Download - Ross Lab - Biophysics
Ross Lab - BiophysicsCytoskeleton: Rich Biological System
of Interesta) Microtubules Shape the Cell
b) Motor Proteins Move Objects and Microtubules
c) Microtubule regulation through modifications and motor proteins
1. Microtubule Motors Traffic ProblemsDynein, Kinesin, Eg5, MAPs
Using Total Internal Reflection Fluorescence (TIRF) Microscopy
Optical trapping of motors to measure force
2. Microtubule Severing EnzymesKatanin, Spastin, Fidgetin
Using TIRF microscopy
March of Dimes Funded
3. Microtubule MechanicsStability, Flexibility, Structural Studies
NSF funded
Ross, et. al., Biophysical Journal 2008
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10 m
Green = MicrotubulesBlue = DNA
Website: www.people.umass.edu/rossj
Email: [email protected]
Ross Lab - Biophysics
1. Biochemistry and Molecular Biology:
Protein Design, Purification, and Characterization
2. Microscopy:
Epi-fluorescence, TIRF, electron microscopy, AFM
3. Analysis:
Image analysis, MATLAB analysis, measure velocity, intensity, Fourier modes
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BioBootCamp 2010
