Alimentazione, fibre, stipsi
Annamaria StaianoDipartimento di Scienze Mediche
TraslazionaliUniversità di Napoli
“Federico II”
< 5%
5 - 10%
10 - 15%15 - 20%
CanadaFinland
Saudi Arabia
Japan
Brazil
USATurkey
UK
Greece
> 20%
Italy
●Hong Kong
Prevalence of constipation
van den Berg MM et al. Am J Gastroenterol 2006; 101:2401-09
Rajindrajith S. et al. J Pediatr gastr Nutr 2010; 51:472-6
Sri Lanka
Health Utilization and Cost Impact of Childhood Constipation in the United States
O Liem, J Harman, M Benninga, H Mousa, K Kelleher, C Di LorenzoJ Pediatr 2009; 154: 258-62
Children with constipation impose a significant burden on healthcare
utilization and costs
Children with constipation$ 3.430/yr
vsChildren without constipation
$ 1.099/yr
PREVALENCE AND ECONOMIC BURDEN
Journal Pediatr Gastroenterol Nutr 2014;58: 258–274
What is the definition of functional constipation?
1. Based on expert opinion, we recommend the ROME III criteria for the definition of functional constipation for all age groups.
Rasquin A et al. Gastroenterology. 2006 Apr;130(5):1527-37.Hyman PE et al. Gastroenterology. 2006 Apr;130(5):1519-26.
Suzanne M. Mugie et al. Rev. Gastroenterol. Hepatol. 8, 502–511 (2011)
Causes and risk factors for childhood constipation
Functional Constipation (90% - 95%)
Most commonly used initial interventions
Without FIWith FI
? ??
Yang CH, Punati J. JPGN 2015
Journal of Pediatric Gastroenterology and Nutrition 2003 36:329–337
LE FIBRE ALIMENTARI INSOLUBILI
CELLULOSA, LIGNINA, EMICELLULOSAsi comportano prevalentemente come
agenti di rigonfiamento in relazione alla loro
CAPACITÀ DI ASSORBIRE ACQUA
PECTINE, GOMME, MUCILLAGINI
il parametro responsabile dell’effetto
funzionale è
la FERMENTABILITÀ
LE FIBRE ALIMENTARI SOLUBILI
CELLULOSA Polimeri non ramificati del glucosio
Cereali integrali, verdura legumi, frutta
Trattiene acquaAumenta massa fecaleDiminuisce transito intestinaleLega i sali biliari
EMI-CELLULOSA
Polimeri di esosi Cereali integrali, verdura, legumi, frutta
Trattiene acquaAumenta massa fecaleDiminuisce transito intestinaleLega i sali biliari
LIGNINA Polimeri non saccaridici
Cereali integrali, verdura, legumi, frutta
AntiossidanteAumenta massa fecaleDiminuisce transito intestinaleLega i sali biliari
Es. CRUSCA DI FRUMENTOEs. CRUSCA DI FRUMENTO
FIBRA INSOLUBILE
PECTINA Polimeri di acido galatturonico
Frutta, patate, carote, fagioli
Aumenta il tempo di svuotamento gastrico e transito intestinaleAumenta SCFAAumento attività disaccarasica
GOMME Polisaccaridi di riserva
Avena, orzo, legumi
Aumenta il tempo di transito intestinaleDiminuisce colesteroloLegano i sali biliariFormano sostanze viscose
MUCILLAGINI Mucopolisaccaridi Avena, orzo, legumi
Aumenta il tempo di transito intestinaleDiminuisce colesteroloLegano i sali biliariFormano sostanze viscose
Es. GOMMA GUAR (Cyamopsis tetragonolubus), PECTINAEs. GOMMA GUAR (Cyamopsis tetragonolubus), PECTINA
FIBRA SOLUBILE
LA FIBRA SOLUBILEPREBIOTICO (COLONIC FOOD)
Alimento NON digeribile (dall’organismo umano) che influenza l’ospite stimolando selettivamente la crescita e/o l’attività di batteri residenti benefici nel colon producendo diversi metaboliti tra cui acidi grassi a corta catena (SCFA)
GIBSON E ROBERFROID, 1995
Journal of Pediatric Gastroenterology and Nutrition 36:329–337
Attalauri, et al. Aliment Pharmacol Ther 2011
The laxative effects a combination:
• sorbitol (14.7g ⁄ 100g)• dietary fiber (6g ⁄ 100)• polyphenols (184 mg ⁄ 100g) • exact mechanism has not been
established
Prunes (dried plums) are high in fibre and are perceived to promote healthy gastrointestinal (GI) function.
In constipation, prunes appear superior to psyllium for improving stool frequency and consistency, however, the evidence for other outcomes and the effects in non-constipated subjects is weak.
Although prunes may be a promising intervention for the management of constipation and increasing stool weight, this needs to be confirmed by further rigorous research.
Lever E et al. Aliment Pharmacol Ther. 2014 Oct;40(7):750-8.
• Kivia powder containing Zyactinase™ is a freeze-dried powder from kiwifruit (Actinidia deliciosa var. Deliciosa) containing the enzyme actinidin, plant polyphenols, dietary fiber, carbohydrates, and oligosaccharides.
Pediatrics 1962
Udani JK1, Bloom DW. Nutr J. 2013 Jun 8;12:78
Udani JK1, Bloom DW. Nutr J. 2013 Jun 8;12:78
• In this randomized, doubleblind, placebo-controlled study, we examined the effects of Actazin and Gold, kiwifruit derived nutritional ingredients, on stool frequency, stool form, and gastrointestinal comfort in healthy and functionally constipated (Rome III criteria for C3 functional constipation) individuals
• In the healthy cohort the Actazin-H and Gold interventions significantly increased the mean daily bowel movements compared with the washout.
• In a subgroup analysis of responders in the healthy cohort, Actazin-L, Actazin-H, and Gold consumption significantly increased the number of daily bowel movements by greater than 1 bowel movement per week.
• This study demonstrated that Actazin and Gold produced clinically meaningful increases in bowel movements in healthy individuals.
Ansell J et al. Nutr Res. 2015 Apr 11.
• Rhei rhizoma-based Japanese herbal medicines (JHMs) including Daiokanzoto and Mashiningan, and Kenchuto-based JHMs including Keishikashakuyakuto and Daikenchuto, which coordinate the motility of the alimentary tract.
Shimoyama T, et al. J Gastroenterol Hepatol 2015
Lizuka N & Hamamota Y, Frontiers in Pharmacol 2015
Rhei Rhizoma (rhubarb)•Dianthrone glucosides (sennosides A to F) and anthraquinones
Daikenchuto•Ginger, Ginseng Radix Rubra, Zanthoxyli Fructus and Saccharum Granorum (maltose powder derived from rice)
•Has been successfully used to treat postoperative ileus since it stimulates peristalsis of the gastrointestinal tract
Effect of Vegetables and Whole Grain Powder That Is Rich in Dietary Fibers on Bowel Functions and Defecation in
Constipated Young Adults
• 51 subjects were supplied with rice flakes-powder (RFP)
• 45 subjects in the VP group (whole grain, chicory (inulin↑), and broccoli) were provided with 30 g of VP twice daily for 4 weeks
Woo H-I, et al. J Cancer Prev 2015
• In addition, significant differences between RFP and VP groups in stool hardness, amount, sensation of incomplete evacuation, and straining to defecate at day 14 and 28 of experimental diet
A Randomized, Prospective, Comparison Study of a Mixture of Acacia Fiber, Psyllium Fiber and Fructose (AFPFF) versus Polyethylene Glycol
3350 with Electrolytes (PEG+E) for the Treatment of Chronic Functional Constipation in Childhood
No significant difference were found between the efficacy of AFPFF and PEG+E in the treatment of children with CFC.
Both medications were proved to be safe for CFC treatment, but PEG+E was better accepted by children.
Quitadamo P. et al. J Pediatr. 2012
“Prospective evaluation of dietary treatment in childhood constipation: high dietary fiber (DF) and wheat bran intake are associated with
constipation amelioration”
High DF and bran intake are feasible in constipated children and contribute to amelioration of constipation
• BH and dietary data of 28 children with functional constipation defined by the "Boston criteria" were obtained at visit 1 (V1,n = 28) and at 4 follow-up visits (V2-V5, n = 80)
•At V1, median DF intake was 29.9% below the minimum recommended and at the last visit 49.9% above it
•At the last visit 21 children presented RECOVERY (REC) (improved, no complications; asymptomatic) (75%); 20 of them were asymptomatic and 18 were off washout/laxatives
Maffei HV et al. JPGN 2011 Jan;52(1):55-9
• Low fibre intake is associated with constipation. We found insufficient evidence from RCTs showing that extra fibre reduces constipation compared with placebo. We found insufficient evidence on the effects of increased fibre intake compared with lactulose.
• We found insufficient evidence from RCTs on the effects of probiotics versus placebo or versus osmotic laxatives at improving symptoms of constipation.
• Overall, many of the studies we found used different definitions and outcomes measures, and the quality of evidence was low. There is a need for further large high-quality RCTs in this condition.
Tabbers MM, Benninga MA. BMJ Clin Evid. 2015 Mar 10;2015
Tabbers MM, Benninga MA. BMJ Clin Evid. 2015 Mar 10;2015
What is the additional effect of nonpharmacological treatments in children with functional constipation?
We recommend a normal fiber intake in children with constipation.
We recommend a normal fluid intake in children with constipation.
We recommend a normal physical activity in children with constipation.
We do not recommend the routine use of prebiotics or probiotics in the treatment of childhood constipation.
Journal Pediatr Gastroenterol Nutr 2014;58: 258–274
CONCLUSIONI
Si raccomanda una normale assunzione di fibre (5g+anni d’eta’ al giorno)
Si raccomanda una normale assunzione di fluidi
Al momento mancano studi RCT che provino l’efficacia terapeutica delle fibre nella stipsi cronica funzionale
Alimentazione, fibre, stipsi
