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Page 1: Major IngredientsIngredients help in the treatment and management of all types of liver disorders Used as a prophylatic for the protection of liver Manages liver disorders Major Ingredients

LIVOKOT

Combination of herbal ingredients havinghepatoprotective activity

Ingredients help in the treatment and management of all types of liver disorders

Used as a prophylatic for the protection ofliver

Manages liver disorders

Major Ingredients

Swertia chirata Well known for its liver-protective properties

Piper longum A good rejuvenator that soothes and relieves from pain and inflammation. It is also a potent bioenhancer

Life is Complete when

LIVER IS SAFE

Dosage: 1 tablet thrice daily or as direted by the physician

Add Livokot, Add life...Liver Disorders

Phyllanthus niruri Used to protect liver, helpful in treating jaundice and actsas a potent liver detoxifier

TABLET

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Page 2: Major IngredientsIngredients help in the treatment and management of all types of liver disorders Used as a prophylatic for the protection of liver Manages liver disorders Major Ingredients

Swertia chirata

Phyllanthus niruri

Piper longum

“The protective effect observed against two hepatotoxins (paracetamol and galactosamine) which are different in their mechanisms of inducing hepatotoxicity, suggests broader and non-specific protection of the liver against these two toxins by

1non-bitter components of Swertia chirata” .

“Aqueous extraction of the intact plant provided an acidic arabinogalactan, which was characterized chemically, and its effects on peritoneal macrophage activation were determined. In immunological studies, the arabinogalactan stimulated superoxide anion production, when tested using peritoneal macrophages of mice, but did not interfere with the nitric oxide pathway. Thus, traditional aqueous extraction methods, such as decoction and infusion, provide a major polysaccharide,

2 which stimulates an intense biological response in macrophages” .The beneficial use of phyllanthus niruri in the treatment of 3 4Kamala has been described in Arogyakalpadrumam , Sahasrayogam .

“Following CCl(4) administration hydroxy proline (HP) was significantly increased and serum enzyme levels were elevated. Treatment with the ethanol extract of Piper longum Linn. reduced the HP and also the serum enzymes. The liver weight that increased following CCl(4) administration due to the deposition of collagen was reduced by the ethanol extract. Hence, it is

5concluded that this extract inhibits liver fibrosis induced by CCl(4)” . The use of Drakshadi leham having piper longum as an 6ingredient in treating Kamala has been described in Ashtangahridaya Pandurogachikitsa .

1. Phytotherapy research PTR (1999) Volume: 13, Issue: 2, Pages: 95-101 Antihepatotoxic activity of Swertia chirata on paracetamol and galactosamine induced hepatotoxicity in rats. M Karan, K Vasisht, S S Handa

2. J Nat Prod. 2005 Oct;68(10):1479-83. Chemical and biological properties of an arabinogalactan from Phyllanthus niruri.Mellinger CG, Carbonero ER, Noleto GR et al. Departamento de Bioquimica e Biologia Molecular, Universidade Federal doParana, CP-19046, CEP-81531-990, Curitiba, PR, Brazil.

3 Arogyakalpadrumam (Paedeatric ayurveda), Sulabha books, Trissur, 6th edition, December 2002 Page No. 109, By Kaikkulangara Rama Varier.

4 Sahasrayogam (Vaidyapriya Vyaghyanam) Sree Ramavilasam Press & Book Depot. Kollam, 8th edition, 1968, page No. 98, 99By Velayudha Kurup

5. Phytomedicine 2006 Feb;13(3):196-8. Epub 2005 Jun 24.Inhibition of CCl4-induced liver fibrosis by Piper longum Linn.?Christina AJ, Saraswathy GR, Robert SJ, Kothai R, Chidambaranathan N, Nalini G, Therasal RL.Department of Pharmacology, KM College of Pharmacy, Uthangudi, Madurai, Tamil Nadu, India.

6 Ashtangahridayam, Chaukhambha Sanskrit Series, Varanasi, Reprint 2000. Dr. Anna Moreswar Kunte (Demonstrator of Anatomy,Grant Medical College) & Krishna Ramachandra Shastri Navre page No. 703

References

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LIVOKOTTABLET

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