Management of
Common Common
Fungal Skin Infections
• Superficial fungal infections of
the skin are one of the most
common dermatologic
conditions seen in clinical conditions seen in clinical
practice.
Fungi: Common Groups
1. Dermatophytes: Superficial Ring
worm type
2. Candida Albacans: Yeast infection2. Candida Albacans: Yeast infection
3. Pityrosporium: Yeast, present in
normal flora of skin, esp. scalp &
trunk.
CLASSIFICATION OF
FUNGAL INFECTION
1.Superficial
2.Cutaneous
3.Subcutaneous3.Subcutaneous
4.Systemic
5.Opportunistic
1. Superficial mycoses- Pityriasis versicolor – pigmented lesion
on torso (trunk of the human body). ( Dubo? )
- Tinea nigra – gray to black macular lesion
on palms.
- Black piedra – dark gritty deposits on hair.
- White piedra – soft whitish granules along
hair shaft.
- All diagnosed by microscopy and easily
treated by topical preparation.
2. Cutaneous infections
• Infections of skin and its appendages (nails, hair)
20 Spp. of dermatophytes cause • 20 Spp. of dermatophytes cause ringworm.
3. Subcutaneous mycoses
-Subcutaneous infections, over 35 spp.
Produce chronic inflammatory disease
of subcutaneous tissue & lymphatics, of subcutaneous tissue & lymphatics,
e.g. sporotrichosis (Ulcerated lesion at
site of inculasion followed by multiple
nodules)
4. Systemic fungal infections
- Uncommon: if Natural immunity is high
- Physiologic barriers include:
- Skin and mucus membranes
- Tissue temperature: fungi grow better at- Tissue temperature: fungi grow better at
less than 37°C
5. Opportunistic Mycoses
- Do not normally cause disease in healthy people.
- Cause disease in immuno-compromised people.
- Weakened immune function may occure due to:
▪ Inherited immunodeficiency disease▪ Inherited immunodeficiency disease
▪ Drugs that suppress immune system:
cancer chemotherapy, corticosteroids, drugs
to prevent organ transplant Rejection.
▪ Radiation therapy
▪ Infection (HIV)
▪ Cancer, diabetes, advanced age and mal-nutrition.
Most common opportunistic mycotic
infections: (commonly seen in PLWHA)
1. Candidiasis
2. Aspergillosis2. Aspergillosis
3. Cryptococcosis
4. Zygomycosis/mucormycosis
5. Pneumocystis carinii
Superficial Fungal
Infections
• Tinea infections• Tinea infections
TINEA Infection
• T.Corporis- ringworm of body
• T.Cruris- groin• T.Cruris- groin
• T.Pedis- foot
• T.Unguium- nail
• T.Capitis scalp
T.Corporis (ring of the body)
• Superficial skin infection
• Itchy
• Annular patch (ring shaped)• Annular patch (ring shaped)
• Well defined edge
• Scaling more obvious at
edges(central clearing)
Tinea Corporis
Tinea corporis – body ringworm
Tinea corporis
Tinea Corporis Tinea of the face
Psoriasis Tinea corporis(Scaly lesion)Psoriasis (for differential diagnosis)
Tinea corporis(Scaly lesion)
TineaManum (hand) Tinea Corporis
• Often assoc with T.pedis
• “Jock itch”
TINEA CRURIS (groin)
• “Jock itch”
• Tight hot sweaty groin e.g. athletes, obese
• Infection of groin, genitalia, perinium
Tinea Cruris – Jock Itch
Tinea Pedis –
Athlete’s Foot Infection
Tinea Pedis�Clinical features
• Dermatitis
• Peeling • Peeling
• Maceration
• Fissuring
Sites
Toe clefts
Tinea Unguium – Nail Infection
Tinea Unguium (nail)
1. Disto-lateral
subungual
onychomycosis
1
onychomycosis
2. Superficial white
onychomycosis
3. Total dystrophic
onychomycosis
2
3
Regimes-Tinea Unguium
• TERBINAFINE
– Terbinafine250mg od
• ITRACONAZOLE• ITRACONAZOLE
– Pulse rx Itraconazole - 1wk/mth 200mg bid
– Itraconazole 200mg od
• FLUCANAZOLE
– Fluconazole 150mg once weekly
T.Pedis
TINEA CAPITIS - KERION
Ringworm of the scalp
TINEA CAPITIS – Black dot
Tinea Capitis
Tinea Capitis
Gray Patch
Rx-Tinea Capitis
• MUST use oral Rx- prolonged course
–Griseofulvin-20mg/kg/od x 6-8/52 –Griseofulvin-20mg/kg/od x 6-8/52
Terbinafine-250mg od x 4/52
–Flucanazole-50mg-150mg/wk x 4-6/52
Rx-Tinea Capitis
Adjunctive Measures
• Shampoo- antifungal/ antiseptic/antidandruff
• Antibiotics
• NO STEROIDS
Other Fungal InfectionsOther Fungal Infections
Tinea Manuum
�Dry hyperkeratotic
Palmer aspect
Dorsal aspect
Tinea Barbae
Tinea Faciei
• Infection of the
skin of the face
excluded excluded
moustache &beard
areas
Peri-oral dermatophytosis
Investigation:
- Microscopy of scrapings
KOH preparation and looking KOH preparation and looking for the fungal elements from skin scraping, nail or hair.
Management
• General Measures
• Non-specific Keratolytics
-eg Whitfield’s ointment
Specific Antifungal Rx
• Griseofulvin
• Azoles-
-Imidazole eg ketoconazole (liver toxicity: oral prep)
topical prepstopical preps
-Triazole eg itraconazole,fluconazole
• Allylamines eg terbinafine, naftifine
TOPICAL Rx
• Localized disease of skin
– extend rx for 3-5/7 after apparent cure
– 1% clotrimazole less effective
• Sprays & solutions
– tinea pedis /hairy areas
• Limited nail disease
– Batrafen nail lacquer
ORAL Rx• Extensive disease
• Nail disease
• Tinea Capitis
FDA approved drugs for empirical therapy
Drug Dosing regimen used in controlled trials
Ampho B 0.6 – 1.0 mg/kg/day (IV)
__________________________________________________
Liposomal 3 mg/kg/day (IV)
Ampho B
For Systemic Fungal Infections
Ampho B
________________________________________________
Itraconazole 400 mg/day/or two days then 200 mg/d for
5-12 days (IV), followed by oral solution
400 mg/day for 14 days
__________________________________________________
Caspofungin 70 mg day 1, then 50 mg/daily
In BPKIHS D-OPDCOMMON FUNGAL PROBLEMS: All types
Rx: prescribed:
1. Hygiene teaching.
2. Antifungal: 2. Antifungal:
a. Topical: Ketaconazole, Clotrimazole,
Butrinazole
b. Oral: Fluconazole, Ketaconazole, itrazole
Thank YouThank You
7. Yeasts• Pityrosporum.
• Candida.
• Ordinarily commensals.
• Can become pathogens under favourable conditions.
Pityriasis Versicolor
• Asymptomatic
scaly maculeshypopigmented
• Chest, back, face
P.Versicolor• Hyperpigmented
Like Dubi
Pityriasis Versicolor
8. Tinea Versicolor
(In Head)(In Head)
Dandruff
Tinea Versicolor
�Skin infection caused by a yeast
�Warm and humid environment
Tinea Versicolor� S/S
- oval or irregularly shaped spots
- pale, dark , or pink in color
- sharp border- sharp border
- itching, worsens with heating and
sweating
� Tx
- Topical antifungal medications
Management• Many Rx
• No Rx eradicates yeast permanently
• NONSPECIFIC
• Keratolytics • Keratolytics
– whitfield onit, sulphur
• Antiseptics
– selenium sulphide, Na thiosulphate
Antifungal Rx
Azoles-oral/topical
• Ketoconazole 200mg od x7
• Itraconazole 200mg od x 7• Itraconazole 200mg od x 7
• Fluconazole 300mg-400mg stat
• Terbinafine tabs for P.V
9. Candidiasis
o Candida sp- commensal of GIT
o Precipitating Factors
�Endocrinopathy�Endocrinopathy
�Immunosuppression
�Fe/Zn deficiency
�Oral antibiotic Rx
o Oropharyngeal candidiasis is marker for AIDS
Candidiasis
• Oropharnygeal
• Candidal intertrigo-breasts, groin
• Chronic Paronychia - nail fold infection• Chronic Paronychia - nail fold infection
• Vaginitis/balanitis
Risk Factors for Candidiasis:
▪ Post-operative status
▪ Cytotoxic cancer chemotherapy
▪ Antibiotic therapy▪ Antibiotic therapy
▪ Burns
▪ Drug abuse
▪ GI damage
Candidal Intertrigo
• Moist folds
• Erythematous patch • Erythematous patch
with satellite lesions
Management
• Rx underlying disorder
• Reduce moisture-
– Wt loss, cotton underwear
– Absorbent/antifungal powder eg Zeasorb AF
• Rx partner in recurrent genital candidiasis• Rx partner in recurrent genital candidiasis
• Rx-Nystatin
Azoles
• Oral antifungal (itraconazole): immune suppressed
10. Chronic Paronychia
• Infection of nail fold
• Wet alkaline work
Excess manicuring
• Damage to cuticle • Damage to cuticle
• Swelling of nail fold
(bolstering)
• Nail dystrophy
Chronic Paronychia
• Keep hands dry /Wear gloves
• Long term Rx
• Oral Azoles
• Antifungal solution-(high alcohol content)• Antifungal solution-(high alcohol content)
• +/-Broad spectrum antibiotics-cover staph
Rx Summary
• Tinea capitis should be treated with
systemic therapy.
• Griseofulvin in a dose of 10-20 mg per
kg for six weeks to 8weeks is the first-kg for six weeks to 8weeks is the first-
line treatment of Tinea capitis.
• Ketoconazole 2-4mg per kg for ten
days, itraconazole and terbinafine
(Lamisil) are good alternatives.
• Griseofulvin should be taken after fatty meal.
• Topical treatment can be added to decrease
the transmission and accelerate resolution.
• Whitefield ointment is preferred in the
absence of secondary bacterial infection.
• Other family members should also be • Other family members should also be
examined and treated.
• Small and single lesion can be treated with
topical agents. Clotrimazole 1%, ketoconazole
2%, meconazole 1%. BID for two weeks
• Systemic: ketoconazole 2-4mg per kg
of weight for 10 days. Itraconazole and
fluconazole are choices if available.
Griseofulvin is also effective for the Griseofulvin is also effective for the
treatment of Tinea corporis.
• Topical anti fungal creams or
ointments applied regularly for 4 - 6
wks.
• Systemic treatments provide better skin
penetration than most topical preparations,
Itraconazole, terbinafine and griseofulvin
are good choices for oral therapy.
• Itraconazole and terbinafine are more
effective than griseofulvin. Once-weekly effective than griseofulvin. Once-weekly
dosing with fluconazole is another option,
especially in noncompliant patients.
• Personal hygiene (foot hygiene) is highly
advised.
Thank YouThank You