Magnesium for aneurysmal SHA: panacea or illusion?

EBS presentation 26/07/2012

David Bervini, Nazih Assaad

Searchable question

• “Is i.v. MgSO4 treatment effective in improving the outcome of patient experiencing aneurysmal SAH?”

• Databases– Ovid Medline, using MeSH– Ovid EMBASE, using Emtree– Scopus using review articles and tracking references– The Cochrane Collaboration

• P Patient with aneurysmal subarachnoid haemorrhage

• I i.v. MgSO4

• C no MgSO4

• O clinical outcome

Medline VS EMBASE

Search strategy

Cochrane 2008

• MgSO4 VS placebo in addition of nimodipine

National Health and Medical Research Council (NHMRC) Evidence Hierarchy

• At least 6 level II studies

• At least 10 level I reviews (including Cochrane)

Conclusion and discussion