Download - Pedigrees ppt notes full
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UNIT 7 DAY 6
Pedigrees
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TODAY’S PROBLEM What information does a family tree show?
Answer what do you think in 1 – 2 sentences
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REVIEW: WHAT ARE THE TYPES OF CHROMOSOMES?
Karyotype pictureAutosomal: Chromosomes 1-22
Sex: X and Y chromosomes, determine whether a person is a male or female
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KP1: WHAT ARE GENETIC DISORDERS?
Genetic disorders are diseases caused by mutations in DNA in gametes
These disorders are passed down from parent to child
Different disorders have different modes of inheritance
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KP2: WHAT ARE MODES OF INHERITANCE?
The way something is passed down from parent to offspring
There are three main modes of inheritance
1. Autosomal dominant—only need one copy of a gene to be affected
2. Autosomal recessive—need two copies of the gene to be affected
3. Sex-linked recessive—gene is on the X chromosome, need 2 copies to be affected (UNLESS MALE—only need 1, b/c only have 1 X chromosome)
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CHECK
What mode of inheritance is this showing???
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KP3: WHAT IS A PEDIGREE AND HOW DO I INTERPRET IT?
A Pedigree is a chart or family tree that traces the inheritance of a trait.
Females are always circles, males are always squares Half-shaded = carrier of gene
(but not affected) Solid shaded = affected
Each horizontal line represents a generation.
Children will always appear on a line directly below their parents.
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CHECK
Circle a carrier Square a male Star an affected person
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KP4: HOW CAN I USE A PEDIGREE TO DETERMINE MODES OF INHERITANCE?
You can use clues in the pedigree to determine mode of inheritance
1. If… Autosomal dominant All generations affected, no carriers! Equal number of males and females affected
2. If… Autosomal recessive Generations are skipped Equal number of males and females affected
3. If… Sex-linked recessive Generations are skipped Female carriers only More males are affected
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KP5: WHAT ARE THE STEPS TO SOLVE A PEDIGREE PROBLEM?
Step 1: Are generations skipped? Yes=recessive, No=dominant
Step 2: Are there carriers? Yes=recessive, No=dominant
Step 3: If “Yes=recessive”
Are more men affected? Yes=sex-linked, No=autosomal
Are there only female carriers? Yes=sex-linked, no=autosomal
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KP6: HOW DO I PREDICT THE GENOTYPE OF INDIVIDUALS IN A PEDIGREE? Determine mode of inheritance shown in
pedigree Determine genotype options (BB, bb, or
Bbcarrier) Use children as clues
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EXAMPLE
What is the mode of inheritance ? What are my options? Are generations skipped? Are there carriers? Are more men affected? Are there only female carriers?
?
SEX-LINKED RECESSIVE!