreal RPE transplantation. Dig. J. Ophthalmol. 5(1).

Young, M., Ray, J., Whiteley, S., Klassen, H., Gage, F. (2000) Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystropic rats. Mol. Cell. Neurosci. 16 (3):1997-2005.

Shatos, M., Mizumoto, K., Mizumoto, H., Kurimoto, Y., Klassen, H., Young, M. (2001) Multipotent stem cells from the brain and retina of green mice. e-biomed: The Journal of Regenerative Medicine 2:13-15.

Mizumoto, H., Mizumoto, K., Whiteley, S., Shatos, S., Klassen, H., Young, M. (2001) Transplantation of human neural progenitor cells to the vitreous cavity of the Royal College of the Surgeons rat. Cell Transplant. 10:223-233.

Klassen, H., Whiteley, S., Young, M., Lund, R. (2001) Graft location affects functional rescue following RPE cell transplantation in the RCS rat. Exp. Neurol. 169:114-121.

Klassen, H., Schwartz, M., Bailey, A., Young, M. (2001) Surface markers expressed by multipotent human and mouse neural progenitor cells include tetraspanins and non-protein epitopes. Neurosci. Lett. 312:180-182.

Whiteley, S., Klassen, H., Coffey, P., Young, M. (2001) Photoreceptor rescue after low dose intravitreal

interleukin-1 injection in the RCS rat. Exp. Eye Res. 73:557-568.

Huncharek, M., Klassen, H., Kupelnick, B. (2001) Dietary beta-carotene intake and the risk of epithelial ovarian cancer: a meta-analysis of 3,782 subjects from five observational studies. In Vivo 15:339-343.

13

Huncharek, M., Kupelnick, B., Klassen, H. (2001) Paternal smoking during pregnancy and the risk of childhood brain tumors: Results of a meta-analysis. In Vivo 15:535-542.

Huncharek, M., Kupelnick, B., Klassen, H. (2002) Maternal smoking during pregnancy and the risk of childhood brain tumors: A meta-analysis of 6,566 subjects from twelve epidemiological studies. J. Neurooncol. 57(1):51-57.

Klassen, H., Imfeld, K., Ray, J., Young, Gage, F., M., Berman, M. (2003) The immunological properties of adult hippocampal progenitor cells. Vision Res. 43(8):947-956.

Mizumoto, H., Mizumoto, K., Shatos, M., Klassen, H., Young, M. (2003) Retinal transplantation of neural progenitor cells derived from the brain of GFP transgenic mice. Vision Res. 43(16):1699-1708.

Hori, J., Ng, T.-F., Shatos, M., Klassen, H., Streilein, J. W., Young, M. (2003) Neural stem cells lack immunogenicity and resist destruction as allografts. Stem Cells. 21(4):405-416.

Klassen, H., Imfeld, K., Kirov, I., Gage, F., Young, M., Berman, M. (2003) Expression of cytokines by multipotent neural progenitor cells. Cytokine. 22(3-4):101-106.

Schwartz, P., Bryant, P., Fuja, T., Su, H., O'Dowd, D., Klassen, H. (2003) Isolation and characterization of neural progenitor cells from post-mortem human cortex. J. Neurosci. Res. 74:838-851.

Klassen, H., Ziaeian, B., Kirov, I., Young, M., Schwartz, P. (2004) Isolation of retinal progenitor cells from postmortem human tissue with comparison to autologous brain progenitors. J. Neurosci. Res. 77(3):334-343.

Klassen, H., Ng, T.-F., Kurimoto, Y., Kirov, I., Shatos, M., Coffey, P., Young, M. (2004) Multipotent progenitor cells express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior. Invest. Ophthalmol. Vis. Sci. 45:4167-4173.

Lavik, E., Klassen, H., Warfvinge, K., Langer, R., Young, M. (2005) Fabrication of degradable polymer scaffolds to direct the integration and differentiation of retinal progenitors. Biomaterials 26:3187-3196.

Zahir, T., Klassen, H., Young, M. (2005) Effects of ciliary neurotrophic factor on differentiation of late retinal progenitor cells. Stem Cells 23: 424-432.

Warfvinge, K., Kiilgaard, J., Lavik, E., Scherfig, E., Langer, R., Klassen, H., Young, M. (2005) Retinal progenitor cell xenografts to the pig retina: morphological integration and cytochemical differentiation. Arch. Ophthalmol. 123:1385-1393.

Schwartz, P., Nethercott, H., Kirov, I., Ziaeian, B., Young, M., Klassen, H. (2005) Expression of neurodevelopmental markers by cultured porcine neural precursor cells. Stem Cells 23:1286-1294.

2. Tomita, M., Lavik, E., Klassen, H., Zahir, T., Langer, R., and Young, M. (2005) Biodegradable polymer composite grafts promote the survival and differentiation of retinal progenitor cells. Stem Cells 23:1579-1588.

3. Warfvinge, K., Kiilgaard, J., Klassen, H., Zamiri, P., Scherfig, E., Streilein, J.W., Prause, J., Young, M. (2006) Retinal progenitor cell xenografts to the pig retina: immunological reactions. Cell Transplant. 15(7):603-612.

4. Yang, J., Klassen, H., Pries, M., Wang, W., Nissen, M. (2006) Aqueous humor enhances the proliferation of rat retinal precursor cells in culture and this effect is partially reproduced by ascorbic acid. Stem Cells 24:2766-2775.

5. Zahir, T., Tomita, M., Klassen, H., Young, M. (2006) Sorbitol promotes differentiation of late retinal progenitor cells into Müller glia in vitro. Molec. Vis. 12:1606-1614.

6. Klassen, H. (2007) Recruitment of endogenous neural progenitor cells by malignant neoplasms of the central nervous system. Curr. Stem Cell Res. & Ther. 2:113-119.

14

7. Zhang, Y., Klassen, H., Tucker, B., Perez, M-T, Young, M. (2007) CNS progenitor cells promote a permissive environment for neurite outgrowth via an MMP-dependent mechanism. J. Neurosci. 27:4499-4506.

8. Klassen, H., Kiilgaard, J., Zahir, T., Ziaeian, B., Kirov, I., Scherfig, E., Warfvinge, K., Young, M. (2007) Progenitor cells from the porcine neural retina express photoreceptor markers after transplantation to the subretinal space of allorecipients. Stem Cells 25:1222-1230.

9. Tao, S., Young, C., Redenti, S., Zhang, Y., Klassen, H., Desai, T., Young, M. (2007) Survival, migration and differentiation of retinal progenitor cells transplanted on micro-machined poly(methyl methacrylate) scaffolds to the subretinal space. Lab Chip 7:695-701.

10. Klassen, H., Schwartz, P., Nethercott, H., Ziaeian, B., Young, M., Narfstrom, K. (2007) Neural precursors isolated from the developing cat brain show retinal integration following transplantation to the retina of the dystrophic cat. Vet. Ophthalmol. 10: 245-253.

11. Jiang, C., Moore, M., Zhang, X., Klassen, H., Langer, R., Young, M. (2007) Intravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glaucoma. Molec. Vis. 13:1783-1792.

12. Neeley, W., Redenti, S., Klassen, H., Young, M., Langer, R. (2008) A microfabricated scaffold for retinal progenitor cell grafting. Biomaterials 29: 418-426.

13. Tucker, B., Klassen, H., Yang, L., Chen, DF, Young, M. (2008) Elevated MMP expression in the MRL mouse retina creates a permissive environment for retinal regeneration. Invest. Ophthalmol. Vis. Sci. 49:1686-1695.

14. Redenti, S., Tao, S., Yang , J., Gu, P., Klassen, H., Saigal, S., Desai, T., Young, M. (2008) Retinal tissue engineering using mouse retinal progenitor cells and a novel biodegradable, thin-film poly(e-caprolactone) nanowire scaffold. J. Oc. Biol. Dis. Informat. 1: 19-29.

Klassen, H., Warfvinge, K., Schwartz, P, Kiilgaard, J., Shamie. N., Jiang, C., Samuel, M., Scherfig, E., Prather, R., Young, M. (2008) Isolation of progenitor cells from GFP-transgenic pigs and transplantation to the retina of allorecipients. Cloning Stem Cells 10:391-402.

Yang, J., Klassen, H., Pries, M., Wang, W., Nissen, M. (2009) Vitreous humor and albumin augment the proliferation of cultured retinal precursor cells. J. Neurosci. Res. 87:495-502.

Redenti, S., Neeley, W., Rampani, S., Saigal, S., Yang, J., Klassen, H., Cepko, C., Langer, R., Young, M. (2009) Engineering retinal progenitor cell and scrollable poly(glycerol-sebacate) composites for expansion and subretinal transplantation. Biomaterials 30:3405-3414.

Voss Kyhn, M., Warfvinge, K., Scherfig, E., Kiilgaard, J., Prause, J., Klassen, H., Young, M., la Cour, M. (2009) Acute retinal ischemia caused by controlled low ocular perfusion pressure in a porcine model. Electrophysiological and histological characterisation. Exp. Eye Res. 88:1100-1106.

Aftab, U., Jiang, C., Tucker, B., Kim, J.-Y., Klassen, H., Miljan, E., Sinden, J., Young, M. (2009) Growth kinetics and transplantation of human retinal progenitor cells. Exp. Eye Res. 89:301-310.

Schmitt, S., Aftab, U., Jiang, C., Redenti, S., Klassen, H., Miljan, E., Sinden, J., Young, M. (2009) Molecular characterization of human retinal progenitor cells. Invest. Ophthalmol. Vis. Sci. 50:5901-5908.

Gu, P., Yang, J., Young, M., Klassen, H. (2009) Sequential changes in the gene expression profile of murine retinal progenitor cells during the induction of differentiation. Molec. Vis. 15:2111-2122.

Kyhn, M.V., Klassen, H., Johansson, U., Warfvinge, K., Lavik, E., Kiilgaard, J., Prause, J., Scherfig, E., Young, M., la Cour, M. (2009) Delayed administration of glial cell line-derived neurotrophic factor (GDNF) protects retinal ganglion cells in a pig model of acute retinal ischemia. Exp. Eye Res. 89:1012-1020.

15

Tucker, B., Redenti, S., Jiang, C., Swift, J., Klassen. H., Smith, M., Wnek, G., Young, M. (2010) The use of progenitor cell/biodegradable MMP2-PLGA polymer constructs to enhance cellular integration and retinal repopulation. Biomaterials 31:9-19.

Steedman, M., Tao, S., Klassen, H., Desai, T. (2010) Enhanced differentiation of retinal progenitor cells using microfabricated topographical cues. Biomed. Microdevices 12:363-369.

Jiang, C., Klassen, H., Zhang, X., Young, M. (2010) Laser injury promotes migration and integration of retinal progenitor cells into host retina. Molec. Vis. 16:983-990.

Sodha, S., Wall, K., Redenti, S., Klassen, H., Young, M., Tao, S. (2011) Microfabrication of a three-dimensional polycaprolactone thin film scaffold for retinal progenitor cell encapsulation. J. Biomater. Sci. Polym Ed. 22:443-456.

Cho, S., Lee, Y., Lee, J., Yang, J., Klassen, H., Kong, I. (2010) Conformation of germ-line transmission in the red fluorescence protein (RFP) transgenic cloned male cat. Cell. Reprogram. 12:739-747.

Ejstrup, R., Kiilgaard, J., Tucker, B., Klassen, H., Young, M. La Cour, M. (2010) Pharmacokinetics of intravitreal glial cell line-derived neurotrophic factor: experimental studies in pigs. Exp. Eye Res. 91:890-895.

15. You, X.J., Gu, P., Wang, J., Song, T., Yang, J., Liew, C.G., Klassen, H. (2011) Efficient transduction of feline neural progenitor cells for delivery of glial cell line-derived neurotrophic factor using a feline immunodeficiency virus-based lentiviral construct. J. Ophthalmol. pii: 378965, Epub September 20, 2010.

Wang, J., Yang, J., Gu, P., Klassen, H. (2010) Effects of glial cell line-derived neurotrophic factor on cultured murine retinal progenitor cells. Molec. Vis. 16:2850-2866.

Tucker, B., Park, I.H., Klassen, H., Redenti, S., Jiang, C., Qi, S., Daley, G., Young, M. (2011) Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in retinal degenerative mice. PLoS ONE 6(4): e18992. doi:10.1371/journal.pone.0018992.

Warfvinge, K., Schwartz, P., Kiilgaard, J., la Cour, M., Young, M., Scherfig, E., Klassen, H. (2011) Xenotransplantation of human neural progenitor cells to the subretinal space of non-immunosuppressed pigs. J. Transplant. 2011:948740, doi:10.1155/2011/948740.

a. Christiansen, A., Kiilgaard, J., Smith, M., Ejstrup, R., Wnek, G., Prause, J., Young, M., Klassen, H., Kaplan, H., la Cour, M. (2012) The influence of brightness on functional assessment by mfERG; a study on scaffolds used in retinal cell transplantation in pigs. Stem Cells Intl. 2012:263264, 7 pages, doi:10.1155/2012/263264.

Torrez, L.B., Perez, Y., Yang, J., zur Nieden, N., Klassen, H., Liew, C. (2012) Derivation of neural progenitors and retinal pigment epithelium from common marmoset and human pluripotent stem cells. Stem Cells Intl. 2012: 417865, 9 pages, doi:10.1155/2012/417865.

b. Christiansen, A., Tao, S., Smith, M., Wnek, G., Prause, J., Young, M., Klassen, H., Kaplan, H., la Cour, M., Kiilgaard, J. (2012) Subretinal implantation of electrospun, short nanowire and smooth poly (ε-caprolactone) (PCL) scaffolds to the subretinal space of porcine eyes. Stem Cells Intl. 2012:454295, 8 pages, doi:10.1155/2012/454295.

Klassen, H., Kiilgaard, J.F., Warfvinge, K., Prather, R., Petters, R., la Cour, M., Young, M. (2012) Cultured retinal progenitor cells exhibit an advanced level of photoreceptor differentiation following transplantation to the retinal dystrophic pig. Stem Cells Intl. 2012:939801, 9 pages, doi:10.1155/2012/939801.

Yang, J., Wang, J., Gu, P., You, J., Klassen, H. (2012) Feline neural progenitor cells I: Long-term expansion under defined culture conditions. Stem Cells Intl. 2012:108340. 10 ages, doi:10.1155/2012/108340.

16

You, J., Yang, J., Gu, P., Liew, C., Klassen, H. (2012) Feline neural progenitor cells II: Use of a novel plasmid vector and hybrid promoter to drive expression of a glial cell line-derived neurotrophic factor transgene in feline neural progenitor cells. Stem Cells Intl. 2012: 604982, 9 pages, doi:10.1155/2012/604982.

Yang, J., Gu, P., Menges, S., Klassen, H. (2012) Quantitative changes in gene transcription during induction of differentiation in porcine neural progenitor cells. Molec. Vis. 18:1484-1504.

Qin, Z., Yang, J., Klassen, H., Aswad, D. (2014) Isoaspartyl protein damage and repair in mouse retina. Invest. Ophthalmol. Vis. Sci. 55:1572-1579.

Reviews

1. Klassen, H., Sakaguchi, D., Young, M. (2004) Stem cells and retinal repair. Prog. Retin. Eye Res. 23:149-181.

2. Klassen, H. (2006) Transplantation of cultured progenitor cells to the mammalian retina. Expert Opin. Biol. Ther. 6:443-451.

Book Chapters

1. Lund, R., Radel, J., Hankin, M., Klassen, H., Coffey, P. and Rawlins, J. (1989) Developmental and functional integration of retinal transplants with host rat brains. Brain Repair Symposium, Wenner Gren Center International Conference, Stockholm, Sweden.

2. Flaxel, C., Klassen, H. and Gregor, Z. (1997) Antiangiogenic agents in vitreoretinal disease. In Ophthalmology Clinics of North America: Advances in Ocular Pharmacology. 10(3):421-433.

3. Lund, R., Klassen, H. and Young, M. (2000) Retinal transplantation and the pupillary light reflex. In Nervous Control of the Eye, Burnstock, G. and Sillito, A., eds., Volume 13 in the series: The Autonomic Nervous System, Harwood Academic Publishers, Amsterdam. 13:211-234.

4. Klassen, H., Young, M., Ritch, R., Richards, J., Borras, T., Levin, L. (2007) Retinal stem cell research. Chapter 68 in Vitreoretinal Surgical Techniques, 2nd edition, Peyman, Meffert, and Conway, eds. Abingdon, Oxfordshire, UK: Taylor & Francis. 668-676.

5. Yau, J., Klassen, H., Zahir, T., and Young, M. (2007) Stem cells and retinal transplantation. Chapter 20 in Retinal Degenerations: Biology, Diagnostics, and Therapeutics, Tombran-Tink, J. and Barnstable, C. eds. Humana Press. 385-400.

6. Li, S., Kirov, I., Klassen, H., Schwartz, P. (2007) Characterization of human stem cells using reverse transcriptase-polymerase chain reaction (RT-PCR) and real-time quantitative RT-PCR (rtqRT-PCR). Chapter 10 in Human Stem Cell Manual: A Laboratory Guide, Loring, J, Wesselschmidt, R., and Schwartz, P., eds., Elsevier. 129-150.

7. Ng, T.-F., Klassen, H., Hori, J., and Young, M. (2007) Retinal transplantation. In Immune Response and the Eye, 2nd edition. Niederkorn, J. and Kaplan, H., eds. A volume in the series Chemical Immunology and Allergy. Karger AG (Basel). 92:300-16.

8. Hori, J., Ng, T.-F., Shatos, M., Klassen, H., Streilein, J. W., Young, M. (2007) Neural stem cells lack immunogenicity and resist destruction as allografts. In Ocul. Immunol. Inflamm. 15(3):261-273.

9. Sakaguchi, D., Klassen, H., Young, M. (2007) Transplantation of neural progenitors to the developing retina. In Strategies for retinal tissue repair and regeneration in vertebrates: from fish to human. Chiba, C., ed., Research Signpost. 113-137.

10. Klassen, H. (2008) Progenitor cell transplantation for retinal disease. In Stem Cell Research and Therapeutics, Shi, Y., and Clegg, D., ed.s. Springer. 25-44.

17

11. Tucker, B., Klassen, H., Young, M. (2010) Cellular repopulation of the retina. Chapter 77 in Ocular Disease: Mechanisms and Management. Levin, L., and Albert, D., eds. 607-611.

12. Tucker, B., Klassen, H., Young, M. (2010) Injury and repair: stem cells and transplantation. Chapter 221 in Encyclopedia of the Eye. Dart, D., ed. Elsevier. 421-427.

13. Redenti, S., Klassen, H., Young, M. (2011) Tissue Engineering of Organs: Eye/retina. In The Tissue Engineering Book: State of the Art, Visions, and Limitations. Pallua, ed. Springer. Part 2, 335-346.

14. Tao, S., Klassen, H. Tissue engineering in the retina. In Stem Cell Transplantation to the Retina: Development, Plasticity, Regeneration and Repair. Sakaguchi, D., Young, M., and Klassen H., eds. World Scientific. In press.

15. Klassen, H., translated from English to Portuguese by Abud, M. (2010) Perspectivas do potencial das células progenitoras e seu uso para o tratamento de doenças da retina (Perspective on the potential use of progenitor cells for treatment of retinal disease). Chapter 37 in Vitrectomia 20, 23 E 25G. Avila, M., Isaac, D., and Santos, R., eds. Cultura Medica. 387-394.

16. Sheu, J., Klassen, H., Bauer, G. (2014) Cellular manufacturing for clinical applications. In Cell-Based Therapy for Retinal Degenerative Disease. Casaroli and Zarbin, eds. Karger, vol 53, 178-188. DOI: 10.1159/000357362.

Invited Commentaries, Editorials, and Published Letters

1. Klassen, H. (1990) The discovery of the graft-mediated pupillary reflex. JAMA 263:760.

2. Huncharek, M., Klassen, H. (1993) Acyclovir in varicella pneumonia in healthy adults. Respiration 60:254-255.

6. Young, M., Klassen, H. (2006) Polymeric delivery of neuroprotective compounds to the vitreous cavity: a potential treatment for glaucoma. Arch. Soc. Esp. Oftalmol. 81:429-432.

3. Young, M., Tucker, B., Klassen, H. (2007) Stemming the tide of retinal degeneration. Retinal Physician. May issue, online article 100301.

4. Klassen, H. and Reubinoff, B. (2008) Stem cells in a new light. Nature Biotechnol. 26: 187-188.

5. Klassen, H. (2012) New tool for retinal degeneration research. Invest. Ophthalmol. Vis. Sci. 53:926.

6. Klassen, H., Tucker, B, Liew, C, la Cour, M., Wang, H. (2012) Stem cells in large animal models of retinal and neurological disease. Stem Cells Intl. 2012:460504, 2 pages, doi: 10.1155/2012/460504.

7. Klassen, H. (2013) Stem cell clinical trials: toward cell-based therapy for retinal degenerations. Clin. Invest. 3:703-705.

Published Abstracts

1. Thind, K., Neiman, R. and Klassen, H. (1985) Contact liquid crystal thermography in carpal tunnel syndrome. Proceedings of the 1985 Meeting of the Archives of Physical Medicine and Rehabilitation.

2. Klassen, H. and Lund, R. (1987) Retinal transplants mediate a pupillary reflex in host rats. Soc. for Neurosci. Abstr. 13:290.

3. Klassen, H. and Lund, R. (1988) Anatomical and behavioral correlates of xenograft-mediated pupillary reflex. Soc. for Neurosci. Abstr. 14:1276.

4. Klassen, H. and Lund, R. (1988) Retinal transplants can make functional connections with the mature brain. Soc. for Neurosci. Abstr. 14:1277.

5. Radel, J., Klassen, H. and Lund, R. (1988) Transplant and host retinal inputs interact to drive pupillary reflex. Soc. for Neurosci. Abstr. 14:1277.

18

6. Radel, J., Klassen, H. and Lund, R. (1989) Functional interactions of transplant and host retinal inputs: the pupillary reflex. IIIrd International Symposium on Neural Transplantation, Restorative Neurology and Neuroscience, Suppl.

7. Klassen, H. and Lund, R. (1990) The magnitude of a graft-mediated reflex correlates with the amount of graft-specific immunoreactivity in the appropriate target nucleus. The Second Annual Bristol-Myers Squibb Symposium on Neuroscience Research: Plasticity and Pathology in the Damaged Brain.

8. Young, M., Klassen, H. and Lund, R. (1991) Effects of lesions of the olivary pretectal nucleus on the direct and consensual pupillary reflexes. Soc. for Neurosci. Abstr. 17:558.

9. Klassen, H., Klassen, M. and Barnstable, C. (1993) Cotransplantation of embryonic whole eye and tectum to the anterior chamber of the rat. Invest. Ophthalmol. & Vis. Sci. 34 (4, suppl): 1097.

10. Klassen, H., Klassen, M., Chaudhry, N., Liggett, P. and Barnstable, C. (1993) Successful development of mammalian embryonic eye transplants within the anterior chamber. Soc. for Neurosci. Abstr. 19:1513.

11. Klassen, H., Klassen, M., Chaudhry, N. and Liggett, P. (1994) Transplantation of embryonic eyes to the rabbit anterior chamber. Invest. Ophthalmol. & Vis. Sci. 35 (4, suppl):1524.

12. Klassen, H., Chaudhry, N., Klassen, M. and Liggett, P. (1995) In vivo evaluation of vascular integrity in intraocular grafts using fluorescein angiography. Invest. Ophthalmol. & Vis. Sci. 36 (4, suppl):551.

13. Sauvé, Y., Klassen, H., Whiteley, S., Litchfield, T. and Lund, R. (1996) Functional preservation following RPE grafting: I. Retinotopic mapping in the superior colliculus. Invest. Ophthalmol. & Vis. Sci. 37 (3, suppl):93.

14. Whiteley, S., Klassen, H., Sauvé, Y., Litchfield, T. and Lund, R. (1996) Functional preservation following RPE grafting: II. Correlation of SC responses with pupillometry and anatomy. Invest. Ophthalmol. & Vis. Sci. 37 (3, suppl):93.

15. Sauvé, Y., Klassen, H., Whiteley, S., Litchfield, T. and Lund, R. (1996) Retinotopic analysis of response parameters in the superior colliculus of RCS rats following retinal pigment epithelial cell transplantation. Soc. for Neurosci. Abstr. 22:1978.

16. Klassen, H., Sauvé, Y., Whiteley, S., and Lund, R. (1997) Pigment epithelial cell grafting in the dystrophic rat: Correlation of function and anatomy. Invest. Ophthalmol. & Vis. Sci. 38 (suppl):946.

17. Whiteley, S., Klassen, H., and Lund, R. (1998) Altitudinal position of subretinal RPE grafts affects pupillary performance in RCS rats. Invest. Ophthalmol. & Vis. Sci. 39 (4, suppl):440.

18. Klassen, H., Whiteley, S., and Lund, R. (1998) Reaction of non-neuronal cells to subretinal injury in the dystrophic rat. Invest. Ophthalmol. & Vis. Sci. 39 (4, suppl):441.

19. Young, M., Klassen, H., Whiteley, S., and Lund, R. (1998) Long-term assessment of photoreceptor rescue in the RCS rat following laser photocoagulation. Invest. Ophthalmol. & Vis. Sci. 39 (4, suppl):3839.

20. Klassen, H., Whiteley, S., and Young, M. (1999) Photoreceptor rescue in the RCS rat following intravitreal

IL-1 injections without concomitant retinal dysplasia. Invest. Ophthalmol. & Vis. Sci. 40 (suppl):43.

21. Whiteley, S., Ray, J., Klassen, H., Young, M., and Gage, H. (1999) Survival and integration of neural progenitor cells transplanted into the dystrophic mouse retina. Invest. Ophthalmol. & Vis. Sci. 40 (suppl):113.

22. Young, M., Ray, J., Whiteley, S., Klassen, H., and Gage, H. (1999) Integration of transplanted neural progenitor cells into the retina of the dystrophic rat. Invest. Ophthalmol. & Vis. Sci. 40 (suppl):113.

23. Klassen, H., Imfeld, K., Whiteley, S., Ray, J., Young, Gage, F., Berman, M. (1999) Immunological characteristics of clonally-derived adult hippocampal progenitor cells. EMBO Workshop: Stem Cells, Growth Factors and Cancer.

19

24. Klassen, H., Imfeld, K., Young, M., Berman, M. (1999) Production of interleukin-1 by human neural progenitor cells. Soc. for Neurosci. Abstr. 25:1535.

25. Whiteley, S., Mizumoto, K., Mizumoto, H., Klassen, H., Young, M. (1999) Transplantation of human embryonic progenitor cells into an animal model of retinal degeneration. Soc. for Neurosci. Abstr. 25:213.

26. Young, M., Ray, J., Whiteley, S., Klassen, H., and Gage, F. (1999) Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats. Soc. for Neurosci. Abstr. 25:2263.

27. Klassen, H., Imfeld, K., Young, M., Ray, J., Gage, F., Berman, M. (2000) Immunological characteristics of a progenitor cell line capable of retinal integration. Invest. Ophthalmol. & Vis. Sci. 41 (suppl):15.

28. Shatos, M., Mizumoto, K., Mizumoto, H., Whiteley, S., Klassen, H., Young, M. (2000) Isolation and characterization of retinal progenitor cells from GFP transgenic mice. Invest. Ophthalmol. & Vis. Sci. 41 (suppl):747.

29. Klassen, H., Young, M. (2000) Adult hippocampal progenitor cells: immunological characteristics in vitro. ISDN 2000:63.

30. Young, M., Klassen, H. (2000) CNS stem cell transplants in rodent models of retinal degeneration. ISDN 2000:67.

31. Klassen, H., Imfeld, K., Young, M., Ray, J., Gage, F., Berman, M. (2000) Rat hippocampal progenitor cells do not elicit an immunological response in vitro. Soc. for Neurosci. Abstr. 26: 12.

32. Klassen, H., Young, M. (2001) Transplantation of stem cells to the retina. Twenty First Moorfields Alumni Meeting.

33. Klassen, H., Gage, F., Young, M. (2001) Retino-tropic neural stem cells up-regulate transplantation

antigens in response to IFN-. Invest. Ophthalmol. & Vis. Sci. 42 (suppl):198.

34. Lauritzen, D., Kurimoto, Y., Gage, F., Klassen, H., Young, M. (2001) Retinal transplantation of neural progenitor cells in rats transgenic for mutant rhodopsin. Invest. Ophthalmol. & Vis. Sci. 42 (suppl):198.

35. Whiteley, S., Klassen, H., Coffey, P., Young, M. (2001) IL-1 ameliorates visual function deterioration and photoreceptor degeneration in the RCS rat. Invest. Ophthalmol. & Vis. Sci. 42 (suppl):631.

36. Schwartz, M., Bailey, A., Young, M., Klassen, H. (2001) Surface marker expression by neural progenitor cells. Soc. for Neurosci. Abstr. 27:1525.

37. Ng, TF, Hori, J, Klassen, H., Streilein, JW, Young, M. (2001) Comparison of the immunogenicity of neonatal brain and neural stem cells. Soc. for Neurosci. Abstr. 27:1565.

38. Klassen, H., Schwartz, M., Shatos, M., Young, M. (2002) Multipotent progenitor cells from the neural retina express identified surface markers and respond to cytokines. Invest. Ophthalmol. & Vis. Sci. 43 (suppl):157.

39. Klassen, H., Young, M. (2002) Expression of transplantation antigens by CNS stem cells. Sixth Annual Vision Research Conference, Retinal Cell Rescue.

40. Klassen, H., Young, M. (2002) Expression of MHC antigens by stem cells of the central nervous system. XV International Congress of Eye Research.

41. Warfvinge, K., Kiilgaard, J., Lavik, E., Klassen, H., Scherfig, E., Langer, R., Young, M. (2003) Survival, integration and differentiation of retinal progenitor cells from GFP transgenic mice transplanted subretinally to adult, normal pigs. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 483.

20

42. Kiilgaard, J., Scherfig, E., Klassen, H., Warfvinge, K., Prause, J., Young, M. (2003) Transplantation of xenogeneic retinal stem cells to pig subretinal space. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 487.

43. Lavik, E., Klassen, H., Warfvinge, K., Scherfig, E., Kiilgaard, J., Langer, R., Young, M. (2003) Polymer scaffolds provide support and guidance for retinal stem cells in retinal degeneration models. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 508.

44. Zahir, T., Lavik, E., Klassen, H., Langer, R., Young, M. (2003) Differentiation of retinal progenitor cells into specific cell types. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 1666.

45. Klassen, H., Schwartz, M., Zahir, T., Schwartz, P., Young, M. (2003) Human retinal progenitors can be cultured from cadaveric tissue and express GD2 ganglioside and other known surface markers. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 1691.

46. Shatos, M., Klassen, H., Scherfig, E., Kiilgaard, J., Warfvinge, K., Prause, J., Young, M. (2003) Isolation, characterization, and expansion of porcine retinal progenitor cells. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 1694.

47. Klassen, H., Schwartz, P., Ziaeian, B., Kirov, I., Young, M. (2003) Human retinal progenitors can be cultured from postmortem tissue and express a range of known primitive and mature markers. Soc. for Neurosci. Abstr. 453.3

48. Schwartz, P., Ziaeian, B., Kirov, I., Fuja, T., Su, H., Bryant, P., O'Dowd, D., Klassen, H. (2003) Banking human neural stem cells from postmortem brain. Soc. for Neurosci. Abstr. 453.4

49. Warfvinge, K., Kiilgaard, J., Klassen, H., Scherfig, E., Shatos, M., Holmqvist, B., Young, M. (2003) Survival, integration and differentiation of retinal progenitor cells from fetal pigs after subretinal transplantation to adult normal pigs. Soc. for Neurosci. Abstr. 453.5

50. Ng, T.-F., Young, M., Mwidau, A., Klassen, H., Coffey, P. (2003) Photoreceptor rescue, differentiation and light perception In Rhodopsin knock-out mice with transplantation of retinal progenitor cells. Soc. for Neurosci. Abstr. 453.6

51. Lavik, E., Coffey, P., Klassen, H., Warfvinge, K., Kiilgaard, J., Scherfig, E., Langer, R., Young, M. (2003) Biodegradable polymer scaffolds promote survival and differentiation of retinal progenitor cells. Soc. for Neurosci. Abstr. 697.9

52. Klassen, H., Lavik, E., Warfvinge, Langer, R., Young, M. (2003) Polymer scaffolds and stem cells in retinal transplantation. 7th US-Japan Symposium on Drug Delivery Systems Abstr. 13

53. Shamie, N., Almeda, T., Schwartz, P., Klassen, H., Kenney, M. (2004) Localization of P-63 to fluorescent GFP expressing cells in a corneal epithelial cell culture derived from cornea-scleral rim explants of GFP transgenic pig. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 1440.

54. Zahir, T., Shatos, M., Young, M., Klassen, H. (2004) Ubiquitous expression of protein kinase C (PKC) alpha by retinal progenitor cells. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 5391.

55. Klassen, H., Warfvinge, K., Kiilgaard, J., Scherfig, E., Prause, J., Shatos, M., Samuel, M., Prather, R., Young, M. (2004) Transplantation of retinal progenitor cells from GFP-transgenic pigs to the injured retina of allogeneic recipients. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 5400.

21

56. Shatos, M., Klassen, H., Schwartz, P., Doherty, J., Ziaeian, B., Kirov, I., Nethercott, H., Samuel, M., Prather, R., Young, M. (2004) Isolation of progenitor cells from the retina and brain of the GFP-transgenic pig. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 5406.

57. Klassen, H., Young, M., Schwartz, P. (2004) Human retinal progenitor cells from postmortem tissue. XVI International Congress of Eye Research.

58. Klassen, H., Young, M. (2004) Marker expression by cultured CNS progenitor cells. Vision Down Under, Fraser Island, Australia.

59. Schwartz, P., Loring, J., Derzic, S., Nethercott, H., Ziaeian, B., Kirov, I., Klassen, H. (2004) Differences among neural progenitor cell cultures determined by gene expression analysis. Soc. for Neurosci. Abstr.

7. Klassen, H. (2005) Roles for micro- and nanotechnology in retinal ganglion cell rescue and replacement. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 1087.

8. Klassen, H., Warfvinge, K., Schwartz, P., Young, M., Bragadóttir, R., Meyer, J., Nethercott, H., Kirk, M., Narfström, K. (2005) Isolation and characterization of feline neural progenitor cells and transplantation to the retina of the Abyssinian cat with hereditary rod cone degeneration. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 3218.

9. Tomita, M., Lavik, E., Klassen, H., Zahir, T., Langer, R., Young, M. (2005) Enhanced survival and differentiation into photoreceptor in retinal progenitor cells transplantation using polymer composite graft. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 3227.

a. Warfvinge, K., Schwartz, P., Kiilgaard, J., Nethercott, H., Scherfig, E., Young, M., Klassen, H. (2005) Transplantation of human neural progenitor cells to pig subretinal space. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 3228.

b. Young, M., Klassen, H., Warfvinge, K. (2005) Morphological characterization of fetal GFP transgenic pig retinal progenitor cells after subretinal transplantation to adult normal pigs. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 3251.

10. Yang, J, Wang, W, Pries, M, Ropke, C, Klassen, H., Nissen, M (2006) The role of aqueous humor in the proliferation of retinal progenitor cells Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 5739.

11. Zhang, Y., Klassen, H., Perez, M-T, Young, M. (2006) CNS progenitor cells promote a permissive environment for neurite outgrowth via an MMP-dependent mechanism. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 5751.

60. Li, S., Loudon, W., Lavik, E., Young, M., Klassen, H. (2006) Monitoring marker gene expression of stem cells cultured in biodegradable polymer scaffolds. Gordon Conference.

12. Klassen, H. (2007) Culturing progenitor cells from the mammalian retina. Asia ARVO, presentation S13.2.

61. Yang, J., Klassen, H., Pries, M., Wang, W., Nissen, M. (2007) Vitreous humor enhances the proliferation of retinal precursor cells. Asia ARVO, abstract 260.

62. Voss Kyhn, M., Kiilgaard, J., Young, M., Klassen, H., Lavik, E., Scherfig, E., Warfvinge, K., la Cour, M. (2007) Neuroprotection of ischemic injury in pig retina, Part I: The injury model. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 566.

22

63. Eftekhari, S., Voss Kyhn, M., Lavik, E., Kiilgaard, J., Klassen, H., Scherfig, E., Young, M., Warfvinge, K. (2007) Neuroprotection of ischemic injury in pig retina, Part II: Ganglion cell rescue. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 567.

64. Lavik, E., Voss Kyhn, M., Warfvinge K., Kiilgaard, J., Scherfig, E., la Cour, M., Klassen, H., Young, M. (2007) Neuroprotection of ischemic injury in pig retina, Part III--Functional assessment. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 568.

65. Redenti, S., Tao, S., Young, C., Zhang, Y., Klassen, H., Desai, T., Young, M. (2007) Retinal progenitor cells delivered on micro-machined poly(methyl methacrylate) scaffolds survive, migrate and differentiate in host retina after sub-retinal transplantation. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 4067.

66. Yang, J., Klassen, H., Pries, M., Wang, W., Nissen, M. (2007) Vitreous humor enhances the proliferation of retinal precursor cells. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 4075.

67. Narfstrom, K., Warfvinge, K., Schwartz, P., Young, M., Tullis, G., Eftekhari, S., Hamm C., Hainsworth, D., Klassen, H. (2007) Integration of feline neural precursor cells after subretinal transplantation into Abyssinian cats affected with hereditary retinal degeneration. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 4064.

68. Aftab, U., Jiang, C., Klassen, H., Miljan, E., Sinden, J., Young, M. (2007) Isolation, growth kinetics and differentiation of human retinal progenitor cells in culture. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 4076.

69. Steedman, M., Tao S.L., Klassen, H., Desai, T. (2007) Biodegradable thin film scaffolds for retina. Biomedical Engineering Society, Annual Fall Meeting.

70. Tucker, B., Redenti, S., Klassen, H., Smith, M., Wnek, G., Young, M. (2007) Delivery of active matrix metalloproteinase-2 via a biodegradable polymer induces degradation of inhibitory ECM molecules and enhanced stem cell migration. Pacific Ocular Regenerative Biology Conference.

71. Redenti, S., Tao, S., Klassen, H., Desai, T., Young, M. (2007) Tissue engineering using mouse retinal

progenitor cells and a novel biodegradable poly(-caprolactone) nanofiber scaffold. Pacific Ocular Regenerative Biology Conference.

72. Jiang, C., Klassen, H., Young, M. (2007) Reconstruction of outer retina following retinal laser injury by retinal progenitor cell transplantation. Pacific Ocular Regenerative Biology Conference.

73. Aftab, U., Jiang, C., Klassen, H., Miljan, E., Sinden, J., Young, M. (2007) Isolation, growth kinetics and differentiation of human retinal progenitor cells in culture. Pacific Ocular Regenerative Biology Conference.

74. Gu, P., Yang, J., Young, M., Klassen, H. (2008) Sequential changes in the gene expression profile of retinal progenitor cells during the induction of differentiation. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 3560.

75. Yang, J., Gu, P., Tao, S., Desai, T., Klassen, H. (2008) Sequential quantitative profiling of porcine CNS progenitor cells on biodegradable nanowire scaffolds. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 4777.

a. Jiang, C., Klassen, H., Zhang, X., Young, M. (2008) Repopulation of outer retina following retinal laser injury by retinal progenitor cell transplantation. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 3556.

23

b. Tucker, B., Redenti, S., Klassen, H., Smith, M., Wnek, G., Young, M. (2008) Enhanced progenitor cell integration following transplantation of progenitor cell/MMP2-polymer constructs. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 3567.

c. Schmitt, S., Aftab, U., Jiang, C., Tucker, B., Stevanato, L., Chander, S., Miljan, E., Sinden, J., Klassen, H., Young, M. (2008) Molecular characterization and transplantation of human retinal progenitor cells. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 3571.

76. Klassen, H. (2008) Transplantation of CNS progenitor cells to the mammalian retina. International Molecular Medicine Tri-Conference, Stem Cell Congress, San Francisco, 2008

13. Klassen, H. (2008) Stem Cell Transplants in Animal Models of Retinal Degeneration. World Congress of Ophthalmology, Program on New Technology: Bioengineering/Nano-technology.

77. Klassen, H. (2008) Cultured Retinal Progenitor Cells. World Congress of Ophthalmology, Program on Immunology, Molecular Biology and Genetics.

78. Gu, P., Yang, J., Young, M., Klassen, H. (2008) Quantitative changes in the gene expression profile of murine retinal progenitor cells during early differentiation. XVIII International Congress of Eye Research.

79. Yang, J., Gu, P., Tao, S., Desai, T., Klassen, H. (2008) Quantitative changes in the gene expression of porcine CNS progenitor cells cultured on nanowire scaffolds. XVIII International Congress of Eye Research.

80. Klassen, H. (2008) Cultured CNS progenitors in animal models of retinal disease. XVIII International Congress of Eye Research.

81. Yang, J., Gu, P., Klassen, H. (2009) CNTF induces rapid expression of neuronal and glial transcripts in cultured porcine retinal progenitor cells. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 1266.

82. Gu, P., Yang, J., Lee, Y.-S., Narfstrom, K., Kong, I.-K., Klassen, H. (2009) Isolation, proliferation, and characterization of retinal progenitor cells from domestic and RFP-transgenic cats. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 5137.

83. Wang, J.-M., Yang, J., Gu, P., Young, M., Klassen, H. (2009) The proliferation of murine retinal progenitor cells is fundamentally dependant on EGF yet relatively independent of GDNF. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 1272.

14. Redenti, S., Neeley W., Rampani, S., Yang, J., Klassen, H., Langer, R.,Young, M. (2009) Engineering retinal progenitor cell and scrollable poly(Glycerol-Sebacate) composites for expansion and subretinal transplantation. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 2409.

15. Ejstrup, R., Kiilgaard, J., Tucker, B., Klassen, H., Young, M., la Cour, M. (2009) Pharmacokinetics of intravitreal glial cell line-derived neurotrophic factor: experimental studies in pigs. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 6234.

16. Jiang, C., Aftab, U., Klassen, H., Zhang, X., Young, M. (2009) Human retinal progenitor cells integrate as photoreceptors after transplantation into the subretinal space of mice. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 1289.

17. Tucker, B., Park, I.H., Klassen, H., Redenti, S., Jiang, C.H., Qi, S., Daley, G., Young, M. (2010) Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in retinal degenerative mice. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 1233.

http://www.arvo.org/

24

18. Yang, J., Gu, P., Klassen, H. (2010) Molecular characterization of human retinal progenitor cells during long term culture. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 2649.

19. Wang, J., Yang, J., Klassen, H. (2010) GDNF augments proliferation and reduces apoptosis of murine retinal progenitor cells. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 2650.

20. Narfstrom, K., Yang, J., Lewis, G., Bragadottir, R., Luna, G., Fisher, S., Whiting, R., Kong, I., Klassen, H. (2010) Development of Müller-like cells after subretinal transplantation of feline red fluorescent retinal progenitors in Abyssinian cat hereditary retinal degeneration. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 3148.

84. Klassen, H. (2010) Progenitor-based delivery of neurotrophic factors for photoreceptor degenerations. XIX Biennial Meeting of the International Society for Eye Research. Abstract number O330.

21. Yang, J., Wang, J., Checa, P., Molina-Martinez, I., R Herrero-Vanrell R., Klassen, H. (2011) Effects of Glial Cell Line-Derived Neurotrophic Factor (GDNF) releasing Poly Lactic-co-Glycolic Acid (PLGA) microparticles on retinal progenitor cells (RPCs). Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 2245.

22. Kamjoo, S., Sharma, V., Yang, J., Checa, P., Molina-Martinez, I., Herrero-Vanrell, R., Limb, G.A., Klassen, H., Kenney, M.C., Kuppermann, B. (2011) Glial Cell Line-Derived Neurotrophic Factor (GDNF) Enriched Poly Lactic-co-Glycolic Acid (PLGA) Microspheres Suppress Apoptosis In Vitro. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 4443.

23. Yang, J., Klassen, H. (2012) Effects of clinically relevant agents on human retinal progenitor cells (hRPCs) in culture: a pre-clinical cytotoxicity study. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 5918.

24. Yang, J., Lewis, G., Lu, B., Turovets, N., Luna, G., Girman, S., Bauer, G., Fisher, S., Wang, S., Klassen, H. (2012) Retinal progenitor cells for treatment of retinitis pigmentosa. 2nd Cedars-Sinai Regenerative Medicine Scientific Symposium.

85. Yang, J., Lewis, G., Lu, B., Turovets, N., Luna, G., Girman, S., Bauer, G., Fisher, S., Wang, S., Klassen, H. (2013) Retinal progenitor cells for treatment of retinitis pigmentosa. CIRM Grantee Meeting.

86. Klassen, H. (2013) Cell-based therapeutics for the retina. 10th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT) Clinical, Paris.

87. Klassen, H. (2013) Transplantation of retinal progenitor cells in photoreceptor degenerations. American Society of Cataract and Refractive Surgery, Innovators at the ASCRS Symposium.

25. Yang, J., Lewis, G., Lu, B., Turovets, N., Luna, G., Girman, S., Bauer, G., Fisher, S., Wang, S., Klassen, H. (2013) Translational development of human retinal progenitor cells for treatment of retinitis pigmentosa. Association for Research In Vision and Ophthalmology, Annual Meeting, accessed at www.arvo.org, abstract 2237.

88. Klassen, H. (2014) Retinal Progenitor Cell Transplantation for Treatment of Retinal Degeneration. 11th Annual International Symposium in Ocular Pharmacology and Therapeutics (ISOPT) Clinical, Reykjavik.

89. Klassen, H. (2014) Stem Cells as Therapeutic Agents for Retinal Degeneration: Clinical Trials. 11th Annual International Symposium in Ocular Pharmacology and Therapeutics (ISOPT) Clinical, Reykjavik.

90. Yang, J., Lewis, G., Lu, B., Turovets, N., Luna, G., Girman, S., Bauer, G., Fisher, S., Wang, S., Klassen, H. (2014) Retinal progenitor cells for treatment of retinitis pigmentosa. 2014 Pathways to Cures: Clinical Translational Research Day at UCI, Poster Session Abstracts, University of California, Irvine.








dr. klassen's cv

Documents