Download - Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

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Page 1: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Nanotechnology

Page 2: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Outline

Page 3: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

3

What is nano?

Page 4: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

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Evolving landscapes

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Nanoproducts

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Nanotechnology

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Page 7: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Benefits

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Page 8: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Immunotherapy Toxicity

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Vaccines

Page 10: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Toxicity

Page 11: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Immune system

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Bidirectional communication

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Particle size

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Protein binding

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Biodistribution

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MPS uptake

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Hemolysis

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Hemolysis

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Coagulation system

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Undesirable effects

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Zeta potential

Page 22: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Platelets

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Allergenicity

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Allerginicity Complement activation

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Allergenicity

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Cytokine storm

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Carrier properties

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IL-8 induction

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IL-1 Immunogenicity

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API properties

Page 31: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Immunogenicity

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Anti-PEG antibody

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Future directions

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Take home message

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Acknowledgements

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CANCER AND BIOTECHNOLOGY

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