dr david keegan - agm 2011 - dccr overview
DESCRIPTION
Dr David Keegan gives an overview of the Dublin Centre for Clinical Trails at the Fighting Blindness AGM - Oct 1, 2011TRANSCRIPT
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DCCRDublin Centre for Clinical Research
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Wellcome Trust – HRB Dublin Centre for Clinical
Research
01 October 2011
By
David KeeganChair of Ophthalmology Division of
DCCR
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DCCRDublin Centre for Clinical Research
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• In 2006 three Dublin Medical Schools (TCD, RCSI and UCD) responded to a Wellcome Trust call to fund clinical research infrastructure.
• Dublin application scored second and this resulted in €23M in funding from the Wellcome Trust and Health Research Board:– ~€10m the development of a Clinical Research Centre (CRC) at
St. James’s Hospital
– Five years operational funding (~€13m) for DCCR Network and St. James’s Hospital Clinical Research Facility
About the Dublin Centre for Clinical Research (DCCR)
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DCCRDublin Centre for Clinical Research
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Transformation of clinical research in Dublin through development of physical, human resource and administrative infrastructure for safe, ethical and excellent patient-focused research
DCCR’s Vision
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DCCRDublin Centre for Clinical Research
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Components of Vision
• Excellence in research• Up-skilling and enlargement of research nursing and
clinician scientist pool• Provision of a clinical research IT Infrastructure• Streamlining inter-institutional research protocols• Integration of research programmes with clinical
research infrastructure• Completion of Dublin’s clinical research facility
infrastructure with the construction of a CRC at St. James’s Hospital
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DCCRDublin Centre for Clinical Research
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DCCRDublin Centre for Clinical Research
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Research Nursing Development:• Recruitment of Network Research
Nurses – 8 Network Nurses Now in Place
• Common GCP Training – 4 courses in 2009 and 5 courses in 2010
• Certificate Course in Research Nursing – 12 candidates 2009- 10 candidates 2010
• Revival of Irish Research Nurses Network
• Further post graduate education for nurses and other clinical research
DCCR’s Research Network Infrastructure
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DCCRDublin Centre for Clinical Research
Information Technology Infrastructure
• Professional IT Manager (John McCourt) started in April 2009
• IT function has a cross institutional mandate
• IT Priority: IT that supports multisite clinical research activities:
• Study Management
• eCRF
• Sample tracking
• Research Ethics
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DCCRDublin Centre for Clinical Research
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Wellcome Trust – HRB Clinical Research Facility at St. James’s Hospital
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DCCRDublin Centre for Clinical Research
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Wellcome Trust – HRB Clinical Research Centre at St. James’s Hospital
Neurophysiology Suite (EEG)
CAMI 3T MRI
Exercise Physiology
Lab
Six Bed Unit
Four Isolation Rooms
Gene Therapy
Pharmacy
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DCCRDublin Centre for Clinical Research
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• Ophthalmology – David Keegan• Registry of Patients with Severe Retinal Dystrophy
• Diabetes Group – John Nolan– GUIDANCE Study (EASD) – completed with 946+ patients recruited by 17 Consultants
• Respiratory Medicine Group – Michael Keane• IPF/Sarcoidosis – Bio – repository - 215+ patients recruited to date
• Device for Asthma Patients – Going through ethics for six hospital sites
• Gastroenterology Group – Ross McManus• Coeliac Disease DNA collection – ongoing – 200 + samples collected in 9 months
• Barrett’s Oesophagus – Invited to participate in WT Case Control Consortium
• Inflammatory Skin Disease – Alan Irvine• WT and Children’s Research Foundation funding for international collection of 4000 samples from
Children with Eczema to start in 2010
• Neuropsychiatry – Michael Gill• Extension of Wellcome Trust Case Control Consortium Study of patients with psychosis
• Prostate Cancer Research Consortium – Mark Lawler• Continued investigation of potential biomarkers
• Infectious Diseases (HIV/TB) – Paddy Mallon/Colm Bergin• Latent TB Incidence, HIV and TB and TB immunity and Vitamin D (studies in planning)
• Neurodegeneration – Hardiman• Registry for Young Onset Neurodegeneration
DCCR’s Clinical Research Networks
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DCCRDublin Centre for Clinical Research
Ophthalmology and the DCCR
• An important part of DCCR strategy• To integrate existing registers while
designing new items• To develop the regulatory strategy• Successful gene therapy trials in
eye disease• Develop more novel treatments 1
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DCCRDublin Centre for Clinical Research
Progress to Date
• Commenced process for ethical approval for specific registers to identify patients with inherited retinal disease
• Modular fashion• Ethical approval and CRF
developed• First three clinics have taken place
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DCCRDublin Centre for Clinical Research
The Team
• Jeremy Townes• John McCourt• Marie Burke• Paul Kenna• Jane Farrar• Andrew Greene• Avril Daly• Anna Moran 1
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DCCRDublin Centre for Clinical Research
Next Phase
• Build numbers• Collate the various registers that
exist• Expand and include more
comprehensive information
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DCCRDublin Centre for Clinical Research
Regulation
• Experience of other groups• Major stumbling black• There for a reason• Safety • Pathway to therapy
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DCCRDublin Centre for Clinical Research
Therapy
• Gene Therapy• Neuro-protectants• Retinal implants• Stem cells
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DCCRDublin Centre for Clinical Research
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Any Questions