double-strand break repair-independent role for brca2 in blocking stalled replication fork...
TRANSCRIPT
![Page 1: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/1.jpg)
Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11
Katharina Schlacher, Nicole Christ, Nicolas Siaud, Akinori Egashira, Hong Wu, Maria Jasin
Cell Volume 145, Issue 4, Pages 529-542 (May 2011)
DOI: 10.1016/j.cell.2011.03.041
Copyright © 2011 Elsevier Inc. Terms and Conditions
![Page 2: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/2.jpg)
Figure 1
Cell 2011 145, 529-542DOI: (10.1016/j.cell.2011.03.041) Copyright © 2011 Elsevier Inc. Terms and Conditions
![Page 3: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/3.jpg)
Figure 2
Cell 2011 145, 529-542DOI: (10.1016/j.cell.2011.03.041) Copyright © 2011 Elsevier Inc. Terms and Conditions
![Page 4: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/4.jpg)
Figure 3
Cell 2011 145, 529-542DOI: (10.1016/j.cell.2011.03.041) Copyright © 2011 Elsevier Inc. Terms and Conditions
![Page 5: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/5.jpg)
Figure 4
Cell 2011 145, 529-542DOI: (10.1016/j.cell.2011.03.041) Copyright © 2011 Elsevier Inc. Terms and Conditions
![Page 6: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/6.jpg)
Figure 5
Cell 2011 145, 529-542DOI: (10.1016/j.cell.2011.03.041) Copyright © 2011 Elsevier Inc. Terms and Conditions
![Page 7: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/7.jpg)
Figure 6
Cell 2011 145, 529-542DOI: (10.1016/j.cell.2011.03.041) Copyright © 2011 Elsevier Inc. Terms and Conditions
![Page 8: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/8.jpg)
Figure 7
Cell 2011 145, 529-542DOI: (10.1016/j.cell.2011.03.041) Copyright © 2011 Elsevier Inc. Terms and Conditions
![Page 9: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/9.jpg)
Figure S1
Cell 2011 145, 529-542DOI: (10.1016/j.cell.2011.03.041) Copyright © 2011 Elsevier Inc. Terms and Conditions
![Page 10: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/10.jpg)
Figure S2
Cell 2011 145, 529-542DOI: (10.1016/j.cell.2011.03.041) Copyright © 2011 Elsevier Inc. Terms and Conditions
![Page 11: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/11.jpg)
Figure S3
Cell 2011 145, 529-542DOI: (10.1016/j.cell.2011.03.041) Copyright © 2011 Elsevier Inc. Terms and Conditions
![Page 12: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/12.jpg)
Figure S4
Cell 2011 145, 529-542DOI: (10.1016/j.cell.2011.03.041) Copyright © 2011 Elsevier Inc. Terms and Conditions
![Page 13: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/13.jpg)
Figure S5
Cell 2011 145, 529-542DOI: (10.1016/j.cell.2011.03.041) Copyright © 2011 Elsevier Inc. Terms and Conditions
![Page 14: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/14.jpg)
Figure S6
Cell 2011 145, 529-542DOI: (10.1016/j.cell.2011.03.041) Copyright © 2011 Elsevier Inc. Terms and Conditions
![Page 15: Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11 Katharina Schlacher, Nicole Christ, Nicolas](https://reader034.vdocuments.mx/reader034/viewer/2022052702/56649f1f5503460f94c3781a/html5/thumbnails/15.jpg)
Cell 2011 145, 529-542DOI: (10.1016/j.cell.2011.03.041) Copyright © 2011 Elsevier Inc. Terms and Conditions