Download - BMR, MMR, BMI? Breaking Kleiber's Law
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BMR, MMR, BMI, WTF?
-or-Breaking Kleiber’s Law
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How do we determine an accurate Basal Metabolic Rate?
■ Accounts for 60-70% of calories used per day.
■ Impacts longevity.
■ Optimal feeding for patients with disease states.
■ Athletic performance.
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Conflicting TheoriesAllometric Cascade Theory
BMR = MR0ΣC1(M/M0)
Kleiber’s Law
q0 ~ 73.3*M¾
Kleiber, M. 1961. The Fire of Life. Wiley. 454 p. Hochachka, P., et al. 2003. Allometric cascade: a model for resolving body mass effects on metabolism. Nature.doi:10.1016/S1095-6433(02)00364-1
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Strengths of Kleiber’s Law1 2
3
♀ = 1500 ♂ = 1700 = 150
Works across a wide range of species Easy to calculate
Pretty close to what we already believe
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Weaknesses of Kleiber’s Law
21
Doesn’t work well with creatures rapidly growing
Struggles to be accurate across a single species
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Strengths of Allometric Cascade Theory1
3
♂ = 1603 = 153
2
Super accurate Works well with creatures growing
Even closer to what we believe
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Weaknesses of Allometric Cascade Theory1
2
Bad Math
Really complicated
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Allometric Cascade Theory is Better Than
What we Have■ Easy enough to generalize for humans.
■ WAY better than Harris Benedict.
■ Can take into account variables such as disease states.
■ Scalable from bacteria to blue whales.
■ Easily modified to take into consideration periods of growth.