“We suggest that early restoration of basal ganglia physiology will support the compensatory events and delay the irreversible modification of circuitry that characterizes the clinical progression of PD”
Schapira & Obeso 2006
In de novo disease, early initiation of effective therapy provides long-term benefits vs no treatment
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AkinesiaAkinesia
DyskinesiaDyskinesia
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( 0.25, 1, 2)

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